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0 Td 63.194444 Tz (by ) Tj 1.011111 0 Td 58.333333 Tz (0 ) Tj 0.602778 0 Td 49.259259 Tz (days. ) Tj 51.428571 0 0 51.428571 0 1925.075728 Tm 11.588889 0 Td 53.472222 Tz (This ) Tj 1.594444 0 Td 50.231481 Tz (patent ) Tj 2.1 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 48.611111 Tz (Subject ) Tj 2.313889 0 Td 48.611111 Tz (to ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 50.636574 Tz (terminal ) Tj 2.761111 0 Td 59.41358 Tz (dis ) Tj 40 0 0 40 0 1888 Tm 14.9 0 Td 63.020833 Tz (claimer. ) Tj 50 0 0 50 0 1804.191083 Tm 8.44 0 Td 55.333333 Tz (Appl. ) Tj 1.96 0 Td 51.666667 Tz (No.: ) Tj 3.04 0 Td 56.333333 Tz (14/771,617 ) Tj 44.285714 0 0 44.285714 0 1726.605714 Tm 9.529032 0 Td 86.55914 Tz (PCT ) Tj 1.851613 0 Td 78.091398 Tz (Fed: ) Tj 3.770968 0 Td 73.387097 Tz (Mar. ) Tj 2.032258 0 Td 57.706093 Tz (14, ) Tj 1.309677 0 Td 69.623656 Tz (2013 ) Tj 38.571429 0 0 38.571429 0 1651 Tm 10.940741 0 Td 99.382716 Tz (PCT ) Tj 2.074074 0 Td 68.055556 Tz (No.: ) Tj 4.562963 0 Td 82.098765 Tz (PCT/US2O13/031622 ) Tj 51.428571 0 0 51.428571 0 1580 Tm 8.244444 0 Td 48.611111 Tz (S ) Tj 0.544444 0 Td 56.17284 Tz (371 ) Tj 1.380556 0 Td 42.592593 Tz (\(c\)\(1\), ) Tj 50.571429 0 0 50.571429 0 1539.679128 Tm 8.364407 0 Td 47.237916 Tz (\(2\) ) Tj 1.107345 0 Td 51.412429 Tz (Date: ) Tj 3.79661 0 Td 63.44162 Tz (Aug. ) Tj 1.740113 0 Td 52.730697 Tz (31, ) Tj 1.166667 0 Td 61.793785 Tz (2015 ) Tj 40 0 0 40 0 1467 Tm 10.55 0 Td 95.833333 Tz (PCT ) Tj 2.05 0 Td 66.666667 Tz (Pub. ) Tj 1.975 0 Td 64.583333 Tz (No.: ) Tj 2.175 0 Td 84.935897 Tz (WO2O14/142915 ) Tj 51.428571 0 0 51.428571 0 1398.369727 Tm 8.205556 0 Td 74.537037 Tz (PCT ) Tj 1.575 0 Td 52.662037 Tz (Pub. ) Tj 1.555556 0 Td 51.203704 Tz (Date: ) Tj 1.711111 0 Td 55.902778 Tz (Sep. ) Tj 1.594444 0 Td 49.691358 Tz (18, ) Tj 1.108333 0 Td 60.763889 Tz (2014 ) Tj 38.571429 0 0 38.571429 0 1326 Tm 16.566667 0 Td 71.728395 Tz (Prior ) Tj 2.514815 0 Td 70.314254 Tz (Publication ) Tj 5.107407 0 Td 77.777778 Tz (Data ) Tj 48.571429 0 0 48.571429 0 1257 Tm 8.688235 0 Td 80.637255 Tz (US ) Tj 1.235294 0 Td 62.050654 Tz (2016/0000924 ) Tj 4.694118 0 Td 68.627451 Tz (A1 ) Tj 2.285294 0 Td 50.612745 Tz (Jan. ) Tj 1.502941 0 Td 44.607843 Tz (7, ) Tj 0.802941 0 Td 63.480392 Tz (2016 ) Tj 38.571429 0 0 38.571429 0 1184 Tm 11.018519 0 Td 58.333333 Tz (Int. ) Tj 1.737037 0 Td 99.382716 Tz (C. ) Tj 41.785714 0 0 41.785714 0 1139.340694 Tm 10.051282 0 Td 93.732194 Tz (A6 ) Tj 1.244444 0 Td 79.77208 Tz (IK ) Tj 1.220513 0 Td 67.806268 Tz (47/36 ) Tj 5.958974 0 Td 64.260842 Tz (\(2006.01\) ) Tj 41.785714 0 0 41.785714 0 1097.31746 Tm 10.051282 0 Td 93.732194 Tz (A6 ) Tj 1.244444 0 Td 79.77208 Tz (IK ) Tj 1.220513 0 Td 66.210826 Tz (38/14 ) Tj 5.958974 0 Td 64.260842 Tz (\(2006.01\) ) Tj 41.785714 0 0 41.785714 0 1056.329114 Tm 10.051282 0 Td 93.732194 Tz (A6 ) Tj 1.244444 0 Td 79.77208 Tz (IK ) Tj 1.220513 0 Td 67.008547 Tz (38/12 ) Tj 5.958974 0 Td 64.260842 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 1014.830601 Tm 9.8 0 Td 91.388889 Tz (A6 ) Tj 1.213333 0 Td 75.185185 Tz (IK3I/7036 ) Tj 7 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 973.094276 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.753333 0 Td 64.166667 Tz (5/28 ) Tj 5.46 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 931.29393 Tm 9.893333 0 Td 108.888889 Tz (C8B ) Tj 2.31 0 Td 65.333333 Tz (37/08 ) Tj 5.81 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 889.081081 Tm 9.893333 0 Td 80.694444 Tz (COSL ) Tj 2.17 0 Td 66.111111 Tz (5/08 ) Tj 5.95 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 848.329114 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.333333 0 Td 66.111111 Tz (27/20 ) Tj 5.88 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 806.305732 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.333333 0 Td 64.555556 Tz (27/54 ) Tj 5.88 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 765.329114 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.333333 0 Td 66.111111 Tz (27/56 ) Tj 5.88 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 723.094276 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.753333 0 Td 64.166667 Tz (5/42 ) Tj 5.46 0 Td 62.654321 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 682.282051 Tm 9.8 0 Td 83.611111 Tz (A6IL ) Tj 2.426667 0 Td 63 Tz (I5/46 ) Tj 5.786667 0 Td 62.654321 Tz (\(2006.01\) ) Tj 41.785714 0 0 41.785714 0 640.054422 Tm 10.051282 0 Td 95.726496 Tz (A ) Tj 0.717949 0 Td 81.101614 Tz (6LX ) Tj 1.77094 0 Td 63.817664 Tz (9/19 ) Tj 5.935043 0 Td 64.260842 Tz (\(2006.01\) ) Tj 41.785714 0 0 41.785714 0 598.067797 Tm 10.051282 0 Td 95.726496 Tz (A ) Tj 0.717949 0 Td 81.101614 Tz (6LX ) Tj 1.77094 0 Td 64.814815 Tz (9/70 ) Tj 5.935043 0 Td 64.260842 Tz (\(2006.01\) ) Tj 41.785714 0 0 41.785714 0 557.013746 Tm 10.051282 0 Td 93.732194 Tz (A6 ) Tj 1.244444 0 Td 67.806268 Tz (IL ) Tj 1.62735 0 Td 64.814815 Tz (7/10 ) Tj 5.552137 0 Td 64.260842 Tz (\(2006.01\) ) Tj 42.857143 0 0 42.857143 0 515.29393 Tm 9.776667 0 Td 75.185185 Tz (A61 ) Tj 1.54 0 Td 93.333333 Tz (K ) Tj 0.816667 0 Td 66.888889 Tz (38/00 ) Tj 5.88 0 Td 62.654321 Tz (\(2006.01\) ) Tj 38.571429 0 0 38.571429 0 474 Tm 10.940741 0 Td 71.296296 Tz (U.S. ) Tj 2.048148 0 Td 99.382716 Tz (C. ) Tj 47.755102 0 0 47.755102 0 426.477273 Tm 8.836752 0 Td 82.597341 Tz (CPC ) Tj 1.863675 0 Td 32.064637 Tz (................ ) Tj 3.64359 0 Td 79.398148 Tz (A61K ) Tj 2.135897 0 Td 60.02849 Tz (47/36 ) Tj 2.052137 0 Td 54.095442 Tz (\(2013.01\); ) Tj 3.538889 0 Td 77.653134 Tz (A61K ) Tj 2.114957 0 Td 56.712963 Tz (9/19 ) Tj 51.428571 0 0 51.428571 0 382 Tm 11.977778 0 Td 50.231481 Tz (\(2013.01\); ) Tj 3.266667 0 Td 72.916667 Tz (A61K ) Tj 1.963889 0 Td 54.282407 Tz (9/70 ) Tj 1.516667 0 Td 50.555556 Tz (\(2013.01\); ) Tj 3.286111 0 Td 65.895062 Tz (A61 ) Tj 1.263889 0 Td 87.5 Tz (K ) Tj 51.428571 0 0 51.428571 0 341 Tm 10.888889 0 Td 64.814815 Tz (3 ) Tj 0.505556 0 Td 53.472222 Tz (1/7036 ) Tj 2.158333 0 Td 50.231481 Tz (\(2013.01\); ) Tj 3.286111 0 Td 72.916667 Tz (A61K ) Tj 1.925 0 Td 55.740741 Tz (38/12 ) Tj 1.905556 0 Td 50.555556 Tz (\(2013.01\); ) Tj 51.428571 0 0 51.428571 0 299 Tm 9.722222 0 Td 74.537037 Tz (A61K ) Tj 1.983333 0 Td 55.740741 Tz (38/14 ) Tj 1.905556 0 Td 50.231481 Tz (\(2013.01\); ) Tj 3.286111 0 Td 65.895062 Tz (A61 ) Tj 1.263889 0 Td 68.055556 Tz (L ) Tj 0.719444 0 Td 51.851852 Tz (15/28 ) Tj 1.808333 0 Td 50.231481 Tz (\(2013.01\); ) Tj 51.428571 0 0 51.428571 0 258 Tm 12.736111 0 Td 70.486111 Tz (A61L ) Tj 2.002778 0 Td 53.472222 Tz (15/425 ) Tj 2.177778 0 Td 50.555556 Tz (\(2013.01\); ) Tj 3.286111 0 Td 64.814815 Tz (A61 ) Tj 1.244444 0 Td 68.055556 Tz (L ) Tj 0.738889 0 Td 51.851852 Tz (15/46 ) Tj 51.428571 0 0 51.428571 0 216 Tm 9.858333 0 Td 49.907407 Tz (\(2013.01\); ) Tj 3.247222 0 Td 69.675926 Tz (A61L ) Tj 2.002778 0 Td 52.5 Tz (17/10 ) Tj 1.788889 0 Td 50.555556 Tz (\(2013.01\); ) Tj 3.286111 0 Td 69.675926 Tz (A61L ) Tj 1.886111 0 Td 55.740741 Tz (27/20 ) Tj 51.428571 0 0 51.428571 0 174 Tm 9.858333 0 Td 49.907407 Tz (\(2013.01\); ) Tj 3.247222 0 Td 69.675926 Tz (A61L ) Tj 1.905556 0 Td 55.092593 Tz (27/54 ) Tj 1.886111 0 Td 50.555556 Tz (\(2013.01\); ) Tj 3.286111 0 Td 69.675926 Tz (A61L ) Tj 1.886111 0 Td 55.740741 Tz (27/56 ) Tj 51.428571 0 0 51.428571 0 2764 Tm 28.719444 0 Td 50.555556 Tz (\(2013.01\); ) Tj 3.325 0 Td 68.865741 Tz (C08B ) Tj 1.866667 0 Td 57.253086 Tz (37/003 ) Tj 2.313889 0 Td 50.231481 Tz (\(2013.01\); ) Tj 3.286111 0 Td 68.865741 Tz (C08L ) Tj 1.866667 0 Td 53.472222 Tz (5/08 ) Tj 51.428571 0 0 51.428571 0 2724 Tm 30.722222 0 Td 49.907407 Tz (\(2013.01\); ) Tj 3.247222 0 Td 69.675926 Tz (A6 ) Tj 0.933333 0 Td 63.194444 Tz (IK ) Tj 0.991667 0 Td 55.092593 Tz (38/00 ) Tj 1.925 0 Td 49.907407 Tz (\(2013.01\); ) Tj 3.247222 0 Td 63.734568 Tz (A61 ) Tj 1.225 0 Td 61.574074 Tz (L ) Tj 51.428571 0 0 51.428571 0 2685 Tm 36.827778 0 Td 56.712963 Tz (2300/404 ) Tj 2.975 0 Td 52.932099 Tz (\(2013.01\) ) Tj 51.428571 0 0 51.428571 0 2643 Tm 25.219444 0 Td 50.231481 Tz (\(58\) ) Tj 1.963889 0 Td 50.555556 Tz (Field ) Tj 1.808333 0 Td 53.472222 Tz (of ) Tj 0.836111 0 Td 49.074074 Tz (Classification ) Tj 4.355556 0 Td 59.953704 Tz (Search ) Tj 46.071429 0 0 46.071429 0 2606.048711 Tm 30.300775 0 Td 83.204134 Tz (CPC ) Tj 1.931783 0 Td 31.955211 Tz (...... ) Tj 1.541085 0 Td 82.299742 Tz (A61K ) Tj 2.235659 0 Td 57.278208 Tz (47/36; ) Tj 2.322481 0 Td 82.299742 Tz (A61K ) Tj 2.235659 0 Td 57.278208 Tz (31/00; ) Tj 2.322481 0 Td 82.299742 Tz (A61K ) Tj 2.257364 0 Td 58.397933 Tz (9/7007; ) Tj 48.571429 0 0 48.571429 0 2566 Tm 32.261765 0 Td 78.063725 Tz (A61K ) Tj 2.120588 0 Td 55.882353 Tz (9/0024; ) Tj 2.614706 0 Td 66.339869 Tz (A61 ) Tj 1.317647 0 Td 75.490196 Tz (L ) Tj 0.741176 0 Td 52.042484 Tz (15/28: ) Tj 2.141176 0 Td 73.77451 Tz (A61L ) Tj 2.017647 0 Td 53.75817 Tz (27/20; ) Tj 48.571429 0 0 48.571429 0 2526 Tm 32.117647 0 Td 76.348039 Tz (A61L ) Tj 2.038235 0 Td 53.75817 Tz (27/58: ) Tj 2.202941 0 Td 75.490196 Tz (A61L ) Tj 1.997059 0 Td 55.392157 Tz (31/042; ) Tj 2.614706 0 Td 74.632353 Tz (C08B ) Tj 2.058824 0 Td 58.333333 Tz (37/003 ) Tj 45.238095 0 0 45.238095 0 2490.268156 Tm 30.858947 0 Td 86.578947 Tz (USPC ) Tj 2.586316 0 Td 34.078947 Tz (................................ ) Tj 6.941053 0 Td 58.421053 Tz (514/23, ) Tj 2.741053 0 Td 56.491228 Tz (40, ) Tj 1.326316 0 Td 59.868421 Tz (777; ) Tj 1.746316 0 Td 63.859649 Tz (536/20 ) Tj 51.428571 0 0 51.428571 0 2450.068702 Tm 27.163889 0 Td 58.333333 Tz (See ) Tj 1.244444 0 Td 49.200337 Tz (application ) Tj 3.519444 0 Td 38.078704 Tz (file ) Tj 1.166667 0 Td 47.530864 Tz (for ) Tj 1.069444 0 Td 55.902778 Tz (complete ) Tj 2.916667 0 Td 51.311728 Tz (search ) Tj 2.080556 0 Td 44.560185 Tz (history. ) Tj 42.857143 0 0 42.857143 0 2393.465409 Tm 30.263333 0 Td 59.305556 Tz (\(56\) ) Tj 7.326667 0 Td 66.111111 Tz (References ) Tj 4.293333 0 Td 67.666667 Tz (Cited ) Tj 38.571429 0 0 38.571429 0 2324 Tm 39.277778 0 Td 70.216049 Tz (U.S. ) Tj 2.1 0 Td 96.502058 Tz (PATENT ) Tj 3.837037 0 Td 110.42524 Tz (DOCUMENTS ) Tj 41.836735 0 0 41.836735 0 2248.356822 Tm 32.841951 0 Td 52.98374 Tz (4,895,724. ) Tj 3.609268 0 Td 99.593496 Tz (A ) Tj 1.07561 0 Td 59.756098 Tz (* ) Tj 1.505854 0 Td 57.100271 Tz (1/1990 ) Tj 2.677073 0 Td 56.270325 Tz (Cardinal ) Tj 3.202927 0 Td 32.439024 Tz (.............. ) Tj 3.179024 0 Td 72.105691 Tz (A61K9/0024 ) Tj 35.714286 0 0 35.714286 0 2214 Tm 57.652 0 Td 68.444444 Tz (424,278.1 ) Tj 43.571429 0 0 43.571429 0 2176.069252 Tm 31.580328 0 Td 55.251973 Tz (5,541,233 ) Tj 3.419672 0 Td 95.628415 Tz (A ) Tj 2.363934 0 Td 58.652095 Tz (7/1996 ) Tj 2.685246 0 Td 62.295082 Tz (Roenigk ) Tj 44.285714 0 0 44.285714 0 2141.391858 Tm 31.070968 0 Td 54.360812 Tz (5,958,443 ) Tj 3.364516 0 Td 94.086022 Tz (A ) Tj 2.325806 0 Td 57.078853 Tz (9/1999 ) Tj 2.641935 0 Td 56.451613 Tz (Viegas ) Tj 2.280645 0 Td 47.043011 Tz (et ) Tj 0.767742 0 Td 40.143369 Tz (al. ) Tj 37.619048 0 0 37.619048 0 2109.691257 Tm 36.550633 0 Td 64.978903 Tz (6,699,287 ) Tj 4.013924 0 Td 81.962025 Tz (B2 ) Tj 2.711392 0 Td 67.194093 Tz (3/2004 ) Tj 3.110127 0 Td 73.839662 Tz (Son ) Tj 1.674684 0 Td 55.379747 Tz (et ) Tj 0.93038 0 Td 45.780591 Tz (al. ) Tj 37.619048 0 0 37.619048 0 2074.805195 Tm 36.550633 0 Td 64.978903 Tz (6,989,157 ) Tj 4.013924 0 Td 81.962025 Tz (B2 ) Tj 2.817722 0 Td 64.240506 Tz (1/2006 ) Tj 3.03038 0 Td 53.164557 Tz (Gillis ) Tj 2.232911 0 Td 55.379747 Tz (et ) Tj 0.903797 0 Td 47.257384 Tz (al. ) Tj 44.285714 0 0 44.285714 0 2038.855876 Tm 31.048387 0 Td 54.778973 Tz (7,371.403 ) Tj 3.409677 0 Td 69.623656 Tz (B2 ) Tj 2.325806 0 Td 56.451613 Tz (5/2008 ) Tj 2.619355 0 Td 63.978495 Tz (McCarthy ) Tj 3.296774 0 Td 47.043011 Tz (et ) Tj 0.767742 0 Td 40.143369 Tz (al. ) Tj 41.428571 0 0 41.428571 0 2006.719457 Tm 31.765517 0 Td 57.931034 Tz (2003, ) Tj 1.858621 0 Td 64.942529 Tz (OO15825 ) Tj 3.186207 0 Td 76.436782 Tz (A1 ) Tj 2.582759 0 Td 57.662835 Tz (1/2003 ) Tj 2.751724 0 Td 60.344828 Tz (Sugie ) Tj 2.051724 0 Td 52.298851 Tz (et ) Tj 0.844828 0 Td 42.911877 Tz (al. ) Tj 35.714286 0 0 35.714286 0 1974 Tm 36.848 0 Td 74.277778 Tz (2003/0206958 ) Tj 5.88 0 Td 84 Tz (A1 ) Tj 2.52 0 Td 68 Tz (11/2003 ) Tj 3.64 0 Td 67.666667 Tz (Cattaneo ) Tj 3.584 0 Td 58.333333 Tz (et ) Tj 0.98 0 Td 48.222222 Tz (al. ) Tj 35.714286 0 0 35.714286 0 1940 Tm 36.848 0 Td 68.205128 Tz (2007/00594.73 ) Tj 5.852 0 Td 88.666667 Tz (A1 ) Tj 2.884 0 Td 70.777778 Tz (3/2007 ) Tj 3.248 0 Td 76.416667 Tz (Yamazaki ) Tj 4.06 0 Td 53.666667 Tz (et ) Tj 0.924 0 Td 49.777778 Tz (al. ) Tj 35.714286 0 0 35.714286 0 1906 Tm 36.848 0 Td 74.277778 Tz (2009,0004276 ) Tj 5.852 0 Td 88.666667 Tz (A1 ) Tj 2.996 0 Td 67.666667 Tz (1/2009 ) Tj 3.192 0 Td 76.533333 Tz (Ben-Shalom ) Tj 4.956 0 Td 56 Tz (et ) Tj 0.924 0 Td 49.777778 Tz (al. ) Tj 35.714286 0 0 35.714286 0 1871 Tm 36.848 0 Td 73.888889 Tz (2009.0075383 ) Tj 5.852 0 Td 88.666667 Tz (A1 ) Tj 2.884 0 Td 70.777778 Tz (3/2009 ) Tj 3.332 0 Td 79.851852 Tz (Buschmann ) Tj 4.676 0 Td 56 Tz (et ) Tj 0.924 0 Td 49.777778 Tz (al. ) Tj 42.380952 0 0 42.380952 0 1834.895706 Tm 31.051685 0 Td 62.593633 Tz (2012fO149659 ) Tj 4.931461 0 Td 74.719101 Tz (A1 ) Tj 2.430337 0 Td 59.644195 Tz (6/2012 ) Tj 2.807865 0 Td 63.483146 Tz (Haggard ) Tj 2.902247 0 Td 49.157303 Tz (et ) Tj 0.849438 0 Td 40.636704 Tz (al. ) Tj 38.571429 0 0 38.571429 0 1723 Tm 38.059259 0 Td 99.382716 Tz (FOREIGN ) Tj 4.562963 0 Td 96.502058 Tz (PATENT ) Tj 3.837037 0 Td 110.42524 Tz (DOCUMENTS ) Tj 35 0 0 35 0 1651 Tm 37.057143 0 Td 90.47619 Tz (EP ) Tj 6.742857 0 Td 73.809524 Tz (1308.177 ) Tj 7 0 Td 50 Tz (5, ) Tj 0.714286 0 Td 77.380952 Tz (2003 ) Tj 35 0 0 35 0 1616 Tm 37.028571 0 Td 76.190476 Tz (JP ) Tj 6.228571 0 Td 75.661376 Tz (O2-268766 ) Tj 7.171429 0 Td 55.555556 Tz (11, ) Tj 1.171429 0 Td 75 Tz (1990 ) Tj 35.357143 0 0 35.357143 0 1581 Tm 36.654545 0 Td 75.420875 Tz (JP ) Tj 5.345455 0 Td 73.706765 Tz (2003/511120 ) Tj 8.258586 0 Td 54.208754 Tz (3, ) Tj 0.707071 0 Td 77.777778 Tz (2003 ) Tj 35.428571 0 0 35.428571 0 1547 Tm 36.580645 0 Td 75.268817 Tz (JP ) Tj 5.25 0 Td 66.801075 Tz (2004, ) Tj 2.116935 0 Td 78.405018 Tz (231604 ) Tj 6.237903 0 Td 47.043011 Tz (8, ) Tj 0.705645 0 Td 77.620968 Tz (2004 ) Tj 35.357143 0 0 35.357143 0 1513 Tm 36.654545 0 Td 75.420875 Tz (JP ) Tj 5.260606 0 Td 74.992348 Tz (2006,347999 ) Tj 8.343434 0 Td 54.208754 Tz (6, ) Tj 0.707071 0 Td 77.777778 Tz (2005 ) Tj 35.357143 0 0 35.357143 0 1479 Tm 36.654545 0 Td 75.420875 Tz (JP ) Tj 5.260606 0 Td 74.992348 Tz (2006,516988 ) Tj 8.343434 0 Td 70.707071 Tz (T ) Tj 0.707071 0 Td 78.956229 Tz (2006 ) Tj 35 0 0 35 0 1444 Tm 37.028571 0 Td 76.190476 Tz (JP ) Tj 5.314286 0 Td 75.757576 Tz (2008-110207 ) Tj 8.457143 0 Td 50 Tz (5, ) Tj 0.714286 0 Td 78.571429 Tz (2008 ) Tj 35.428571 0 0 35.428571 0 1410 Tm 36.580645 0 Td 75.268817 Tz (JP ) Tj 5.25 0 Td 66.801075 Tz (2008, ) Tj 2.28629 0 Td 73.700717 Tz (161502 ) Tj 6.040323 0 Td 70.564516 Tz (T ) Tj 0.705645 0 Td 78.797043 Tz (2008 ) Tj 35.357143 0 0 35.357143 0 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47.170782 Tz (fractures ) Tj 2.780556 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 46.666667 Tz (ideal ) Tj 1.633333 0 Td 42.777778 Tz (sites ) Tj 51.428571 0 0 51.428571 0 1912.303548 Tm 6.261111 0 Td 49.691358 Tz (for ) Tj 1.225 0 Td 45.694444 Tz (infection. ) Tj 3.130556 0 Td 50.231481 Tz (Surgical ) Tj 2.8 0 Td 41.319444 Tz (site ) Tj 1.361111 0 Td 47.638889 Tz (infections ) Tj 3.266667 0 Td 43.75 Tz (in ) Tj 0.913889 0 Td 51.851852 Tz (closed ) Tj 2.255556 0 Td 46.450617 Tz (fractures ) Tj 51.428571 0 0 51.428571 0 1872.01005 Tm 6.261111 0 Td 54.444444 Tz (range ) Tj 1.866667 0 Td 56.712963 Tz (from ) Tj 1.613889 0 Td 52.211934 Tz (3.6-8.1%. ) Tj 3.091667 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 45.010288 Tz (contrast, ) Tj 2.702778 0 Td 46.990741 Tz (Surgical ) Tj 2.508333 0 Td 41.319444 Tz (site ) Tj 1.205556 0 Td 47.314815 Tz (infections ) Tj 3.111111 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 1832.014545 Tm 6.261111 0 Td 58.333333 Tz (open ) Tj 1.613889 0 Td 46.8107 Tz (fractures ) Tj 2.741667 0 Td 52.5 Tz (range ) Tj 1.769444 0 Td 59.143519 Tz (from ) Tj 1.672222 0 Td 52.73569 Tz (17.5-21.2%. ) Tj 3.713889 0 Td 54.73251 Tz (Pathogens ) Tj 3.130556 0 Td 50.462963 Tz (present ) Tj 2.275 0 Td 46.990741 Tz (at ) Tj 51.428571 0 0 51.428571 0 1789.29233 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 42.939815 Tz (site ) Tj 1.438889 0 Td 55.092593 Tz (of ) Tj 0.972222 0 Td 56.712963 Tz (an ) Tj 1.108333 0 Td 57.523148 Tz (open ) Tj 1.808333 0 Td 46.990741 Tz (fracture ) Tj 2.683333 0 Td 66.975309 Tz (may ) Tj 1.613889 0 Td 48.070988 Tz (create ) Tj 2.138889 0 Td 51.851852 Tz (not ) Tj 1.322222 0 Td 52.662037 Tz (only ) Tj 1.711111 0 Td 46.018519 Tz (local ) Tj 48.571429 0 0 48.571429 0 1747 Tm 6.629412 0 Td 48.975045 Tz (infections, ) Tj 3.458824 0 Td 54.901961 Tz (but ) Tj 1.194118 0 Td 59.477124 Tz (can ) Tj 1.297059 0 Td 51.470588 Tz (also ) Tj 1.461765 0 Td 57.647059 Tz (cause ) Tj 1.935294 0 Td 51.470588 Tz (serious ) Tj 2.429412 0 Td 50.098039 Tz (infections ) Tj 3.252941 0 Td 48.039216 Tz (in ) Tj 0.782353 0 Td 53.75817 Tz (the ) Tj 1.194118 0 Td 62.622549 Tz (bone ) Tj 51.428571 0 0 51.428571 0 1705.830325 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.186111 0 Td 50.231481 Tz (associated ) Tj 3.15 0 Td 44.155093 Tz (tissues. ) Tj 2.294444 0 Td 63.425926 Tz (Complex ) Tj 2.838889 0 Td 57.523148 Tz (open ) Tj 1.575 0 Td 62.114198 Tz (wounds ) Tj 2.391667 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 46.990741 Tz (also ) Tj 1.322222 0 Td 55.740741 Tz (prone ) Tj 51.428571 0 0 51.428571 0 1662.662484 Tm 6.241667 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 47.170782 Tz (infection ) Tj 2.780556 0 Td 53.472222 Tz (with ) Tj 1.497222 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 61.574074 Tz (number ) Tj 2.391667 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 45.010288 Tz (bacteria. ) Tj 2.683333 0 Td 62.654321 Tz (The ) Tj 1.341667 0 Td 53.472222 Tz (type ) Tj 1.438889 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 48.611111 Tz (bacteria ) Tj 52.857143 0 0 52.857143 0 1623.092796 Tm 6.091892 0 Td 46.596597 Tz (infecting ) Tj 2.705405 0 Td 48.348348 Tz (the ) Tj 1.059459 0 Td 63.693694 Tz (wound ) Tj 2.062162 0 Td 45.895896 Tz (typically ) Tj 2.705405 0 Td 45.720721 Tz (varies ) Tj 1.854054 0 Td 54.304304 Tz (depending ) Tj 3.102703 0 Td 58.333333 Tz (on ) Tj 0.889189 0 Td 48.348348 Tz (the ) Tj 1.059459 0 Td 52.342342 Tz (cause ) Tj 48.571429 0 0 48.571429 0 1580 Tm 6.629412 0 Td 61.764706 Tz (of ) Tj 0.947059 0 Td 52.614379 Tz (the ) Tj 1.255882 0 Td 54.411765 Tz (trauma. ) Tj 2.552941 0 Td 68.627451 Tz (To ) Tj 1.132353 0 Td 57.189542 Tz (reduce ) Tj 2.347059 0 Td 52.614379 Tz (the ) Tj 1.255882 0 Td 48.039216 Tz (risk ) Tj 1.441176 0 Td 60.04902 Tz (of ) Tj 0.947059 0 Td 48.382353 Tz (infection, ) Tj 3.211765 0 Td 51.470588 Tz (the ) Tj 1.194118 0 Td 52.941176 Tz (current ) Tj 51.428571 0 0 51.428571 0 1538.042131 Tm 6.280556 0 Td 51.041667 Tz (standard ) Tj 2.722222 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 51.041667 Tz (care ) Tj 1.497222 0 Td 51.041667 Tz (involves ) Tj 2.702778 0 Td 52.932099 Tz (debridement, ) Tj 4.083333 0 Td 43.308081 Tz (irrigation, ) Tj 3.111111 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 63.734568 Tz (sys ) Tj 51.428571 0 0 51.428571 0 1497.947431 Tm 6.241667 0 Td 54.444444 Tz (temic ) Tj 1.788889 0 Td 46.018519 Tz (antibiotic ) Tj 2.955556 0 Td 47.800926 Tz (therapy. ) Tj 2.508333 0 Td 60.763889 Tz (Even ) Tj 1.652778 0 Td 53.472222 Tz (with ) Tj 1.458333 0 Td 51.527778 Tz (aggressive ) Tj 3.247222 0 Td 48.971193 Tz (therapies ) Tj 2.8 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 1455.711058 Tm 6.280556 0 Td 51.851852 Tz (systemic ) Tj 2.702778 0 Td 45.37037 Tz (antibiotic ) Tj 2.916667 0 Td 48.287037 Tz (treatment, ) Tj 3.111111 0 Td 47.314815 Tz (infections ) Tj 3.013889 0 Td 55.632716 Tz (remain ) Tj 2.158333 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 46.254209 Tz (significant ) Tj 51.428571 0 0 51.428571 0 1416.104946 Tm 6.280556 0 Td 52.391975 Tz (Source ) Tj 2.080556 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 51.851852 Tz (morbidity ) Tj 2.994444 0 Td 60.493827 Tz (and ) Tj 1.302778 0 Td 46.018519 Tz (mortality. ) Tj 2.955556 0 Td 51.388889 Tz (Tissues ) Tj 2.372222 0 Td 60.10101 Tz (compromised ) Tj 4.141667 0 Td 63.194444 Tz (by ) Tj 48.571429 0 0 48.571429 0 1372 Tm 6.608824 0 Td 60.04902 Tz (trauma ) Tj 2.532353 0 Td 61.764706 Tz (and ) Tj 1.482353 0 Td 49.945534 Tz (infection ) Tj 3.088235 0 Td 52.156863 Tz (often ) Tj 1.935294 0 Td 60.906863 Tz (have ) Tj 1.832353 0 Td 57.843137 Tz (reduced ) Tj 2.820588 0 Td 49.969363 Tz (vascularization, ) Tj 51.428571 0 0 51.428571 0 1333.150685 Tm 6.241667 0 Td 59.62963 Tz (which ) Tj 2.352778 0 Td 45.910494 Tz (limits ) Tj 2.216667 0 Td 50.771605 Tz (the ) Tj 1.458333 0 Td 49.016204 Tz (delivery ) Tj 2.936111 0 Td 58.333333 Tz (of ) Tj 1.147222 0 Td 47.43266 Tz (circulating ) Tj 3.694444 0 Td 46.866097 Tz (therapeutics. ) Tj 51.428571 0 0 51.428571 0 1289.296651 Tm 6.280556 0 Td 51.49177 Tz (Increased ) Tj 2.994444 0 Td 50 Tz (concentrations ) Tj 4.452778 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 53.06713 Tz (systemic ) Tj 2.741667 0 Td 45.959596 Tz (antibiotics ) Tj 3.266667 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 50.462963 Tz (usually ) Tj 51.428571 0 0 51.428571 0 1249.990196 Tm 6.261111 0 Td 50.636574 Tz (required ) Tj 2.625 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 57.037037 Tz (compensate ) Tj 3.636111 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 57.523148 Tz (poor ) Tj 1.555556 0 Td 47.138047 Tz (circulation ) Tj 3.325 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 63.425926 Tz (damaged ) Tj 51.428571 0 0 51.428571 0 1205.609396 Tm 6.241667 0 Td 43.518519 Tz (tissue. ) Tj 2.236111 0 Td 48.935185 Tz (Antibiotic ) Tj 3.383333 0 Td 45.775463 Tz (toxicity ) Tj 2.644444 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 52.662037 Tz (systemic ) Tj 2.975 0 Td 48.611111 Tz (side ) Tj 1.575 0 Td 44.907407 Tz (effects ) Tj 2.313889 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 1164.663212 Tm 6.280556 0 Td 48.611111 Tz (serious ) Tj 2.411111 0 Td 55.902778 Tz (problems ) Tj 3.052778 0 Td 50.231481 Tz (associated ) Tj 3.363889 0 Td 54.282407 Tz (with ) Tj 1.633333 0 Td 44.560185 Tz (this ) Tj 1.458333 0 Td 52.391975 Tz (course ) Tj 2.236111 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 48.206019 Tz (therapy. ) Tj 51.428571 0 0 51.428571 0 1123.307597 Tm 6.280556 0 Td 47.962963 Tz (Infections ) Tj 3.169444 0 Td 52.211934 Tz (following ) Tj 3.072222 0 Td 47.800926 Tz (Surgery, ) Tj 2.566667 0 Td 55.902778 Tz (drug ) Tj 1.594444 0 Td 48.611111 Tz (side ) Tj 1.419444 0 Td 42.939815 Tz (effects, ) Tj 2.313889 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 47.222222 Tz (related ) Tj 51.428571 0 0 51.428571 0 1084.743842 Tm 6.261111 0 Td 52.10114 Tz (complications ) Tj 4.355556 0 Td 55.092593 Tz (can ) Tj 1.283333 0 Td 45.619658 Tz (significantly ) Tj 3.869444 0 Td 49.421296 Tz (increase ) Tj 2.625 0 Td 47.800926 Tz (hospital ) Tj 2.586111 0 Td 47.314815 Tz (stays ) Tj 1.691667 0 Td 60.493827 Tz (and ) Tj 40 0 0 40 0 1045 Tm 8.05 0 Td 58.333333 Tz (result ) Tj 2.5 0 Td 56.25 Tz (in ) Tj 1.125 0 Td 69.047619 Tz (adverse ) Tj 3.3 0 Td 70.37037 Tz (outcomes. ) Tj 4.3 0 Td 73.214286 Tz (Because ) Tj 3.475 0 Td 63.095238 Tz (current ) Tj 3.1 0 Td 74.404762 Tz (methods ) Tj 3.6 0 Td 61.111111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1000.669261 Tm 6.241667 0 Td 46.990741 Tz (treating ) Tj 2.761111 0 Td 51.851852 Tz (or ) Tj 1.088889 0 Td 52.175926 Tz (preventing ) Tj 3.636111 0 Td 46.018519 Tz (infection, ) Tj 3.247222 0 Td 46.720679 Tz (particularly ) Tj 3.888889 0 Td 47.638889 Tz (infections ) Tj 51.428571 0 0 51.428571 0 958.889976 Tm 6.261111 0 Td 47.222222 Tz (related ) Tj 2.197222 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 58.333333 Tz (open ) Tj 1.633333 0 Td 45.37037 Tz (fractures, ) Tj 2.916667 0 Td 50.771605 Tz (are ) Tj 1.147222 0 Td 50.378788 Tz (inadequate, ) Tj 3.538889 0 Td 58.333333 Tz (improved ) Tj 3.033333 0 Td 73.240741 Tz (compo ) Tj 51.428571 0 0 51.428571 0 915.513648 Tm 6.280556 0 Td 44.444444 Tz (sitions ) Tj 2.061111 0 Td 60.493827 Tz (and ) Tj 1.302778 0 Td 57.87037 Tz (methods ) Tj 2.663889 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 52.932099 Tz (providing ) Tj 3.052778 0 Td 50.771605 Tz (agents ) Tj 2.061111 0 Td 48.611111 Tz (to ) Tj 0.777778 0 Td 52.314815 Tz (prevent ) Tj 2.411111 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 44.074074 Tz (treat ) Tj 51.428571 0 0 51.428571 0 873.901849 Tm 6.261111 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 47.530864 Tz (infection ) Tj 2.819444 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 41.319444 Tz (site ) Tj 1.244444 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 56.17284 Tz (trauma ) Tj 2.236111 0 Td 50.771605 Tz (are ) Tj 1.166667 0 Td 49.826389 Tz (urgently ) Tj 2.663889 0 Td 47.530864 Tz (required. ) Tj 38.571429 0 0 38.571429 0 800 Tm 12.859259 0 Td 117.283951 Tz (SUMMARY ) Tj 5.211111 0 Td 101.54321 Tz (OF ) Tj 1.555556 0 Td 105.144033 Tz (THE ) Tj 2.22963 0 Td 98.902606 Tz (INVENTION ) Tj 51.428571 0 0 51.428571 0 710.575923 Tm 7 0 Td 66.435185 Tz (As ) Tj 1.205556 0 Td 51.851852 Tz (described ) Tj 3.188889 0 Td 53.472222 Tz (below, ) Tj 2.352778 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 50.411523 Tz (invention ) Tj 3.169444 0 Td 47.395833 Tz (features ) Tj 2.722222 0 Td 58.333333 Tz (improved ) Tj 51.428571 0 0 51.428571 0 672.064677 Tm 6.261111 0 Td 58.333333 Tz (methods ) Tj 2.838889 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 51.203704 Tz (generating ) Tj 3.422222 0 Td 53.098291 Tz (biodegradable ) Tj 4.511111 0 Td 50.231481 Tz (chitosan ) Tj 2.8 0 Td 63.888889 Tz (composi ) Tj 51.428571 0 0 51.428571 0 630.389642 Tm 6.241667 0 Td 44.830247 Tz (tions, ) Tj 1.866667 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 48.611111 Tz (therapeutic ) Tj 3.5 0 Td 57.87037 Tz (methods ) Tj 2.683333 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 52.5 Tz (using ) Tj 1.808333 0 Td 55.092593 Tz (such ) Tj 1.594444 0 Td 53.742284 Tz (compositions ) Tj 51.428571 0 0 51.428571 0 588.362694 Tm 6.241667 0 Td 46.990741 Tz (to ) Tj 0.933333 0 Td 48.611111 Tz (deliver ) Tj 2.352778 0 Td 48.905724 Tz (therapeutic ) Tj 3.597222 0 Td 47.685185 Tz (agents. ) Tj 2.411111 0 Td 45.37037 Tz (In ) Tj 0.894444 0 Td 44.781145 Tz (particular, ) Tj 3.305556 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 51.131687 Tz (invention ) Tj 51.428571 0 0 51.428571 0 545.932203 Tm 6.261111 0 Td 51.446759 Tz (provides ) Tj 2.722222 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 57.87037 Tz (methods ) Tj 2.644444 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 51.851852 Tz (generating ) Tj 3.325 0 Td 49.826389 Tz (chitosan ) Tj 2.625 0 Td 55.092593 Tz (Sponges ) Tj 2.527778 0 Td 59.62963 Tz (where ) Tj 51.428571 0 0 51.428571 0 504.576994 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 57.87037 Tz (methods ) Tj 2.683333 0 Td 50.925926 Tz (include ) Tj 2.372222 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 50.231481 Tz (buffering ) Tj 3.266667 0 Td 46.450617 Tz (step. ) Tj 51.428571 0 0 51.428571 0 462.186992 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 58.333333 Tz (one ) Tj 1.302778 0 Td 47.222222 Tz (aspect, ) Tj 2.236111 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 50.411523 Tz (invention ) Tj 2.975 0 Td 52.662037 Tz (provides ) Tj 2.8 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 60.493827 Tz (method ) Tj 2.430556 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 66.975309 Tz (pro ) Tj 51.428571 0 0 51.428571 0 424.340819 Tm 6.261111 0 Td 54.552469 Tz (ducing ) Tj 2.430556 0 Td 51.851852 Tz (a ) Tj 0.777778 0 Td 52.849003 Tz (biodegradable ) Tj 4.569444 0 Td 50.231481 Tz (chitosan ) Tj 2.877778 0 Td 54.503367 Tz (composition ) Tj 4.063889 0 Td 55.092593 Tz (having ) Tj 2.430556 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 381.131258 Tm 6.261111 0 Td 50 Tz (desired ) Tj 2.333333 0 Td 51.851852 Tz (biodegradation ) Tj 4.608333 0 Td 43.344907 Tz (profile, ) Tj 2.333333 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 59.953704 Tz (method ) Tj 2.430556 0 Td 51.49177 Tz (involving ) Tj 51.428571 0 0 51.428571 0 340.51861 Tm 7.019444 0 Td 43.209877 Tz (\(a\) ) Tj 0.933333 0 Td 49.907407 Tz (dissolving ) Tj 3.130556 0 Td 50.231481 Tz (chitosan ) Tj 2.566667 0 Td 55.632716 Tz (having ) Tj 2.138889 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 53.472222 Tz (degree ) Tj 2.080556 0 Td 55.092593 Tz (of ) Tj 0.719444 0 Td 49.85755 Tz (deacetylation ) Tj 4.063889 0 Td 56.712963 Tz (of ) Tj 48.571429 0 0 48.571429 0 295 Tm 8.173529 0 Td 48.039216 Tz (at ) Tj 0.823529 0 Td 47.352941 Tz (least ) Tj 1.688235 0 Td 57.647059 Tz (about ) Tj 1.997059 0 Td 76.633987 Tz (51% ) Tj 1.667647 0 Td 48.039216 Tz (in ) Tj 0.864706 0 Td 62.908497 Tz (one ) Tj 1.4 0 Td 54.901961 Tz (or ) Tj 0.926471 0 Td 65.196078 Tz (more ) Tj 1.811765 0 Td 52.843137 Tz (acids ) Tj 1.894118 0 Td 46.323529 Tz (in ) Tj 0.844118 0 Td 58.333333 Tz (a ) Tj 0.617647 0 Td 49.754902 Tz (solvent, ) Tj 51.428571 0 0 51.428571 0 252.342503 Tm 7.7 0 Td 56.018519 Tz (wherein ) Tj 2.605556 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 51.041667 Tz (acid ) Tj 1.438889 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 50 Tz (solvent ) Tj 2.275 0 Td 51.851852 Tz (are ) Tj 1.127778 0 Td 49.016204 Tz (selected ) Tj 2.586111 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 56.481481 Tz (produce ) Tj 2.586111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 212.681023 Tm 7.719444 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 45.37037 Tz (that ) Tj 1.263889 0 Td 53.324916 Tz (biodegrades ) Tj 3.694444 0 Td 55.902778 Tz (over ) Tj 1.516667 0 Td 43.75 Tz (at ) Tj 0.738889 0 Td 44.074074 Tz (least ) Tj 1.477778 0 Td 55.092593 Tz (about ) Tj 1.905556 0 Td 52.662037 Tz (1-30 ) Tj 1.458333 0 Td 55.092593 Tz (days ) Tj 48.571429 0 0 48.571429 0 170 Tm 8.173529 0 Td 48.039216 Tz (in ) Tj 0.885294 0 Td 50.784314 Tz (vivo; ) Tj 1.791176 0 Td 64.052288 Tz (and ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.677778 0 Td 74.537037 Tz (2 ) Tj 51.428571 0 0 51.428571 0 2915.395349 Tm 25.938889 0 Td 46.450617 Tz (\(b\) ) Tj 1.263889 0 Td 55.555556 Tz (forming ) Tj 2.761111 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 49.826389 Tz (chitosan ) Tj 2.838889 0 Td 46.180556 Tz (into ) Tj 1.516667 0 Td 58.333333 Tz (a ) Tj 0.758333 0 Td 50.462963 Tz (desired ) Tj 2.527778 0 Td 55.740741 Tz (shape ) Tj 2.1 0 Td 55.740741 Tz (under ) Tj 51.428571 0 0 51.428571 0 2872.439822 Tm 26.658333 0 Td 50.231481 Tz (conditions ) Tj 3.441667 0 Td 46.180556 Tz (that ) Tj 1.536111 0 Td 52.932099 Tz (reduce ) Tj 2.372222 0 Td 48.611111 Tz (the ) Tj 1.283333 0 Td 55.092593 Tz (water ) Tj 2.041667 0 Td 51.388889 Tz (content ) Tj 2.566667 0 Td 59.953704 Tz (by ) Tj 1.127778 0 Td 55.092593 Tz (about ) Tj 38.571429 0 0 38.571429 0 2838 Tm 35.622222 0 Td 83.058985 Tz (10%-100%. ) Tj 51.428571 0 0 51.428571 0 2793.802891 Tm 25.938889 0 Td 43.209877 Tz (\(c\) ) Tj 1.127778 0 Td 47.800926 Tz (neutralizing ) Tj 3.733333 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 49.826389 Tz (chitosan ) Tj 2.722222 0 Td 54.208754 Tz (composition ) Tj 3.888889 0 Td 58.333333 Tz (by ) Tj 1.030556 0 Td 50.231481 Tz (contacting ) Tj 51.428571 0 0 51.428571 0 2749.050139 Tm 26.638889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 54.208754 Tz (composition ) Tj 3.811111 0 Td 53.472222 Tz (with ) Tj 1.516667 0 Td 49.151235 Tz (water, ) Tj 2.002778 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 44.965278 Tz (neutral, ) Tj 2.391667 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 49.907407 Tz (basic ) Tj 1.730556 0 Td 60.763889 Tz (solu ) Tj 48.571429 0 0 48.571429 0 2707 Tm 28.205882 0 Td 46.666667 Tz (tion, ) Tj 1.770588 0 Td 58.333333 Tz (wherein ) Tj 2.8 0 Td 52.614379 Tz (the ) Tj 1.297059 0 Td 51.470588 Tz (water, ) Tj 2.223529 0 Td 47.610294 Tz (neutral, ) Tj 2.635294 0 Td 56.617647 Tz (or ) Tj 0.988235 0 Td 52.156863 Tz (basic ) Tj 1.935294 0 Td 51.041667 Tz (solution ) Tj 2.820588 0 Td 41.176471 Tz (is ) Tj 51.428571 0 0 51.428571 0 2668.503243 Tm 26.677778 0 Td 48.611111 Tz (Selected ) Tj 2.488889 0 Td 43.75 Tz (to ) Tj 0.777778 0 Td 55.902778 Tz (modulate ) Tj 2.838889 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 52.363548 Tz (physical-mechanical ) Tj 6.144444 0 Td 51.446759 Tz (property ) Tj 2.644444 0 Td 58.333333 Tz (of ) Tj 48.571429 0 0 48.571429 0 2624 Tm 28.205882 0 Td 53.75817 Tz (the ) Tj 1.235294 0 Td 50.708061 Tz (chitosan; ) Tj 3.026471 0 Td 62.908497 Tz (and ) Tj 51.428571 0 0 51.428571 0 2584.788301 Tm 25.938889 0 Td 46.450617 Tz (\(d\) ) Tj 1.225 0 Td 50.555556 Tz (contacting ) Tj 3.402778 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 50.231481 Tz (chitosan ) Tj 2.838889 0 Td 54.208754 Tz (composition ) Tj 3.966667 0 Td 53.472222 Tz (with ) Tj 1.672222 0 Td 56.712963 Tz (an ) Tj 1.108333 0 Td 51.041667 Tz (acid ) Tj 51.428571 0 0 51.428571 0 2544.040951 Tm 26.638889 0 Td 49.151235 Tz (buffer ) Tj 1.983333 0 Td 55.092593 Tz (wash, ) Tj 1.886111 0 Td 51.388889 Tz (thereby ) Tj 2.391667 0 Td 54.73251 Tz (producing ) Tj 3.169444 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 53.347578 Tz (biodegradable ) Tj 4.375 0 Td 56.388889 Tz (chito ) Tj 51.428571 0 0 51.428571 0 2503.433333 Tm 26.677778 0 Td 50.771605 Tz (San ) Tj 1.186111 0 Td 52.121914 Tz (composition. ) Tj 51.428571 0 0 51.428571 0 2458.381443 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 52.314815 Tz (another ) Tj 2.372222 0 Td 47.222222 Tz (aspect, ) Tj 2.197222 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.411523 Tz (invention ) Tj 2.916667 0 Td 52.256944 Tz (provides ) Tj 2.722222 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 82.098765 Tz (com ) Tj 51.428571 0 0 51.428571 0 2419.293383 Tm 25.2 0 Td 48.611111 Tz (position ) Tj 2.547222 0 Td 57.118056 Tz (produced ) Tj 2.936111 0 Td 59.953704 Tz (by ) Tj 0.952778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 59.953704 Tz (method ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 52.256944 Tz (previous ) Tj 2.722222 0 Td 47.685185 Tz (aspect, ) Tj 2.255556 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 2373.885246 Tm 25.2 0 Td 58.333333 Tz (any ) Tj 1.283333 0 Td 51.203704 Tz (other ) Tj 1.788889 0 Td 59.41358 Tz (method ) Tj 2.391667 0 Td 51.49177 Tz (described ) Tj 3.013889 0 Td 47.222222 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 2333.445323 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 52.777778 Tz (another ) Tj 2.430556 0 Td 47.685185 Tz (aspect, ) Tj 2.255556 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 50.771605 Tz (invention ) Tj 2.975 0 Td 52.256944 Tz (provides ) Tj 2.780556 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 66.759259 Tz (wound ) Tj 2.275 0 Td 81.018519 Tz (man ) Tj 51.428571 0 0 51.428571 0 2295.753555 Tm 25.2 0 Td 58.796296 Tz (agement ) Tj 2.644444 0 Td 52.391975 Tz (device ) Tj 2.041667 0 Td 50.87963 Tz (containing ) Tj 3.227778 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 53.914141 Tz (composition ) Tj 3.752778 0 Td 56.712963 Tz (produced ) Tj 51.428571 0 0 51.428571 0 2251.059459 Tm 25.180556 0 Td 61.574074 Tz (by ) Tj 1.069444 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 60.493827 Tz (method ) Tj 2.508333 0 Td 51.49177 Tz (described ) Tj 3.130556 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 51.851852 Tz (previous ) Tj 2.819444 0 Td 47.395833 Tz (aspects. ) Tj 2.663889 0 Td 43.75 Tz (In ) Tj 0.875 0 Td 59.41358 Tz (one ) Tj 48.571429 0 0 48.571429 0 2208 Tm 26.682353 0 Td 60.828877 Tz (embodiment, ) Tj 4.302941 0 Td 53.75817 Tz (the ) Tj 1.276471 0 Td 55.473856 Tz (device ) Tj 2.285294 0 Td 52.757353 Tz (contains ) Tj 2.820588 0 Td 60.04902 Tz (an ) Tj 1.008824 0 Td 49.183007 Tz (effective ) Tj 2.923529 0 Td 65.196078 Tz (amount ) Tj 2.635294 0 Td 58.333333 Tz (of ) Tj 0.905882 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2167.673575 Tm 25.180556 0 Td 49.200337 Tz (therapeutic ) Tj 3.636111 0 Td 49.151235 Tz (agent. ) Tj 2.236111 0 Td 48.611111 Tz (In ) Tj 0.991667 0 Td 52.777778 Tz (another ) Tj 2.566667 0 Td 57.744108 Tz (embodiment, ) Tj 4.258333 0 Td 48.611111 Tz (the ) Tj 1.302778 0 Td 46.450617 Tz (effective ) Tj 51.428571 0 0 51.428571 0 2123.859764 Tm 25.2 0 Td 61.033951 Tz (amount ) Tj 2.469444 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 53.148148 Tz (agent ) Tj 1.866667 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 44.074074 Tz (sufficient ) Tj 2.916667 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 53.472222 Tz (reduce ) Tj 2.177778 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 48.611111 Tz (Survival ) Tj 2.625 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 2083.814634 Tm 25.2 0 Td 46.367521 Tz (proliferation ) Tj 3.811111 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 46.090535 Tz (bacterial ) Tj 2.683333 0 Td 40.185185 Tz (cell. ) Tj 1.438889 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 35 Tz (still ) Tj 1.244444 0 Td 52.777778 Tz (another ) Tj 2.372222 0 Td 57.449495 Tz (embodiment, ) Tj 51.428571 0 0 51.428571 0 2043.1644 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 53.148148 Tz (agent ) Tj 1.769444 0 Td 40.509259 Tz (is ) Tj 0.661111 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 46.018519 Tz (antibiotic ) Tj 2.975 0 Td 48.611111 Tz (selected ) Tj 2.527778 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 56.388889 Tz (group ) Tj 1.905556 0 Td 48.935185 Tz (consisting ) Tj 51.428571 0 0 51.428571 0 2002.709001 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 54.208754 Tz (daptomycin, ) Tj 3.830556 0 Td 56.565657 Tz (Vancomycin, ) Tj 3.986111 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 52.211934 Tz (amikacin. ) Tj 3.111111 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 35.648148 Tz (still ) Tj 1.322222 0 Td 52.777778 Tz (another ) Tj 51.428571 0 0 51.428571 0 1959.429109 Tm 25.2 0 Td 57.449495 Tz (embodiment, ) Tj 4.025 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 53.148148 Tz (agent ) Tj 1.808333 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 58.333333 Tz (any ) Tj 1.263889 0 Td 57.253086 Tz (one ) Tj 1.263889 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 61.574074 Tz (more ) Tj 1.652778 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 57.253086 Tz (growth ) Tj 2.275 0 Td 43.518519 Tz (factor, ) Tj 51.428571 0 0 51.428571 0 1917.676364 Tm 25.2 0 Td 49.691358 Tz (anti-inflammatory, ) Tj 5.638889 0 Td 50.378788 Tz (hemostatic, ) Tj 3.597222 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 48.813657 Tz (anti-thrombotic. ) Tj 5.016667 0 Td 45.37037 Tz (In ) Tj 0.836111 0 Td 35.648148 Tz (still ) Tj 51.428571 0 0 51.428571 0 1874.837209 Tm 25.2 0 Td 52.777778 Tz (another ) Tj 2.508333 0 Td 58.038721 Tz (embodiment, ) Tj 4.180556 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 52.5 Tz (agent ) Tj 1.925 0 Td 38.888889 Tz (is ) Tj 0.816667 0 Td 58.333333 Tz (an ) Tj 1.05 0 Td 44.722222 Tz (anti-bacterial, ) Tj 4.394444 0 Td 55.092593 Tz (anti ) Tj 51.428571 0 0 51.428571 0 1837.567123 Tm 25.2 0 Td 42.12963 Tz (viral, ) Tj 1.75 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 48.611111 Tz (anti-fungal ) Tj 3.461111 0 Td 48.070988 Tz (agent. ) Tj 51.428571 0 0 51.428571 0 1793.52973 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.894444 0 Td 52.777778 Tz (another ) Tj 2.469444 0 Td 48.148148 Tz (aspect, ) Tj 2.313889 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 50.411523 Tz (invention ) Tj 3.013889 0 Td 52.662037 Tz (provides ) Tj 2.819444 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 59.953704 Tz (method ) Tj 2.45 0 Td 49.691358 Tz (for ) Tj 51.428571 0 0 51.428571 0 1753.047556 Tm 25.180556 0 Td 46.990741 Tz (treating ) Tj 2.508333 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 52.175926 Tz (preventing ) Tj 3.363889 0 Td 58.333333 Tz (an ) Tj 0.991667 0 Td 47.170782 Tz (infection ) Tj 2.838889 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 49.074074 Tz (subject ) Tj 2.313889 0 Td 43.75 Tz (at ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 42.12963 Tz (site ) Tj 1.283333 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1709.693351 Tm 25.180556 0 Td 52.777778 Tz (trauma, ) Tj 2.605556 0 Td 50.771605 Tz (the ) Tj 1.322222 0 Td 59.953704 Tz (method ) Tj 2.547222 0 Td 51.446759 Tz (involves ) Tj 2.877778 0 Td 50.555556 Tz (contacting ) Tj 3.402778 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 42.939815 Tz (site ) Tj 1.419444 0 Td 52.662037 Tz (with ) Tj 1.691667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1670.0908 Tm 25.2 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 54.208754 Tz (composition ) Tj 3.772222 0 Td 51.851852 Tz (or ) Tj 0.719444 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 66.111111 Tz (wound ) Tj 2.177778 0 Td 61.574074 Tz (management ) Tj 3.830556 0 Td 52.932099 Tz (device ) Tj 2.061111 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 58.333333 Tz (any ) Tj 52.857143 0 0 52.857143 0 1625.263223 Tm 24.518919 0 Td 50.45045 Tz (previous ) Tj 2.667568 0 Td 45.945946 Tz (aspect. ) Tj 2.213514 0 Td 45.720721 Tz (In ) Tj 0.775676 0 Td 50.45045 Tz (other ) Tj 1.702703 0 Td 55.442943 Tz (embodiments, ) Tj 4.218919 0 Td 49.399399 Tz (the ) Tj 1.154054 0 Td 58.333333 Tz (method ) Tj 2.308108 0 Td 47.297297 Tz (further ) Tj 51.428571 0 0 51.428571 0 1584.767726 Tm 25.2 0 Td 51.041667 Tz (involves ) Tj 2.663889 0 Td 45.046296 Tz (irrigating ) Tj 2.877778 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 51.851852 Tz (debriding ) Tj 2.975 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 42.12963 Tz (site ) Tj 1.186111 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 52.314815 Tz (trauma. ) Tj 2.430556 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 51.203704 Tz (other ) Tj 51.428571 0 0 51.428571 0 1542.627451 Tm 25.2 0 Td 56.983025 Tz (embodiments, ) Tj 4.336111 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 54.79798 Tz (composition ) Tj 3.85 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 52.932099 Tz (device ) Tj 2.138889 0 Td 50.636574 Tz (contains ) Tj 2.644444 0 Td 56.712963 Tz (an ) Tj 0.952778 0 Td 53.148148 Tz (agent ) Tj 51.428571 0 0 51.428571 0 1501.422466 Tm 25.180556 0 Td 46.990741 Tz (that ) Tj 1.263889 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 57.253086 Tz (any ) Tj 1.205556 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 60.763889 Tz (more ) Tj 1.594444 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 49.85755 Tz (antimicrobial ) Tj 4.025 0 Td 48.611111 Tz (agent, ) Tj 1.925 0 Td 56.712963 Tz (growth ) Tj 2.216667 0 Td 43.518519 Tz (factor, ) Tj 51.428571 0 0 51.428571 0 1460.425904 Tm 25.2 0 Td 49.691358 Tz (anti-inflammatory, ) Tj 5.541667 0 Td 52.5 Tz (hemostatic ) Tj 3.305556 0 Td 49.151235 Tz (agent, ) Tj 1.905556 0 Td 60.493827 Tz (and ) Tj 1.225 0 Td 48.813657 Tz (anti-thrombotic. ) Tj 4.919444 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 1415.805442 Tm 25.219444 0 Td 35.648148 Tz (still ) Tj 1.477778 0 Td 50.555556 Tz (other ) Tj 1.866667 0 Td 57.253086 Tz (embodiments, ) Tj 4.511111 0 Td 50.771605 Tz (the ) Tj 1.283333 0 Td 56.712963 Tz (trauma ) Tj 2.469444 0 Td 37.268519 Tz (is ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 0.738889 0 Td 44.650206 Tz (fracture, ) Tj 2.838889 0 Td 59.953704 Tz (open ) Tj 51.428571 0 0 51.428571 0 1376.783593 Tm 25.2 0 Td 45.010288 Tz (fracture, ) Tj 2.702778 0 Td 59.41358 Tz (wound, ) Tj 2.411111 0 Td 59.259259 Tz (complex ) Tj 2.722222 0 Td 59.953704 Tz (wound, ) Tj 2.391667 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 47.800926 Tz (Surgical ) Tj 2.527778 0 Td 38.888889 Tz (site. ) Tj 51.428571 0 0 51.428571 0 1336.005161 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 52.314815 Tz (another ) Tj 2.391667 0 Td 47.222222 Tz (aspect, ) Tj 2.177778 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 50.411523 Tz (invention ) Tj 2.916667 0 Td 52.256944 Tz (provides ) Tj 2.741667 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 43.209877 Tz (kit ) Tj 0.991667 0 Td 50.87963 Tz (containing ) Tj 51.428571 0 0 51.428571 0 1295.852632 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 49.421296 Tz (chitosan ) Tj 2.722222 0 Td 54.208754 Tz (composition ) Tj 3.888889 0 Td 58.333333 Tz (of ) Tj 0.913889 0 Td 58.333333 Tz (any ) Tj 1.361111 0 Td 51.851852 Tz (previous ) Tj 2.8 0 Td 51.311728 Tz (aspect ) Tj 2.158333 0 Td 47.530864 Tz (for ) Tj 1.127778 0 Td 55.092593 Tz (use ) Tj 1.302778 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 1252.537888 Tm 25.180556 0 Td 46.990741 Tz (treating ) Tj 2.430556 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 56.712963 Tz (trauma ) Tj 2.216667 0 Td 42.12963 Tz (site ) Tj 1.205556 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 48.935185 Tz (delivering ) Tj 3.091667 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 48.070988 Tz (agent. ) Tj 1.963889 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 66.975309 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1209.865653 Tm 25.2 0 Td 54.444444 Tz (ment, ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 54.208754 Tz (composition ) Tj 3.772222 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 53.472222 Tz (device ) Tj 2.1 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 56.712963 Tz (form ) Tj 1.594444 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1171.21697 Tm 25.180556 0 Td 48.611111 Tz (plug, ) Tj 1.672222 0 Td 55.740741 Tz (mesh, ) Tj 1.866667 0 Td 39.969136 Tz (strip, ) Tj 1.613889 0 Td 46.296296 Tz (Suture, ) Tj 2.119444 0 Td 47.890947 Tz (dressing, ) Tj 2.780556 0 Td 52.314815 Tz (sponge, ) Tj 2.391667 0 Td 44.074074 Tz (film, ) Tj 1.477778 0 Td 51.49177 Tz (hydrogel, ) Tj 2.955556 0 Td 53.472222 Tz (or ) Tj 48.571429 0 0 48.571429 0 1126 Tm 26.682353 0 Td 57.47549 Tz (combinations ) Tj 4.405882 0 Td 48.468137 Tz (thereof. ) Tj 2.635294 0 Td 49.754902 Tz (In ) Tj 0.844118 0 Td 55.882353 Tz (another ) Tj 2.552941 0 Td 61.452763 Tz (embodiment, ) Tj 4.323529 0 Td 51.470588 Tz (the ) Tj 1.152941 0 Td 54.044118 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1085.690176 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 52.932099 Tz (device ) Tj 2.177778 0 Td 49.826389 Tz (contains ) Tj 2.663889 0 Td 55.092593 Tz (an ) Tj 0.913889 0 Td 53.796296 Tz (agent ) Tj 1.847222 0 Td 49.016204 Tz (selected ) Tj 2.605556 0 Td 57.523148 Tz (from ) Tj 1.652778 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1045.183133 Tm 25.2 0 Td 56.388889 Tz (group ) Tj 1.905556 0 Td 48.935185 Tz (consisting ) Tj 3.15 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.85755 Tz (antimicrobial ) Tj 4.063889 0 Td 49.151235 Tz (agent, ) Tj 1.963889 0 Td 56.712963 Tz (growth ) Tj 2.255556 0 Td 43.518519 Tz (factor, ) Tj 2.041667 0 Td 55.092593 Tz (anti ) Tj 51.428571 0 0 51.428571 0 1004.516129 Tm 25.2 0 Td 51.851852 Tz (inflammatory, ) Tj 4.316667 0 Td 45.37037 Tz (clot ) Tj 1.322222 0 Td 56.17284 Tz (promoting ) Tj 3.247222 0 Td 49.151235 Tz (agent, ) Tj 2.002778 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 48.813657 Tz (anti-thrombotic. ) Tj 51.428571 0 0 51.428571 0 959.853107 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.991667 0 Td 50.462963 Tz (various ) Tj 2.508333 0 Td 59.217172 Tz (embodiments ) Tj 4.316667 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 50.771605 Tz (the ) Tj 1.283333 0 Td 58.333333 Tz (above ) Tj 2.119444 0 Td 50.462963 Tz (aspects ) Tj 2.508333 0 Td 51.851852 Tz (or ) Tj 0.952778 0 Td 59.41358 Tz (any ) Tj 51.428571 0 0 51.428571 0 918.395577 Tm 25.2 0 Td 51.311728 Tz (aspect ) Tj 2.002778 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.411523 Tz (invention ) Tj 2.916667 0 Td 49.907407 Tz (delineated ) Tj 3.15 0 Td 50.231481 Tz (herein ) Tj 2.022222 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 49.151235 Tz (buffer ) Tj 1.925 0 Td 52.932099 Tz (has ) Tj 1.127778 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 76.157407 Tz (pH ) Tj 51.428571 0 0 51.428571 0 875.787234 Tm 25.180556 0 Td 57.87037 Tz (between ) Tj 2.663889 0 Td 48.611111 Tz (2.5 ) Tj 1.108333 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 46.450617 Tz (6.5 ) Tj 1.069444 0 Td 55.092593 Tz (or ) Tj 0.836111 0 Td 57.407407 Tz (between ) Tj 2.644444 0 Td 58.333333 Tz (5 ) Tj 0.563889 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 55.092593 Tz (6 ) Tj 0.583333 0 Td 39.969136 Tz (\(e.g., ) Tj 1.691667 0 Td 44.560185 Tz (5.1, ) Tj 1.322222 0 Td 43.75 Tz (5.2, ) Tj 1.302778 0 Td 43.75 Tz (5.3, ) Tj 51.428571 0 0 51.428571 0 833 Tm 25.219444 0 Td 44.560185 Tz (5.4, ) Tj 1.322222 0 Td 43.75 Tz (5.5, ) Tj 1.322222 0 Td 44.560185 Tz (5.6, ) Tj 1.302778 0 Td 45.37037 Tz (5.7, ) Tj 1.341667 0 Td 43.75 Tz (5.8, ) Tj 1.322222 0 Td 44.560185 Tz (5.9, ) Tj 1.283333 0 Td 60.493827 Tz (and ) Tj 1.302778 0 Td 44.722222 Tz (6.0\). ) Tj 1.594444 0 Td 48.611111 Tz (In ) Tj 0.816667 0 Td 50.555556 Tz (other ) Tj 1.730556 0 Td 56.712963 Tz (embodiments, ) Tj 51.428571 0 0 51.428571 0 792.512696 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 49.691358 Tz (buffer ) Tj 1.925 0 Td 38.888889 Tz (is ) Tj 0.602778 0 Td 57.253086 Tz (any ) Tj 1.244444 0 Td 57.253086 Tz (one ) Tj 1.186111 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 61.574074 Tz (more ) Tj 1.613889 0 Td 45.775463 Tz (acetate, ) Tj 2.352778 0 Td 49.421296 Tz (bicarbonate, ) Tj 3.752778 0 Td 49.583333 Tz (carbonate, ) Tj 51.428571 0 0 51.428571 0 753.678487 Tm 25.2 0 Td 40.914352 Tz (citrate, ) Tj 2.197222 0 Td 49.826389 Tz (formate, ) Tj 2.605556 0 Td 48.206019 Tz (glycine, ) Tj 2.508333 0 Td 50 Tz (malate, ) Tj 2.294444 0 Td 50.636574 Tz (maleate, ) Tj 2.605556 0 Td 54.6875 Tz (2-\(N-morpholino\) ) Tj 51.428571 0 0 51.428571 0 712.344743 Tm 25.2 0 Td 49.421296 Tz (ethanesulfonate, ) Tj 5.055556 0 Td 51.851852 Tz (phosphate, ) Tj 3.422222 0 Td 49.151235 Tz (proprionate, ) Tj 3.811111 0 Td 60.493827 Tz (and ) Tj 1.4 0 Td 47.314815 Tz (Succinate. ) Tj 3.208333 0 Td 48.611111 Tz (In ) Tj 51.428571 0 0 51.428571 0 668.357753 Tm 25.2 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 50.05144 Tz (preferred ) Tj 2.858333 0 Td 58.038721 Tz (embodiment, ) Tj 4.044444 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 49.151235 Tz (buffer ) Tj 1.925 0 Td 40.509259 Tz (is ) Tj 0.641667 0 Td 58.333333 Tz (an ) Tj 0.875 0 Td 48.611111 Tz (acetate ) Tj 2.216667 0 Td 43.981481 Tz (buffer. ) Tj 2.080556 0 Td 51.851852 Tz (In ) Tj 51.428571 0 0 51.428571 0 627.080255 Tm 25.2 0 Td 50.555556 Tz (other ) Tj 1.75 0 Td 57.253086 Tz (embodiments, ) Tj 4.413889 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 57.253086 Tz (sponge ) Tj 2.333333 0 Td 40.509259 Tz (is ) Tj 0.777778 0 Td 51.49177 Tz (contacted ) Tj 3.072222 0 Td 52.662037 Tz (with ) Tj 1.575 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 51.851852 Tz (acid ) Tj 40 0 0 40 0 592 Tm 32.375 0 Td 63.194444 Tz (buffer ) Tj 2.7 0 Td 78.125 Tz (wash ) Tj 2.3 0 Td 62.5 Tz (for ) Tj 1.525 0 Td 73.809524 Tz (between ) Tj 3.5 0 Td 70.833333 Tz (about ) Tj 2.5 0 Td 81.25 Tz (30 ) Tj 1.375 0 Td 70.238095 Tz (seconds ) Tj 3.35 0 Td 76.388889 Tz (and ) Tj 1.9 0 Td 66.666667 Tz (12 ) Tj 1.225 0 Td 69.166667 Tz (hours ) Tj 51.428571 0 0 51.428571 0 542.840909 Tm 25.219444 0 Td 39.969136 Tz (\(e.g., ) Tj 1.730556 0 Td 38.888889 Tz (1, ) Tj 0.7 0 Td 43.75 Tz (3, ) Tj 0.777778 0 Td 40.509259 Tz (5, ) Tj 0.797222 0 Td 45.37037 Tz (10, ) Tj 1.127778 0 Td 46.450617 Tz (15, ) Tj 1.030556 0 Td 50.771605 Tz (30, ) Tj 1.147222 0 Td 49.691358 Tz (45, ) Tj 1.147222 0 Td 59.953704 Tz (60 ) Tj 0.933333 0 Td 51.041667 Tz (minutes, ) Tj 2.722222 0 Td 38.888889 Tz (1, ) Tj 0.680556 0 Td 46.990741 Tz (3, ) Tj 0.777778 0 Td 45.37037 Tz (5, ) Tj 0.816667 0 Td 46.450617 Tz (10, ) Tj 1.05 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 55.092593 Tz (12 ) Tj 51.428571 0 0 51.428571 0 502.034146 Tm 25.180556 0 Td 48.611111 Tz (hours\). ) Tj 2.275 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 36.296296 Tz (still ) Tj 1.283333 0 Td 52.777778 Tz (another ) Tj 2.372222 0 Td 57.744108 Tz (embodiment, ) Tj 3.986111 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 57.253086 Tz (sponge ) Tj 2.255556 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 51.49177 Tz (contacted ) Tj 51.428571 0 0 51.428571 0 460.035533 Tm 25.180556 0 Td 54.282407 Tz (with ) Tj 1.594444 0 Td 47.530864 Tz (the ) Tj 1.147222 0 Td 51.041667 Tz (acid ) Tj 1.477778 0 Td 49.151235 Tz (buffer ) Tj 2.022222 0 Td 60.763889 Tz (wash ) Tj 1.75 0 Td 55.092593 Tz (having ) Tj 2.216667 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 50.605413 Tz (concentration ) Tj 4.2 0 Td 58.796296 Tz (between ) Tj 48.571429 0 0 48.571429 0 420 Tm 26.682353 0 Td 57.647059 Tz (about ) Tj 1.873529 0 Td 54.901961 Tz (0.05 ) Tj 1.502941 0 Td 61.764706 Tz (and ) Tj 1.255882 0 Td 54.901961 Tz (2.0 ) Tj 1.152941 0 Td 52.614379 Tz (molar. ) Tj 2.1 0 Td 49.754902 Tz (In ) Tj 0.802941 0 Td 37.745098 Tz (still ) Tj 1.276471 0 Td 55.882353 Tz (another ) Tj 2.45 0 Td 61.452763 Tz (embodiment, ) Tj 4.2 0 Td 61.764706 Tz (a ) Tj 0.555882 0 Td 53.186275 Tz (0.25 ) Tj 51.428571 0 0 51.428571 0 376.486129 Tm 25.2 0 Td 62.789352 Tz (Macetate ) Tj 3.344444 0 Td 49.151235 Tz (buffer ) Tj 2.1 0 Td 37.268519 Tz (is ) Tj 0.816667 0 Td 49.259259 Tz (used. ) Tj 1.886111 0 Td 46.990741 Tz (In ) Tj 0.913889 0 Td 49.691358 Tz (yet ) Tj 1.205556 0 Td 51.851852 Tz (other ) Tj 1.866667 0 Td 56.712963 Tz (embodiments, ) Tj 4.433333 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 337.887139 Tm 25.219444 0 Td 56.712963 Tz (sponge ) Tj 2.333333 0 Td 53.472222 Tz (degrades ) Tj 2.838889 0 Td 61.574074 Tz (by ) Tj 1.030556 0 Td 43.75 Tz (at ) Tj 0.836111 0 Td 44.074074 Tz (least ) Tj 1.594444 0 Td 54.444444 Tz (about ) Tj 1.905556 0 Td 62.384259 Tz (20%, ) Tj 1.769444 0 Td 63.194444 Tz (30%, ) Tj 1.847222 0 Td 61.574074 Tz (40%, ) Tj 1.769444 0 Td 62.384259 Tz (50%, ) Tj 51.428571 0 0 51.428571 0 295.932953 Tm 25.219444 0 Td 71.296296 Tz (60% ) Tj 1.691667 0 Td 51.851852 Tz (or ) Tj 0.991667 0 Td 60.763889 Tz (more ) Tj 1.847222 0 Td 43.75 Tz (in ) Tj 0.894444 0 Td 56.712963 Tz (an ) Tj 1.069444 0 Td 45.37037 Tz (in ) Tj 0.972222 0 Td 44.074074 Tz (vitro ) Tj 1.691667 0 Td 51.851852 Tz (degradation ) Tj 3.791667 0 Td 52.5 Tz (assay ) Tj 1.944444 0 Td 46.990741 Tz (in ) Tj 0.933333 0 Td 54.444444 Tz (about ) Tj 51.428571 0 0 51.428571 0 255.410383 Tm 25.258333 0 Td 49.826389 Tz (10-days. ) Tj 2.663889 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 50.771605 Tz (yet ) Tj 1.108333 0 Td 49.907407 Tz (other ) Tj 1.652778 0 Td 57.253086 Tz (embodiments, ) Tj 4.336111 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 56.712963 Tz (sponge ) Tj 2.236111 0 Td 53.877315 Tz (degrades ) Tj 2.780556 0 Td 61.574074 Tz (by ) Tj 48.571429 0 0 48.571429 0 212 Tm 26.682353 0 Td 48.039216 Tz (at ) Tj 0.802941 0 Td 47.352941 Tz (least ) Tj 1.647059 0 Td 58.333333 Tz (about ) Tj 1.976471 0 Td 66.911765 Tz (20%, ) Tj 1.852941 0 Td 66.911765 Tz (30%, ) Tj 1.873529 0 Td 66.911765 Tz (40%, ) Tj 1.873529 0 Td 66.053922 Tz (50%, ) Tj 1.873529 0 Td 76.633987 Tz (60% ) Tj 1.626471 0 Td 56.617647 Tz (or ) Tj 0.947059 0 Td 64.338235 Tz (more ) Tj 1.791176 0 Td 49.754902 Tz (in ) Tj 0.864706 0 Td 55.759804 Tz (vivo ) Tj 51.428571 0 0 51.428571 0 169.296732 Tm 25.2 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 53.796296 Tz (about ) Tj 1.963889 0 Td 50.231481 Tz (10-days. ) Tj 2.780556 0 Td 45.37037 Tz (In ) Tj 0.894444 0 Td 35 Tz (still ) Tj 1.341667 0 Td 51.851852 Tz (other ) Tj 1.827778 0 Td 56.983025 Tz (embodiments, ) Tj 4.433333 0 Td 48.611111 Tz (the ) Tj 1.186111 0 Td 60.493827 Tz (method ) Tj ET Q endstream endobj 121 0 obj << /Length 1 >> stream q endstream endobj 122 0 obj << /Length 47401 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.359459 0 Td 72.522523 Tz (3 ) Tj 51.428571 0 0 51.428571 0 2914.973138 Tm 6.261111 0 Td 47.685185 Tz (further ) Tj 2.197222 0 Td 51.041667 Tz (involves ) Tj 2.683333 0 Td 47.530864 Tz (\(d\) ) Tj 1.069444 0 Td 50.356125 Tz (incorporating ) Tj 4.122222 0 Td 58.333333 Tz (an ) Tj 0.933333 0 Td 46.090535 Tz (effective ) Tj 2.683333 0 Td 61.574074 Tz (amount ) Tj 2.411111 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 46.990741 Tz (at ) Tj 51.428571 0 0 51.428571 0 2873.565891 Tm 6.261111 0 Td 44.722222 Tz (least ) Tj 1.613889 0 Td 57.253086 Tz (one ) Tj 1.263889 0 Td 53.148148 Tz (agent ) Tj 1.827778 0 Td 46.990741 Tz (into ) Tj 1.4 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 43.75 Tz (at ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 51.203704 Tz (point ) Tj 1.788889 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 2826.719212 Tm 6.261111 0 Td 44.722222 Tz (care. ) Tj 1.613889 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 35 Tz (still ) Tj 1.225 0 Td 51.851852 Tz (other ) Tj 1.691667 0 Td 56.712963 Tz (embodiments, ) Tj 4.277778 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 51.041667 Tz (acid ) Tj 1.4 0 Td 49.151235 Tz (buffer ) Tj 1.925 0 Td 47.314815 Tz (type, ) Tj 1.594444 0 Td 44.444444 Tz (buffer, ) Tj 51.428571 0 0 51.428571 0 2783.660194 Tm 6.261111 0 Td 49.305556 Tz (concentration, ) Tj 4.336111 0 Td 48.611111 Tz (buffer ) Tj 1.905556 0 Td 59.41358 Tz (pH, ) Tj 1.263889 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 49.151235 Tz (buffer ) Tj 1.944444 0 Td 53.703704 Tz (soaking ) Tj 2.430556 0 Td 53.472222 Tz (time ) Tj 1.477778 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 50.231481 Tz (varied ) Tj 51.428571 0 0 51.428571 0 2744.096862 Tm 6.241667 0 Td 46.990741 Tz (to ) Tj 0.952778 0 Td 53.06713 Tz (optimize ) Tj 2.897222 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 52.146465 Tz (degradation ) Tj 3.830556 0 Td 56.712963 Tz (of ) Tj 0.933333 0 Td 50.771605 Tz (the ) Tj 1.283333 0 Td 52.777778 Tz (Sponge. ) Tj 2.625 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 48.611111 Tz (yet ) Tj 1.244444 0 Td 51.203704 Tz (other ) Tj 51.428571 0 0 51.428571 0 2696.880559 Tm 6.261111 0 Td 56.983025 Tz (embodiments, ) Tj 4.394444 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 49.826389 Tz (chitosan ) Tj 2.702778 0 Td 54.503367 Tz (composition ) Tj 3.908333 0 Td 42.12963 Tz (is ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 65.462963 Tz (wound ) Tj 2.275 0 Td 82.098765 Tz (man ) Tj 51.428571 0 0 51.428571 0 2653.11378 Tm 6.261111 0 Td 58.796296 Tz (agement ) Tj 2.702778 0 Td 48.611111 Tz (device. ) Tj 2.333333 0 Td 45.37037 Tz (In ) Tj 0.797222 0 Td 35.648148 Tz (still ) Tj 1.322222 0 Td 49.907407 Tz (other ) Tj 1.672222 0 Td 56.983025 Tz (embodiments, ) Tj 4.336111 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 53.148148 Tz (agent ) Tj 1.827778 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 2608.480418 Tm 6.261111 0 Td 48.148148 Tz (antimicrobial. ) Tj 4.433333 0 Td 48.611111 Tz (In ) Tj 0.952778 0 Td 49.691358 Tz (yet ) Tj 1.263889 0 Td 50.555556 Tz (other ) Tj 1.847222 0 Td 56.712963 Tz (embodiments, ) Tj 4.452778 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 49.826389 Tz (chitosan ) Tj 2.761111 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2564.528678 Tm 6.241667 0 Td 47.685185 Tz (treated ) Tj 2.177778 0 Td 52.662037 Tz (with ) Tj 1.419444 0 Td 58.333333 Tz (an ) Tj 0.855556 0 Td 51.041667 Tz (acid ) Tj 1.4 0 Td 50 Tz (solvent ) Tj 2.216667 0 Td 46.990741 Tz (that ) Tj 1.283333 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 57.253086 Tz (any ) Tj 1.205556 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 60.763889 Tz (more ) Tj 1.613889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 43.981481 Tz (acetic, ) Tj 51.428571 0 0 51.428571 0 2523.347518 Tm 6.261111 0 Td 39.814815 Tz (citric, ) Tj 1.866667 0 Td 45.833333 Tz (oxalic, ) Tj 2.1 0 Td 49.259259 Tz (propionic, ) Tj 3.111111 0 Td 48.611111 Tz (ascorbic, ) Tj 2.761111 0 Td 50.356125 Tz (hydrochloric, ) Tj 4.102778 0 Td 50 Tz (formic, ) Tj 2.275 0 Td 51.851852 Tz (Sali ) Tj 51.428571 0 0 51.428571 0 2478.237971 Tm 6.261111 0 Td 46.666667 Tz (cylic ) Tj 1.691667 0 Td 60.493827 Tz (and ) Tj 1.341667 0 Td 43.209877 Tz (lactic ) Tj 1.847222 0 Td 46.450617 Tz (acids. ) Tj 2.022222 0 Td 45.37037 Tz (In ) Tj 0.836111 0 Td 50.771605 Tz (yet ) Tj 1.205556 0 Td 49.907407 Tz (other ) Tj 1.730556 0 Td 57.253086 Tz (embodiments, ) Tj 4.413889 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 52.662037 Tz (acid ) Tj 51.428571 0 0 51.428571 0 2433.468193 Tm 6.280556 0 Td 50 Tz (Solvent ) Tj 2.333333 0 Td 50.231481 Tz (contains ) Tj 2.683333 0 Td 43.209877 Tz (lactic ) Tj 1.788889 0 Td 51.041667 Tz (acid ) Tj 1.458333 0 Td 52.932099 Tz (and/or ) Tj 2.1 0 Td 47.530864 Tz (acetic ) Tj 1.944444 0 Td 46.018519 Tz (acid. ) Tj 1.691667 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 49.691358 Tz (yet ) Tj 1.127778 0 Td 51.203704 Tz (other ) Tj 48.571429 0 0 48.571429 0 2391 Tm 6.629412 0 Td 60.334967 Tz (embodiments, ) Tj 4.735294 0 Td 49.754902 Tz (at ) Tj 1.008824 0 Td 46.666667 Tz (least ) Tj 1.811765 0 Td 57.647059 Tz (about ) Tj 2.120588 0 Td 53.75817 Tz (30, ) Tj 1.379412 0 Td 52.614379 Tz (40, ) Tj 1.379412 0 Td 66.911765 Tz (50 ) Tj 1.173529 0 Td 56.617647 Tz (or ) Tj 1.070588 0 Td 76.633987 Tz (60% ) Tj 1.811765 0 Td 61.764706 Tz (of ) Tj 1.070588 0 Td 52.614379 Tz (the ) Tj 51.428571 0 0 51.428571 0 2349.533981 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 53.914141 Tz (composition ) Tj 3.772222 0 Td 53.324916 Tz (biodegrades ) Tj 3.733333 0 Td 55.092593 Tz (over ) Tj 1.497222 0 Td 46.990741 Tz (at ) Tj 0.758333 0 Td 44.074074 Tz (least ) Tj 1.516667 0 Td 54.444444 Tz (about ) Tj 1.827778 0 Td 56.388889 Tz (three ) Tj 51.428571 0 0 51.428571 0 2305.301746 Tm 6.261111 0 Td 46.180556 Tz (five ) Tj 1.283333 0 Td 55.092593 Tz (days ) Tj 1.497222 0 Td 66.435185 Tz (when ) Tj 1.769444 0 Td 54.012346 Tz (implanted ) Tj 3.111111 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 45.775463 Tz (subject. ) Tj 2.430556 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 35.648148 Tz (still ) Tj 1.244444 0 Td 51.203704 Tz (other ) Tj 1.672222 0 Td 67.515432 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 2260.663252 Tm 6.261111 0 Td 52.932099 Tz (ments, ) Tj 2.158333 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 59.953704 Tz (molded ) Tj 2.372222 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 58.333333 Tz (form ) Tj 1.633333 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 49.259259 Tz (plug, ) Tj 51.428571 0 0 51.428571 0 2219.229885 Tm 6.261111 0 Td 57.037037 Tz (mesh, ) Tj 1.963889 0 Td 40.509259 Tz (Strip, ) Tj 1.730556 0 Td 45.833333 Tz (Suture, ) Tj 2.197222 0 Td 47.890947 Tz (dressing, ) Tj 2.858333 0 Td 52.777778 Tz (sponge, ) Tj 2.469444 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 44.074074 Tz (film. ) Tj 51.428571 0 0 51.428571 0 2175.70648 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.419444 0 Td 50.411523 Tz (invention ) Tj 2.994444 0 Td 52.662037 Tz (provides ) Tj 2.819444 0 Td 53.742284 Tz (compositions ) Tj 4.180556 0 Td 48.251029 Tz (featuring ) Tj 2.897222 0 Td 51.041667 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2130.036735 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.458333 0 Td 58.333333 Tz (methods ) Tj 2.877778 0 Td 47.530864 Tz (for ) Tj 1.225 0 Td 52.5 Tz (using ) Tj 1.963889 0 Td 55.092593 Tz (Such ) Tj 1.75 0 Td 53.472222 Tz (compositions ) Tj 4.258333 0 Td 48.611111 Tz (for ) Tj 1.225 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 46.666667 Tz (local ) Tj 51.428571 0 0 51.428571 0 2088.785714 Tm 6.261111 0 Td 49.421296 Tz (delivery ) Tj 2.683333 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 48.341049 Tz (biologically ) Tj 3.772222 0 Td 49.151235 Tz (active ) Tj 2.022222 0 Td 51.851852 Tz (agents ) Tj 2.138889 0 Td 48.611111 Tz (to ) Tj 0.855556 0 Td 58.333333 Tz (an ) Tj 0.991667 0 Td 58.333333 Tz (open ) Tj 1.730556 0 Td 44.290123 Tz (fracture, ) Tj 51.428571 0 0 51.428571 0 2043.246377 Tm 6.261111 0 Td 59.259259 Tz (complex ) Tj 2.702778 0 Td 65.462963 Tz (wound ) Tj 2.158333 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 49.907407 Tz (other ) Tj 1.652778 0 Td 42.12963 Tz (site ) Tj 1.205556 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 45.694444 Tz (infection. ) Tj 2.936111 0 Td 56.17284 Tz (Compositions ) Tj 4.219444 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1996.355117 Tm 6.261111 0 Td 43.75 Tz (articles ) Tj 2.313889 0 Td 51.388889 Tz (defined ) Tj 2.372222 0 Td 58.333333 Tz (by ) Tj 0.933333 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 50.771605 Tz (invention ) Tj 2.994444 0 Td 58.333333 Tz (were ) Tj 1.613889 0 Td 47.395833 Tz (isolated ) Tj 2.469444 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 52.572016 Tz (otherwise ) Tj 51.428571 0 0 51.428571 0 1955.829517 Tm 6.261111 0 Td 55.632716 Tz (manufactured ) Tj 4.375 0 Td 45.37037 Tz (in ) Tj 0.933333 0 Td 52.824074 Tz (connection ) Tj 3.538889 0 Td 53.472222 Tz (with ) Tj 1.672222 0 Td 48.611111 Tz (the ) Tj 1.225 0 Td 57.523148 Tz (examples ) Tj 3.111111 0 Td 55.092593 Tz (provided ) Tj 51.428571 0 0 51.428571 0 1912.657568 Tm 6.241667 0 Td 52.932099 Tz (below. ) Tj 2.158333 0 Td 57.037037 Tz (Other ) Tj 1.925 0 Td 47.395833 Tz (features ) Tj 2.508333 0 Td 61.574074 Tz (and ) Tj 1.302778 0 Td 54.12037 Tz (advantages ) Tj 3.480556 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 50.411523 Tz (invention ) Tj 2.994444 0 Td 46.180556 Tz (will ) Tj 51.428571 0 0 51.428571 0 1873.253333 Tm 6.241667 0 Td 61.574074 Tz (be ) Tj 1.05 0 Td 52.256944 Tz (apparent ) Tj 2.877778 0 Td 58.333333 Tz (from ) Tj 1.808333 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 47.395833 Tz (detailed ) Tj 2.644444 0 Td 47.530864 Tz (description, ) Tj 3.772222 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 58.333333 Tz (from ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 40 0 0 40 0 1836 Tm 8.05 0 Td 63.095238 Tz (claims. ) Tj 38.571429 0 0 38.571429 0 1757 Tm 17.007407 0 Td 90.740741 Tz (DEFINITIONS ) Tj 51.428571 0 0 51.428571 0 1667.743191 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 0.991667 0 Td 51.203704 Tz (chitosan' ) Tj 3.286111 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 58.333333 Tz (meant ) Tj 1.905556 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 48.611111 Tz (chitin-derived ) Tj 4.258333 0 Td 58.796296 Tz (polymer ) Tj 2.644444 0 Td 44.560185 Tz (that ) Tj 1.263889 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 45.37037 Tz (at ) Tj 52.857143 0 0 52.857143 0 1626.447942 Tm 6.091892 0 Td 43.513514 Tz (least ) Tj 1.456757 0 Td 72.522523 Tz (20% ) Tj 1.513514 0 Td 47.054747 Tz (deacetylated. ) Tj 3.878378 0 Td 46.437346 Tz (Preferably, ) Tj 3.216216 0 Td 49.268018 Tz (chitosan ) Tj 2.572973 0 Td 36.261261 Tz (is ) Tj 0.605405 0 Td 45.720721 Tz (at ) Tj 0.7 0 Td 44.144144 Tz (least ) Tj 1.456757 0 Td 53.603604 Tz (about ) Tj 51.428571 0 0 51.428571 0 1586.092121 Tm 6.280556 0 Td 72.376543 Tz (50% ) Tj 1.516667 0 Td 48.860399 Tz (deacetylated. ) Tj 4.005556 0 Td 50.771605 Tz (Chitin ) Tj 2.041667 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 45.910494 Tz (linear ) Tj 1.808333 0 Td 52.314815 Tz (polysaccharide ) Tj 4.569444 0 Td 54.166667 Tz (consist ) Tj 51.428571 0 0 51.428571 0 1545.920193 Tm 6.261111 0 Td 50.771605 Tz (ing ) Tj 1.419444 0 Td 56.712963 Tz (of ) Tj 1.088889 0 Td 48.611111 Tz (\(1-4\)-linked ) Tj 3.966667 0 Td 55.48541 Tz (2-acetamido-2-deoxy-b-D-glucopyra ) Tj 51.428571 0 0 51.428571 0 1503.032086 Tm 6.261111 0 Td 49.907407 Tz (nose. ) Tj 1.944444 0 Td 53.472222 Tz (Chitosan ) Tj 3.013889 0 Td 38.888889 Tz (is ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 0.758333 0 Td 46.450617 Tz (linear ) Tj 2.061111 0 Td 52.083333 Tz (polysaccharide ) Tj 4.802778 0 Td 49.259259 Tz (consisting ) Tj 3.383333 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1463.074866 Tm 6.280556 0 Td 48.611111 Tz (\(1-4\)-linked ) Tj 3.752778 0 Td 54.139434 Tz (2-amino-2-deoxy-b-D-glucopyranose. ) Tj 51.428571 0 0 51.428571 0 1417.46568 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.05 0 Td 55.387205 Tz (composite' ) Tj 3.908333 0 Td 42.12963 Tz (is ) Tj 0.777778 0 Td 58.333333 Tz (meant ) Tj 1.983333 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 53.240741 Tz (mixture ) Tj 2.488889 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 46.666667 Tz (materials. ) Tj 3.091667 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 60.493827 Tz (one ) Tj 51.428571 0 0 51.428571 0 1379.414044 Tm 6.261111 0 Td 57.449495 Tz (embodiment, ) Tj 4.044444 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 55.452675 Tz (composite ) Tj 3.208333 0 Td 54.372428 Tz (comprises ) Tj 3.169444 0 Td 57.253086 Tz (sponge ) Tj 2.294444 0 Td 53.292181 Tz (fragments ) Tj 3.130556 0 Td 59.41358 Tz (dis ) Tj 51.428571 0 0 51.428571 0 1337.47851 Tm 6.261111 0 Td 52.932099 Tz (persed ) Tj 2.158333 0 Td 50.771605 Tz (within ) Tj 2.080556 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 50.771605 Tz (hydrogel. ) Tj 51.428571 0 0 51.428571 0 1291.481645 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.225 0 Td 51.851852 Tz (acid ) Tj 1.983333 0 Td 46.759259 Tz (treated ) Tj 2.391667 0 Td 50.411523 Tz (chitosan' ) Tj 3.169444 0 Td 38.888889 Tz (is ) Tj 0.933333 0 Td 58.333333 Tz (meant ) Tj 2.138889 0 Td 50.636574 Tz (chitosan ) Tj 2.897222 0 Td 44.560185 Tz (that ) Tj 1.477778 0 Td 40.509259 Tz (is ) Tj 40 0 0 40 0 1257 Tm 8.075 0 Td 62.121212 Tz (solubilized ) Tj 4.425 0 Td 56.25 Tz (in ) Tj 1 0 Td 72.916667 Tz (an ) Tj 1.175 0 Td 62.5 Tz (acidic ) Tj 2.6 0 Td 58.796296 Tz (Solution. ) Tj 51.428571 0 0 51.428571 0 1213.444156 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.05 0 Td 53.796296 Tz (degrades' ) Tj 3.480556 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 58.981481 Tz (meant ) Tj 2.002778 0 Td 49.583333 Tz (physically ) Tj 3.227778 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 53.148148 Tz (chemically ) Tj 3.441667 0 Td 52.932099 Tz (breaks ) Tj 51.428571 0 0 51.428571 0 1170.797927 Tm 6.261111 0 Td 67.24537 Tz (down ) Tj 1.886111 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 58.981481 Tz (whole ) Tj 2.002778 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 44.074074 Tz (part. ) Tj 1.613889 0 Td 47.43266 Tz (Preferably, ) Tj 3.441667 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 51.851852 Tz (degradation ) Tj 3.733333 0 Td 62.654321 Tz (rep ) Tj 51.428571 0 0 51.428571 0 1125.719626 Tm 6.261111 0 Td 47.685185 Tz (resents ) Tj 2.294444 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 50.231481 Tz (physical ) Tj 2.702778 0 Td 50.771605 Tz (reduction ) Tj 3.052778 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 59.143519 Tz (mass ) Tj 1.711111 0 Td 59.953704 Tz (by ) Tj 1.011111 0 Td 45.37037 Tz (at ) Tj 0.836111 0 Td 44.074074 Tz (least ) Tj 1.594444 0 Td 54.444444 Tz (about ) Tj 47.142857 0 0 47.142857 0 1085 Tm 6.893939 0 Td 65.40404 Tz (10%, ) Tj 1.845455 0 Td 68.055556 Tz (25%, ) Tj 1.930303 0 Td 67.171717 Tz (50%, ) Tj 1.909091 0 Td 68.055556 Tz (75%, ) Tj 1.909091 0 Td 68.055556 Tz (80%, ) Tj 1.909091 0 Td 69.823232 Tz (85%, ) Tj 1.930303 0 Td 68.939394 Tz (90%, ) Tj 1.951515 0 Td 78.956229 Tz (95% ) Tj 1.69697 0 Td 58.333333 Tz (or ) Tj 0.975758 0 Td 65.757576 Tz (100%. ) Tj 51.428571 0 0 51.428571 0 1042.708029 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.05 0 Td 49.907407 Tz (film ) Tj 2.080556 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 58.981481 Tz (meant ) Tj 2.002778 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 46.180556 Tz (thin ) Tj 1.380556 0 Td 49.259259 Tz (layer ) Tj 1.691667 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 46.450617 Tz (material. ) Tj 51.428571 0 0 51.428571 0 1002.191489 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.05 0 Td 53.796296 Tz (long ) Tj 1.788889 0 Td 55.902778 Tz (term ) Tj 1.575 0 Td 48.611111 Tz (release' ) Tj 2.566667 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 58.333333 Tz (meant ) Tj 1.925 0 Td 48.611111 Tz (elution ) Tj 2.275 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 53.148148 Tz (agent ) Tj 1.808333 0 Td 55.092593 Tz (over ) Tj 51.428571 0 0 51.428571 0 962.07762 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 52.391975 Tz (course ) Tj 2.119444 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 52.73569 Tz (twenty-four ) Tj 3.675 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 52.314815 Tz (seventy ) Tj 2.45 0 Td 60.493827 Tz (two ) Tj 1.341667 0 Td 53.796296 Tz (hours ) Tj 1.886111 0 Td 50.231481 Tz (or ) Tj 0.816667 0 Td 47.222222 Tz (longer. ) Tj 51.428571 0 0 51.428571 0 919.841972 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.011111 0 Td 55.902778 Tz (sponge' ) Tj 2.877778 0 Td 40.509259 Tz (is ) Tj 0.7 0 Td 58.981481 Tz (meant ) Tj 1.905556 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 51.66122 Tz (three-dimensional ) Tj 5.444444 0 Td 55.092593 Tz (porous ) Tj 2.197222 0 Td 48.611111 Tz (matrix. ) Tj 51.428571 0 0 51.428571 0 878.752407 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.225 0 Td 64.274691 Tz (wound ) Tj 2.8 0 Td 61.574074 Tz (management ) Tj 4.102778 0 Td 52.777778 Tz (device' ) Tj 2.663889 0 Td 53.472222 Tz (or ) Tj 1.011111 0 Td 64.814815 Tz (wound ) Tj 2.761111 0 Td 50.925926 Tz (healing ) Tj 51.428571 0 0 51.428571 0 835.971129 Tm 6.261111 0 Td 52.777778 Tz (device' ) Tj 2.508333 0 Td 40.509259 Tz (is ) Tj 0.797222 0 Td 58.981481 Tz (meant ) Tj 2.041667 0 Td 58.333333 Tz (any ) Tj 1.361111 0 Td 48.611111 Tz (material ) Tj 2.663889 0 Td 55.092593 Tz (used ) Tj 1.594444 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 48.148148 Tz (protect ) Tj 2.313889 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 57.87037 Tz (promote ) Tj 51.428571 0 0 51.428571 0 794.531073 Tm 6.241667 0 Td 51.851852 Tz (healing ) Tj 2.411111 0 Td 43.75 Tz (at ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 42.12963 Tz (site ) Tj 1.263889 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 51.851852 Tz (trauma. ) Tj 51.428571 0 0 51.428571 0 755.790368 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.263889 0 Td 51.851852 Tz ("agent' ) Tj 2.586111 0 Td 40.509259 Tz (is ) Tj 0.933333 0 Td 58.333333 Tz (meant ) Tj 2.138889 0 Td 58.333333 Tz (any ) Tj 1.477778 0 Td 51.851852 Tz (Small ) Tj 1.963889 0 Td 60.133745 Tz (compound, ) Tj 3.655556 0 Td 49.331276 Tz (antibody, ) Tj 51.428571 0 0 51.428571 0 712.230955 Tm 6.261111 0 Td 50 Tz (nucleic ) Tj 2.275 0 Td 51.041667 Tz (acid ) Tj 1.458333 0 Td 51.851852 Tz (molecule, ) Tj 2.994444 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 50.231481 Tz (polypeptide, ) Tj 3.85 0 Td 50.231481 Tz (or ) Tj 0.797222 0 Td 53.292181 Tz (fragments ) Tj 3.072222 0 Td 46.180556 Tz (thereof. ) Tj 51.428571 0 0 51.428571 0 668.871895 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.127778 0 Td 51.311728 Tz (ameliorate' ) Tj 3.986111 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 58.981481 Tz (meant ) Tj 2.061111 0 Td 49.331276 Tz (decrease, ) Tj 2.955556 0 Td 49.691358 Tz (Suppress, ) Tj 2.955556 0 Td 46.666667 Tz (attenuate, ) Tj 51.428571 0 0 51.428571 0 629.529132 Tm 6.261111 0 Td 50.411523 Tz (diminish, ) Tj 2.916667 0 Td 42.592593 Tz (arrest, ) Tj 1.963889 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 45.010288 Tz (stabilize ) Tj 2.586111 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 57.154882 Tz (development ) Tj 3.927778 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 52.146465 Tz (progression ) Tj 40 0 0 40 0 592 Tm 8.05 0 Td 75 Tz (of ) Tj 1.1 0 Td 66.666667 Tz (a ) Tj 0.75 0 Td 59.895833 Tz (disease. ) Tj 51.428571 0 0 51.428571 0 543.542933 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.069444 0 Td 46.720679 Tz (alteration' ) Tj 3.616667 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 58.981481 Tz (meant ) Tj 1.983333 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 56.712963 Tz (change ) Tj 2.294444 0 Td 48.251029 Tz (\(increase ) Tj 2.858333 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 50.411523 Tz (decrease\) ) Tj 51.428571 0 0 51.428571 0 501.397906 Tm 6.261111 0 Td 50.231481 Tz (as ) Tj 0.913889 0 Td 50.231481 Tz (detected ) Tj 2.663889 0 Td 61.574074 Tz (by ) Tj 1.030556 0 Td 51.446759 Tz (Standard ) Tj 2.722222 0 Td 45.37037 Tz (art ) Tj 1.088889 0 Td 64.814815 Tz (known ) Tj 2.275 0 Td 57.87037 Tz (methods ) Tj 2.741667 0 Td 54.282407 Tz (such ) Tj 1.613889 0 Td 46.990741 Tz (as ) Tj 0.855556 0 Td 52.5 Tz (those ) Tj 40 0 0 40 0 467 Tm 8.05 0 Td 66.666667 Tz (described ) Tj 3.9 0 Td 60.119048 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 419.717391 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.011111 0 Td 54.166667 Tz (analog ) Tj 2.8 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 58.981481 Tz (meant ) Tj 1.925 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 54.6875 Tz (molecule ) Tj 2.838889 0 Td 44.560185 Tz (that ) Tj 1.283333 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 50.771605 Tz (not ) Tj 1.088889 0 Td 44.398148 Tz (identical, ) Tj 2.858333 0 Td 54.012346 Tz (but ) Tj 51.428571 0 0 51.428571 0 378.730539 Tm 6.241667 0 Td 54.012346 Tz (has ) Tj 1.147222 0 Td 54.012346 Tz (analogous ) Tj 3.130556 0 Td 48.611111 Tz (functional ) Tj 3.111111 0 Td 50.231481 Tz (or ) Tj 0.738889 0 Td 45.694444 Tz (structural ) Tj 2.916667 0 Td 45.37037 Tz (features. ) Tj 2.663889 0 Td 56.17284 Tz (For ) Tj 1.127778 0 Td 54.6875 Tz (example, ) Tj 51.428571 0 0 51.428571 0 338.661188 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 54.552469 Tz (analog ) Tj 2.197222 0 Td 45.833333 Tz (retains ) Tj 2.158333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 48.611111 Tz (biological ) Tj 3.15 0 Td 44.965278 Tz (activity ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 57.685185 Tz (corre ) Tj 51.428571 0 0 51.428571 0 296.359006 Tm 6.280556 0 Td 55.497685 Tz (sponding ) Tj 3.013889 0 Td 50.05144 Tz (reference ) Tj 3.072222 0 Td 49.826389 Tz (chitosan ) Tj 2.741667 0 Td 58.796296 Tz (polymer ) Tj 2.819444 0 Td 39.969136 Tz (\(e.g., ) Tj 1.847222 0 Td 55.362654 Tz (manufactured ) Tj 51.428571 0 0 51.428571 0 252 Tm 6.261111 0 Td 47.314815 Tz (chitosan\), ) Tj 3.169444 0 Td 53.796296 Tz (while ) Tj 1.905556 0 Td 55.092593 Tz (having ) Tj 2.313889 0 Td 45.833333 Tz (certain ) Tj 2.236111 0 Td 54.208754 Tz (biochemical ) Tj 3.908333 0 Td 50.356125 Tz (modifications ) Tj 51.428571 0 0 51.428571 0 211.287001 Tm 6.241667 0 Td 46.990741 Tz (that ) Tj 1.419444 0 Td 57.407407 Tz (enhance ) Tj 2.663889 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 50.636574 Tz (analog's ) Tj 2.761111 0 Td 50.231481 Tz (function ) Tj 2.741667 0 Td 45.37037 Tz (relative ) Tj 2.45 0 Td 48.611111 Tz (to ) Tj 0.875 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 50.05144 Tz (reference ) Tj 51.428571 0 0 51.428571 0 169.321652 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.780556 0 Td 53.472222 Tz (polymer. ) Tj 2.975 0 Td 59.953704 Tz (Such ) Tj 1.808333 0 Td 53.914141 Tz (biochemical ) Tj 3.966667 0 Td 50.356125 Tz (modifications ) Tj 4.336111 0 Td 54.444444 Tz (could ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.677778 0 Td 77.777778 Tz (4 ) Tj 51.428571 0 0 51.428571 0 2917.905263 Tm 25.2 0 Td 49.826389 Tz (increase ) Tj 2.683333 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 58.796296 Tz (analogs ) Tj 2.780556 0 Td 43.518519 Tz (ability ) Tj 2.138889 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 58.333333 Tz (be ) Tj 1.011111 0 Td 52.211934 Tz (degraded, ) Tj 3.130556 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 54.012346 Tz (uptake ) Tj 2.255556 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 2872.477791 Tm 25.2 0 Td 47.314815 Tz (elute ) Tj 1.536111 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 49.200337 Tz (therapeutic ) Tj 3.383333 0 Td 49.151235 Tz (agent, ) Tj 1.925 0 Td 53.472222 Tz (or ) Tj 0.738889 0 Td 48.611111 Tz (to ) Tj 0.738889 0 Td 49.826389 Tz (increase ) Tj 2.547222 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 52.256944 Tz (decrease ) Tj 2.683333 0 Td 63.425926 Tz (mechani ) Tj 51.428571 0 0 51.428571 0 2831.988304 Tm 25.2 0 Td 46.450617 Tz (cal ) Tj 1.108333 0 Td 46.090535 Tz (strength. ) Tj 51.428571 0 0 51.428571 0 2783.389831 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.186111 0 Td 50.339506 Tz (antimicrobial' ) Tj 4.919444 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 58.333333 Tz (meant ) Tj 2.080556 0 Td 58.333333 Tz (an ) Tj 1.088889 0 Td 52.5 Tz (agent ) Tj 1.944444 0 Td 46.180556 Tz (that ) Tj 1.458333 0 Td 44.965278 Tz (inhibits ) Tj 2.527778 0 Td 55.092593 Tz (or ) Tj 51.428571 0 0 51.428571 0 2740.901391 Tm 25.219444 0 Td 44.722222 Tz (stabilizes ) Tj 2.936111 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 46.866097 Tz (proliferation ) Tj 3.85 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 48.206019 Tz (survival ) Tj 2.547222 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 52.662037 Tz (microbe. ) Tj 2.819444 0 Td 45.37037 Tz (In ) Tj 0.797222 0 Td 59.41358 Tz (one ) Tj 51.428571 0 0 51.428571 0 2695.83208 Tm 25.2 0 Td 57.449495 Tz (embodiment, ) Tj 4.083333 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 46.296296 Tz (bacteriostatic ) Tj 4.161111 0 Td 53.796296 Tz (agent ) Tj 1.886111 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 59.953704 Tz (an ) Tj 0.972222 0 Td 48.37963 Tz (antimicrobial. ) Tj 4.413889 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 2653.215223 Tm 25.2 0 Td 50.555556 Tz (other ) Tj 1.808333 0 Td 57.253086 Tz (embodiments, ) Tj 4.452778 0 Td 58.333333 Tz (any ) Tj 1.4 0 Td 53.148148 Tz (agent ) Tj 1.925 0 Td 45.37037 Tz (that ) Tj 1.4 0 Td 42.12963 Tz (kills ) Tj 1.594444 0 Td 58.333333 Tz (a ) Tj 0.7 0 Td 56.481481 Tz (microbe ) Tj 2.702778 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 2609.427653 Tm 25.180556 0 Td 51.851852 Tz (bacterium, ) Tj 3.344444 0 Td 51.388889 Tz (fungus, ) Tj 2.45 0 Td 45.910494 Tz (virus\) ) Tj 1.925 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 56.712963 Tz (an ) Tj 0.913889 0 Td 48.148148 Tz (antimicrobial. ) Tj 51.428571 0 0 51.428571 0 2568.291457 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 0.991667 0 Td 51.681287 Tz (anti-inflammatory' ) Tj 6.066667 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 58.981481 Tz (meant ) Tj 1.886111 0 Td 58.333333 Tz (an ) Tj 0.855556 0 Td 53.148148 Tz (agent ) Tj 1.730556 0 Td 46.990741 Tz (that ) Tj 1.283333 0 Td 52.314815 Tz (reduces ) Tj 2.352778 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2525.101764 Tm 25.219444 0 Td 47.395833 Tz (severity ) Tj 2.683333 0 Td 51.851852 Tz (or ) Tj 1.011111 0 Td 61.574074 Tz (symptoms ) Tj 3.363889 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 56.712963 Tz (an ) Tj 1.088889 0 Td 54.282407 Tz (inflammatory ) Tj 4.336111 0 Td 48.206019 Tz (reaction ) Tj 2.702778 0 Td 46.990741 Tz (in ) Tj 0.972222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2480.385768 Tm 25.180556 0 Td 43.518519 Tz (tissue. ) Tj 2.080556 0 Td 72.916667 Tz (An ) Tj 1.166667 0 Td 54.012346 Tz (inflammatory ) Tj 4.180556 0 Td 47.800926 Tz (reaction ) Tj 2.586111 0 Td 50.771605 Tz (within ) Tj 2.1 0 Td 46.990741 Tz (tissue ) Tj 1.925 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 50.05144 Tz (generally ) Tj 51.428571 0 0 51.428571 0 2435.413146 Tm 25.2 0 Td 49.85755 Tz (characterized ) Tj 4.025 0 Td 59.953704 Tz (by ) Tj 0.875 0 Td 52.572016 Tz (leukocyte ) Tj 2.994444 0 Td 41.381766 Tz (infiltration, ) Tj 3.363889 0 Td 58.333333 Tz (edema, ) Tj 2.255556 0 Td 49.016204 Tz (redness, ) Tj 2.488889 0 Td 47.962963 Tz (pain, ) Tj 40 0 0 40 0 2397 Tm 32.4 0 Td 67.361111 Tz (and/or ) Tj 2.8 0 Td 62.719298 Tz (neovascularization. ) Tj 7.6 0 Td 69.444444 Tz (Inflammation ) Tj 5.375 0 Td 72.222222 Tz (can ) Tj 1.65 0 Td 63.541667 Tz (also ) Tj 1.9 0 Td 75 Tz (be ) Tj 1.3 0 Td 101.388889 Tz (mea ) Tj 51.428571 0 0 51.428571 0 2349.814768 Tm 25.219444 0 Td 51.851852 Tz (Sured ) Tj 1.75 0 Td 61.574074 Tz (by ) Tj 0.972222 0 Td 52.572016 Tz (analyzing ) Tj 3.072222 0 Td 46.450617 Tz (levels ) Tj 1.925 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 51.131687 Tz (cytokines ) Tj 2.994444 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 59.41358 Tz (any ) Tj 1.302778 0 Td 50.555556 Tz (other ) Tj 1.730556 0 Td 57.79321 Tz (inflam ) Tj 51.428571 0 0 51.428571 0 2305.888889 Tm 25.2 0 Td 56.712963 Tz (matory ) Tj 2.313889 0 Td 51.388889 Tz (marker. ) Tj 51.428571 0 0 51.428571 0 2262.891656 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 0.991667 0 Td 52.932099 Tz (biodegradable' ) Tj 4.919444 0 Td 42.12963 Tz (is ) Tj 0.661111 0 Td 58.981481 Tz (meant ) Tj 1.925 0 Td 49.200337 Tz (susceptible ) Tj 3.402778 0 Td 45.37037 Tz (to ) Tj 0.680556 0 Td 60.133745 Tz (breakdown ) Tj 3.422222 0 Td 59.953704 Tz (by ) Tj 51.428571 0 0 51.428571 0 2221.217722 Tm 25.180556 0 Td 48.611111 Tz (biological ) Tj 3.325 0 Td 42.489712 Tz (activity. ) Tj 2.780556 0 Td 55.092593 Tz (For ) Tj 1.380556 0 Td 54.282407 Tz (example, ) Tj 3.052778 0 Td 52.849003 Tz (biodegradable ) Tj 4.530556 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2176.509044 Tm 25.2 0 Td 53.742284 Tz (compositions ) Tj 4.277778 0 Td 49.691358 Tz (are ) Tj 1.302778 0 Td 48.611111 Tz (susceptible ) Tj 3.597222 0 Td 46.990741 Tz (to ) Tj 0.972222 0 Td 59.773663 Tz (breakdown ) Tj 3.636111 0 Td 59.953704 Tz (by ) Tj 1.108333 0 Td 61.111111 Tz (enzymes ) Tj 51.428571 0 0 51.428571 0 2134.124706 Tm 25.2 0 Td 50.462963 Tz (present ) Tj 2.275 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 52.662037 Tz (vivo ) Tj 1.458333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.652778 0 Td 54.372428 Tz (lysozyme, ) Tj 3.130556 0 Td 52.599715 Tz (N-acetyl-O-glucosaminidase ) Tj 51.428571 0 0 51.428571 0 2088.876095 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 43.930041 Tz (lipases\). ) Tj 2.683333 0 Td 53.619529 Tz (Degradation ) Tj 3.811111 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 53.914141 Tz (composition ) Tj 3.830556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2043.259259 Tm 25.2 0 Td 50.771605 Tz (invention ) Tj 3.013889 0 Td 55.902778 Tz (need ) Tj 1.575 0 Td 51.851852 Tz (not ) Tj 1.127778 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 52.211934 Tz (complete. ) Tj 3.013889 0 Td 87.5 Tz (A ) Tj 0.719444 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 54.503367 Tz (composition ) Tj 3.85 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 2003.975845 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.05144 Tz (invention ) Tj 2.916667 0 Td 66.975309 Tz (may ) Tj 1.361111 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 52.572016 Tz (degraded, ) Tj 3.033333 0 Td 47.530864 Tz (for ) Tj 0.952778 0 Td 55.497685 Tz (example, ) Tj 2.8 0 Td 61.574074 Tz (by ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 53.472222 Tz (cleavage ) Tj 51.428571 0 0 51.428571 0 1959.414698 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 58.333333 Tz (one ) Tj 1.380556 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 61.574074 Tz (more ) Tj 1.808333 0 Td 54.282407 Tz (chemical ) Tj 2.955556 0 Td 57.685185 Tz (bonds ) Tj 2.080556 0 Td 41.049383 Tz (\(e.g., ) Tj 1.808333 0 Td 49.907407 Tz (glycosidic ) Tj 3.344444 0 Td 50.925926 Tz (bonds\). ) Tj 51.428571 0 0 51.428571 0 1919.597015 Tm 25.2 0 Td 54.012346 Tz (Advantageously, ) Tj 5.075 0 Td 51.557239 Tz (degradation ) Tj 3.636111 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 45.37037 Tz (at ) Tj 0.738889 0 Td 44.074074 Tz (least ) Tj 1.497222 0 Td 54.444444 Tz (about ) Tj 1.827778 0 Td 49.691358 Tz (20, ) Tj 1.088889 0 Td 50.771605 Tz (30, ) Tj 1.108333 0 Td 49.691358 Tz (40, ) Tj 47.142857 0 0 47.142857 0 1876 Tm 27.512121 0 Td 51.851852 Tz (50, ) Tj 1.272727 0 Td 51.851852 Tz (60, ) Tj 1.230303 0 Td 53.030303 Tz (70, ) Tj 1.230303 0 Td 54.208754 Tz (80, ) Tj 1.230303 0 Td 54.208754 Tz (90, ) Tj 1.272727 0 Td 80.13468 Tz (95% ) Tj 1.739394 0 Td 54.79798 Tz (or ) Tj 0.912121 0 Td 67.171717 Tz (more ) Tj 1.887879 0 Td 58.333333 Tz (over ) Tj 1.633333 0 Td 53.030303 Tz (3-5, ) Tj 1.527273 0 Td 52.146465 Tz (57, ) Tj 1.527273 0 Td 52.146465 Tz (7-9, ) Tj 1.569697 0 Td 54.79798 Tz (10-15, ) Tj 51.428571 0 0 51.428571 0 1835.175258 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.913889 0 Td 54.444444 Tz (15-30 ) Tj 1.866667 0 Td 49.907407 Tz (days. ) Tj 51.428571 0 0 51.428571 0 1793.394702 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.108333 0 Td 47.43266 Tz (clinician' ) Tj 3.422222 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 58.981481 Tz (meant ) Tj 2.022222 0 Td 57.253086 Tz (any ) Tj 1.302778 0 Td 50.231481 Tz (healthcare ) Tj 3.286111 0 Td 47.170782 Tz (provider. ) Tj 2.897222 0 Td 79.398148 Tz (Exem ) Tj 51.428571 0 0 51.428571 0 1749.823848 Tm 25.2 0 Td 49.259259 Tz (plary ) Tj 1.886111 0 Td 46.018519 Tz (clinicians ) Tj 3.169444 0 Td 47.800926 Tz (include, ) Tj 2.663889 0 Td 52.932099 Tz (but ) Tj 1.302778 0 Td 49.691358 Tz (are ) Tj 1.302778 0 Td 49.691358 Tz (not ) Tj 1.283333 0 Td 48.611111 Tz (limited ) Tj 2.411111 0 Td 41.049383 Tz (to, ) Tj 1.127778 0 Td 47.800926 Tz (doctors, ) Tj 51.428571 0 0 51.428571 0 1712.69871 Tm 25.2 0 Td 46.759259 Tz (veterinarians, ) Tj 4.141667 0 Td 49.200337 Tz (osteopaths, ) Tj 3.480556 0 Td 55.092593 Tz (physicians ) Tj 3.519444 0 Td 44.191919 Tz (assistants, ) Tj 3.15 0 Td 59.053498 Tz (emergency ) Tj 51.428571 0 0 51.428571 0 1667.864447 Tm 25.2 0 Td 54.62963 Tz (medical ) Tj 2.469444 0 Td 47.800926 Tz (technicians, ) Tj 3.655556 0 Td 52.314815 Tz (medics, ) Tj 2.391667 0 Td 51.851852 Tz (nurse ) Tj 1.691667 0 Td 45.37037 Tz (practitioners, ) Tj 4.005556 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 47.685185 Tz (nurses. ) Tj 52.857143 0 0 52.857143 0 1627.111959 Tm 25.237838 0 Td 47.297297 Tz (In ) Tj 0.832432 0 Td 42.567568 Tz (this ) Tj 1.324324 0 Td 45.577396 Tz (disclosure, ) Tj 3.291892 0 Td 50.713213 Tz ("comprises. ) Tj 3.916216 0 Td 51.178101 Tz (comprising, ) Tj 4.275676 0 Td 54.786036 Tz (contain ) Tj 51.428571 0 0 51.428571 0 1585.604651 Tm 25.2 0 Td 51.851852 Tz (ing ) Tj 1.672222 0 Td 58.333333 Tz (and ) Tj 1.458333 0 Td 55.092593 Tz (having ) Tj 3.033333 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 50.771605 Tz (the ) Tj 1.322222 0 Td 44.560185 Tz (like ) Tj 1.477778 0 Td 54.012346 Tz (can ) Tj 1.419444 0 Td 57.523148 Tz (have ) Tj 1.769444 0 Td 50.771605 Tz (the ) Tj 1.361111 0 Td 58.796296 Tz (meaning ) Tj 51.428571 0 0 51.428571 0 1541.135878 Tm 25.2 0 Td 50.636574 Tz (ascribed ) Tj 2.936111 0 Td 46.990741 Tz (to ) Tj 1.088889 0 Td 59.953704 Tz (them ) Tj 1.983333 0 Td 45.37037 Tz (in ) Tj 1.108333 0 Td 51.851852 Tz (U.S. ) Tj 1.769444 0 Td 50.231481 Tz (patent ) Tj 2.333333 0 Td 56.17284 Tz (law ) Tj 1.536111 0 Td 60.493827 Tz (and ) Tj 1.594444 0 Td 57.253086 Tz (can ) Tj 1.555556 0 Td 65.625 Tz (mean ) Tj 51.428571 0 0 51.428571 0 1503.843602 Tm 25.2 0 Td 49.494949 Tz (includes, ) Tj 3.422222 0 Td 49.691358 Tz (including, ) Tj 3.752778 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 42.12963 Tz (like: ) Tj 1.477778 0 Td 49.494949 Tz (consisting ) Tj 3.422222 0 Td 46.843434 Tz (essentially ) Tj 51.428571 0 0 51.428571 0 1460.352697 Tm 25.2 0 Td 56.712963 Tz (of ) Tj 1.361111 0 Td 53.472222 Tz (or ) Tj 1.069444 0 Td 48.251029 Tz (consists ) Tj 3.052778 0 Td 47.260802 Tz (essentially' ) Tj 3.869444 0 Td 50.231481 Tz (likewise ) Tj 2.858333 0 Td 52.932099 Tz (has ) Tj 1.438889 0 Td 48.611111 Tz (the ) Tj 1.322222 0 Td 59.259259 Tz (meaning ) Tj 51.428571 0 0 51.428571 0 1418.004082 Tm 25.2 0 Td 50.636574 Tz (ascribed ) Tj 2.761111 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 51.851852 Tz (U.S. ) Tj 1.613889 0 Td 49.691358 Tz (patent ) Tj 2.119444 0 Td 56.17284 Tz (law ) Tj 1.380556 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 48.611111 Tz (the ) Tj 1.225 0 Td 54.282407 Tz (term ) Tj 1.652778 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 54.208754 Tz (open-ended, ) Tj 51.428571 0 0 51.428571 0 1376.636704 Tm 25.2 0 Td 53.06713 Tz (allowing ) Tj 2.761111 0 Td 47.530864 Tz (for ) Tj 1.05 0 Td 47.530864 Tz (the ) Tj 1.030556 0 Td 53.877315 Tz (presence ) Tj 2.741667 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 61.574074 Tz (more ) Tj 1.652778 0 Td 51.041667 Tz (than ) Tj 1.477778 0 Td 44.560185 Tz (that ) Tj 1.283333 0 Td 58.333333 Tz (which ) Tj 1.944444 0 Td 42.12963 Tz (is ) Tj 0.7 0 Td 47.222222 Tz (recited ) Tj 51.428571 0 0 51.428571 0 1332.729223 Tm 25.219444 0 Td 51.851852 Tz (So ) Tj 0.933333 0 Td 55.092593 Tz (long ) Tj 1.575 0 Td 51.851852 Tz (as ) Tj 0.933333 0 Td 49.907407 Tz (basic ) Tj 1.827778 0 Td 51.851852 Tz (or ) Tj 0.913889 0 Td 53.148148 Tz (novel ) Tj 1.905556 0 Td 46.234568 Tz (characteristics ) Tj 4.472222 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 45.37037 Tz (that ) Tj 1.4 0 Td 58.981481 Tz (which ) Tj 2.080556 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1294.129032 Tm 25.2 0 Td 47.222222 Tz (recited ) Tj 2.275 0 Td 40.509259 Tz (is ) Tj 0.816667 0 Td 50.771605 Tz (not ) Tj 1.225 0 Td 57.407407 Tz (changed ) Tj 2.702778 0 Td 58.333333 Tz (by ) Tj 1.030556 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 53.06713 Tz (presence ) Tj 2.877778 0 Td 55.092593 Tz (of ) Tj 0.894444 0 Td 62.384259 Tz (more ) Tj 1.788889 0 Td 51.851852 Tz (than ) Tj 1.555556 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 1249.824176 Tm 25.180556 0 Td 59.62963 Tz (which ) Tj 2.041667 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 44.560185 Tz (recited, ) Tj 2.391667 0 Td 50.771605 Tz (but ) Tj 1.147222 0 Td 53.06713 Tz (excludes ) Tj 2.8 0 Td 48.611111 Tz (prior ) Tj 1.672222 0 Td 43.209877 Tz (art ) Tj 1.011111 0 Td 56.442901 Tz (embodiments. ) Tj 51.428571 0 0 51.428571 0 1211.268817 Tm 25.919444 0 Td 53.06713 Tz (Detect ) Tj 2.916667 0 Td 44.290123 Tz (refers ) Tj 1.944444 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 48.316498 Tz (identifying ) Tj 3.5 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 50.411523 Tz (presence, ) Tj 3.052778 0 Td 55.092593 Tz (absence ) Tj 2.605556 0 Td 55.092593 Tz (or ) Tj 51.428571 0 0 51.428571 0 1167.752988 Tm 25.2 0 Td 61.033951 Tz (amount ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 50.925926 Tz (analyte ) Tj 2.372222 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 47.890947 Tz (detected. ) Tj 51.428571 0 0 51.428571 0 1124.488372 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.186111 0 Td 54.208754 Tz (customize' ) Tj 3.947222 0 Td 37.268519 Tz (is ) Tj 0.816667 0 Td 58.981481 Tz (meant ) Tj 2.119444 0 Td 43.209877 Tz (tailor ) Tj 1.866667 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 44.560185 Tz (suit ) Tj 1.419444 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 54.444444 Tz (needs ) Tj 1.944444 0 Td 61.574074 Tz (of ) Tj 0.952778 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 1091 Tm 25.2 0 Td 46.990741 Tz (particular ) Tj 3.033333 0 Td 46.180556 Tz (Subject. ) Tj 51.428571 0 0 51.428571 0 1045.187135 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.225 0 Td 52.391975 Tz (degradation ) Tj 4.219444 0 Td 46.018519 Tz (rate' ) Tj 1.788889 0 Td 40.509259 Tz (is ) Tj 0.913889 0 Td 58.981481 Tz (meant ) Tj 2.197222 0 Td 48.611111 Tz (the ) Tj 1.283333 0 Td 54.282407 Tz (time ) Tj 1.730556 0 Td 49.421296 Tz (required ) Tj 2.819444 0 Td 43.75 Tz (to ) Tj 51.428571 0 0 51.428571 0 1006.993582 Tm 25.219444 0 Td 46.616809 Tz (Substantially ) Tj 4.063889 0 Td 54.62963 Tz (degrade ) Tj 2.644444 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 51.851852 Tz (composition. ) Tj 4.122222 0 Td 84.259259 Tz (A ) Tj 0.855556 0 Td 54.208754 Tz (composition ) Tj 3.966667 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 961.132121 Tm 25.219444 0 Td 46.616809 Tz (substantially ) Tj 3.85 0 Td 55.092593 Tz (degraded ) Tj 2.819444 0 Td 58.981481 Tz (where ) Tj 1.925 0 Td 45.37037 Tz (at ) Tj 0.7 0 Td 44.722222 Tz (least ) Tj 1.497222 0 Td 53.796296 Tz (about ) Tj 1.788889 0 Td 62.384259 Tz (20%, ) Tj 1.652778 0 Td 62.384259 Tz (30%, ) Tj 1.691667 0 Td 62.384259 Tz (40%, ) Tj 48.571429 0 0 48.571429 0 919 Tm 26.702941 0 Td 65.196078 Tz (50%, ) Tj 2.1 0 Td 65.196078 Tz (60%, ) Tj 2.058824 0 Td 66.053922 Tz (75%, ) Tj 2.079412 0 Td 66.911765 Tz (85%, ) Tj 2.079412 0 Td 66.911765 Tz (90%, ) Tj 2.1 0 Td 77.777778 Tz (95% ) Tj 1.894118 0 Td 56.617647 Tz (or ) Tj 1.173529 0 Td 64.338235 Tz (more ) Tj 2.017647 0 Td 56.045752 Tz (has ) Tj 1.502941 0 Td 61.764706 Tz (been ) Tj 51.428571 0 0 51.428571 0 879.678133 Tm 25.2 0 Td 52.211934 Tz (degraded. ) Tj 3.130556 0 Td 60.648148 Tz (Methods ) Tj 2.838889 0 Td 48.611111 Tz (for ) Tj 1.166667 0 Td 55.812757 Tz (measuring ) Tj 3.286111 0 Td 51.851852 Tz (degradation ) Tj 3.713889 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 834.57377 Tm 25.2 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 65.462963 Tz (known ) Tj 2.197222 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 43.209877 Tz (art ) Tj 0.952778 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 51.388889 Tz (include ) Tj 2.352778 0 Td 56.17284 Tz (measuring ) Tj 3.188889 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 60.493827 Tz (amount ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 796.475248 Tm 25.219444 0 Td 52.777778 Tz (sponge, ) Tj 2.469444 0 Td 44.074074 Tz (film, ) Tj 1.575 0 Td 55.452675 Tz (composite ) Tj 3.208333 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 50.555556 Tz (other ) Tj 1.730556 0 Td 54.208754 Tz (composition ) Tj 3.811111 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 60.925926 Tz (inven ) Tj 51.428571 0 0 51.428571 0 754.695187 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.497222 0 Td 46.180556 Tz (that ) Tj 1.477778 0 Td 54.166667 Tz (remains ) Tj 2.663889 0 Td 52.211934 Tz (following ) Tj 3.169444 0 Td 50.771605 Tz (implantation ) Tj 4.044444 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 0.7 0 Td 49.074074 Tz (subject ) Tj 2.430556 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 714.02 Tm 25.2 0 Td 52.572016 Tz (following ) Tj 3.072222 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 44.722222 Tz (vitro ) Tj 1.575 0 Td 55.092593 Tz (exposure ) Tj 2.858333 0 Td 48.611111 Tz (to ) Tj 0.816667 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 63.194444 Tz (enzyme ) Tj 2.488889 0 Td 55.632716 Tz (having ) Tj 2.255556 0 Td 55.092593 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 675 Tm 25.2 0 Td 54.012346 Tz (degrading ) Tj 3.130556 0 Td 42.849794 Tz (activity. ) Tj 51.428571 0 0 51.428571 0 627.079545 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.186111 0 Td 51.131687 Tz (disease' ) Tj 3.15 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 58.333333 Tz (meant ) Tj 2.119444 0 Td 57.253086 Tz (any ) Tj 1.419444 0 Td 50.771605 Tz (condition ) Tj 3.130556 0 Td 51.851852 Tz (or ) Tj 0.991667 0 Td 49.826389 Tz (disorder ) Tj 2.741667 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 585.373844 Tm 25.2 0 Td 60.185185 Tz (damages ) Tj 2.858333 0 Td 51.851852 Tz (or ) Tj 0.913889 0 Td 45.37037 Tz (interferes ) Tj 3.033333 0 Td 53.472222 Tz (with ) Tj 1.575 0 Td 51.851852 Tz (the ) Tj 1.244444 0 Td 56.17284 Tz (normal ) Tj 2.333333 0 Td 50.231481 Tz (function ) Tj 2.761111 0 Td 55.092593 Tz (of ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 40.185185 Tz (cell, ) Tj 51.428571 0 0 51.428571 0 544.378096 Tm 25.180556 0 Td 43.981481 Tz (tissue, ) Tj 2.080556 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 49.151235 Tz (organ. ) Tj 2.061111 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 58.333333 Tz (one ) Tj 1.244444 0 Td 55.497685 Tz (example, ) Tj 2.877778 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 49.537037 Tz (disease ) Tj 2.333333 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 46.8107 Tz (bacterial ) Tj 2.780556 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 502.096855 Tm 25.2 0 Td 49.907407 Tz (other ) Tj 1.711111 0 Td 47.890947 Tz (infection ) Tj 2.8 0 Td 50.462963 Tz (present ) Tj 2.352778 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 66.111111 Tz (wound ) Tj 2.197222 0 Td 38.888889 Tz (site. ) Tj 1.438889 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 52.777778 Tz (another ) Tj 2.391667 0 Td 68.055556 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 461.348624 Tm 25.2 0 Td 54.444444 Tz (ment, ) Tj 1.886111 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 49.537037 Tz (disease ) Tj 2.333333 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 44.444444 Tz (sepsis. ) Tj 51.428571 0 0 51.428571 0 419.342282 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.108333 0 Td 46.990741 Tz (effective ) Tj 3.072222 0 Td 59.259259 Tz (amount' ) Tj 2.780556 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 58.981481 Tz (meant ) Tj 2.022222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 61.574074 Tz (amount ) Tj 2.469444 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 58.333333 Tz (an ) Tj 0.952778 0 Td 53.796296 Tz (agent ) Tj 51.428571 0 0 51.428571 0 378.73865 Tm 25.2 0 Td 50.636574 Tz (required ) Tj 2.625 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 51.527778 Tz (ameliorate ) Tj 3.286111 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 62.384259 Tz (symptoms ) Tj 3.188889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 50 Tz (disease ) Tj 2.313889 0 Td 45.37037 Tz (relative ) Tj 2.352778 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 337.223827 Tm 25.2 0 Td 56.712963 Tz (an ) Tj 0.875 0 Td 50.05144 Tz (untreated ) Tj 2.877778 0 Td 44.560185 Tz (patient. ) Tj 2.313889 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 46.450617 Tz (effective ) Tj 2.663889 0 Td 61.033951 Tz (amount ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 48.611111 Tz (active ) Tj 1.905556 0 Td 49.016204 Tz (agent\(s\) ) Tj 51.428571 0 0 51.428571 0 296.92528 Tm 25.180556 0 Td 56.712963 Tz (used ) Tj 1.594444 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 48.206019 Tz (practice ) Tj 2.527778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 50.462963 Tz (present ) Tj 2.352778 0 Td 50.411523 Tz (invention ) Tj 2.994444 0 Td 47.530864 Tz (for ) Tj 1.05 0 Td 48.905724 Tz (therapeutic ) Tj 3.461111 0 Td 51.851852 Tz (treat ) Tj 51.428571 0 0 51.428571 0 253.455764 Tm 25.2 0 Td 60.763889 Tz (ment ) Tj 1.788889 0 Td 56.712963 Tz (of ) Tj 0.952778 0 Td 55.092593 Tz (a ) Tj 0.680556 0 Td 50 Tz (disease ) Tj 2.469444 0 Td 46.990741 Tz (varies ) Tj 2.061111 0 Td 55.812757 Tz (depending ) Tj 3.363889 0 Td 59.953704 Tz (upon ) Tj 1.769444 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 61.033951 Tz (manner ) Tj 2.527778 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 213.521578 Tm 25.2 0 Td 48.611111 Tz (administration, ) Tj 4.588889 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (age, ) Tj 1.438889 0 Td 59.953704 Tz (body ) Tj 1.691667 0 Td 51.388889 Tz (weight, ) Tj 2.372222 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.925926 Tz (general ) Tj 2.352778 0 Td 49.691358 Tz (health ) Tj 2.041667 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 173.419976 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 45.775463 Tz (Subject. ) Tj 2.430556 0 Td 48.905724 Tz (Ultimately, ) Tj 3.402778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.411523 Tz (attending ) Tj 2.877778 0 Td 51.851852 Tz (physician ) Tj 2.994444 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 51.131687 Tz (veterinar ) Tj ET Q endstream endobj 123 0 obj << /Length 1 >> stream q endstream endobj 124 0 obj << /Length 49133 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 51.428571 0 0 51.428571 0 2968 Tm 14.777778 0 Td 74.537037 Tz (5 ) Tj 51.428571 0 0 51.428571 0 2916.9511 Tm 6.261111 0 Td 48.611111 Tz (ian ) Tj 1.108333 0 Td 45.37037 Tz (will ) Tj 1.322222 0 Td 52.391975 Tz (decide ) Tj 2.061111 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.084175 Tz (appropriate ) Tj 3.480556 0 Td 61.574074 Tz (amount ) Tj 2.372222 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 55.632716 Tz (dosage ) Tj 2.177778 0 Td 53.06713 Tz (regimen. ) Tj 40 0 0 40 0 2878 Tm 8.075 0 Td 76.041667 Tz (Such ) Tj 2.125 0 Td 79.166667 Tz (amount ) Tj 3.175 0 Td 47.916667 Tz (is ) Tj 0.9 0 Td 61.979167 Tz (referred ) Tj 3.3 0 Td 58.333333 Tz (to ) Tj 1.025 0 Td 62.5 Tz (as ) Tj 1.075 0 Td 72.916667 Tz (an ) Tj 1.2 0 Td 60.984848 Tz (effective ) Tj 4.35 0 Td 72.02381 Tz (amount. ) Tj 51.428571 0 0 51.428571 0 2828.670256 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.030556 0 Td 48.611111 Tz (elution ) Tj 2.605556 0 Td 45.37037 Tz (rate' ) Tj 1.613889 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 58.981481 Tz (meant ) Tj 1.983333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 53.472222 Tz (time ) Tj 1.497222 0 Td 50.231481 Tz (required ) Tj 2.644444 0 Td 47.530864 Tz (for ) Tj 1.030556 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 53.796296 Tz (agent ) Tj 51.428571 0 0 51.428571 0 2785.716381 Tm 6.241667 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 56.712963 Tz (be ) Tj 0.913889 0 Td 46.616809 Tz (substantially ) Tj 3.830556 0 Td 49.826389 Tz (released ) Tj 2.566667 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 52.121914 Tz (composition. ) Tj 4.005556 0 Td 49.537037 Tz (Elution ) Tj 2.275 0 Td 58.333333 Tz (can ) Tj 51.428571 0 0 51.428571 0 2741.954601 Tm 6.241667 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 57.928241 Tz (measured ) Tj 2.936111 0 Td 61.574074 Tz (by ) Tj 0.952778 0 Td 53.324916 Tz (determining ) Tj 3.694444 0 Td 66.975309 Tz (how ) Tj 1.458333 0 Td 66.435185 Tz (much ) Tj 1.788889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 53.148148 Tz (agent ) Tj 1.769444 0 Td 54.62963 Tz (remains ) Tj 51.428571 0 0 51.428571 0 2698.927083 Tm 6.241667 0 Td 51.851852 Tz (within ) Tj 2.177778 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 54.208754 Tz (composition ) Tj 3.888889 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 61.574074 Tz (by ) Tj 1.05 0 Td 55.812757 Tz (measuring ) Tj 3.305556 0 Td 66.975309 Tz (how ) Tj 1.575 0 Td 64.814815 Tz (much ) Tj 1.866667 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 2655.704762 Tm 6.261111 0 Td 53.148148 Tz (agent ) Tj 1.711111 0 Td 54.012346 Tz (has ) Tj 1.108333 0 Td 57.523148 Tz (been ) Tj 1.555556 0 Td 49.421296 Tz (released ) Tj 2.547222 0 Td 46.180556 Tz (into ) Tj 1.263889 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 52.350427 Tz (compositions ) Tj 4.277778 0 Td 50.356125 Tz (Surroundings. ) Tj 51.428571 0 0 51.428571 0 2609.645244 Tm 6.261111 0 Td 51.388889 Tz (Elution ) Tj 2.391667 0 Td 70.216049 Tz (may ) Tj 1.497222 0 Td 56.712963 Tz (be ) Tj 0.933333 0 Td 43.981481 Tz (partial ) Tj 2.119444 0 Td 57.685185 Tz (\(10%, ) Tj 1.983333 0 Td 62.384259 Tz (25%, ) Tj 1.769444 0 Td 61.574074 Tz (50%, ) Tj 1.730556 0 Td 62.384259 Tz (75%, ) Tj 1.769444 0 Td 61.574074 Tz (80%, ) Tj 1.75 0 Td 62.384259 Tz (85%, ) Tj 51.428571 0 0 51.428571 0 2566.882427 Tm 6.280556 0 Td 61.574074 Tz (90%. ) Tj 1.711111 0 Td 73.45679 Tz (95% ) Tj 1.555556 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 57.037037 Tz (more\) ) Tj 1.925 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 52.932099 Tz (complete. ) Tj 3.15 0 Td 45.37037 Tz (In ) Tj 0.797222 0 Td 58.333333 Tz (one ) Tj 1.263889 0 Td 49.691358 Tz (preferred ) Tj 2.897222 0 Td 67.515432 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 2520.802974 Tm 6.261111 0 Td 54.444444 Tz (ment, ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 52.5 Tz (agent ) Tj 1.75 0 Td 51.49177 Tz (continues ) Tj 2.975 0 Td 45.37037 Tz (to ) Tj 0.719444 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 49.421296 Tz (released ) Tj 2.527778 0 Td 45.37037 Tz (at ) Tj 0.7 0 Td 58.333333 Tz (an ) Tj 0.875 0 Td 46.8107 Tz (effective ) Tj 2.722222 0 Td 46.018519 Tz (level ) Tj 51.428571 0 0 51.428571 0 2478.088339 Tm 6.261111 0 Td 49.691358 Tz (for ) Tj 1.069444 0 Td 46.990741 Tz (at ) Tj 0.797222 0 Td 44.722222 Tz (least ) Tj 1.555556 0 Td 54.444444 Tz (about ) Tj 1.866667 0 Td 45.37037 Tz (3, ) Tj 0.797222 0 Td 43.75 Tz (4, ) Tj 0.797222 0 Td 43.75 Tz (5, ) Tj 0.797222 0 Td 43.75 Tz (6, ) Tj 0.777778 0 Td 43.75 Tz (7, ) Tj 0.777778 0 Td 45.37037 Tz (8, ) Tj 0.777778 0 Td 45.37037 Tz (9, ) Tj 0.797222 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 58.333333 Tz (10 ) Tj 0.913889 0 Td 49.907407 Tz (days. ) Tj 51.428571 0 0 51.428571 0 2435.300254 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.302778 0 Td 50.411523 Tz (invention ) Tj 2.897222 0 Td 52.256944 Tz (provides ) Tj 2.683333 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 62.114198 Tz (number ) Tj 2.372222 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 44.907407 Tz (targets ) Tj 2.1 0 Td 45.37037 Tz (that ) Tj 1.225 0 Td 51.851852 Tz (are ) Tj 1.088889 0 Td 49.151235 Tz (useful ) Tj 51.428571 0 0 51.428571 0 2394.118734 Tm 6.261111 0 Td 48.611111 Tz (for ) Tj 1.147222 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 57.154882 Tz (development ) Tj 4.063889 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 51.851852 Tz (highly ) Tj 2.158333 0 Td 46.180556 Tz (specific ) Tj 2.547222 0 Td 52.5 Tz (drugs ) Tj 1.866667 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 44.722222 Tz (treat ) Tj 1.613889 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2346.352941 Tm 6.261111 0 Td 50.231481 Tz (disorder ) Tj 2.605556 0 Td 49.85755 Tz (characterized ) Tj 4.102778 0 Td 58.333333 Tz (by ) Tj 0.952778 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 57.407407 Tz (methods ) Tj 2.663889 0 Td 49.583333 Tz (delineated ) Tj 3.188889 0 Td 47.222222 Tz (herein. ) Tj 2.236111 0 Td 51.851852 Tz (In ) Tj 51.428571 0 0 51.428571 0 2303.233244 Tm 6.261111 0 Td 47.530864 Tz (addition, ) Tj 2.955556 0 Td 49.691358 Tz (the ) Tj 1.302778 0 Td 57.87037 Tz (methods ) Tj 2.819444 0 Td 61.574074 Tz (of ) Tj 1.030556 0 Td 49.691358 Tz (the ) Tj 1.283333 0 Td 50.771605 Tz (invention ) Tj 3.130556 0 Td 53.240741 Tz (provide ) Tj 2.605556 0 Td 55.092593 Tz (a ) Tj 0.680556 0 Td 46.450617 Tz (facile ) Tj 51.428571 0 0 51.428571 0 2261.852978 Tm 6.261111 0 Td 61.574074 Tz (means ) Tj 2.041667 0 Td 48.611111 Tz (to ) Tj 0.797222 0 Td 46.990741 Tz (identify ) Tj 2.469444 0 Td 48.611111 Tz (therapies ) Tj 2.838889 0 Td 46.180556 Tz (that ) Tj 1.302778 0 Td 49.691358 Tz (are ) Tj 1.127778 0 Td 47.800926 Tz (safe ) Tj 1.361111 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 54.012346 Tz (use ) Tj 1.205556 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 46.450617 Tz (Subjects. ) Tj 51.428571 0 0 51.428571 0 2216.151365 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.758333 0 Td 47.530864 Tz (addition, ) Tj 2.780556 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 56.944444 Tz (methods ) Tj 2.586111 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.771605 Tz (invention ) Tj 2.916667 0 Td 53.703704 Tz (provide ) Tj 2.430556 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.259259 Tz (route ) Tj 1.672222 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 2175.801932 Tm 6.261111 0 Td 52.572016 Tz (analyzing ) Tj 3.033333 0 Td 45.010288 Tz (virtually ) Tj 2.605556 0 Td 58.333333 Tz (any ) Tj 1.302778 0 Td 61.574074 Tz (number ) Tj 2.372222 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 61.934156 Tz (compounds ) Tj 3.538889 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 45.37037 Tz (effects ) Tj 2.1 0 Td 63.194444 Tz (on ) Tj 51.428571 0 0 51.428571 0 2129.425428 Tm 6.241667 0 Td 66.759259 Tz (wound ) Tj 2.236111 0 Td 50.925926 Tz (healing ) Tj 2.352778 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 55.902778 Tz (pathogen ) Tj 2.916667 0 Td 47.530864 Tz (infection ) Tj 2.838889 0 Td 51.131687 Tz (described ) Tj 2.975 0 Td 50.231481 Tz (herein ) Tj 2.061111 0 Td 54.282407 Tz (with ) Tj 51.428571 0 0 51.428571 0 2090.972652 Tm 6.241667 0 Td 56.860269 Tz (high-volume ) Tj 3.888889 0 Td 51.557239 Tz (throughput, ) Tj 3.577778 0 Td 53.472222 Tz (high ) Tj 1.497222 0 Td 42.939815 Tz (sensitivity, ) Tj 3.266667 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 57.253086 Tz (low ) Tj 1.263889 0 Td 64.814815 Tz (complex ) Tj 51.428571 0 0 51.428571 0 2048 Tm 6.261111 0 Td 36.458333 Tz (ity. ) Tj 51.428571 0 0 51.428571 0 2004.574048 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.186111 0 Td 53.796296 Tz ("fragment' ) Tj 3.577778 0 Td 38.888889 Tz (is ) Tj 0.836111 0 Td 58.333333 Tz (meant ) Tj 2.061111 0 Td 51.851852 Tz (a ) Tj 0.641667 0 Td 50 Tz (portion ) Tj 2.469444 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 52.73569 Tz (polypeptide ) Tj 3.811111 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1959.643735 Tm 6.261111 0 Td 50 Tz (nucleic ) Tj 2.313889 0 Td 51.851852 Tz (acid ) Tj 1.497222 0 Td 51.851852 Tz (molecule. ) Tj 3.052778 0 Td 53.472222 Tz (This ) Tj 1.536111 0 Td 49.537037 Tz (portion ) Tj 2.333333 0 Td 48.251029 Tz (contains, ) Tj 2.819444 0 Td 47.727273 Tz (preferably, ) Tj 3.363889 0 Td 46.990741 Tz (at ) Tj 48.571429 0 0 48.571429 0 1917 Tm 6.65 0 Td 46.666667 Tz (least ) Tj 1.688235 0 Td 63.480392 Tz (10%, ) Tj 1.75 0 Td 66.053922 Tz (20%, ) Tj 1.811765 0 Td 66.911765 Tz (30%, ) Tj 1.832353 0 Td 66.911765 Tz (40%, ) Tj 1.852941 0 Td 65.196078 Tz (50%, ) Tj 1.832353 0 Td 65.196078 Tz (60%, ) Tj 1.811765 0 Td 64.338235 Tz (70%, ) Tj 1.770588 0 Td 67.769608 Tz (80%, ) Tj 1.852941 0 Td 56.617647 Tz (or ) Tj 0.844118 0 Td 78.921569 Tz (90% ) Tj 51.428571 0 0 51.428571 0 1874.898657 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 45.910494 Tz (entire ) Tj 1.847222 0 Td 49.691358 Tz (length ) Tj 1.944444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 49.691358 Tz (reference ) Tj 2.858333 0 Td 49.537037 Tz (nucleic ) Tj 2.236111 0 Td 51.041667 Tz (acid ) Tj 1.419444 0 Td 55.497685 Tz (molecule ) Tj 2.819444 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 1835.857868 Tm 6.261111 0 Td 49.96142 Tz (polypeptide. ) Tj 3.791667 0 Td 84.259259 Tz (A ) Tj 0.680556 0 Td 54.282407 Tz (fragment ) Tj 2.838889 0 Td 65.895062 Tz (may ) Tj 1.4 0 Td 50.925926 Tz (contain ) Tj 2.411111 0 Td 46.450617 Tz (10, ) Tj 1.030556 0 Td 48.611111 Tz (20, ) Tj 1.069444 0 Td 50.771605 Tz (30, ) Tj 1.127778 0 Td 49.691358 Tz (40, ) Tj 1.108333 0 Td 49.691358 Tz (50, ) Tj 1.108333 0 Td 48.611111 Tz (60, ) Tj 47.142857 0 0 47.142857 0 1793 Tm 6.830303 0 Td 55.387205 Tz (70, ) Tj 1.230303 0 Td 55.387205 Tz (80, ) Tj 1.251515 0 Td 54.208754 Tz (90, ) Tj 1.230303 0 Td 56.565657 Tz (or ) Tj 0.975758 0 Td 53.914141 Tz (100, ) Tj 1.569697 0 Td 56.565657 Tz (200, ) Tj 1.612121 0 Td 56.565657 Tz (300, ) Tj 1.612121 0 Td 58.333333 Tz (400, ) Tj 1.675758 0 Td 55.681818 Tz (500, ) Tj 1.654545 0 Td 55.681818 Tz (600, ) Tj 1.612121 0 Td 56.565657 Tz (700, ) Tj 1.590909 0 Td 58.333333 Tz (800, ) Tj 1.654545 0 Td 56.565657 Tz (900, ) Tj 40 0 0 40 0 1757 Tm 8.05 0 Td 68.75 Tz (or ) Tj 1.175 0 Td 76.041667 Tz (1000 ) Tj 2.125 0 Td 64.015152 Tz (nucleotides ) Tj 4.575 0 Td 66.666667 Tz (or ) Tj 1.025 0 Td 78.333333 Tz (amino ) Tj 2.675 0 Td 59.027778 Tz (acids. ) Tj 51.428571 0 0 51.428571 0 1710.157068 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.05 0 Td 48.611111 Tz (inhibitory ) Tj 3.5 0 Td 49.074074 Tz (nucleic ) Tj 2.313889 0 Td 51.203704 Tz (acid' ) Tj 1.808333 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 58.981481 Tz (meant ) Tj 2.002778 0 Td 51.851852 Tz (a ) Tj 0.602778 0 Td 52.283951 Tz (double-stranded ) Tj 51.428571 0 0 51.428571 0 1667.208163 Tm 6.280556 0 Td 70.486111 Tz (RNA, ) Tj 2.119444 0 Td 60.493827 Tz (siRNA, ) Tj 2.566667 0 Td 65.895062 Tz (shRNA, ) Tj 2.761111 0 Td 53.472222 Tz (or ) Tj 1.011111 0 Td 49.331276 Tz (antisense ) Tj 3.111111 0 Td 68.865741 Tz (RNA, ) Tj 2.061111 0 Td 51.851852 Tz (or ) Tj 0.991667 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 51.388889 Tz (portion ) Tj 50 0 0 50 0 1625 Tm 6.42 0 Td 48.333333 Tz (thereof, ) Tj 2.58 0 Td 56.666667 Tz (or ) Tj 0.88 0 Td 60 Tz (a ) Tj 0.68 0 Td 57.142857 Tz (mimetic ) Tj 2.66 0 Td 48.333333 Tz (thereof, ) Tj 2.54 0 Td 49.166667 Tz (that ) Tj 1.42 0 Td 67.5 Tz (when ) Tj 1.88 0 Td 54.166667 Tz (administered ) Tj 4.14 0 Td 50 Tz (to ) Tj 0.88 0 Td 56.666667 Tz (a ) Tj 51.428571 0 0 51.428571 0 1583.183246 Tm 6.261111 0 Td 63.374486 Tz (mammalian ) Tj 3.733333 0 Td 42.12963 Tz (cell ) Tj 1.322222 0 Td 44.444444 Tz (results ) Tj 2.158333 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 52.662037 Tz (decrease ) Tj 2.780556 0 Td 41.049383 Tz (\(e.g., ) Tj 1.75 0 Td 59.953704 Tz (by ) Tj 1.069444 0 Td 59.953704 Tz (10%, ) Tj 1.711111 0 Td 62.384259 Tz (25%, ) Tj 51.428571 0 0 51.428571 0 1542.512821 Tm 6.280556 0 Td 62.384259 Tz (50%, ) Tj 1.730556 0 Td 63.194444 Tz (75%, ) Tj 1.75 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 57.523148 Tz (even ) Tj 1.594444 0 Td 61.168981 Tz (90-100%\) ) Tj 3.188889 0 Td 46.990741 Tz (in ) Tj 0.816667 0 Td 47.530864 Tz (the ) Tj 1.108333 0 Td 51.851852 Tz (expression ) Tj 3.344444 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 45.910494 Tz (target ) Tj 51.428571 0 0 51.428571 0 1503 Tm 6.261111 0 Td 51.203704 Tz (gene. ) Tj 1.788889 0 Td 54.282407 Tz (Chitosan ) Tj 2.858333 0 Td 53.742284 Tz (compositions ) Tj 4.141667 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 49.151235 Tz (useful ) Tj 2.041667 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 51.851852 Tz (the ) Tj 1.186111 0 Td 49.016204 Tz (delivery ) Tj 2.644444 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1460.843137 Tm 6.261111 0 Td 49.826389 Tz (polynucleotides, ) Tj 5.055556 0 Td 53.472222 Tz (such ) Tj 1.536111 0 Td 50.231481 Tz (as ) Tj 0.875 0 Td 47.314815 Tz (inhibitory ) Tj 3.111111 0 Td 49.074074 Tz (nucleic ) Tj 2.313889 0 Td 50.231481 Tz (acid ) Tj 1.458333 0 Td 51.527778 Tz (molecules, ) Tj 51.428571 0 0 51.428571 0 1417.889697 Tm 6.241667 0 Td 49.691358 Tz (useful ) Tj 2.002778 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 50.411523 Tz (treatment ) Tj 2.916667 0 Td 55.092593 Tz (or ) Tj 0.816667 0 Td 52.175926 Tz (prevention ) Tj 3.305556 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 55.497685 Tz (pathogen ) Tj 2.897222 0 Td 48.251029 Tz (infection ) Tj 51.428571 0 0 51.428571 0 1375.451852 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 47.222222 Tz (related ) Tj 2.197222 0 Td 46.585648 Tz (disease. ) Tj 2.45 0 Td 47.638889 Tz (Typically, ) Tj 3.091667 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 49.074074 Tz (nucleic ) Tj 2.275 0 Td 51.041667 Tz (acid ) Tj 1.419444 0 Td 46.8107 Tz (inhibitor ) Tj 2.702778 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 1334.830615 Tm 6.261111 0 Td 47.530864 Tz (prises ) Tj 1.886111 0 Td 45.37037 Tz (at ) Tj 0.738889 0 Td 44.722222 Tz (least ) Tj 1.497222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 50 Tz (portion ) Tj 2.313889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.450617 Tz (target ) Tj 1.866667 0 Td 49.537037 Tz (nucleic ) Tj 2.275 0 Td 51.041667 Tz (acid ) Tj 1.438889 0 Td 51.851852 Tz (molecule, ) Tj 3.033333 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1295.057667 Tm 6.261111 0 Td 56.712963 Tz (an ) Tj 0.952778 0 Td 51.851852 Tz (ortholog ) Tj 2.741667 0 Td 46.585648 Tz (thereof, ) Tj 2.527778 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 54.012346 Tz (comprises ) Tj 3.208333 0 Td 43.75 Tz (at ) Tj 0.816667 0 Td 44.074074 Tz (least ) Tj 1.594444 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 50.462963 Tz (portion ) Tj 2.391667 0 Td 58.333333 Tz (of ) Tj 0.894444 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1252.066505 Tm 6.261111 0 Td 57.834758 Tz (complementary ) Tj 4.705556 0 Td 49.691358 Tz (strand ) Tj 1.983333 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 45.910494 Tz (target ) Tj 1.847222 0 Td 49.074074 Tz (nucleic ) Tj 2.216667 0 Td 52.662037 Tz (acid ) Tj 1.458333 0 Td 51.49177 Tz (molecule. ) Tj 2.994444 0 Td 57.253086 Tz (For ) Tj 51.428571 0 0 51.428571 0 1212.309227 Tm 6.261111 0 Td 55.092593 Tz (example, ) Tj 2.877778 0 Td 58.333333 Tz (an ) Tj 0.972222 0 Td 47.314815 Tz (inhibitory ) Tj 3.15 0 Td 49.537037 Tz (nucleic ) Tj 2.313889 0 Td 51.851852 Tz (acid ) Tj 1.536111 0 Td 54.6875 Tz (molecule ) Tj 2.897222 0 Td 54.012346 Tz (comprises ) Tj 3.188889 0 Td 45.37037 Tz (at ) Tj 51.428571 0 0 51.428571 0 1167.666667 Tm 6.261111 0 Td 44.722222 Tz (least ) Tj 1.555556 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 49.537037 Tz (portion ) Tj 2.352778 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 57.253086 Tz (any ) Tj 1.302778 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 39.969136 Tz (all ) Tj 0.972222 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 48.611111 Tz (nucleic ) Tj 2.313889 0 Td 49.907407 Tz (acids ) Tj 1.769444 0 Td 49.907407 Tz (delineated ) Tj 40 0 0 40 0 1132 Tm 8.025 0 Td 61.309524 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 1084.982808 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.166667 0 Td 48.905724 Tz (infection' ) Tj 3.616667 0 Td 37.268519 Tz (is ) Tj 0.836111 0 Td 58.981481 Tz (meant ) Tj 2.138889 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 53.472222 Tz (presence ) Tj 2.916667 0 Td 59.953704 Tz (of ) Tj 0.972222 0 Td 58.333333 Tz (one ) Tj 1.4 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 61.574074 Tz (more ) Tj 51.428571 0 0 51.428571 0 1043.685714 Tm 6.261111 0 Td 54.372428 Tz (pathogens ) Tj 3.344444 0 Td 46.990741 Tz (in ) Tj 0.972222 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 45.37037 Tz (tissue ) Tj 2.061111 0 Td 51.851852 Tz (or ) Tj 0.991667 0 Td 54.444444 Tz (organ ) Tj 2.041667 0 Td 56.712963 Tz (of ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 46.018519 Tz (host. ) Tj 1.75 0 Td 72.916667 Tz (An ) Tj 1.283333 0 Td 48.611111 Tz (infection ) Tj 51.428571 0 0 51.428571 0 1002.851701 Tm 6.261111 0 Td 50.231481 Tz (includes ) Tj 2.877778 0 Td 50.771605 Tz (the ) Tj 1.361111 0 Td 46.616809 Tz (proliferation ) Tj 4.102778 0 Td 58.333333 Tz (of ) Tj 1.05 0 Td 58.333333 Tz (a ) Tj 0.816667 0 Td 56.481481 Tz (microbe ) Tj 2.838889 0 Td 40.509259 Tz (\(e.g., ) Tj 1.944444 0 Td 45.37037 Tz (bacteria, ) Tj 51.428571 0 0 51.428571 0 959.945409 Tm 6.261111 0 Td 46.585648 Tz (viruses, ) Tj 2.430556 0 Td 48.611111 Tz (fungi\) ) Tj 1.925 0 Td 51.311728 Tz (within ) Tj 2.022222 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 46.450617 Tz (tissue ) Tj 1.827778 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 49.074074 Tz (Subject ) Tj 2.216667 0 Td 43.75 Tz (at ) Tj 0.661111 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 42.939815 Tz (site ) Tj 1.186111 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 51.851852 Tz (trauma. ) Tj 51.428571 0 0 51.428571 0 921.788732 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.205556 0 Td 56.712963 Tz (marker' ) Tj 3.15 0 Td 37.268519 Tz (is ) Tj 0.933333 0 Td 57.685185 Tz (meant ) Tj 2.119444 0 Td 59.41358 Tz (any ) Tj 1.477778 0 Td 49.074074 Tz (protein ) Tj 2.469444 0 Td 53.472222 Tz (or ) Tj 1.030556 0 Td 51.62037 Tz (polynucleotide ) Tj 51.428571 0 0 51.428571 0 878.926509 Tm 6.241667 0 Td 55.632716 Tz (having ) Tj 2.275 0 Td 56.712963 Tz (an ) Tj 0.991667 0 Td 45.694444 Tz (alteration ) Tj 3.052778 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 51.527778 Tz (expression ) Tj 3.422222 0 Td 45.37037 Tz (level ) Tj 1.672222 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 45.37037 Tz (activity ) Tj 2.469444 0 Td 46.180556 Tz (that ) Tj 1.380556 0 Td 40.509259 Tz (is ) Tj 40 0 0 40 0 841 Tm 8.05 0 Td 64.166667 Tz (associated ) Tj 4.175 0 Td 67.708333 Tz (with ) Tj 1.95 0 Td 70.833333 Tz (a ) Tj 0.75 0 Td 64.285714 Tz (disease ) Tj 3.025 0 Td 66.666667 Tz (or ) Tj 1.075 0 Td 59.259259 Tz (disorder. ) Tj 51.428571 0 0 51.428571 0 792.414665 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 0.991667 0 Td 56.064815 Tz ("modulate ) Tj 3.519444 0 Td 40.509259 Tz (is ) Tj 0.680556 0 Td 58.981481 Tz (meant ) Tj 1.925 0 Td 44.074074 Tz (alter ) Tj 1.477778 0 Td 48.611111 Tz (\(increase ) Tj 2.761111 0 Td 55.092593 Tz (or ) Tj 0.797222 0 Td 48.287037 Tz (decrease\). ) Tj 3.111111 0 Td 60.763889 Tz (Such ) Tj 51.428571 0 0 51.428571 0 750.358788 Tm 6.261111 0 Td 45.664983 Tz (alterations ) Tj 3.208333 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 50.231481 Tz (detected ) Tj 2.586111 0 Td 59.953704 Tz (by ) Tj 0.894444 0 Td 51.446759 Tz (Standard ) Tj 2.625 0 Td 44.290123 Tz (art ) Tj 0.952778 0 Td 65.462963 Tz (known ) Tj 2.177778 0 Td 57.87037 Tz (methods ) Tj 2.625 0 Td 55.902778 Tz (such ) Tj 40 0 0 40 0 717 Tm 8.05 0 Td 64.583333 Tz (as ) Tj 1.1 0 Td 65.833333 Tz (those ) Tj 2.275 0 Td 66.666667 Tz (described ) Tj 3.875 0 Td 60.714286 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 671.574616 Tm 7 0 Td 66.435185 Tz (As ) Tj 1.108333 0 Td 55.092593 Tz (used ) Tj 1.613889 0 Td 47.685185 Tz (herein, ) Tj 2.352778 0 Td 50.555556 Tz ("obtaining ) Tj 3.636111 0 Td 48.611111 Tz (as ) Tj 0.894444 0 Td 46.990741 Tz (in ) Tj 0.933333 0 Td 50.231481 Tz ("obtaining ) Tj 3.286111 0 Td 58.333333 Tz (an ) Tj 0.991667 0 Td 53.472222 Tz (agent' ) Tj 51.428571 0 0 51.428571 0 631.03813 Tm 6.261111 0 Td 50.231481 Tz (includes ) Tj 2.761111 0 Td 48.860399 Tz (synthesizing, ) Tj 4.141667 0 Td 51.262626 Tz (purchasing, ) Tj 3.733333 0 Td 51.851852 Tz (or ) Tj 0.933333 0 Td 52.211934 Tz (otherwise ) Tj 3.15 0 Td 51.131687 Tz (acquiring ) Tj 51.428571 0 0 51.428571 0 589.235294 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 48.070988 Tz (agent. ) Tj 51.428571 0 0 51.428571 0 543.986357 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.166667 0 Td 50.771605 Tz (physical ) Tj 3.111111 0 Td 47.260802 Tz (interaction' ) Tj 3.772222 0 Td 40.509259 Tz (is ) Tj 0.875 0 Td 58.333333 Tz (meant ) Tj 2.061111 0 Td 58.333333 Tz (an ) Tj 1.030556 0 Td 49.200337 Tz (association ) Tj 3.577778 0 Td 46.990741 Tz (that ) Tj 51.428571 0 0 51.428571 0 503.443299 Tm 6.261111 0 Td 55.092593 Tz (does ) Tj 1.672222 0 Td 49.691358 Tz (not ) Tj 1.166667 0 Td 49.537037 Tz (require ) Tj 2.352778 0 Td 51.446759 Tz (covalent ) Tj 2.761111 0 Td 52.662037 Tz (bonding. ) Tj 2.877778 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 59.41358 Tz (one ) Tj 1.322222 0 Td 58.038721 Tz (embodiment, ) Tj 4.141667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 462.223733 Tm 6.261111 0 Td 50.231481 Tz (physical ) Tj 2.722222 0 Td 46.843434 Tz (interaction ) Tj 3.402778 0 Td 50.231481 Tz (includes ) Tj 2.683333 0 Td 50.356125 Tz (incorporation ) Tj 4.219444 0 Td 46.180556 Tz (into ) Tj 1.380556 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 421.546988 Tm 6.261111 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 48.287037 Tz (invention. ) Tj 51.428571 0 0 51.428571 0 377.374046 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 0.991667 0 Td 50.771605 Tz (point ) Tj 1.944444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.87963 Tz (treatment' ) Tj 3.247222 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 57.685185 Tz (meant ) Tj 1.905556 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 41.319444 Tz (site ) Tj 1.166667 0 Td 59.62963 Tz (where ) Tj 1.925 0 Td 50.231481 Tz (healthcare ) Tj 51.428571 0 0 51.428571 0 336.045392 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.855556 0 Td 47.638889 Tz (delivered. ) Tj 3.188889 0 Td 87.5 Tz (A ) Tj 0.816667 0 Td 51.311728 Tz (point ) Tj 2.197222 0 Td 59.953704 Tz (of ) Tj 0.972222 0 Td 51.131687 Tz (treatment ) Tj 3.441667 0 Td 47.890947 Tz (includes, ) Tj 2.916667 0 Td 54.012346 Tz (but ) Tj 1.322222 0 Td 38.888889 Tz (is ) Tj 0.836111 0 Td 51.851852 Tz (not ) Tj 51.428571 0 0 51.428571 0 296.098516 Tm 6.261111 0 Td 49.074074 Tz (limited ) Tj 2.430556 0 Td 41.049383 Tz (to, ) Tj 1.108333 0 Td 58.333333 Tz (a ) Tj 0.738889 0 Td 46.990741 Tz (Surgical ) Tj 2.663889 0 Td 42.12963 Tz (Suite, ) Tj 1.886111 0 Td 55.416667 Tz (physicians ) Tj 3.694444 0 Td 42.12963 Tz (office, ) Tj 2.197222 0 Td 42.12963 Tz (clinic, ) Tj 2.158333 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 259 Tm 6.241667 0 Td 46.090535 Tz (hospital. ) Tj 51.428571 0 0 51.428571 0 214.91954 Tm 7.019444 0 Td 66.435185 Tz (By ) Tj 1.166667 0 Td 57.928241 Tz (polymer ) Tj 3.422222 0 Td 40.509259 Tz (is ) Tj 0.855556 0 Td 58.333333 Tz (meant ) Tj 2.1 0 Td 58.333333 Tz (a ) Tj 0.7 0 Td 47.685185 Tz (natural ) Tj 2.372222 0 Td 51.851852 Tz (or ) Tj 0.972222 0 Td 47.890947 Tz (synthetic ) Tj 2.955556 0 Td 51.388889 Tz (organic ) Tj 51.428571 0 0 51.428571 0 170.213483 Tm 6.261111 0 Td 55.902778 Tz (molecule ) Tj 2.936111 0 Td 57.79321 Tz (formed ) Tj 2.313889 0 Td 59.953704 Tz (by ) Tj 0.972222 0 Td 57.613169 Tz (combining ) Tj 3.363889 0 Td 51.388889 Tz (Smaller ) Tj 2.391667 0 Td 51.527778 Tz (molecules. ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.805405 0 Td 69.369369 Tz (6 ) Tj 51.428571 0 0 51.428571 0 2914.81866 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.030556 0 Td 47.170782 Tz (profile' ) Tj 2.761111 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 58.981481 Tz (meant ) Tj 1.925 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 44.290123 Tz (set ) Tj 0.991667 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 46.234568 Tz (characteristics ) Tj 4.394444 0 Td 44.560185 Tz (that ) Tj 1.283333 0 Td 49.691358 Tz (define ) Tj 1.944444 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2876.970701 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.986111 0 Td 50.231481 Tz (or ) Tj 0.933333 0 Td 49.421296 Tz (process. ) Tj 2.8 0 Td 56.17284 Tz (For ) Tj 1.341667 0 Td 55.092593 Tz (example, ) Tj 2.994444 0 Td 58.333333 Tz (a ) Tj 0.719444 0 Td 52.283951 Tz (biodegradation ) Tj 51.428571 0 0 51.428571 0 2829.548556 Tm 25.2 0 Td 46.180556 Tz (profile ) Tj 2.625 0 Td 45.37037 Tz (refers ) Tj 2.022222 0 Td 45.37037 Tz (to ) Tj 0.952778 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 51.851852 Tz (biodegradation ) Tj 4.744444 0 Td 46.234568 Tz (characteristics ) Tj 4.55 0 Td 56.712963 Tz (of ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2786.295758 Tm 25.2 0 Td 52.121914 Tz (composition. ) Tj 4.005556 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 52.777778 Tz (another ) Tj 2.372222 0 Td 55.092593 Tz (example, ) Tj 2.819444 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 48.611111 Tz (elution ) Tj 2.527778 0 Td 46.180556 Tz (profile ) Tj 2.469444 0 Td 44.830247 Tz (refers ) Tj 51.428571 0 0 51.428571 0 2741.612521 Tm 25.180556 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 47.685185 Tz (elution ) Tj 2.255556 0 Td 45.802469 Tz (characteristics ) Tj 4.394444 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 52.121914 Tz (composition. ) Tj 51.428571 0 0 51.428571 0 2698.869565 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.166667 0 Td 48.316498 Tz (prosthetic ) Tj 3.519444 0 Td 52.777778 Tz (device' ) Tj 2.547222 0 Td 40.509259 Tz (is ) Tj 0.855556 0 Td 58.333333 Tz (meant ) Tj 2.080556 0 Td 56.712963 Tz (an ) Tj 1.011111 0 Td 54.012346 Tz (implanted ) Tj 3.286111 0 Td 53.703704 Tz (medical ) Tj 51.428571 0 0 51.428571 0 2654.254422 Tm 25.2 0 Td 52.932099 Tz (device ) Tj 2.275 0 Td 46.180556 Tz (that ) Tj 1.516667 0 Td 45.959596 Tz (Substitutes ) Tj 3.441667 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 50.231481 Tz (or ) Tj 0.991667 0 Td 54.503367 Tz (Supplements ) Tj 4.005556 0 Td 55.092593 Tz (a ) Tj 0.758333 0 Td 52.777778 Tz (missing ) Tj 2.625 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 2611.106145 Tm 25.2 0 Td 49.331276 Tz (defective ) Tj 2.916667 0 Td 47.800926 Tz (part ) Tj 1.341667 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 51.851852 Tz (body. ) Tj 51.428571 0 0 51.428571 0 2566.765563 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.127778 0 Td 51.311728 Tz ("small ) Tj 2.138889 0 Td 54.372428 Tz (molecule' ) Tj 3.188889 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 58.981481 Tz (meant ) Tj 2.002778 0 Td 57.253086 Tz (any ) Tj 1.322222 0 Td 53.877315 Tz (chemical ) Tj 2.838889 0 Td 59.773663 Tz (compound. ) Tj 51.428571 0 0 51.428571 0 2523.313984 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.05 0 Td 55.092593 Tz (trauma' ) Tj 2.838889 0 Td 40.509259 Tz (is ) Tj 0.7 0 Td 58.981481 Tz (meant ) Tj 1.944444 0 Td 58.333333 Tz (any ) Tj 1.263889 0 Td 47.530864 Tz (injury ) Tj 1.925 0 Td 46.180556 Tz (that ) Tj 1.302778 0 Td 60.185185 Tz (damages ) Tj 2.722222 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 45.910494 Tz (tissue ) Tj 1.847222 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 2479.830467 Tm 25.2 0 Td 54.444444 Tz (organ ) Tj 1.808333 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 46.585648 Tz (subject. ) Tj 2.372222 0 Td 64.814815 Tz (The ) Tj 1.322222 0 Td 48.070988 Tz (injury ) Tj 1.963889 0 Td 55.902778 Tz (need ) Tj 1.516667 0 Td 51.851852 Tz (not ) Tj 1.069444 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 47.685185 Tz (severe. ) Tj 2.158333 0 Td 50.87963 Tz (Therefore, ) Tj 51.428571 0 0 51.428571 0 2434.730711 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 56.17284 Tz (trauma ) Tj 2.255556 0 Td 50.636574 Tz (includes ) Tj 2.663889 0 Td 58.333333 Tz (any ) Tj 1.302778 0 Td 48.070988 Tz (injury ) Tj 1.983333 0 Td 46.180556 Tz (that ) Tj 1.322222 0 Td 52.932099 Tz (breaks ) Tj 2.138889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 45.37037 Tz (skin. ) Tj 51.428571 0 0 51.428571 0 2390.749361 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.069444 0 Td 54.012346 Tz ("modulation' ) Tj 4.083333 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 58.333333 Tz (meant ) Tj 1.886111 0 Td 59.41358 Tz (any ) Tj 1.244444 0 Td 45.694444 Tz (alteration ) Tj 2.955556 0 Td 39.969136 Tz (\(e.g., ) Tj 1.613889 0 Td 49.826389 Tz (increase ) Tj 2.566667 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 2349.535188 Tm 25.2 0 Td 50.771605 Tz (decrease\) ) Tj 3.013889 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 48.935185 Tz (biological ) Tj 3.169444 0 Td 50.231481 Tz (function ) Tj 2.683333 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 42.849794 Tz (activity. ) Tj 51.428571 0 0 51.428571 0 2305.799139 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.225 0 Td 49.691358 Tz ('subject' ) Tj 3.091667 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 58.981481 Tz (meant ) Tj 2.138889 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 64.351852 Tz (mammal, ) Tj 3.091667 0 Td 48.935185 Tz (including, ) Tj 3.325 0 Td 51.851852 Tz (but ) Tj 1.341667 0 Td 50.771605 Tz (not ) Tj 48.571429 0 0 48.571429 0 2260 Tm 26.682353 0 Td 51.960784 Tz (limited ) Tj 2.594118 0 Td 43.464052 Tz (to, ) Tj 1.173529 0 Td 61.764706 Tz (a ) Tj 0.761765 0 Td 69.313725 Tz (human ) Tj 2.532353 0 Td 53.186275 Tz (or ) Tj 1.05 0 Td 64.052288 Tz (non-human ) Tj 3.911765 0 Td 67.156863 Tz (mammal. ) Tj 3.252941 0 Td 58.333333 Tz (Such ) Tj 1.811765 0 Td 53.186275 Tz (as ) Tj 1.05 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2216.597043 Tm 25.180556 0 Td 51.851852 Tz (bovine, ) Tj 2.430556 0 Td 50 Tz (equine, ) Tj 2.372222 0 Td 49.074074 Tz (canine, ) Tj 2.333333 0 Td 49.151235 Tz (Ovine, ) Tj 2.022222 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 42.592593 Tz (feline. ) Tj 51.428571 0 0 51.428571 0 2174.65685 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.030556 0 Td 55.092593 Tz (uniform ) Tj 2.858333 0 Td 54.012346 Tz (degree ) Tj 2.119444 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 49.768519 Tz (deacetylation ) Tj 4.413889 0 Td 44.290123 Tz (refers ) Tj 1.808333 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 51.041667 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2131.219668 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 65.625 Tz (made ) Tj 1.808333 0 Td 57.523148 Tz (from ) Tj 1.633333 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 48.611111 Tz (single ) Tj 1.983333 0 Td 52.662037 Tz (type ) Tj 1.516667 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 47.890947 Tz (chitosan, ) Tj 2.858333 0 Td 39.969136 Tz (\(e.g., ) Tj 1.711111 0 Td 51.851852 Tz (61 ) Tj 51.428571 0 0 51.428571 0 2087.157629 Tm 25.2 0 Td 52.777778 Tz (degrees ) Tj 2.508333 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 49.608262 Tz (deacetylation ) Tj 4.2 0 Td 61.574074 Tz (\(DDA\), ) Tj 2.547222 0 Td 68.055556 Tz (71DDA, ) Tj 2.761111 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 64.351852 Tz (81DDA\). ) Tj 3.052778 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 2042.814268 Tm 25.2 0 Td 58.333333 Tz (one ) Tj 1.263889 0 Td 58.038721 Tz (embodiment, ) Tj 4.063889 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 49.421296 Tz (chitosan ) Tj 2.644444 0 Td 54.208754 Tz (composition ) Tj 3.830556 0 Td 55.092593 Tz (having ) Tj 2.197222 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 56.018519 Tz (uniform ) Tj 51.428571 0 0 51.428571 0 2000.666667 Tm 25.2 0 Td 54.012346 Tz (degree ) Tj 2.080556 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.608262 Tz (deacetylation ) Tj 4.044444 0 Td 53.06713 Tz (excludes ) Tj 2.722222 0 Td 49.826389 Tz (chitosan ) Tj 2.566667 0 Td 53.472222 Tz (compositions ) Tj 4.005556 0 Td 72.376543 Tz (hav ) Tj 51.428571 0 0 51.428571 0 1954.224787 Tm 25.2 0 Td 50.771605 Tz (ing ) Tj 1.108333 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 54.79798 Tz (combination ) Tj 3.791667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 51.203704 Tz (types ) Tj 1.730556 0 Td 56.712963 Tz (of ) Tj 0.738889 0 Td 48.611111 Tz (chitosans, ) Tj 3.091667 0 Td 58.981481 Tz (where ) Tj 1.944444 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 49.691358 Tz (chitosans ) Tj 51.428571 0 0 51.428571 0 1913.612613 Tm 25.180556 0 Td 58.333333 Tz (have ) Tj 1.652778 0 Td 45.37037 Tz (different ) Tj 2.702778 0 Td 52.314815 Tz (degrees ) Tj 2.430556 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 47.916667 Tz (deacetylation. ) Tj 51.428571 0 0 51.428571 0 1867.434839 Tm 25.919444 0 Td 66.435185 Tz (As ) Tj 1.05 0 Td 55.902778 Tz (used ) Tj 1.555556 0 Td 48.148148 Tz (herein, ) Tj 2.255556 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 53.148148 Tz (terms ) Tj 1.827778 0 Td 44.155093 Tz (treat, ) Tj 2.372222 0 Td 45.046296 Tz (treating, ) Tj 2.955556 0 Td 49.96142 Tz (treatment, ) Tj 51.428571 0 0 51.428571 0 1825.413333 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 45.37037 Tz (like ) Tj 1.438889 0 Td 46.018519 Tz (refer ) Tj 1.652778 0 Td 46.990741 Tz (to ) Tj 0.933333 0 Td 52.662037 Tz (reducing ) Tj 2.877778 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 51.311728 Tz (ameliorating ) Tj 4.005556 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 50.231481 Tz (disorder ) Tj 51.428571 0 0 51.428571 0 1781.10107 Tm 25.2 0 Td 52.391975 Tz (and/or ) Tj 2.002778 0 Td 61.979167 Tz (symptoms ) Tj 3.15 0 Td 49.907407 Tz (associated ) Tj 3.15 0 Td 48.287037 Tz (therewith. ) Tj 3.130556 0 Td 34.027778 Tz (It ) Tj 0.544444 0 Td 46.990741 Tz (will ) Tj 1.283333 0 Td 58.333333 Tz (be ) Tj 0.855556 0 Td 50.968013 Tz (appreciated ) Tj 51.428571 0 0 51.428571 0 1738.893462 Tm 25.180556 0 Td 42.777778 Tz (that, ) Tj 1.438889 0 Td 53.472222 Tz (although ) Tj 2.780556 0 Td 49.691358 Tz (not ) Tj 1.069444 0 Td 50.555556 Tz (precluded, ) Tj 3.227778 0 Td 46.180556 Tz (treating ) Tj 2.372222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.826389 Tz (disorder ) Tj 2.566667 0 Td 48.611111 Tz (or ) Tj 0.777778 0 Td 50.771605 Tz (condition ) Tj 51.428571 0 0 51.428571 0 1693.653009 Tm 25.2 0 Td 55.092593 Tz (does ) Tj 1.652778 0 Td 50.771605 Tz (not ) Tj 1.186111 0 Td 49.074074 Tz (require ) Tj 2.313889 0 Td 46.990741 Tz (that ) Tj 1.380556 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 46.450617 Tz (disorder, ) Tj 2.819444 0 Td 50.411523 Tz (condition ) Tj 3.013889 0 Td 53.472222 Tz (or ) Tj 0.913889 0 Td 61.979167 Tz (symptoms ) Tj 52.857143 0 0 52.857143 0 1647.993958 Tm 24.518919 0 Td 48.243243 Tz (associated ) Tj 3.140541 0 Td 49.399399 Tz (therewith ) Tj 2.913514 0 Td 56.756757 Tz (be ) Tj 0.908108 0 Td 52.027027 Tz (completely ) Tj 3.348649 0 Td 47.870598 Tz (eliminated. ) Tj 51.428571 0 0 51.428571 0 1607.474227 Tm 25.919444 0 Td 66.435185 Tz (As ) Tj 1.05 0 Td 55.902778 Tz (used ) Tj 1.555556 0 Td 47.685185 Tz (herein, ) Tj 2.255556 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 53.796296 Tz (terms ) Tj 1.866667 0 Td 50.231481 Tz (prevent, ) Tj 3.247222 0 Td 50.356125 Tz (preventing, ) Tj 4.161111 0 Td 62.384259 Tz (pre ) Tj 51.428571 0 0 51.428571 0 1561.146082 Tm 25.2 0 Td 49.691358 Tz (vention, ) Tj 3.091667 0 Td 50.356125 Tz (prophylactic ) Tj 4.375 0 Td 50.555556 Tz (treatment ) Tj 3.422222 0 Td 59.41358 Tz (and ) Tj 1.477778 0 Td 49.691358 Tz (the ) Tj 1.302778 0 Td 44.560185 Tz (like ) Tj 1.477778 0 Td 46.666667 Tz (refer ) Tj 1.75 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1519.568603 Tm 25.2 0 Td 53.06713 Tz (reducing ) Tj 2.761111 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 48.611111 Tz (probability ) Tj 3.441667 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 53.796296 Tz (developing ) Tj 3.441667 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 49.421296 Tz (disorder ) Tj 2.625 0 Td 50.231481 Tz (or ) Tj 0.816667 0 Td 61.574074 Tz (condi ) Tj 51.428571 0 0 51.428571 0 1473.304721 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.458333 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 46.180556 Tz (Subject, ) Tj 2.527778 0 Td 66.975309 Tz (who ) Tj 1.555556 0 Td 55.092593 Tz (does ) Tj 1.652778 0 Td 50.771605 Tz (not ) Tj 1.186111 0 Td 51.203704 Tz (have, ) Tj 1.847222 0 Td 52.932099 Tz (but ) Tj 1.263889 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 43.75 Tz (at ) Tj 0.816667 0 Td 46.180556 Tz (risk ) Tj 1.380556 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1431.888726 Tm 25.219444 0 Td 48.905724 Tz (Susceptible ) Tj 3.461111 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 53.796296 Tz (developing ) Tj 3.461111 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 50.231481 Tz (disorder ) Tj 2.625 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 48.287037 Tz (condition. ) Tj 51.428571 0 0 51.428571 0 1384.440367 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.05 0 Td 50.968013 Tz (reference' ) Tj 3.616667 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 58.333333 Tz (meant ) Tj 1.944444 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 51.041667 Tz (standard ) Tj 2.683333 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 49.537037 Tz (control ) Tj 2.313889 0 Td 48.611111 Tz (condition. ) Tj 51.428571 0 0 51.428571 0 1343.091503 Tm 25.938889 0 Td 68.055556 Tz (By ) Tj 1.011111 0 Td 65.354938 Tz (siRNA ) Tj 2.838889 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 58.981481 Tz (meant ) Tj 1.905556 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 54.012346 Tz (double ) Tj 2.138889 0 Td 51.446759 Tz (stranded ) Tj 2.663889 0 Td 68.865741 Tz (RNA. ) Tj 1.847222 0 Td 51.203704 Tz (Optimally, ) Tj 51.428571 0 0 51.428571 0 1297.967825 Tm 25.2 0 Td 56.712963 Tz (an ) Tj 0.855556 0 Td 66.759259 Tz (siRNA ) Tj 2.119444 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 44.290123 Tz (18, ) Tj 1.069444 0 Td 45.37037 Tz (19, ) Tj 0.991667 0 Td 49.691358 Tz (20, ) Tj 1.069444 0 Td 48.611111 Tz (21, ) Tj 1.05 0 Td 49.691358 Tz (22, ) Tj 1.069444 0 Td 56.712963 Tz (23 ) Tj 0.855556 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 59.953704 Tz (24 ) Tj 0.894444 0 Td 49.789562 Tz (nucleotides ) Tj 3.480556 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 50.771605 Tz (length ) Tj 51.428571 0 0 51.428571 0 1254.455497 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 55.092593 Tz (has ) Tj 1.205556 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 58.333333 Tz (2 ) Tj 0.583333 0 Td 54.282407 Tz (base ) Tj 1.516667 0 Td 56.30787 Tz (overhang ) Tj 2.897222 0 Td 46.990741 Tz (at ) Tj 0.777778 0 Td 35.648148 Tz (its ) Tj 0.875 0 Td 43.75 Tz (3' ) Tj 0.738889 0 Td 50.231481 Tz (end. ) Tj 1.419444 0 Td 57.685185 Tz (These ) Tj 1.983333 0 Td 67.515432 Tz (dsRNAs ) Tj 2.644444 0 Td 58.333333 Tz (can ) Tj 48.571429 0 0 48.571429 0 1212 Tm 26.661765 0 Td 63.480392 Tz (be ) Tj 0.947059 0 Td 54.901961 Tz (introduced ) Tj 3.520588 0 Td 46.323529 Tz (to ) Tj 0.761765 0 Td 61.764706 Tz (an ) Tj 0.947059 0 Td 51.813725 Tz (individual ) Tj 3.335294 0 Td 45.465686 Tz (cell ) Tj 1.338235 0 Td 53.186275 Tz (or ) Tj 0.844118 0 Td 46.323529 Tz (to ) Tj 0.761765 0 Td 61.764706 Tz (a ) Tj 0.576471 0 Td 62.45098 Tz (whole ) Tj 2.058824 0 Td 54.411765 Tz (animal; ) Tj 2.511765 0 Td 52.614379 Tz (for ) Tj 51.428571 0 0 51.428571 0 1170.302521 Tm 25.2 0 Td 55.092593 Tz (example, ) Tj 2.780556 0 Td 51.851852 Tz (they ) Tj 1.458333 0 Td 66.975309 Tz (may ) Tj 1.361111 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 51.851852 Tz (introduced ) Tj 3.266667 0 Td 50.231481 Tz (systemically ) Tj 3.811111 0 Td 48.611111 Tz (via ) Tj 1.011111 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 63.518519 Tz (blood ) Tj 51.428571 0 0 51.428571 0 1124.165333 Tm 25.219444 0 Td 49.537037 Tz (stream. ) Tj 2.488889 0 Td 59.953704 Tz (Such ) Tj 1.866667 0 Td 63.194444 Tz (siRNAs ) Tj 2.683333 0 Td 49.691358 Tz (are ) Tj 1.263889 0 Td 55.902778 Tz (used ) Tj 1.75 0 Td 43.75 Tz (to ) Tj 0.952778 0 Td 54.822531 Tz (downregulate ) Tj 4.375 0 Td 86.689815 Tz (mRNA ) Tj 51.428571 0 0 51.428571 0 1084.481481 Tm 25.2 0 Td 46.990741 Tz (levels ) Tj 1.944444 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 56.712963 Tz (promoter ) Tj 2.916667 0 Td 42.849794 Tz (activity. ) Tj 15.714286 0 0 15.714286 0 1891.5 Tm 126.063636 0 Td 84.848485 Tz (99 ) Tj 1.845455 0 Td 84.848485 Tz (&g ) Tj 38.571429 0 0 38.571429 0 1006 Tm 35.933333 0 Td 90.740741 Tz (BRIEF ) Tj 3.137037 0 Td 94.276094 Tz (DESCRIPTION ) Tj 6.559259 0 Td 101.54321 Tz (OF ) Tj 1.555556 0 Td 105.144033 Tz (THE ) Tj 2.22963 0 Td 106.404321 Tz (DRAWINGS ) Tj 51.428571 0 0 51.428571 0 912.724092 Tm 25.938889 0 Td 55.092593 Tz (FIG. ) Tj 1.633333 0 Td 45.37037 Tz (1 ) Tj 0.583333 0 Td 60.277778 Tz (shows ) Tj 2.080556 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 47.260802 Tz (neutralized, ) Tj 3.655556 0 Td 48.611111 Tz (large ) Tj 1.730556 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 55.092593 Tz (sponges ) Tj 2.605556 0 Td 63.734568 Tz (\(ap ) Tj 51.428571 0 0 51.428571 0 870.660432 Tm 25.2 0 Td 53.030303 Tz (proximately ) Tj 3.752778 0 Td 55.092593 Tz (5"x5"\) ) Tj 2.216667 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 54.444444 Tz (water ) Tj 1.847222 0 Td 61.574074 Tz (wash ) Tj 1.730556 0 Td 48.611111 Tz (step ) Tj 1.419444 0 Td 50.555556 Tz (\(Step ) Tj 1.769444 0 Td 43.209877 Tz (5\). ) Tj 51.428571 0 0 51.428571 0 828.248408 Tm 25.938889 0 Td 55.092593 Tz (FIG. ) Tj 1.497222 0 Td 61.574074 Tz (2 ) Tj 0.563889 0 Td 60.277778 Tz (shows ) Tj 2.002778 0 Td 57.253086 Tz (sponge ) Tj 2.255556 0 Td 55.092593 Tz (samples ) Tj 2.508333 0 Td 58.333333 Tz (from ) Tj 1.575 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 51.851852 Tz (ten-day ) Tj 2.372222 0 Td 52.441077 Tz (degradation ) Tj 51.428571 0 0 51.428571 0 784.340369 Tm 25.219444 0 Td 46.450617 Tz (study. ) Tj 1.963889 0 Td 64.814815 Tz (The ) Tj 1.477778 0 Td 56.712963 Tz (sponge ) Tj 2.372222 0 Td 56.712963 Tz 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2968 Tm 14.777778 0 Td 77.777778 Tz (7 ) Tj 51.428571 0 0 51.428571 0 2918.85902 Tm 6.241667 0 Td 56.17284 Tz (weight ) Tj 2.177778 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 56.712963 Tz (sponge ) Tj 2.197222 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 41.540404 Tz (triplicate. ) Tj 2.897222 0 Td 87.5 Tz (A ) Tj 0.602778 0 Td 57.037037 Tz (lower ) Tj 1.808333 0 Td 51.851852 Tz (percent ) Tj 2.352778 0 Td 54.372428 Tz (remaining ) Tj 51.428571 0 0 51.428571 0 2872.995951 Tm 6.261111 0 Td 47.890947 Tz (indicates ) Tj 2.819444 0 Td 56.712963 Tz (an ) Tj 0.952778 0 Td 50.771605 Tz (increased ) Tj 2.975 0 Td 49.96142 Tz (degradation. ) Tj 38.571429 0 0 38.571429 0 2796 Tm 12.47037 0 Td 97.762346 Tz (DETAILED ) Tj 5.02963 0 Td 95.061728 Tz (DESCRIPTION ) Tj 6.637037 0 Td 99.382716 Tz (OF ) Tj 1.503704 0 Td 106.584362 Tz (THE ) Tj 38.571429 0 0 38.571429 0 2755 Tm 17.344444 0 Td 98.902606 Tz (INVENTION ) Tj 51.428571 0 0 51.428571 0 2665.258297 Tm 7 0 Td 66.435185 Tz (As ) Tj 1.322222 0 Td 51.851852 Tz (described ) Tj 3.325 0 Td 52.391975 Tz (below, ) Tj 2.469444 0 Td 47.530864 Tz (the ) Tj 1.380556 0 Td 50.462963 Tz (present ) Tj 2.644444 0 Td 50.771605 Tz (invention ) Tj 3.305556 0 Td 47.395833 Tz (features ) Tj 51.428571 0 0 51.428571 0 2627.074627 Tm 6.261111 0 Td 58.333333 Tz (improved ) Tj 3.208333 0 Td 57.407407 Tz (methods ) Tj 2.8 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 55.092593 Tz (producing ) Tj 3.325 0 Td 53.098291 Tz (biodegradable ) Tj 4.530556 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2586.503686 Tm 6.261111 0 Td 53.742284 Tz (compositions ) Tj 4.141667 0 Td 40.509259 Tz (\(e.g., ) Tj 1.75 0 Td 43.518519 Tz (Solids, ) Tj 2.119444 0 Td 52.256944 Tz (sponges, ) Tj 2.780556 0 Td 44.830247 Tz (films, ) Tj 1.866667 0 Td 50.87963 Tz (hydrogels, ) Tj 3.305556 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2544.39417 Tm 6.261111 0 Td 46.990741 Tz (posites\) ) Tj 2.566667 0 Td 45.37037 Tz (that ) Tj 1.341667 0 Td 53.703704 Tz (provide ) Tj 2.527778 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 46.666667 Tz (local ) Tj 1.711111 0 Td 49.016204 Tz (delivery ) Tj 2.625 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 48.341049 Tz (biologically ) Tj 51.428571 0 0 51.428571 0 2500.860645 Tm 6.261111 0 Td 48.611111 Tz (active ) Tj 2.022222 0 Td 51.851852 Tz (agents ) Tj 2.158333 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 57.407407 Tz (methods ) Tj 2.722222 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 51.851852 Tz (using ) Tj 1.866667 0 Td 54.282407 Tz (Such ) Tj 1.633333 0 Td 53.472222 Tz (compositions ) Tj 4.161111 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 2460.341463 Tm 6.241667 0 Td 44.074074 Tz (treat ) Tj 1.555556 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 51.851852 Tz (prevent ) Tj 2.411111 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 47.530864 Tz (infection ) Tj 2.838889 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 58.333333 Tz (promote ) Tj 2.683333 0 Td 47.800926 Tz (healing. ) Tj 51.428571 0 0 51.428571 0 2416.318367 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.380556 0 Td 49.691358 Tz (invention ) Tj 2.955556 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 50.771605 Tz (based, ) Tj 2.080556 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 44.074074 Tz (least ) Tj 1.575 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 43.425926 Tz (part, ) Tj 1.536111 0 Td 59.953704 Tz (on ) Tj 0.952778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 52.572016 Tz (discovery ) Tj 51.428571 0 0 51.428571 0 2377.859259 Tm 6.241667 0 Td 46.990741 Tz (that ) Tj 1.283333 0 Td 56.17284 Tz (adding ) Tj 2.197222 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 49.583333 Tz ("buffering ) Tj 3.169444 0 Td 49.259259 Tz (step ) Tj 1.652778 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 51.851852 Tz (the ) Tj 1.127778 0 Td 60.493827 Tz (method ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 51.527778 Tz (generating ) Tj 3.286111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2334.456919 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 57.253086 Tz (sponge ) Tj 2.372222 0 Td 51.851852 Tz (provides ) Tj 2.838889 0 Td 48.611111 Tz (the ) Tj 1.166667 0 Td 44.907407 Tz (ability ) Tj 2.197222 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 46.450617 Tz (better ) Tj 1.963889 0 Td 49.074074 Tz (control ) Tj 2.391667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2295.275362 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 57.253086 Tz (sponge ) Tj 2.275 0 Td 50.231481 Tz (degradation. ) Tj 3.85 0 Td 44.560185 Tz (Briefly, ) Tj 2.372222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 58.333333 Tz (improved ) Tj 3.052778 0 Td 60.493827 Tz (method ) Tj 51.428571 0 0 51.428571 0 2251.742406 Tm 6.261111 0 Td 51.041667 Tz (involves ) Tj 2.663889 0 Td 49.583333 Tz (dissolving ) Tj 3.169444 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 45.37037 Tz (in ) Tj 0.7 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 64.814815 Tz (weak ) Tj 1.730556 0 Td 50.925926 Tz (organic ) Tj 2.313889 0 Td 51.041667 Tz (acid ) Tj 1.4 0 Td 56.481481 Tz (aqueous ) Tj 51.428571 0 0 51.428571 0 2208.53 Tm 6.280556 0 Td 46.090535 Tz (Solution, ) Tj 2.780556 0 Td 49.826389 Tz (freezing ) Tj 2.625 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 46.8107 Tz (resulting ) Tj 2.8 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 51.041667 Tz (acid ) Tj 1.477778 0 Td 46.8107 Tz (solution; ) Tj 51.428571 0 0 51.428571 0 2168.254068 Tm 6.261111 0 Td 48.881173 Tz (lyophilizing ) Tj 3.811111 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 47.685185 Tz (frozen, ) Tj 2.352778 0 Td 46.018519 Tz (Solid ) Tj 1.691667 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 46.450617 Tz (Solution, ) Tj 2.819444 0 Td 58.333333 Tz (removing ) Tj 51.428571 0 0 51.428571 0 2127.897338 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 50.231481 Tz (water; ) Tj 2.119444 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 52.662037 Tz (then ) Tj 1.594444 0 Td 48.070988 Tz (neutralizing ) Tj 3.772222 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 47.170782 Tz (resulting ) Tj 2.858333 0 Td 51.262626 Tz (dehydrated, ) Tj 51.428571 0 0 51.428571 0 2085.267606 Tm 6.261111 0 Td 48.070988 Tz (acidic ) Tj 1.983333 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 55.902778 Tz ('sponge' ) Tj 2.936111 0 Td 59.953704 Tz (by ) Tj 0.972222 0 Td 51.851852 Tz (hydrating ) Tj 3.072222 0 Td 32.407407 Tz (it ) Tj 0.622222 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 58.333333 Tz (an ) Tj 0.952778 0 Td 52.932099 Tz (excess ) Tj 2.158333 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 2042.725926 Tm 6.261111 0 Td 48.287037 Tz (centration ) Tj 3.169444 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 60.493827 Tz (Volume ) Tj 2.430556 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 58.873457 Tz (Sodium ) Tj 2.372222 0 Td 55.092593 Tz (hydroxide ) Tj 3.208333 0 Td 56.944444 Tz (aqueous ) Tj 2.644444 0 Td 60.763889 Tz (solu ) Tj 51.428571 0 0 51.428571 0 2000.416894 Tm 6.241667 0 Td 43.425926 Tz (tion. ) Tj 1.711111 0 Td 64.814815 Tz (The ) Tj 1.575 0 Td 47.395833 Tz (residual ) Tj 2.683333 0 Td 48.611111 Tz (acidic ) Tj 2.158333 0 Td 59.41358 Tz (and ) Tj 1.458333 0 Td 49.907407 Tz (basic ) Tj 1.886111 0 Td 52.662037 Tz (products ) Tj 2.955556 0 Td 58.333333 Tz (were ) Tj 1.808333 0 Td 53.472222 Tz (then ) Tj 51.428571 0 0 51.428571 0 1961.408602 Tm 6.241667 0 Td 61.574074 Tz (washed ) Tj 2.45 0 Td 63.194444 Tz (away ) Tj 1.788889 0 Td 52.5 Tz (using ) Tj 1.788889 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 53.240741 Tz (copious ) Tj 2.469444 0 Td 61.033951 Tz (amount ) Tj 2.430556 0 Td 48.971193 Tz (ultrapure ) Tj 2.877778 0 Td 48.070988 Tz (water. ) Tj 51.428571 0 0 51.428571 0 1918.989446 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.836111 0 Td 51.851852 Tz (a ) Tj 0.602778 0 Td 49.907407 Tz (buffering ) Tj 3.247222 0 Td 46.450617 Tz (step. ) Tj 1.963889 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 49.691358 Tz (hydrated, ) Tj 3.033333 0 Td 48.316498 Tz (neutralized ) Tj 3.461111 0 Td 51.041667 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1875.47858 Tm 6.280556 0 Td 56.712963 Tz (sponge ) Tj 2.197222 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 56.17284 Tz (soaked ) Tj 2.158333 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 56.712963 Tz (0.25Macetate ) Tj 4.2 0 Td 49.151235 Tz (buffer ) Tj 1.905556 0 Td 48.206019 Tz (solution ) Tj 2.488889 0 Td 45.37037 Tz (at ) Tj 0.661111 0 Td 74.537037 Tz (pH ) Tj 1.088889 0 Td 48.611111 Tz (5.6 ) Tj 51.428571 0 0 51.428571 0 1834.571429 Tm 6.261111 0 Td 49.691358 Tz (for ) Tj 1.088889 0 Td 43.75 Tz (thirty ) Tj 1.847222 0 Td 50.636574 Tz (minutes. ) Tj 51.428571 0 0 51.428571 0 1794.179355 Tm 7.019444 0 Td 55.092593 Tz (Following ) Tj 3.130556 0 Td 44.560185 Tz (this ) Tj 1.225 0 Td 44.722222 Tz (step, ) Tj 1.536111 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 52.932099 Tz (excess ) Tj 2.1 0 Td 46.450617 Tz (liquid ) Tj 1.847222 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 59.722222 Tz (removed ) Tj 2.683333 0 Td 57.523148 Tz (from ) Tj 1.594444 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 1752.083676 Tm 6.280556 0 Td 52.777778 Tz (sponge, ) Tj 2.644444 0 Td 57.685185 Tz (which ) Tj 2.177778 0 Td 37.268519 Tz (is ) Tj 0.836111 0 Td 51.851852 Tz (then ) Tj 1.672222 0 Td 48.148148 Tz (frozen, ) Tj 2.45 0 Td 49.200337 Tz (lyophilized ) Tj 3.636111 0 Td 59.41358 Tz (and ) Tj 1.438889 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 42.777778 Tz (final ) Tj 51.428571 0 0 51.428571 0 1711.129987 Tm 6.241667 0 Td 51.041667 Tz (buffered ) Tj 2.702778 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 56.712963 Tz (Sponge ) Tj 2.313889 0 Td 66.975309 Tz (may ) Tj 1.458333 0 Td 56.712963 Tz (be ) Tj 0.952778 0 Td 49.151235 Tz (stored ) Tj 2.041667 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 58.333333 Tz (low ) Tj 1.322222 0 Td 55.497685 Tz (humidity ) Tj 40 0 0 40 0 1674 Tm 8.05 0 Td 68.402778 Tz (environment. ) Tj 52.857143 0 0 52.857143 0 1628.25523 Tm 6.810811 0 Td 51.238739 Tz (This ) Tj 1.740541 0 Td 57.807808 Tz (method ) Tj 2.497297 0 Td 51.238739 Tz (provides ) Tj 2.913514 0 Td 50.45045 Tz (a ) Tj 0.775676 0 Td 50.187688 Tz (reproducibly ) Tj 4.02973 0 Td 57.807808 Tz (and ) Tj 1.494595 0 Td 52.552553 Tz (uniformly ) Tj 51.428571 0 0 51.428571 0 1586.700621 Tm 6.261111 0 Td 53.472222 Tz (degradable ) Tj 3.461111 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 52.314815 Tz (sponge. ) Tj 2.45 0 Td 48.611111 Tz (Additionally, ) Tj 4.083333 0 Td 32.407407 Tz (it ) Tj 0.622222 0 Td 52.932099 Tz (allows ) Tj 2.177778 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1544.574413 Tm 6.261111 0 Td 51.851852 Tz (degradation ) Tj 3.752778 0 Td 51.851852 Tz (process ) Tj 2.488889 0 Td 48.611111 Tz (to ) Tj 0.913889 0 Td 58.333333 Tz (be ) Tj 1.030556 0 Td 48.935185 Tz (controlled ) Tj 3.247222 0 Td 59.953704 Tz (by ) Tj 1.088889 0 Td 52.314815 Tz (varying ) Tj 2.527778 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 52.662037 Tz (acid ) Tj 51.428571 0 0 51.428571 0 1500.349144 Tm 6.241667 0 Td 49.691358 Tz (buffer ) Tj 2.158333 0 Td 46.666667 Tz (type, ) Tj 1.847222 0 Td 48.611111 Tz (buffer ) Tj 2.119444 0 Td 49.305556 Tz (concentration, ) Tj 4.55 0 Td 48.611111 Tz (buffer ) Tj 2.119444 0 Td 60.493827 Tz (pH, ) Tj 1.497222 0 Td 59.41358 Tz (and ) Tj 1.458333 0 Td 49.151235 Tz (buffer ) Tj 51.428571 0 0 51.428571 0 1461.183486 Tm 6.280556 0 Td 53.703704 Tz (soaking ) Tj 2.527778 0 Td 55.092593 Tz (time ) Tj 1.594444 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 49.259259 Tz (yield ) Tj 1.75 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 49.826389 Tz (chitosan ) Tj 2.722222 0 Td 56.712963 Tz (Sponge ) Tj 2.333333 0 Td 55.092593 Tz (having ) Tj 2.275 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 50.462963 Tz (desired ) Tj 51.428571 0 0 51.428571 0 1423 Tm 6.261111 0 Td 51.851852 Tz (degradation ) Tj 3.655556 0 Td 43.344907 Tz (profile. ) Tj 40 0 0 40 0 1382 Tm 8.05 0 Td 69.791667 Tz (Chitosan ) Tj 51.428571 0 0 51.428571 0 1337.266754 Tm 7 0 Td 53.472222 Tz (Chitosan ) Tj 2.916667 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 47.530864 Tz (naturally ) Tj 2.897222 0 Td 51.851852 Tz (occurring ) Tj 3.111111 0 Td 46.990741 Tz (linear ) Tj 1.983333 0 Td 52.083333 Tz (polysaccharide ) Tj 51.428571 0 0 51.428571 0 1293.889435 Tm 6.261111 0 Td 61.574074 Tz (composed ) Tj 3.363889 0 Td 58.333333 Tz (of ) Tj 1.030556 0 Td 57.523148 Tz (randomly ) Tj 3.169444 0 Td 47.727273 Tz (distributed ) Tj 3.636111 0 Td 52.175926 Tz (B-\(1-4\)-2-amino-2-D- ) Tj 51.428571 0 0 51.428571 0 1252.832335 Tm 6.261111 0 Td 55.976431 Tz (glucosamine ) Tj 4.063889 0 Td 48.611111 Tz (\(deacetylated\) ) Tj 4.452778 0 Td 58.333333 Tz (and ) Tj 1.536111 0 Td 51.446759 Tz (B-\(1-4\)-2-acetamido-2-D- ) Tj 51.428571 0 0 51.428571 0 1211.791045 Tm 6.261111 0 Td 55.632716 Tz (glucoseamine ) Tj 4.316667 0 Td 47.260802 Tz (\(acetylated\) ) Tj 3.713889 0 Td 43.75 Tz (units. ) Tj 1.866667 0 Td 53.472222 Tz (Chitosan ) Tj 2.897222 0 Td 40.509259 Tz (is ) Tj 0.777778 0 Td 52.314815 Tz (derived ) Tj 2.508333 0 Td 58.333333 Tz (from ) Tj 51.428571 0 0 51.428571 0 1169.960976 Tm 6.261111 0 Td 43.518519 Tz (chitin, ) Tj 1.983333 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 47.170782 Tz (naturally ) Tj 2.722222 0 Td 51.851852 Tz (occurring ) Tj 2.955556 0 Td 53.06713 Tz (polymer. ) Tj 2.722222 0 Td 50.231481 Tz (Chitin ) Tj 2.002778 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 49.691358 Tz (white, ) Tj 1.944444 0 Td 48.611111 Tz (hard, ) Tj 51.428571 0 0 51.428571 0 1128.817844 Tm 6.261111 0 Td 43.425926 Tz (inelastic, ) Tj 2.975 0 Td 51.262626 Tz (nitrogenous ) Tj 3.713889 0 Td 52.314815 Tz (polysaccharide ) Tj 4.725 0 Td 46.990741 Tz (isolated ) Tj 2.605556 0 Td 57.523148 Tz (from ) Tj 1.75 0 Td 46.450617 Tz (fungi, ) Tj 51.428571 0 0 51.428571 0 1085.480211 Tm 6.261111 0 Td 51.851852 Tz (mollusks, ) Tj 3.227778 0 Td 51.851852 Tz (or ) Tj 1.011111 0 Td 56.712963 Tz (from ) Tj 1.769444 0 Td 50.771605 Tz (the ) Tj 1.283333 0 Td 52.391975 Tz (exoskeletons ) Tj 4.180556 0 Td 58.333333 Tz (of ) Tj 0.991667 0 Td 51.851852 Tz (arthropods ) Tj 3.519444 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1044.86242 Tm 6.261111 0 Td 48.881173 Tz (crustaceans, ) Tj 3.908333 0 Td 43.930041 Tz (insects\). ) Tj 2.761111 0 Td 62.654321 Tz (The ) Tj 1.536111 0 Td 56.388889 Tz (major ) Tj 2.002778 0 Td 54.372428 Tz (procedure ) Tj 3.305556 0 Td 48.611111 Tz (for ) Tj 1.225 0 Td 50.771605 Tz (obtaining ) Tj 51.428571 0 0 51.428571 0 1002.956962 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 48.206019 Tz (alkaline ) Tj 2.586111 0 Td 49.358974 Tz (deacetylation ) Tj 4.141667 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 44.830247 Tz (chitin ) Tj 1.905556 0 Td 53.472222 Tz (with ) Tj 1.555556 0 Td 50.771605 Tz (strong ) Tj 51.428571 0 0 51.428571 0 959.614583 Tm 6.261111 0 Td 48.206019 Tz (alkaline ) Tj 2.663889 0 Td 45.37037 Tz (Solution. ) Tj 2.819444 0 Td 50.231481 Tz (Generally, ) Tj 3.344444 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 58.333333 Tz (raw ) Tj 1.438889 0 Td 49.016204 Tz (material ) Tj 2.722222 0 Td 37.268519 Tz (is ) Tj 0.816667 0 Td 49.826389 Tz (crushed, ) Tj 51.428571 0 0 51.428571 0 919.734584 Tm 6.241667 0 Td 61.574074 Tz (washed ) Tj 2.586111 0 Td 53.472222 Tz (with ) Tj 1.691667 0 Td 55.092593 Tz (water ) Tj 1.983333 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 47.962963 Tz (detergent, ) Tj 3.266667 0 Td 58.333333 Tz (and ) Tj 1.419444 0 Td 57.79321 Tz (ground ) Tj 2.45 0 Td 46.990741 Tz (into ) Tj 1.516667 0 Td 52.5 Tz (Small ) Tj 51.428571 0 0 51.428571 0 877.35468 Tm 6.261111 0 Td 47.222222 Tz (pieces. ) Tj 2.158333 0 Td 51.203704 Tz (After ) Tj 1.672222 0 Td 49.331276 Tz (grinding, ) Tj 2.838889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 57.253086 Tz (raw ) Tj 1.302778 0 Td 48.611111 Tz (material ) Tj 2.547222 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 47.685185 Tz (treated ) Tj 2.177778 0 Td 53.472222 Tz (with ) Tj 1.458333 0 Td 44.830247 Tz (alkali ) Tj 51.428571 0 0 51.428571 0 834.447293 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 50.231481 Tz (acid ) Tj 1.633333 0 Td 45.37037 Tz (to ) Tj 0.972222 0 Td 45.37037 Tz (isolate ) Tj 2.333333 0 Td 48.611111 Tz (the ) Tj 1.283333 0 Td 58.796296 Tz (polymer ) Tj 2.858333 0 Td 57.523148 Tz (from ) Tj 1.847222 0 Td 48.611111 Tz (the ) Tj 1.302778 0 Td 57.253086 Tz (raw ) Tj 1.477778 0 Td 55.092593 Tz (crushed ) Tj 51.428571 0 0 51.428571 0 795.353293 Tm 6.261111 0 Td 47.170782 Tz (material. ) Tj 2.702778 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 58.333333 Tz (polymer ) Tj 2.586111 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 51.851852 Tz (then ) Tj 1.419444 0 Td 50.501543 Tz (deacetylated ) Tj 3.772222 0 Td 59.953704 Tz (by ) Tj 0.913889 0 Td 50.771605 Tz (treatment ) Tj 2.897222 0 Td 54.282407 Tz (with ) Tj 51.428571 0 0 51.428571 0 752.350061 Tm 6.261111 0 Td 42.12963 Tz (alkali. ) Tj 1.983333 0 Td 50.231481 Tz (Chitin ) Tj 2.002778 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 50.636574 Tz (chitosan ) Tj 2.644444 0 Td 43.75 Tz (differ ) Tj 1.75 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 44.722222 Tz (their ) Tj 1.497222 0 Td 52.777778 Tz (degrees ) Tj 2.372222 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 58.333333 Tz (deacety ) Tj 51.428571 0 0 51.428571 0 712.066667 Tm 6.261111 0 Td 45.910494 Tz (lation ) Tj 1.944444 0 Td 61.033951 Tz (\(DDA\). ) Tj 2.508333 0 Td 50.771605 Tz (Chitin ) Tj 2.080556 0 Td 54.012346 Tz (has ) Tj 1.244444 0 Td 51.851852 Tz (a ) Tj 0.602778 0 Td 54.012346 Tz (degree ) Tj 2.197222 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 49.608262 Tz (deacetylation ) Tj 4.141667 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 79.398148 Tz (0% ) Tj 51.428571 0 0 51.428571 0 670.638166 Tm 6.241667 0 Td 55.092593 Tz (while ) Tj 1.827778 0 Td 55.092593 Tz (pure ) Tj 1.536111 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 55.092593 Tz (has ) Tj 1.205556 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 54.012346 Tz (degree ) Tj 2.158333 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 49.608262 Tz (deacetylation ) Tj 4.083333 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 58.981481 Tz (100%. ) Tj 51.428571 0 0 51.428571 0 631.482587 Tm 6.261111 0 Td 47.638889 Tz (Typically, ) Tj 3.111111 0 Td 65.625 Tz (when ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 54.012346 Tz (degree ) Tj 2.177778 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 49.608262 Tz (deacetylation ) Tj 4.141667 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 48.611111 Tz (greater ) Tj 2.236111 0 Td 54.282407 Tz (than ) Tj 51.428571 0 0 51.428571 0 585.546423 Tm 6.261111 0 Td 54.444444 Tz (about ) Tj 1.866667 0 Td 72.376543 Tz (50% ) Tj 1.575 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 58.796296 Tz (polymer ) Tj 2.683333 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 47.395833 Tz (referred ) Tj 2.527778 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 48.611111 Tz (as ) Tj 0.816667 0 Td 48.251029 Tz (chitosan. ) Tj 51.428571 0 0 51.428571 0 544.149929 Tm 7 0 Td 53.472222 Tz (Chitosan ) Tj 2.975 0 Td 37.268519 Tz (is ) Tj 0.836111 0 Td 55.092593 Tz (a ) Tj 0.7 0 Td 47.395833 Tz (cationic ) Tj 2.683333 0 Td 64.00463 Tz (weak ) Tj 1.866667 0 Td 54.282407 Tz (base ) Tj 1.652778 0 Td 46.990741 Tz (that ) Tj 1.497222 0 Td 38.888889 Tz (is ) Tj 0.836111 0 Td 47.364672 Tz (substantially ) Tj 51.428571 0 0 51.428571 0 503.533007 Tm 6.261111 0 Td 49.691358 Tz (insoluble ) Tj 2.916667 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 54.444444 Tz (water ) Tj 1.808333 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 51.388889 Tz (organic ) Tj 2.391667 0 Td 46.8107 Tz (solvents. ) Tj 2.761111 0 Td 47.962963 Tz (Typically, ) Tj 3.130556 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 459.781211 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 42.669753 Tz (fairly ) Tj 1.730556 0 Td 50 Tz (soluble ) Tj 2.236111 0 Td 46.990741 Tz (in ) Tj 0.738889 0 Td 45.910494 Tz (dilute ) Tj 1.808333 0 Td 50.231481 Tz (acid ) Tj 1.361111 0 Td 46.666667 Tz (solutions, ) Tj 2.975 0 Td 54.282407 Tz (such ) Tj 1.477778 0 Td 50.231481 Tz (as ) Tj 0.758333 0 Td 44.444444 Tz (acetic, ) Tj 2.061111 0 Td 38.888889 Tz (citric, ) Tj 51.428571 0 0 51.428571 0 421.460993 Tm 6.261111 0 Td 46.296296 Tz (oxalic, ) Tj 2.138889 0 Td 48.611111 Tz (proprionic, ) Tj 3.363889 0 Td 48.611111 Tz (ascorbic, ) Tj 2.780556 0 Td 50.106838 Tz (hydrochloric, ) Tj 4.102778 0 Td 50 Tz (formic, ) Tj 2.255556 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 43.75 Tz (lactic ) Tj 51.428571 0 0 51.428571 0 378.587322 Tm 6.261111 0 Td 46.450617 Tz (acids, ) Tj 1.944444 0 Td 48.611111 Tz (as ) Tj 0.855556 0 Td 51.851852 Tz (well ) Tj 1.516667 0 Td 50.231481 Tz (as ) Tj 0.875 0 Td 49.907407 Tz (other ) Tj 1.769444 0 Td 50.925926 Tz (organic ) Tj 2.391667 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 50.411523 Tz (inorganic ) Tj 2.994444 0 Td 45.910494 Tz (acids. ) Tj 1.944444 0 Td 61.574074 Tz (Chito ) Tj 51.428571 0 0 51.428571 0 338.320755 Tm 6.280556 0 Td 47.962963 Tz (sans ) Tj 1.711111 0 Td 53.472222 Tz (charge ) Tj 2.119444 0 Td 52.5 Tz (gives ) Tj 1.808333 0 Td 32.407407 Tz (it ) Tj 0.583333 0 Td 53.324916 Tz (bioadhesive ) Tj 3.713889 0 Td 48.611111 Tz (properties ) Tj 3.130556 0 Td 46.990741 Tz (that ) Tj 1.322222 0 Td 53.148148 Tz (allow ) Tj 1.866667 0 Td 34.027778 Tz (it ) Tj 0.622222 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 297.497992 Tm 6.241667 0 Td 55.092593 Tz (bind ) Tj 1.711111 0 Td 46.990741 Tz (to ) Tj 1.030556 0 Td 49.583333 Tz (negatively ) Tj 3.422222 0 Td 54.166667 Tz (charged ) Tj 2.683333 0 Td 47.170782 Tz (Surfaces, ) Tj 2.994444 0 Td 54.282407 Tz (such ) Tj 1.691667 0 Td 51.851852 Tz (as ) Tj 1.030556 0 Td 48.611111 Tz (biological ) Tj 51.428571 0 0 51.428571 0 255.069057 Tm 6.241667 0 Td 46.296296 Tz (tissues ) Tj 2.275 0 Td 50.925926 Tz (present ) Tj 2.430556 0 Td 46.990741 Tz (at ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 42.939815 Tz (site ) Tj 1.361111 0 Td 55.092593 Tz (of ) Tj 0.933333 0 Td 56.17284 Tz (trauma ) Tj 2.352778 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 49.907407 Tz (negatively ) Tj 3.344444 0 Td 55.092593 Tz (charged ) Tj 51.428571 0 0 51.428571 0 214.718218 Tm 6.261111 0 Td 54.012346 Tz (implanted ) Tj 3.461111 0 Td 48.206019 Tz (devices. ) Tj 2.877778 0 Td 51.527778 Tz (Chitosan's ) Tj 3.655556 0 Td 53.472222 Tz (degree ) Tj 2.469444 0 Td 56.712963 Tz (of ) Tj 1.127778 0 Td 50.106838 Tz (deacetylation ) Tj 51.428571 0 0 51.428571 0 172.626263 Tm 6.261111 0 Td 44.907407 Tz (affects ) Tj 2.177778 0 Td 34.027778 Tz (it ) Tj 0.719444 0 Td 45.959596 Tz (resorption. ) Tj 3.363889 0 Td 53.472222 Tz (Chitosan ) Tj 2.858333 0 Td 53.742284 Tz (compositions ) Tj 4.141667 0 Td 55.632716 Tz (having ) Tj 2.275 0 Td 51.851852 Tz (a ) Tj 0.602778 0 Td 73.45679 Tz (50% ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.786486 0 Td 72.522523 Tz (8 ) Tj 51.428571 0 0 51.428571 0 2918.387952 Tm 25.2 0 Td 54.012346 Tz (degree ) Tj 2.119444 0 Td 55.092593 Tz (of ) Tj 0.719444 0 Td 49.85755 Tz (deacetylation ) Tj 4.044444 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 51.311728 Tz (highly ) Tj 2.022222 0 Td 53.148148 Tz (degradable ) Tj 3.344444 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 47.962963 Tz (vivo. ) Tj 1.575 0 Td 68.055556 Tz (As ) Tj 0.952778 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2874.808009 Tm 25.2 0 Td 54.012346 Tz (degree ) Tj 2.119444 0 Td 55.092593 Tz (of ) Tj 0.719444 0 Td 49.358974 Tz (deacetylation ) Tj 4.063889 0 Td 46.990741 Tz (increases, ) Tj 2.975 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 60.185185 Tz (becomes ) Tj 2.702778 0 Td 54.62963 Tz (increas ) Tj 51.428571 0 0 51.428571 0 2835.320755 Tm 25.2 0 Td 49.259259 Tz (ingly ) Tj 1.672222 0 Td 44.290123 Tz (resistant ) Tj 2.547222 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 50.231481 Tz (degradation. ) Tj 3.772222 0 Td 53.472222 Tz (Chitosan ) Tj 2.741667 0 Td 53.742284 Tz (compositions ) Tj 4.005556 0 Td 55.632716 Tz (having ) Tj 51.428571 0 0 51.428571 0 2793.295775 Tm 25.2 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 54.012346 Tz (degree ) Tj 2.197222 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 49.608262 Tz (deacetylation ) Tj 4.161111 0 Td 44.560185 Tz (that ) Tj 1.322222 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 53.472222 Tz (higher ) Tj 2.158333 0 Td 51.041667 Tz (than ) Tj 1.497222 0 Td 73.45679 Tz (95% ) Tj 1.613889 0 Td 55.092593 Tz (degrade ) Tj 51.428571 0 0 51.428571 0 2748.945946 Tm 25.219444 0 Td 52.932099 Tz (slowly ) Tj 2.313889 0 Td 55.092593 Tz (over ) Tj 1.730556 0 Td 59.62963 Tz (weeks ) Tj 2.197222 0 Td 53.472222 Tz (or ) Tj 1.030556 0 Td 54.166667 Tz (months. ) Tj 2.741667 0 Td 45.37037 Tz (In ) Tj 0.991667 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 59.143519 Tz (body ) Tj 1.866667 0 Td 50.636574 Tz (chitosan ) Tj 2.838889 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 2712.452736 Tm 25.2 0 Td 55.497685 Tz (degraded ) Tj 3.111111 0 Td 61.574074 Tz (by ) Tj 1.225 0 Td 54.372428 Tz (lysozyme, ) Tj 3.402778 0 Td 52.724359 Tz (N-acetyl-O-glucosaminidase ) Tj 8.672222 0 Td 59.41358 Tz (and ) Tj 51.428571 0 0 51.428571 0 2670.343484 Tm 25.2 0 Td 44.560185 Tz (lipases. ) Tj 2.391667 0 Td 61.574074 Tz (Lysozyme ) Tj 3.169444 0 Td 53.06713 Tz (degrades ) Tj 2.761111 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 59.953704 Tz (by ) Tj 0.952778 0 Td 51.041667 Tz (cleaving ) Tj 2.644444 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 61.574074 Tz (glyco ) Tj 51.428571 0 0 51.428571 0 2623.525377 Tm 25.219444 0 Td 44.722222 Tz (sidic ) Tj 1.788889 0 Td 58.333333 Tz (bonds ) Tj 2.216667 0 Td 57.407407 Tz (between ) Tj 2.877778 0 Td 49.691358 Tz (the ) Tj 1.361111 0 Td 50.05144 Tz (repeating ) Tj 3.169444 0 Td 49.826389 Tz (chitosan ) Tj 2.877778 0 Td 43.209877 Tz (units. ) Tj 2.022222 0 Td 62.654321 Tz (The ) Tj 51.428571 0 0 51.428571 0 2584.536082 Tm 25.180556 0 Td 54.12037 Tz (byproducts ) Tj 3.655556 0 Td 58.333333 Tz (of ) Tj 1.030556 0 Td 50.231481 Tz (chitosan ) Tj 2.838889 0 Td 51.851852 Tz (degradation ) Tj 3.85 0 Td 49.691358 Tz (are ) Tj 1.302778 0 Td 50.378788 Tz (saccharides ) Tj 3.733333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2542.948052 Tm 25.2 0 Td 54.822531 Tz (glucosamines ) Tj 4.316667 0 Td 46.180556 Tz (that ) Tj 1.438889 0 Td 50.771605 Tz (are ) Tj 1.263889 0 Td 50.771605 Tz (gradually ) Tj 3.111111 0 Td 55.092593 Tz (absorbed ) Tj 3.013889 0 Td 58.333333 Tz (by ) Tj 1.088889 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 67.407407 Tz (human ) Tj 51.428571 0 0 51.428571 0 2498.980392 Tm 25.180556 0 Td 52.5 Tz (body. ) Tj 1.769444 0 Td 50.555556 Tz (Therefore, ) Tj 3.208333 0 Td 64.814815 Tz (when ) Tj 1.730556 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 55.902778 Tz (used ) Tj 1.516667 0 Td 47.530864 Tz (for ) Tj 0.991667 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 46.666667 Tz (local ) Tj 1.594444 0 Td 49.016204 Tz (delivery ) Tj 51.428571 0 0 51.428571 0 2461.851319 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 48.905724 Tz (therapeutic ) Tj 3.441667 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 50.501543 Tz (prophylactic ) Tj 3.811111 0 Td 49.074074 Tz (agents, ) Tj 2.294444 0 Td 55.092593 Tz (no ) Tj 0.855556 0 Td 54.372428 Tz (secondary ) Tj 3.15 0 Td 56.481481 Tz (removal ) Tj 51.428571 0 0 51.428571 0 2421.378378 Tm 25.2 0 Td 50.771605 Tz (operation ) Tj 3.013889 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 47.530864 Tz (required. ) Tj 51.428571 0 0 51.428571 0 2377.058433 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.497222 0 Td 50.462963 Tz (present ) Tj 2.45 0 Td 50.771605 Tz (invention ) Tj 3.091667 0 Td 52.256944 Tz (provides ) Tj 2.877778 0 Td 58.333333 Tz (improved ) Tj 3.169444 0 Td 58.333333 Tz (methods ) Tj 2.819444 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 2338.038037 Tm 25.2 0 Td 51.203704 Tz (generating ) Tj 3.363889 0 Td 53.347578 Tz (biodegradable ) Tj 4.472222 0 Td 52.121914 Tz (composition. ) Tj 4.122222 0 Td 46.990741 Tz (In ) Tj 0.894444 0 Td 44.781145 Tz (particular, ) Tj 3.286111 0 Td 55.902778 Tz (Such ) Tj 51.428571 0 0 51.428571 0 2292.47014 Tm 25.2 0 Td 57.87037 Tz (methods ) Tj 2.702778 0 Td 50 Tz (include ) Tj 2.313889 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 49.331276 Tz (buffering ) Tj 2.897222 0 Td 47.800926 Tz (step ) Tj 1.380556 0 Td 58.981481 Tz (where ) Tj 1.983333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 49.151235 Tz (buffer ) Tj 1.925 0 Td 54.012346 Tz (has ) Tj 1.205556 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 76.157407 Tz (pH ) Tj 51.428571 0 0 51.428571 0 2248.746803 Tm 25.180556 0 Td 58.333333 Tz (between ) Tj 2.605556 0 Td 49.691358 Tz (2.5 ) Tj 1.069444 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 47.530864 Tz (6.5 ) Tj 1.069444 0 Td 39.429012 Tz (\(e.g., ) Tj 1.613889 0 Td 44.560185 Tz (2.5, ) Tj 1.244444 0 Td 45.37037 Tz (3.0, ) Tj 1.263889 0 Td 45.37037 Tz (4.0, ) Tj 1.283333 0 Td 42.939815 Tz (5.0, ) Tj 1.244444 0 Td 43.75 Tz (5.1, ) Tj 1.263889 0 Td 44.560185 Tz (5.2, ) Tj 1.225 0 Td 45.37037 Tz (5.3, ) Tj 1.283333 0 Td 43.75 Tz (5.4, ) Tj 51.428571 0 0 51.428571 0 2206 Tm 25.219444 0 Td 44.560185 Tz (5.5, ) Tj 1.302778 0 Td 43.75 Tz (5.6, ) Tj 1.283333 0 Td 43.75 Tz (5.7. ) Tj 1.302778 0 Td 44.560185 Tz (5.8, ) Tj 1.283333 0 Td 44.560185 Tz (5.9, ) Tj 1.263889 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 42.777778 Tz (6.0\). ) Tj 1.536111 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 47.222222 Tz (certain ) Tj 2.197222 0 Td 56.712963 Tz (embodiments, ) Tj 4.297222 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2166.470588 Tm 25.180556 0 Td 49.151235 Tz (buffer ) Tj 1.963889 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 58.333333 Tz (sodium ) Tj 2.352778 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 54.012346 Tz (potassium ) Tj 3.169444 0 Td 45.775463 Tz (acetate, ) Tj 2.411111 0 Td 49.691358 Tz (bicarbonate, ) Tj 3.830556 0 Td 61.033951 Tz (carbon ) Tj 51.428571 0 0 51.428571 0 2124.229193 Tm 25.2 0 Td 42.939815 Tz (ate, ) Tj 1.4 0 Td 40.914352 Tz (citrate, ) Tj 2.352778 0 Td 49.826389 Tz (formate, ) Tj 2.741667 0 Td 48.611111 Tz (glycine, ) Tj 2.741667 0 Td 49.074074 Tz (malate, ) Tj 2.45 0 Td 50.231481 Tz (maleate, ) Tj 2.780556 0 Td 62.384259 Tz (2-\(N-mor ) Tj 51.428571 0 0 51.428571 0 2088.848921 Tm 25.2 0 Td 49.96142 Tz (pholino\)ethanesulfonate, ) Tj 7.505556 0 Td 52.5 Tz (phosphate, ) Tj 3.441667 0 Td 49.151235 Tz (proprionate, ) Tj 3.869444 0 Td 51.851852 Tz (or ) Tj 0.933333 0 Td 57.037037 Tz (Succi ) Tj 51.428571 0 0 51.428571 0 2042.80532 Tm 25.2 0 Td 51.041667 Tz (nate ) Tj 1.361111 0 Td 44.907407 Tz (buffer. ) Tj 2.022222 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 50.05144 Tz (buffering ) Tj 2.838889 0 Td 51.131687 Tz (treatment ) Tj 2.936111 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 54.372428 Tz (optimized ) Tj 3.072222 0 Td 45.37037 Tz (to ) Tj 0.719444 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 50 Tz (desired ) Tj 51.428571 0 0 51.428571 0 2003.014406 Tm 25.2 0 Td 51.557239 Tz (degradation ) Tj 3.577778 0 Td 43.344907 Tz (profile. ) Tj 2.236111 0 Td 64.00463 Tz (Time ) Tj 1.691667 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 48.971193 Tz (buffering ) Tj 2.819444 0 Td 50.411523 Tz (treatment ) Tj 2.897222 0 Td 55.092593 Tz (can ) Tj 1.166667 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 59.143519 Tz (from ) Tj 51.428571 0 0 51.428571 0 1958.577465 Tm 25.2 0 Td 50.231481 Tz (as ) Tj 0.855556 0 Td 36.728395 Tz (little ) Tj 1.555556 0 Td 50.231481 Tz (as ) Tj 0.855556 0 Td 61.574074 Tz (30 ) Tj 0.991667 0 Td 54.166667 Tz (seconds ) Tj 2.488889 0 Td 48.611111 Tz (to ) Tj 0.816667 0 Td 50.231481 Tz (as ) Tj 0.875 0 Td 53.472222 Tz (long ) Tj 1.497222 0 Td 51.851852 Tz (as ) Tj 0.952778 0 Td 51.851852 Tz (12 ) Tj 0.855556 0 Td 54.444444 Tz (hours ) Tj 1.886111 0 Td 39.969136 Tz (\(e.g., ) Tj 1.769444 0 Td 38.888889 Tz (1, ) Tj 0.738889 0 Td 42.12963 Tz (3, ) Tj 0.797222 0 Td 42.12963 Tz (5, ) Tj 51.428571 0 0 51.428571 0 1915 Tm 25.258333 0 Td 46.450617 Tz (10, ) Tj 1.263889 0 Td 46.450617 Tz (15, ) Tj 1.166667 0 Td 51.851852 Tz (30, ) Tj 1.263889 0 Td 49.691358 Tz (45, ) Tj 1.283333 0 Td 59.953704 Tz (60 ) Tj 1.069444 0 Td 51.446759 Tz (minutes, ) Tj 2.897222 0 Td 37.268519 Tz (1, ) Tj 0.816667 0 Td 45.37037 Tz (3, ) Tj 0.933333 0 Td 42.12963 Tz (5, ) Tj 0.933333 0 Td 46.450617 Tz (10, ) Tj 1.263889 0 Td 53.472222 Tz (12 ) Tj 1.011111 0 Td 47.685185 Tz (hours\). ) Tj 2.352778 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1874.64 Tm 25.2 0 Td 50.605413 Tz (concentration ) Tj 4.258333 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 49.151235 Tz (buffer ) Tj 2.080556 0 Td 66.975309 Tz (may ) Tj 1.536111 0 Td 56.712963 Tz (be ) Tj 1.011111 0 Td 50.231481 Tz (varied ) Tj 2.080556 0 Td 57.87037 Tz (between ) Tj 2.761111 0 Td 54.444444 Tz (about ) Tj 51.428571 0 0 51.428571 0 1834.898113 Tm 25.2 0 Td 52.662037 Tz (0.05 ) Tj 1.497222 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 51.851852 Tz (2.0 ) Tj 1.186111 0 Td 49.151235 Tz (molar. ) Tj 2.080556 0 Td 47.43266 Tz (Preferably, ) Tj 3.363889 0 Td 55.092593 Tz (such ) Tj 1.613889 0 Td 47.890947 Tz (variables ) Tj 2.819444 0 Td 50.771605 Tz (are ) Tj 1.127778 0 Td 51.446759 Tz (adjusted ) Tj 51.428571 0 0 51.428571 0 1793.821107 Tm 25.219444 0 Td 54.282407 Tz (such ) Tj 1.536111 0 Td 46.180556 Tz (that ) Tj 1.341667 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 57.253086 Tz (sponge ) Tj 2.275 0 Td 53.472222 Tz (degrades ) Tj 2.819444 0 Td 58.333333 Tz (by ) Tj 0.952778 0 Td 43.75 Tz (at ) Tj 0.758333 0 Td 44.722222 Tz (least ) Tj 1.536111 0 Td 54.444444 Tz (about ) Tj 1.866667 0 Td 62.384259 Tz (20%, ) Tj 1.730556 0 Td 62.384259 Tz (30%, ) Tj 51.428571 0 0 51.428571 0 1750.673469 Tm 25.2 0 Td 63.194444 Tz (40%, ) Tj 1.769444 0 Td 62.384259 Tz (50%, ) Tj 1.769444 0 Td 72.376543 Tz (60% ) Tj 1.555556 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 63.194444 Tz (more ) Tj 1.75 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 45.37037 Tz (3, ) Tj 0.816667 0 Td 42.12963 Tz (5, ) Tj 0.777778 0 Td 58.333333 Tz (7 ) Tj 0.583333 0 Td 53.472222 Tz (or ) Tj 0.933333 0 Td 49.826389 Tz (10-days. ) Tj 51.428571 0 0 51.428571 0 1712.167979 Tm 25.919444 0 Td 66.435185 Tz (As ) Tj 1.147222 0 Td 50.231481 Tz (reported ) Tj 2.683333 0 Td 48.148148 Tz (herein, ) Tj 2.333333 0 Td 50.231481 Tz (chitosan ) Tj 2.722222 0 Td 53.742284 Tz (compositions ) Tj 4.2 0 Td 39.969136 Tz (\(e.g., ) Tj 1.769444 0 Td 44.444444 Tz (Solids, ) Tj 51.428571 0 0 51.428571 0 1670.547677 Tm 25.219444 0 Td 51.851852 Tz (sponges, ) Tj 2.702778 0 Td 44.830247 Tz (films, ) Tj 1.808333 0 Td 50.87963 Tz (hydrogels, ) Tj 3.247222 0 Td 53.030303 Tz (composites\) ) Tj 3.694444 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 54.012346 Tz (loaded ) Tj 2.119444 0 Td 53.472222 Tz (with ) Tj 1.497222 0 Td 55.092593 Tz (a ) Tj 52.857143 0 0 52.857143 0 1627.446626 Tm 24.5 0 Td 47.297297 Tz (biologically ) Tj 3.556757 0 Td 47.297297 Tz (active ) Tj 1.854054 0 Td 51.081081 Tz (agent ) Tj 1.664865 0 Td 45.720721 Tz (at ) Tj 0.662162 0 Td 50.45045 Tz (the ) Tj 1.059459 0 Td 40.990991 Tz (site ) Tj 1.135135 0 Td 55.18018 Tz (of ) Tj 0.737838 0 Td 49.662162 Tz (care ) Tj 1.362162 0 Td 38.888889 Tz (\(e.g., ) Tj 1.589189 0 Td 42.567568 Tz (in ) Tj 0.681081 0 Td 56.756757 Tz (a ) Tj 0.472973 0 Td 46.509009 Tz (surgical ) Tj 51.428571 0 0 51.428571 0 1583.692115 Tm 25.219444 0 Td 42.669753 Tz (Suite, ) Tj 1.808333 0 Td 42.592593 Tz (clinic, ) Tj 2.061111 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 54.768519 Tz (physicians ) Tj 3.577778 0 Td 42.12963 Tz (office, ) Tj 2.041667 0 Td 56.712963 Tz (trauma ) Tj 2.313889 0 Td 38.888889 Tz (site, ) Tj 1.419444 0 Td 42.628205 Tz (battlefield\). ) Tj 51.428571 0 0 51.428571 0 1541.253731 Tm 25.2 0 Td 53.472222 Tz (This ) Tj 1.497222 0 Td 51.041667 Tz (property ) Tj 2.663889 0 Td 52.391975 Tz (allows ) Tj 2.1 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 46.450617 Tz (clinician ) Tj 2.722222 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 42.669753 Tz (tailor ) Tj 1.730556 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 45.664983 Tz (antibiotics ) Tj 3.227778 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 1501.86 Tm 25.2 0 Td 50.555556 Tz (other ) Tj 1.711111 0 Td 51.851852 Tz (agents ) Tj 2.119444 0 Td 55.902778 Tz (used ) Tj 1.575 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 53.472222 Tz (load ) Tj 1.497222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 66.111111 Tz (wound ) Tj 2.255556 0 Td 61.574074 Tz (management ) Tj 51.428571 0 0 51.428571 0 1459.908062 Tm 25.2 0 Td 52.932099 Tz (device ) Tj 2.255556 0 Td 48.611111 Tz (to ) Tj 0.991667 0 Td 43.75 Tz (Suit ) Tj 1.4 0 Td 51.851852 Tz (the ) Tj 1.322222 0 Td 54.444444 Tz (needs ) Tj 2.041667 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 47.314815 Tz (particular ) Tj 3.169444 0 Td 44.965278 Tz (patient. ) Tj 2.586111 0 Td 48.611111 Tz (In ) Tj 0.972222 0 Td 59.41358 Tz (one ) Tj 51.428571 0 0 51.428571 0 1419.516644 Tm 25.2 0 Td 57.449495 Tz (embodiment, ) Tj 4.219444 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 53.472222 Tz (degree ) Tj 2.352778 0 Td 55.092593 Tz (of ) Tj 0.991667 0 Td 49.608262 Tz (deacetylation ) Tj 4.297222 0 Td 38.888889 Tz (is ) Tj 0.855556 0 Td 51.041667 Tz (adjusted ) Tj 2.858333 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 1378.466321 Tm 25.2 0 Td 53.240741 Tz (provide ) Tj 2.527778 0 Td 50.231481 Tz (chitosan ) Tj 2.741667 0 Td 53.472222 Tz (compositions ) Tj 4.141667 0 Td 46.990741 Tz (that ) Tj 1.438889 0 Td 54.62963 Tz (degrade ) Tj 2.605556 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 51.851852 Tz (as ) Tj 0.952778 0 Td 36.728395 Tz (little ) Tj 1.613889 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 1338.251588 Tm 25.2 0 Td 54.444444 Tz (about ) Tj 1.963889 0 Td 49.96142 Tz (twenty-four, ) Tj 3.947222 0 Td 43.308081 Tz (thirty-six, ) Tj 3.247222 0 Td 45.640432 Tz (forty-eight, ) Tj 3.655556 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 52.777778 Tz (seventy ) Tj 2.586111 0 Td 59.41358 Tz (two ) Tj 51.428571 0 0 51.428571 0 1293.627595 Tm 25.180556 0 Td 54.444444 Tz (hours ) Tj 1.788889 0 Td 53.472222 Tz (or ) Tj 0.758333 0 Td 46.180556 Tz (that ) Tj 1.263889 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 53.796296 Tz (maintained ) Tj 3.383333 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 52.391975 Tz (longer ) Tj 1.983333 0 Td 52.391975 Tz (period ) Tj 2.041667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 53.472222 Tz (time ) Tj 1.438889 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1249.979592 Tm 25.2 0 Td 43.75 Tz (4, ) Tj 0.836111 0 Td 42.12963 Tz (5, ) Tj 0.836111 0 Td 43.75 Tz (6, ) Tj 0.797222 0 Td 45.37037 Tz (7, ) Tj 0.816667 0 Td 45.37037 Tz (8, ) Tj 0.816667 0 Td 45.37037 Tz (9, ) Tj 0.913889 0 Td 56.712963 Tz (10 ) Tj 0.933333 0 Td 48.611111 Tz (days\). ) Tj 2.061111 0 Td 48.611111 Tz (In ) Tj 0.875 0 Td 50.555556 Tz (other ) Tj 1.769444 0 Td 56.983025 Tz (embodiments, ) Tj 4.355556 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1210.650485 Tm 25.2 0 Td 53.742284 Tz (compositions ) Tj 4.063889 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.411523 Tz (invention ) Tj 2.897222 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 53.796296 Tz (maintained ) Tj 3.402778 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 59.953704 Tz (body ) Tj 1.633333 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1166.862069 Tm 25.2 0 Td 45.37037 Tz (at ) Tj 0.875 0 Td 44.074074 Tz (least ) Tj 1.613889 0 Td 54.444444 Tz (about ) Tj 1.925 0 Td 52.777778 Tz (two-six ) Tj 2.547222 0 Td 59.62963 Tz (weeks ) Tj 2.119444 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 60.763889 Tz (more ) Tj 1.788889 0 Td 40.509259 Tz (\(e.g., ) Tj 1.788889 0 Td 45.37037 Tz (2, ) Tj 0.855556 0 Td 45.37037 Tz (3, ) Tj 0.875 0 Td 45.37037 Tz (4, ) Tj 0.875 0 Td 43.75 Tz (5, ) Tj 0.894444 0 Td 51.851852 Tz (6 ) Tj 51.428571 0 0 51.428571 0 1124 Tm 25.180556 0 Td 55.632716 Tz (weeks, ) Tj 2.313889 0 Td 53.472222 Tz (two, ) Tj 1.594444 0 Td 48.611111 Tz (three ) Tj 1.730556 0 Td 55.092593 Tz (or ) Tj 0.933333 0 Td 51.851852 Tz (four ) Tj 1.555556 0 Td 51.851852 Tz (months\). ) Tj 2.858333 0 Td 46.990741 Tz (In ) Tj 0.875 0 Td 36.296296 Tz (still ) Tj 1.380556 0 Td 51.203704 Tz (other ) Tj 1.788889 0 Td 68.055556 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1085.089239 Tm 25.2 0 Td 52.932099 Tz (ments, ) Tj 2.372222 0 Td 49.826389 Tz (chitosan ) Tj 2.838889 0 Td 53.742284 Tz (compositions ) Tj 4.336111 0 Td 56.712963 Tz (of ) Tj 1.030556 0 Td 49.691358 Tz (the ) Tj 1.341667 0 Td 50.05144 Tz (invention ) Tj 3.169444 0 Td 56.481481 Tz (enhance ) Tj 51.428571 0 0 51.428571 0 1042.16947 Tm 25.180556 0 Td 55.740741 Tz (blood ) Tj 1.963889 0 Td 45.775463 Tz (clotting ) Tj 2.45 0 Td 46.990741 Tz (in ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 65.462963 Tz (wound ) Tj 2.216667 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 50.555556 Tz (other ) Tj 1.75 0 Td 42.12963 Tz (site ) Tj 1.263889 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 57.253086 Tz (trauma ) Tj 2.313889 0 Td 65.895062 Tz (\(hemos ) Tj 51.428571 0 0 51.428571 0 1001.93674 Tm 25.180556 0 Td 41.203704 Tz (tasis\). ) Tj 1.963889 0 Td 46.990741 Tz (In ) Tj 0.797222 0 Td 50.555556 Tz (other ) Tj 1.691667 0 Td 56.983025 Tz (embodiments, ) Tj 4.316667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 53.742284 Tz (compositions ) Tj 4.102778 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 962.789333 Tm 25.2 0 Td 54.012346 Tz (loaded ) Tj 2.352778 0 Td 53.472222 Tz (with ) Tj 1.711111 0 Td 48.905724 Tz (therapeutic ) Tj 3.675 0 Td 50.231481 Tz (or ) Tj 0.991667 0 Td 50.501543 Tz (prophylactic ) Tj 4.044444 0 Td 51.851852 Tz (agents ) Tj 2.294444 0 Td 46.180556 Tz (that ) Tj 1.497222 0 Td 50.771605 Tz (are ) Tj 40 0 0 40 0 925 Tm 32.4 0 Td 58.796296 Tz (clinician ) Tj 3.525 0 Td 63.020833 Tz (selected ) Tj 3.3 0 Td 76.388889 Tz (and ) Tj 1.675 0 Td 58.333333 Tz (that ) Tj 1.675 0 Td 65.277778 Tz (are ) Tj 1.475 0 Td 64.351852 Tz (delivered ) Tj 3.8 0 Td 69.791667 Tz (over ) Tj 1.9 0 Td 60.416667 Tz (at ) Tj 1.025 0 Td 57.5 Tz (least ) Tj 1.975 0 Td 70.833333 Tz (about ) Tj 51.428571 0 0 51.428571 0 878.367164 Tm 25.277778 0 Td 38.888889 Tz (1, ) Tj 0.7 0 Td 45.37037 Tz (2, ) Tj 0.797222 0 Td 45.37037 Tz (3, ) Tj 0.777778 0 Td 45.37037 Tz (4, ) Tj 0.816667 0 Td 43.75 Tz (5, ) Tj 0.797222 0 Td 42.12963 Tz (6, ) Tj 0.758333 0 Td 45.37037 Tz (7, ) Tj 0.797222 0 Td 43.75 Tz (8, ) Tj 0.777778 0 Td 45.37037 Tz (9, ) Tj 0.797222 0 Td 51.851852 Tz (or ) Tj 0.913889 0 Td 55.092593 Tz (10 ) Tj 0.894444 0 Td 55.092593 Tz (days ) Tj 1.555556 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 47.530864 Tz (for ) Tj 1.088889 0 Td 51.851852 Tz (longer ) Tj 2.080556 0 Td 47.800926 Tz (periods. ) Tj 51.428571 0 0 51.428571 0 835.683706 Tm 25.2 0 Td 51.851852 Tz (Antimicrobial ) Tj 4.297222 0 Td 56.712963 Tz (Agents ) Tj 51.428571 0 0 51.428571 0 798.394052 Tm 25.9 0 Td 53.935185 Tz (Staphylococcus ) Tj 4.822222 0 Td 49.074074 Tz (aureus, ) Tj 2.352778 0 Td 52.546296 Tz (Staphylococcus ) Tj 4.686111 0 Td 49.96142 Tz (epidermidis, ) Tj 3.830556 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 754.574163 Tm 25.2 0 Td 60.690236 Tz (Pseudomonas ) Tj 4.258333 0 Td 53.796296 Tz (aeruginosa ) Tj 3.441667 0 Td 50.771605 Tz (are ) Tj 1.088889 0 Td 54.73251 Tz (pathogens ) Tj 3.15 0 Td 46.990741 Tz (that ) Tj 1.302778 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 64.814815 Tz (commonly ) Tj 51.428571 0 0 51.428571 0 710.150396 Tm 25.2 0 Td 50.462963 Tz (present ) Tj 2.430556 0 Td 45.37037 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Td 46.180556 Tz (Sulfate; ) Tj 2.430556 0 Td 57.253086 Tz (Biapenem; ) Tj 3.325 0 Td 52.121914 Tz (Biniramycin; ) Tj 51.428571 0 0 51.428571 0 2339 Tm 6.280556 0 Td 58.333333 Tz (Biphenamine ) Tj 4.511111 0 Td 52.314815 Tz (Hydrochloride; ) Tj 5.075 0 Td 50.356125 Tz (Bispyrithione ) Tj 4.569444 0 Td 54.444444 Tz (Magsulfex; ) Tj 51.428571 0 0 51.428571 0 2291.953827 Tm 6.280556 0 Td 49.907407 Tz (Butikacin; ) Tj 3.325 0 Td 48.971193 Tz (Butirosin ) Tj 2.916667 0 Td 46.585648 Tz (Sulfate; ) Tj 2.527778 0 Td 59.217172 Tz (Capreomycin ) Tj 4.180556 0 Td 46.585648 Tz (Sulfate; ) Tj 2.508333 0 Td 66.111111 Tz (Carba ) Tj 51.428571 0 0 51.428571 0 2249.067296 Tm 6.261111 0 Td 52.662037 Tz (dox; ) Tj 1.458333 0 Td 48.611111 Tz (Carbenicillin ) Tj 4.005556 0 Td 55.452675 Tz (Disodium; ) Tj 3.188889 0 Td 48.361823 Tz (Carbenicillin ) Tj 3.986111 0 Td 52.314815 Tz (Indanyl ) Tj 2.352778 0 Td 58.333333 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 2207.050193 Tm 6.261111 0 Td 48.611111 Tz 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Tm 6.629412 0 Td 54.590018 Tz (Ceforanide; ) Tj 4.241176 0 Td 60.04902 Tz (Cefotaxime ) Tj 4.241176 0 Td 60.294118 Tz (Sodium; ) Tj 3.191176 0 Td 53.186275 Tz (Cefotetan: ) Tj 3.808824 0 Td 56.427015 Tz (Cefotetan ) Tj 51.428571 0 0 51.428571 0 1834.212974 Tm 6.280556 0 Td 56.17284 Tz (Disodium; ) Tj 3.422222 0 Td 56.30787 Tz (Cefotiam ) Tj 3.130556 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.783333 0 Td 49.259259 Tz (Cefoxitin: ) Tj 3.344444 0 Td 51.851852 Tz (Cefoxitin ) Tj 51.428571 0 0 51.428571 0 1796.578692 Tm 6.280556 0 Td 57.87037 Tz (Sodium; ) Tj 2.780556 0 Td 52.391975 Tz (Ce?pimizole; ) Tj 4.122222 0 Td 54.503367 Tz (Ce?pimizole ) Tj 3.927778 0 Td 57.87037 Tz (Sodium; ) Tj 2.761111 0 Td 53.20216 Tz (Ce?piramide: ) Tj 51.428571 0 0 51.428571 0 1754.581864 Tm 6.261111 0 Td 55.387205 Tz (Ce?piramide ) Tj 4.161111 0 Td 57.87037 Tz (Sodium; ) Tj 2.936111 0 Td 58.333333 Tz (Ce?pirome ) Tj 3.636111 0 Td 46.585648 Tz (Sulfate; ) Tj 2.780556 0 Td 60.10101 Tz (Cefpodoxime ) Tj 51.428571 0 0 51.428571 0 1709.451028 Tm 6.280556 0 Td 45.730453 Tz (Proxetil: ) Tj 2.741667 0 Td 48.611111 Tz (Cefprozil; ) Tj 3.188889 0 Td 52.932099 Tz (Cefroxadine; ) Tj 4.063889 0 Td 52.824074 Tz (Cefsulodin ) Tj 3.461111 0 Td 57.87037 Tz (Sodium; ) Tj 2.702778 0 Td 71.296296 Tz (Cef ) Tj 48.571429 0 0 48.571429 0 1668 Tm 6.608824 0 Td 52.995643 Tz (tazidime; ) Tj 3.417647 0 Td 52.094474 Tz (Ceftibuten: ) Tj 3.994118 0 Td 57.709447 Tz (Ceftizoxime ) Tj 4.344118 0 Td 61.27451 Tz (Sodium; ) Tj 3.129412 0 Td 55.213904 Tz (Ceftriaxone ) Tj 50 0 0 50 0 1625 Tm 6.46 0 Td 59.52381 Tz (Sodium; ) Tj 2.76 0 Td 56.969697 Tz (Cefuroxime; ) Tj 4.02 0 Td 59.666667 Tz (Cefuroxime ) Tj 3.8 0 Td 48.571429 Tz (Axetil: ) Tj 2.28 0 Td 60 Tz (Cefuroxime ) Tj 3.84 0 Td 68.888889 Tz (Piv ) Tj 51.428571 0 0 51.428571 0 1584.909976 Tm 6.261111 0 Td 43.981481 Tz (oxetil: ) Tj 2.138889 0 Td 58.009259 Tz (Cefuroxime ) Tj 3.791667 0 Td 57.407407 Tz (Sodium; ) Tj 2.722222 0 Td 51.311728 Tz (Cephacetrile ) Tj 3.966667 0 Td 57.87037 Tz (Sodium; ) Tj 2.722222 0 Td 70.648148 Tz (Cepha ) Tj 51.428571 0 0 51.428571 0 1547.205674 Tm 6.261111 0 Td 45.37037 Tz (lexin; ) Tj 1.886111 0 Td 55.092593 Tz (Cephalexin ) Tj 3.577778 0 Td 52.546296 Tz (Hydrochloride, ) Tj 4.627778 0 Td 52.777778 Tz (Cephaloglycin; ) Tj 4.705556 0 Td 63.425926 Tz (Cephalo ) Tj 51.428571 0 0 51.428571 0 1503.005755 Tm 6.261111 0 Td 44.444444 Tz (ridine; ) Tj 2.858333 0 Td 53.914141 Tz (Cephalothin ) Tj 4.530556 0 Td 57.87037 Tz (Sodium; ) Tj 3.422222 0 Td 53.472222 Tz (Cephapirin ) Tj 4.180556 0 Td 58.333333 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 1465 Tm 6.261111 0 Td 53.619529 Tz (Cephradine; ) Tj 4.2 0 Td 53.030303 Tz (Cetocycline ) Tj 4.122222 0 Td 52.314815 Tz (Hydrochloride; ) Tj 5.055556 0 Td 52.10114 Tz (Cetophenicol; ) Tj 51.428571 0 0 51.428571 0 1420.144945 Tm 6.261111 0 Td 54.484954 Tz (Chloramphenicol; ) Tj 5.736111 0 Td 55.95679 Tz (Chloramphenicol ) Tj 5.561111 0 Td 48.287037 Tz (Palmitate; ) Tj 3.363889 0 Td 66.666667 Tz (Chloram ) Tj 51.428571 0 0 51.428571 0 1379.07109 Tm 6.261111 0 Td 52.256944 Tz (phenicol ) Tj 2.780556 0 Td 52.121914 Tz (Pantothenate ) Tj 3.966667 0 Td 59.953704 Tz (Complex: ) Tj 3.15 0 Td 55.740741 Tz (Chloramphenicol ) Tj 5.327778 0 Td 62.654321 Tz (Sodium ) Tj 51.428571 0 0 51.428571 0 1336.360049 Tm 6.280556 0 Td 49.907407 Tz (Succinate; ) Tj 3.538889 0 Td 53.596866 Tz (Chlorhexidine ) Tj 4.725 0 Td 50.231481 Tz (Phosphanilate; ) Tj 4.783333 0 Td 52.083333 Tz (Chloroxylenol; ) Tj 51.428571 0 0 51.428571 0 1297.636255 Tm 6.261111 0 Td 49.56427 Tz (Chlortetracycline ) Tj 5.483333 0 Td 46.018519 Tz (Bisulfate; ) Tj 3.169444 0 Td 49.754902 Tz (Chlortetracycline ) Tj 5.502778 0 Td 61.213992 Tz (Hydrochlo ) Tj 51.428571 0 0 51.428571 0 1254.754557 Tm 6.261111 0 Td 43.425926 Tz (ride; ) Tj 1.652778 0 Td 53.148148 Tz (Cinoxacin: ) Tj 3.538889 0 Td 50 Tz (Ciprofloxacin: ) Tj 4.55 0 Td 51.353276 Tz (Ciprofloxacin ) Tj 4.413889 0 Td 61.213992 Tz (Hydrochlo ) Tj 51.428571 0 0 51.428571 0 1213.349815 Tm 6.261111 0 Td 43.425926 Tz (ride; ) Tj 1.75 0 Td 52.932099 Tz (Cirolemycin; ) Tj 4.219444 0 Td 51.635802 Tz (Clarithromycin; ) Tj 5.055556 0 Td 50.106838 Tz (Clinafloxacin ) Tj 4.375 0 Td 68.703704 Tz (Hydro ) Tj 51.428571 0 0 51.428571 0 1172.595745 Tm 6.261111 0 Td 47.530864 Tz (chloride; ) Tj 3.5 0 Td 54.552469 Tz (Clindamycin; ) Tj 4.841667 0 Td 56.860269 Tz (Clindamycin ) Tj 4.725 0 Td 52.083333 Tz (Hydrochloride: ) Tj 51.428571 0 0 51.428571 0 1129.860911 Tm 6.261111 0 Td 56.860269 Tz (Clindamycin ) Tj 4.063889 0 Td 50.411523 Tz (Palmitate ) Tj 3.013889 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.705556 0 Td 56.565657 Tz (Clindamycin ) Tj 4.063889 0 Td 67.24537 Tz (Phos ) Tj 51.428571 0 0 51.428571 0 1083.906801 Tm 6.261111 0 Td 48.611111 Tz (phate; ) Tj 2.275 0 Td 52.391975 Tz (Clofazimine; ) Tj 4.277778 0 Td 48.905724 Tz (Cloxacillin ) Tj 3.772222 0 Td 51.557239 Tz (Benzathine; ) Tj 3.888889 0 Td 49.789562 Tz (Cloxacillin ) Tj 51.428571 0 0 51.428571 0 1042.637255 Tm 6.280556 0 Td 57.87037 Tz (Sodium; ) Tj 2.741667 0 Td 54.12037 Tz (Cloxyquin; ) Tj 3.558333 0 Td 50.925926 Tz (Colistimethate ) Tj 4.569444 0 Td 57.87037 Tz (Sodium; ) Tj 2.761111 0 Td 47.395833 Tz (Colistin ) Tj 2.605556 0 Td 66.975309 Tz (Sul ) Tj 51.428571 0 0 51.428571 0 1006.104738 Tm 6.261111 0 Td 42.12963 Tz (fate; ) Tj 1.730556 0 Td 60.493827 Tz (Coumermycin; ) Tj 4.802778 0 Td 63.047138 Tz (Coumermycin ) Tj 4.627778 0 Td 57.87037 Tz (Sodium; ) Tj 2.897222 0 Td 46.990741 Tz (Cyclacillin; ) Tj 51.428571 0 0 51.428571 0 964.640094 Tm 6.261111 0 Td 50.771605 Tz (Cycloserine; ) Tj 3.869444 0 Td 47.115385 Tz (Dalfopristin; ) Tj 3.869444 0 Td 56.30787 Tz (Dapsone; ) Tj 2.936111 0 Td 56.565657 Tz (Daptomycin; ) Tj 3.966667 0 Td 67.12963 Tz (Demeclo ) Tj 51.428571 0 0 51.428571 0 925 Tm 6.261111 0 Td 47.395833 Tz (cycline; ) Tj 2.975 0 Td 56.25 Tz (Demeclocycline ) Tj 5.386111 0 Td 52.083333 Tz (Hydrochloride; ) Tj 5.113889 0 Td 55.092593 Tz (Demecycline: ) Tj 51.428571 0 0 51.428571 0 876.947917 Tm 6.280556 0 Td 55.092593 Tz (Denofungin: ) Tj 4.491667 0 Td 49.421296 Tz (Diaveridine; ) Tj 4.413889 0 Td 46.759259 Tz (Dicloxacillin; ) Tj 4.763889 0 Td 48.860399 Tz (Dicloxacillin ) Tj 51.428571 0 0 51.428571 0 838.463672 Tm 6.280556 0 Td 57.87037 Tz (Sodium; ) Tj 3.344444 0 Td 54.239766 Tz (Dihydrostreptomycin ) Tj 7.058333 0 Td 46.585648 Tz (Sulfate; ) Tj 3.15 0 Td 49.608262 Tz (Dipyrithione: ) Tj 51.428571 0 0 51.428571 0 798.704762 Tm 6.280556 0 Td 51.388889 Tz (Dirithromycin; ) Tj 4.627778 0 Td 53.472222 Tz (Doxycycline; ) Tj 4.141667 0 Td 55.976431 Tz (Doxycycline ) Tj 3.908333 0 Td 55.092593 Tz (Calcium; ) Tj 2.936111 0 Td 76.157407 Tz (Doxy ) Tj 51.428571 0 0 51.428571 0 754.126829 Tm 6.261111 0 Td 50.462963 Tz (cycline ) Tj 2.411111 0 Td 48.611111 Tz (Fosfatex: ) Tj 2.936111 0 Td 56.271044 Tz (Doxycycline ) Tj 4.005556 0 Td 49.826389 Tz (Hyclate; ) Tj 2.722222 0 Td 55.092593 Tz (Droxacin ) Tj 2.916667 0 Td 58.333333 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 715.560386 Tm 6.280556 0 Td 53.652263 Tz (Enoxacin; ) Tj 3.247222 0 Td 44.074074 Tz (Epicillin: ) Tj 2.994444 0 Td 48.395062 Tz (Epitetracycline ) Tj 4.647222 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.744444 0 Td 60.277778 Tz (Eryth ) Tj 51.428571 0 0 51.428571 0 672.330061 Tm 6.261111 0 Td 53.877315 Tz (romycin; ) Tj 3.033333 0 Td 55.362654 Tz (Erythromycin ) Tj 4.316667 0 Td 46.666667 Tz (Acistrate; ) Tj 3.208333 0 Td 55.362654 Tz (Erythromycin ) Tj 4.394444 0 Td 46.090535 Tz (Estolate: ) Tj 51.428571 0 0 51.428571 0 634 Tm 6.280556 0 Td 55.632716 Tz (Erythromycin ) Tj 4.588889 0 Td 49.04321 Tz (Ethylsuccinate; ) Tj 4.997222 0 Td 55.362654 Tz (Erythromycin ) Tj 4.511111 0 Td 50.378788 Tz (Gluceptate; ) Tj 51.428571 0 0 51.428571 0 589.933504 Tm 6.280556 0 Td 55.632716 Tz (Erythromycin ) Tj 4.744444 0 Td 50.356125 Tz (Lactobionate; ) Tj 4.666667 0 Td 55.362654 Tz (Erythromycin ) Tj 4.725 0 Td 49.789562 Tz (Propionate: ) Tj 51.428571 0 0 51.428571 0 546.194647 Tm 6.280556 0 Td 55.632716 Tz (Erythromycin ) Tj 4.336111 0 Td 46.450617 Tz (Stearate; ) Tj 2.877778 0 Td 55.740741 Tz (Ethambutol ) Tj 3.713889 0 Td 52.083333 Tz (Hydrochloride; ) Tj 4.763889 0 Td 58.333333 Tz (Ethio ) Tj 51.428571 0 0 51.428571 0 502.797101 Tm 6.261111 0 Td 55.092593 Tz (namide: ) Tj 2.644444 0 Td 49.494949 Tz (Fleroxacin; ) Tj 3.597222 0 Td 45.910494 Tz (Floxacillin: ) Tj 3.636111 0 Td 49.96142 Tz (Fludalanine: ) Tj 3.947222 0 Td 54.79798 Tz (Flumequine; ) Tj 51.428571 0 0 51.428571 0 462.666667 Tm 6.280556 0 Td 55.092593 Tz (Fosfomycin; ) Tj 4.336111 0 Td 57.037037 Tz (Fosfomycin ) Tj 4.063889 0 Td 56.837607 Tz (Tromethamine; ) Tj 5.113889 0 Td 50.106838 Tz (Fumoxicillin; ) Tj 48.571429 0 0 48.571429 0 420 Tm 6.65 0 Td 58.676471 Tz (Furazolium ) Tj 4.344118 0 Td 53.376906 Tz (Chloride; ) Tj 3.767647 0 Td 58.333333 Tz (Furazolium ) Tj 4.302941 0 Td 48.039216 Tz (Tartrate; ) Tj 3.5 0 Td 53.615196 Tz (Fusidate ) Tj 48.571429 0 0 48.571429 0 378 Tm 6.65 0 Td 61.27451 Tz (Sodium; ) Tj 2.944118 0 Td 53.431373 Tz (Fusidic ) Tj 2.573529 0 Td 54.901961 Tz (Acid; ) Tj 2.017647 0 Td 59.705882 Tz (Gentamicin ) Tj 3.932353 0 Td 49.32598 Tz (Sulfate; ) Tj 2.717647 0 Td 64.572193 Tz (Gloximonam, ) Tj 51.428571 0 0 51.428571 0 336.736585 Tm 6.261111 0 Td 53.030303 Tz (Gramicidin; ) Tj 3.869444 0 Td 52.441077 Tz (Haloprogin: ) Tj 3.830556 0 Td 45.959596 Tz (Hetacillin: ) Tj 3.422222 0 Td 46.990741 Tz (Hetacillin ) Tj 3.188889 0 Td 52.175926 Tz (Potassium; ) Tj 51.428571 0 0 51.428571 0 296.135392 Tm 6.280556 0 Td 54.372428 Tz (Hexedine; ) Tj 3.208333 0 Td 47.260802 Tz (Ibafloxacin; ) Tj 3.675 0 Td 56.893004 Tz (Imipenem; ) Tj 3.325 0 Td 50.231481 Tz (Isoconazole; ) Tj 3.869444 0 Td 50.673401 Tz (Isepamicin; ) Tj 51.428571 0 0 51.428571 0 256.393711 Tm 6.280556 0 Td 46.990741 Tz (Isoniazid; ) Tj 3.286111 0 Td 54.444444 Tz (Josamycin; ) Tj 3.772222 0 Td 61.574074 Tz (Kanamycin ) Tj 3.811111 0 Td 46.180556 Tz (Sulfate; ) Tj 2.722222 0 Td 53.20216 Tz (Kitasamycin; ) Tj 51.428571 0 0 51.428571 0 214.084507 Tm 6.280556 0 Td 51.649306 Tz (Levofuraltadone; ) Tj 5.269444 0 Td 50.231481 Tz (Levopropylcillin ) Tj 5.094444 0 Td 52.5 Tz (Potassium; ) Tj 3.441667 0 Td 60.601852 Tz (Lexithromy ) Tj 51.428571 0 0 51.428571 0 173.781022 Tm 6.261111 0 Td 44.560185 Tz (cin; ) Tj 1.438889 0 Td 55.681818 Tz (Lincomycin; ) Tj 4.044444 0 Td 58.009259 Tz (Lincomycin ) Tj 3.85 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.763889 0 Td 62.294239 Tz (Lomefloxa ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.578378 0 Td 74.099099 Tz (10 ) Tj 51.428571 0 0 51.428571 0 2916.541766 Tm 25.2 0 Td 44.560185 Tz (cin; ) Tj 1.361111 0 Td 55.632716 Tz (Lomefloxacin ) Tj 4.277778 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.705556 0 Td 55.632716 Tz (Lomefloxacin ) Tj 4.277778 0 Td 52.211934 Tz (Mesylate: ) Tj 51.428571 0 0 51.428571 0 2873.929162 Tm 25.219444 0 Td 50.378788 Tz (Loracarbef: ) Tj 3.597222 0 Td 55.092593 Tz (Mafenide; ) Tj 3.208333 0 Td 52.849003 Tz (Meclocycline: ) Tj 4.355556 0 Td 55.092593 Tz (Meclocycline ) Tj 4.2 0 Td 57.79321 Tz (Sulfos ) Tj 51.428571 0 0 51.428571 0 2832.50495 Tm 25.2 0 Td 44.074074 Tz (alicylate; ) Tj 3.072222 0 Td 58.333333 Tz (Megalomicin ) Tj 4.277778 0 Td 54.372428 Tz (Potassium ) Tj 3.363889 0 Td 52.175926 Tz (Phosphate; ) Tj 3.577778 0 Td 58.333333 Tz (Mequidox; ) Tj 51.428571 0 0 51.428571 0 2790 Tm 25.2 0 Td 61.574074 Tz (Meropenem; ) Tj 4.102778 0 Td 53.098291 Tz (Methacycline; ) Tj 4.569444 0 Td 55.092593 Tz (Methacycline ) Tj 4.394444 0 Td 52.083333 Tz (Hydrochloride: ) Tj 51.428571 0 0 51.428571 0 2740.595908 Tm 25.2 0 Td 58.063272 Tz (Methenamine; ) Tj 4.938889 0 Td 60.395623 Tz (Methenamine ) Tj 4.744444 0 Td 50.555556 Tz (Hippurate; ) Tj 3.791667 0 Td 60.690236 Tz (Methenamine ) Tj 51.428571 0 0 51.428571 0 2696.592417 Tm 25.2 0 Td 54.444444 Tz (Mandelate; ) Tj 3.519444 0 Td 48.611111 Tz (Methicillin ) Tj 3.480556 0 Td 57.407407 Tz (Sodium; ) Tj 2.702778 0 Td 54.444444 Tz (Metioprim; ) Tj 3.519444 0 Td 54.594017 Tz (Metronidazole ) Tj 51.428571 0 0 51.428571 0 2654.939086 Tm 25.219444 0 Td 52.314815 Tz (Hydrochloride; ) Tj 5.113889 0 Td 54.344729 Tz (Metronidazole ) Tj 4.919444 0 Td 52.5 Tz (Phosphate; ) Tj 3.85 0 Td 49.151235 Tz (Mezlocillin; ) Tj 51.428571 0 0 51.428571 0 2613.223916 Tm 25.2 0 Td 50.673401 Tz (Mezlocillin ) Tj 3.558333 0 Td 57.407407 Tz (Sodium; ) Tj 2.644444 0 Td 53.20216 Tz (Minocycline; ) Tj 4.044444 0 Td 55.976431 Tz (Minocycline ) Tj 3.908333 0 Td 61.213992 Tz (Hydrochlo ) Tj 51.428571 0 0 51.428571 0 2568.236478 Tm 25.2 0 Td 43.425926 Tz (ride; ) Tj 1.808333 0 Td 56.983025 Tz (Mirincamycin ) Tj 4.588889 0 Td 48.611111 Tz (lydrochloride; ) Tj 4.588889 0 Td 56.893004 Tz (Monensin; ) Tj 3.597222 0 Td 60.358796 Tz (Monensin ) Tj 48.571429 0 0 48.571429 0 2522 Tm 26.702941 0 Td 60.784314 Tz (Sodium; ) Tj 2.944118 0 Td 50.708061 Tz (Nafcillin ) Tj 3.129412 0 Td 61.27451 Tz (Sodium; ) Tj 2.944118 0 Td 54.215686 Tz (Nalidixate ) Tj 3.623529 0 Td 61.27451 Tz (Sodium; ) Tj 2.944118 0 Td 53.376906 Tz (Nalidixic ) Tj 51.428571 0 0 51.428571 0 2482.052121 Tm 25.2 0 Td 53.148148 Tz (Acid; ) Tj 1.866667 0 Td 56.064815 Tz (Natamycin; ) Tj 3.636111 0 Td 57.154882 Tz (Nebramycin; ) Tj 4.063889 0 Td 62.384259 Tz (Neomycin ) Tj 3.286111 0 Td 47.962963 Tz (Palmitate; ) Tj 3.169444 0 Td 79.938272 Tz (Neo ) Tj 51.428571 0 0 51.428571 0 2437.348235 Tm 25.2 0 Td 60.925926 Tz (mycin ) Tj 1.963889 0 Td 46.585648 Tz (Sulfate; ) Tj 2.430556 0 Td 62.789352 Tz (Neomycin ) Tj 3.208333 0 Td 53.098291 Tz (Undecylenate; ) Tj 4.336111 0 Td 51.527778 Tz (Netilmicin ) Tj 3.286111 0 Td 46.180556 Tz (Sulfate; ) Tj 51.428571 0 0 51.428571 0 2390.973398 Tm 25.2 0 Td 55.092593 Tz (Neutramycin; ) Tj 4.316667 0 Td 52.146465 Tz (Nifuradene; ) Tj 3.791667 0 Td 51.157407 Tz (Nifuraldezone; ) Tj 4.647222 0 Td 46.666667 Tz (Nifuratel; ) Tj 3.130556 0 Td 65.625 Tz (Nifu ) Tj 51.428571 0 0 51.428571 0 2349.370038 Tm 25.2 0 Td 46.585648 Tz (ratrone; ) Tj 2.780556 0 Td 48.021886 Tz (Nifurdazil; ) Tj 3.752778 0 Td 51.262626 Tz (Nifurimide: ) Tj 3.966667 0 Td 47.115385 Tz (Nifurpirinol; ) Tj 4.238889 0 Td 56.712963 Tz (Nifurqui ) Tj 51.428571 0 0 51.428571 0 2303.928307 Tm 25.2 0 Td 48.611111 Tz (nazol; ) Tj 2.177778 0 Td 48.148148 Tz (Nifurthiazole; ) Tj 4.491667 0 Td 48.611111 Tz (Nitrocycline; ) Tj 4.219444 0 Td 48.82716 Tz (Nitrofurantoin: ) Tj 4.822222 0 Td 58.333333 Tz (Nitro ) Tj 48.571429 0 0 48.571429 0 2260 Tm 26.723529 0 Td 56.27451 Tz (mide: ) Tj 2.552941 0 Td 53.472222 Tz (Norfloxacin; ) Tj 4.694118 0 Td 60.735294 Tz (Novobiocin ) Tj 4.529412 0 Td 60.784314 Tz (Sodium; ) Tj 3.397059 0 Td 54.215686 Tz (Ofloxacin; ) Tj 51.428571 0 0 51.428571 0 2216.925558 Tm 25.2 0 Td 57.154882 Tz (Ormetoprim: ) Tj 4.219444 0 Td 50.05144 Tz (Oxacillin ) Tj 3.15 0 Td 58.333333 Tz (Sodium; ) Tj 2.897222 0 Td 64.09465 Tz (Oximonam. ) Tj 3.927778 0 Td 68.460648 Tz (Oximonam ) Tj 51.428571 0 0 51.428571 0 2175.740024 Tm 25.219444 0 Td 57.407407 Tz (Sodium; ) Tj 2.780556 0 Td 53.06713 Tz (Oxolinic ) Tj 2.858333 0 Td 53.148148 Tz (Acid: ) Tj 1.944444 0 Td 50.434028 Tz (Oxytetracycline; ) Tj 5.191667 0 Td 52.067901 Tz (Oxytetracycline ) Tj 51.428571 0 0 51.428571 0 2133.603338 Tm 25.2 0 Td 55.092593 Tz (Calcium: ) Tj 3.402778 0 Td 51.635802 Tz (Oxytetracycline ) Tj 5.386111 0 Td 52.314815 Tz (Hydrochloride; ) Tj 5.191667 0 Td 52.441077 Tz (Paldimycin; ) Tj 51.428571 0 0 51.428571 0 2088.701665 Tm 25.219444 0 Td 52.042484 Tz (Parachlorophenol; ) Tj 6.047222 0 Td 54.79798 Tz (Paulomycin; ) Tj 4.394444 0 Td 48.611111 Tz (Pefloxacin; ) Tj 3.966667 0 Td 50.87963 Tz (Pefloxacin ) Tj 51.428571 0 0 51.428571 0 2041.397129 Tm 25.2 0 Td 52.572016 Tz (Mesylate; ) Tj 3.091667 0 Td 50.605413 Tz (Penamecillin; ) Tj 4.219444 0 Td 45.694444 Tz (Penicillin ) Tj 2.936111 0 Td 87.5 Tz (G ) Tj 0.797222 0 Td 51.557239 Tz (Benzathine; ) Tj 3.655556 0 Td 46.666667 Tz (Penicillin ) Tj 48.571429 0 0 48.571429 0 1998 Tm 26.682353 0 Td 85.784314 Tz (G ) Tj 0.844118 0 Td 55.931373 Tz (Potassium; ) Tj 3.685294 0 Td 48.72549 Tz (Penicillin ) Tj 3.232353 0 Td 89.215686 Tz (G ) Tj 0.864706 0 Td 52.995643 Tz (Procaine; ) Tj 3.191176 0 Td 48.72549 Tz (Penicillin ) Tj 3.211765 0 Td 89.215686 Tz (G ) Tj 0.864706 0 Td 61.27451 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 1954.18773 Tm 25.2 0 Td 46.666667 Tz (Penicillin ) Tj 2.994444 0 Td 55.092593 Tz (V: ) Tj 0.913889 0 Td 46.342593 Tz (Penicillin ) Tj 2.994444 0 Td 84.259259 Tz (V ) Tj 0.738889 0 Td 52.146465 Tz (Benzathine; ) Tj 3.694444 0 Td 46.342593 Tz (Penicillin ) Tj 2.975 0 Td 87.5 Tz (V ) Tj 0.797222 0 Td 65.354938 Tz (Hydrab ) Tj 51.428571 0 0 51.428571 0 1909.989196 Tm 25.2 0 Td 54.012346 Tz (amine; ) Tj 2.177778 0 Td 46.018519 Tz (Penicillin ) Tj 2.955556 0 Td 81.018519 Tz (V ) Tj 0.7 0 Td 52.5 Tz (Potassium; ) Tj 3.383333 0 Td 51.557239 Tz (Pentizidone ) Tj 3.577778 0 Td 58.333333 Tz (Sodium; ) Tj 2.663889 0 Td 55.632716 Tz (Phenyl ) Tj 51.428571 0 0 51.428571 0 1869.967404 Tm 25.2 0 Td 51.446759 Tz (Aminosalicylate; ) Tj 5.133333 0 Td 46.450617 Tz (Piperacillin ) Tj 3.5 0 Td 57.87037 Tz (Sodium; ) Tj 2.663889 0 Td 45.37037 Tz (Pirbenicillin ) Tj 3.694444 0 Td 58.333333 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 1827.298204 Tm 25.219444 0 Td 42.939815 Tz (Piridicillin ) Tj 3.363889 0 Td 56.944444 Tz (Sodium; ) Tj 2.702778 0 Td 50.231481 Tz (Pirlimycin ) Tj 3.325 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.705556 0 Td 55.740741 Tz (Pivampicil ) Tj 51.428571 0 0 51.428571 0 1784.250932 Tm 25.2 0 Td 42.12963 Tz (lin ) Tj 1.205556 0 Td 52.546296 Tz (Hydrochloride; ) Tj 4.880556 0 Td 49.85755 Tz (Pivampicillin ) Tj 4.336111 0 Td 55.497685 Tz (Pamoate: ) Tj 3.15 0 Td 50.356125 Tz (Pivampicillin ) Tj 51.428571 0 0 51.428571 0 1740.153846 Tm 25.219444 0 Td 51.527778 Tz (Probenate; ) Tj 3.325 0 Td 58.333333 Tz (Polymyxin ) Tj 3.402778 0 Td 71.296296 Tz (B ) Tj 0.641667 0 Td 46.585648 Tz (Sulfate; ) Tj 2.508333 0 Td 51.103989 Tz (Porfiromycin; ) Tj 4.258333 0 Td 49.789562 Tz (Propikacin: ) Tj 51.428571 0 0 51.428571 0 1694.452632 Tm 25.219444 0 Td 53.347578 Tz (Pyrazinamide: ) Tj 4.355556 0 Td 50.231481 Tz (Pyrithione ) Tj 3.169444 0 Td 49.907407 Tz (Zinc: ) Tj 1.691667 0 Td 58.603395 Tz (Quindecamine ) Tj 4.316667 0 Td 50.231481 Tz (Acetate; ) Tj 2.586111 0 Td 73.45679 Tz (Qui ) Tj 52.857143 0 0 52.857143 0 1654 Tm 24.518919 0 Td 44.459459 Tz (nupristin: ) Tj 2.97027 0 Td 50.935551 Tz (Racephenicol; ) Tj 4.218919 0 Td 54.463554 Tz (Ramoplanin; ) Tj 3.859459 0 Td 53.918919 Tz (Ranimycin; ) Tj 3.5 0 Td 67.792793 Tz (Relomy ) Tj 51.428571 0 0 51.428571 0 1604.892031 Tm 25.2 0 Td 44.560185 Tz (cin; ) Tj 1.516667 0 Td 54.208754 Tz (Repromicin; ) Tj 4.044444 0 Td 47.962963 Tz (Rifabutin; ) Tj 3.344444 0 Td 52.441077 Tz (Rifametane; ) Tj 3.947222 0 Td 50.555556 Tz (Rifamexil; ) Tj 3.5 0 Td 61.574074 Tz (Rif ) Tj 51.428571 0 0 51.428571 0 1564.510253 Tm 25.2 0 Td 54.012346 Tz (amide; ) Tj 2.275 0 Td 52.932099 Tz (Rifampin; ) Tj 3.188889 0 Td 48.341049 Tz (Rifapentine; ) Tj 3.811111 0 Td 51.203704 Tz (Rifaximin: ) Tj 3.402778 0 Td 46.704793 Tz (Rolitetracycline: ) Tj 51.428571 0 0 51.428571 0 1517.597544 Tm 25.219444 0 Td 48.206019 Tz (Rolitetracycline ) Tj 5.638889 0 Td 45.37037 Tz (Nitrate; ) Tj 3.286111 0 Td 52.662037 Tz (Rosaramicin; ) Tj 4.9 0 Td 55.387205 Tz (Rosaramicin ) Tj 51.428571 0 0 51.428571 0 1475.087011 Tm 25.219444 0 Td 49.331276 Tz (Butyrate; ) Tj 3.188889 0 Td 54.79798 Tz (Rosaramicin ) Tj 4.102778 0 Td 49.789562 Tz (Propionate; ) Tj 3.830556 0 Td 54.503367 Tz (Rosaramicin ) Tj 4.083333 0 Td 62.654321 Tz (Sodium ) Tj 51.428571 0 0 51.428571 0 1429.62406 Tm 25.219444 0 Td 52.5 Tz (Phosphate: ) Tj 3.636111 0 Td 54.503367 Tz (Rosaramicin ) Tj 4.025 0 Td 46.8107 Tz (Stearate; ) Tj 3.013889 0 Td 49.907407 Tz (Rosoxacil; ) Tj 3.5 0 Td 54.12037 Tz (Roxarsone: ) Tj 51.428571 0 0 51.428571 0 1387.821596 Tm 25.219444 0 Td 54.398148 Tz (Roxithromycin; ) Tj 4.783333 0 Td 50.673401 Tz (Sancycline: ) Tj 3.558333 0 Td 53.619529 Tz (Sanfetrinem ) Tj 3.752778 0 Td 57.87037 Tz (Sodium; ) Tj 2.663889 0 Td 63.888889 Tz (Sarmoxi ) Tj 51.428571 0 0 51.428571 0 1344.558824 Tm 25.2 0 Td 39.351852 Tz (cillin; ) Tj 1.983333 0 Td 44.560185 Tz (Sarpicillin; ) Tj 3.519444 0 Td 53.472222 Tz (Scopafungin; ) Tj 4.180556 0 Td 50.87963 Tz (Sisomicin; ) Tj 3.383333 0 Td 53.652263 Tz (Sisomicin ) Tj 3.188889 0 Td 66.975309 Tz (Sul ) Tj 51.428571 0 0 51.428571 0 1304.388235 Tm 25.2 0 Td 42.12963 Tz (fate; ) Tj 1.497222 0 Td 49.358974 Tz (Sparfloxacin; ) Tj 4.083333 0 Td 55.591168 Tz (Spectinomycin ) Tj 4.569444 0 Td 52.314815 Tz (Hydrochloride: ) Tj 4.627778 0 Td 63.888889 Tz (Spiramy ) Tj 51.428571 0 0 51.428571 0 1260.473684 Tm 25.2 0 Td 44.560185 Tz (cin; ) Tj 1.361111 0 Td 50.673401 Tz (Stallimycin ) Tj 3.655556 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.725 0 Td 48.611111 Tz (Steflimycin; ) Tj 3.811111 0 Td 54.822531 Tz (Streptomycin ) Tj 51.428571 0 0 51.428571 0 1212.117096 Tm 25.219444 0 Td 46.180556 Tz (Sulfate: ) Tj 2.430556 0 Td 48.82716 Tz (Streptonicozid; ) Tj 4.608333 0 Td 50.87963 Tz (Sulfabenz: ) Tj 3.266667 0 Td 53.796296 Tz (Sulfabenzamide: ) Tj 5.036111 0 Td 58.333333 Tz (Sulfac ) Tj 51.428571 0 0 51.428571 0 1167.706794 Tm 25.2 0 Td 51.041667 Tz (etamide: ) Tj 2.761111 0 Td 53.347578 Tz (Sulfacetamide ) Tj 4.413889 0 Td 57.87037 Tz (Sodium; ) Tj 2.702778 0 Td 48.341049 Tz (Sulfacytine; ) Tj 3.772222 0 Td 48.611111 Tz (Sulfadiazine: ) Tj 48.571429 0 0 48.571429 0 1126 Tm 26.702941 0 Td 53.186275 Tz (Sulfadiazine ) Tj 4.241176 0 Td 60.784314 Tz (Sodium; ) Tj 2.964706 0 Td 54.330065 Tz (Sulfadoxine; ) Tj 4.323529 0 Td 51.813725 Tz (Sulfalene; ) Tj 3.541176 0 Td 62.908497 Tz (Sulfamera ) Tj 48.571429 0 0 48.571429 0 1085 Tm 26.682353 0 Td 48.72549 Tz (Zine; ) Tj 1.667647 0 Td 53.966132 Tz (Sulfameter, ) Tj 3.788235 0 Td 55.130719 Tz (Sulfamethazine; ) Tj 5.188235 0 Td 53.529412 Tz (Sulfamethizole; ) Tj 5.023529 0 Td 67.156863 Tz (Sulfame ) Tj 48.571429 0 0 48.571429 0 1043 Tm 26.661765 0 Td 53.186275 Tz (thoxazole; ) Tj 3.561765 0 Td 59.597523 Tz (Sulfamonomethoxine; ) Tj 7.164706 0 Td 56.903595 Tz (Sulfamoxole; ) Tj 4.467647 0 Td 50.534759 Tz (Sulfanilate ) Tj 48.571429 0 0 48.571429 0 1002 Tm 26.682353 0 Td 53.529412 Tz (Zinc, ) Tj 1.852941 0 Td 50.04085 Tz (Sulfanitran; ) Tj 3.891176 0 Td 50.735294 Tz (Sulfasalazine; ) Tj 4.529412 0 Td 54.656863 Tz (Sulfasomizole; ) Tj 4.858824 0 Td 55.931373 Tz (Sulfathiaz ) Tj 51.428571 0 0 51.428571 0 959.158035 Tm 25.2 0 Td 44.560185 Tz (ole: ) Tj 1.788889 0 Td 52.146465 Tz (Sulfazamet; ) Tj 4.161111 0 Td 48.611111 Tz (Sulfisoxazole; ) Tj 4.802778 0 Td 50.356125 Tz (Sulfisoxazole ) Tj 4.569444 0 Td 50.462963 Tz (Acetyl: ) Tj 51.428571 0 0 51.428571 0 920.373832 Tm 25.219444 0 Td 50.106838 Tz (Sulfisoxazole ) Tj 4.083333 0 Td 53.796296 Tz (Diolamine; ) Tj 3.441667 0 Td 54.208754 Tz (Sulfomyxin; ) Tj 3.791667 0 Td 57.361111 Tz (Sulopenem; ) Tj 3.636111 0 Td 59.259259 Tz (Sultami ) Tj 51.428571 0 0 51.428571 0 879.10628 Tm 25.2 0 Td 39.351852 Tz (cillin; ) Tj 1.963889 0 Td 47.890947 Tz (Suncillin ) Tj 2.858333 0 Td 57.87037 Tz (Sodium; ) Tj 2.683333 0 Td 49.608262 Tz (Talampicillin ) Tj 4.141667 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.647222 0 Td 64.814815 Tz (Tei ) Tj 51.428571 0 0 51.428571 0 837.523754 Tm 25.2 0 Td 49.691358 Tz (coplanin; ) Tj 2.838889 0 Td 54.822531 Tz (Temafloxacin ) Tj 4.161111 0 Td 52.083333 Tz (Hydrochloride; ) Tj 4.530556 0 Td 50.673401 Tz (Temocillin; ) Tj 3.5 0 Td 57.87037 Tz (Tetracy ) Tj 51.428571 0 0 51.428571 0 799.212485 Tm 25.2 0 Td 44.290123 Tz (cline; ) Tj 1.925 0 Td 49.96142 Tz (Tetracycline ) Tj 3.908333 0 Td 52.546296 Tz (Hydrochloride; ) Tj 4.725 0 Td 49.96142 Tz (Tetracycline ) Tj 3.927778 0 Td 55.452675 Tz (Phosphate ) Tj 51.428571 0 0 51.428571 0 758 Tm 25.2 0 Td 59.143519 Tz (Complex; ) Tj 3.597222 0 Td 52.932099 Tz (Tetroxoprim; ) Tj 4.569444 0 Td 54.861111 Tz (Thiamphenicol; ) Tj 5.366667 0 Td 50.605413 Tz (Thiphencillin ) Tj 51.428571 0 0 51.428571 0 709.916175 Tm 25.219444 0 Td 52.5 Tz (Potassium; ) Tj 3.325 0 Td 45.37037 Tz (Ticarcillin ) Tj 3.188889 0 Td 52.391975 Tz (Cresyl ) Tj 2.080556 0 Td 57.407407 Tz (Sodium: ) Tj 2.586111 0 Td 45.664983 Tz (Ticarcillin ) Tj 3.227778 0 Td 55.812757 Tz (Disodium; ) Tj 48.571429 0 0 48.571429 0 669 Tm 26.682353 0 Td 48.039216 Tz (Ticarcillin ) Tj 3.602941 0 Td 64.572193 Tz (Monosodium; ) Tj 4.673529 0 Td 51.470588 Tz (Ticlatone; ) Tj 3.5 0 Td 62.527233 Tz (Tiodonium ) Tj 3.788235 0 Td 53.75817 Tz (Chloride; ) Tj 51.428571 0 0 51.428571 0 631.043275 Tm 25.2 0 Td 55.681818 Tz (Tobramycin; ) Tj 3.869444 0 Td 58.657407 Tz (Tobramycin ) Tj 3.752778 0 Td 46.180556 Tz (Sulfate; ) Tj 2.411111 0 Td 50.356125 Tz (Tosufloxacin; ) Tj 4.141667 0 Td 60.853909 Tz (Trimethop ) Tj 51.428571 0 0 51.428571 0 589.035583 Tm 25.2 0 Td 48.611111 Tz (rim; ) Tj 1.575 0 Td 55.902778 Tz (Trimethoprim ) Tj 4.472222 0 Td 46.180556 Tz (Sulfate; ) Tj 2.586111 0 Td 49.583333 Tz (Trisulfapyrimidines; ) Tj 6.338889 0 Td 59.259259 Tz (Trolean ) Tj 51.428571 0 0 51.428571 0 548.894545 Tm 25.2 0 Td 56.712963 Tz (domycin; ) Tj 3.072222 0 Td 55.787037 Tz (Trospectomycin ) Tj 5.055556 0 Td 46.180556 Tz (Sulfate; ) Tj 2.566667 0 Td 47.800926 Tz (Tyrothricin; ) Tj 3.791667 0 Td 70.833333 Tz (Vancomy ) Tj 50.714286 0 0 50.714286 0 508.52381 Tm 25.55493 0 Td 45.187793 Tz (cin; ) Tj 2.425352 0 Td 61.126761 Tz (Vancomycin ) Tj 5.028169 0 Td 53.051643 Tz (Hydrochloride; ) Tj 5.777465 0 Td 53.051643 Tz (Virginiamycin; ) Tj 51.428571 0 0 51.428571 0 465.472906 Tm 25.2 0 Td 56.271044 Tz (Zorbamycin; ) Tj 4.161111 0 Td 50.231481 Tz (Difloxacin ) Tj 3.422222 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.822222 0 Td 52.932099 Tz (Lauryl ) Tj 2.294444 0 Td 57.523148 Tz (Isoquino ) Tj 48.571429 0 0 48.571429 0 420 Tm 26.682353 0 Td 55.473856 Tz (linium ) Tj 2.326471 0 Td 59.191176 Tz (Bromide; ) Tj 3.191176 0 Td 63.480392 Tz (Moxalactam ) Tj 4.138235 0 Td 59.095861 Tz (Disodium; ) Tj 3.479412 0 Td 54.901961 Tz (Ornidazole; ) Tj 3.973529 0 Td 76.633987 Tz (Pen ) Tj 51.428571 0 0 51.428571 0 379.761118 Tm 25.180556 0 Td 48.287037 Tz (tisomicin; ) Tj 3.344444 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 49.96142 Tz (Sarafloxacin ) Tj 4.063889 0 Td 51.851852 Tz (Hydrochloride. ) Tj 4.822222 0 Td 46.990741 Tz (In ) Tj 0.972222 0 Td 47.314815 Tz (particular ) Tj 51.428571 0 0 51.428571 0 339.59759 Tm 25.2 0 Td 56.983025 Tz (embodiments, ) Tj 4.336111 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 53.914141 Tz (composition ) Tj 3.830556 0 Td 54.372428 Tz (comprises ) Tj 3.208333 0 Td 66.203704 Tz (daptomy ) Tj 27.142857 0 0 27.142857 0 301 Tm 47.747368 0 Td 110.526316 Tz (C1. ) Tj 51.428571 0 0 51.428571 0 254.306804 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 57.253086 Tz (one ) Tj 1.263889 0 Td 49.331276 Tz (preferred ) Tj 2.897222 0 Td 57.744108 Tz (embodiment, ) Tj 4.025 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 54.503367 Tz (composition ) Tj 3.830556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 214.01581 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 50.771605 Tz (invention ) Tj 3.091667 0 Td 54.73251 Tz (comprises ) Tj 3.305556 0 Td 55.092593 Tz (an ) Tj 1.011111 0 Td 53.796296 Tz (agent ) Tj 1.944444 0 Td 46.180556 Tz (that ) Tj 1.4 0 Td 44.290123 Tz (treats ) Tj 1.944444 0 Td 55.092593 Tz (a ) Tj 0.7 0 Td 52.572016 Tz (multidrug ) Tj 51.428571 0 0 51.428571 0 170.071517 Tm 25.2 0 Td 45.010288 Tz (resistant ) Tj 2.586111 0 Td 46.090535 Tz (bacteria. ) Tj 2.722222 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 52.932099 Tz (approach, ) Tj 3.052778 0 Td 47.170782 Tz (lineZolid ) Tj 2.741667 0 Td 68.055556 Tz (may ) Tj 1.419444 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 55.902778 Tz (used ) Tj 1.516667 0 Td 46.990741 Tz (to ) Tj ET Q endstream endobj 129 0 obj << /Length 1 >> stream q endstream endobj 130 0 obj << /Length 40591 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 14.602778 0 Td 66.435185 Tz (11 ) Tj 51.428571 0 0 51.428571 0 2915.68599 Tm 6.241667 0 Td 44.074074 Tz (treat ) Tj 1.594444 0 Td 51.203704 Tz (multi-drug ) Tj 3.305556 0 Td 45.010288 Tz (resistant ) Tj 2.625 0 Td 69.675926 Tz (Gram ) Tj 1.905556 0 Td 48.611111 Tz (positive ) Tj 2.527778 0 Td 46.090535 Tz (bacteria. ) Tj 2.780556 0 Td 51.49177 Tz (Linezolid ) Tj 51.428571 0 0 51.428571 0 2875.221333 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 55.362654 Tz (commercially ) Tj 4.413889 0 Td 48.971193 Tz (available ) Tj 3.033333 0 Td 56.388889 Tz (under ) Tj 2.080556 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 47.962963 Tz (trade ) Tj 1.847222 0 Td 65.625 Tz (name ) Tj 2.002778 0 Td 62.87037 Tz (ZyVox ) Tj 51.428571 0 0 51.428571 0 2830 Tm 6.280556 0 Td 42.849794 Tz (\(Pfizer\). ) Tj 51.428571 0 0 51.428571 0 2791.373737 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.797222 0 Td 50.555556 Tz (other ) Tj 1.691667 0 Td 56.712963 Tz (embodiments, ) Tj 4.277778 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 49.826389 Tz (chitosan ) Tj 2.625 0 Td 53.914141 Tz (composition ) Tj 3.791667 0 Td 54.372428 Tz (comprises ) Tj 51.428571 0 0 51.428571 0 2748.631788 Tm 6.261111 0 Td 59.41358 Tz (one ) Tj 1.458333 0 Td 53.472222 Tz (or ) Tj 1.030556 0 Td 61.574074 Tz (more ) Tj 1.866667 0 Td 59.953704 Tz (of ) Tj 1.011111 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 49.907407 Tz (following: ) Tj 3.480556 0 Td 57.79321 Tz (Benzalkonium ) Tj 4.588889 0 Td 50.05144 Tz (Chloride, ) Tj 51.428571 0 0 51.428571 0 2709.113208 Tm 6.261111 0 Td 53.148148 Tz (Cetylpyridinium ) Tj 5.036111 0 Td 50.771605 Tz (Chloride, ) Tj 2.975 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 53.846154 Tz (Chlorhexidine ) Tj 4.452778 0 Td 51.311728 Tz (Digluconate. ) Tj 51.428571 0 0 51.428571 0 2665.896907 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.913889 0 Td 36.296296 Tz (still ) Tj 1.458333 0 Td 49.907407 Tz (other ) Tj 1.788889 0 Td 56.712963 Tz (embodiments, ) Tj 4.433333 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 50.231481 Tz (chitosan ) Tj 2.741667 0 Td 54.208754 Tz (composition ) Tj 3.927778 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2625.767614 Tm 6.261111 0 Td 46.990741 Tz (prises ) Tj 2.002778 0 Td 60.493827 Tz (one ) Tj 1.380556 0 Td 55.092593 Tz (or ) Tj 0.952778 0 Td 61.574074 Tz (more ) Tj 1.769444 0 Td 61.574074 Tz (of ) Tj 0.913889 0 Td 48.395062 Tz (antimicrobials: ) Tj 4.744444 0 Td 56.045752 Tz (Polyhexamethylene ) Tj 51.428571 0 0 51.428571 0 2585.143742 Tm 6.280556 0 Td 52.5 Tz (Biguanide, ) Tj 3.5 0 Td 53.148148 Tz (Octenidine ) Tj 3.538889 0 Td 51.851852 Tz (Dihydrochloride, ) Tj 5.347222 0 Td 58.333333 Tz (Mild ) Tj 1.75 0 Td 48.611111 Tz (Silver ) Tj 2.080556 0 Td 68.055556 Tz (Pro ) Tj 51.428571 0 0 51.428571 0 2539 Tm 6.241667 0 Td 42.777778 Tz (tein, ) Tj 1.516667 0 Td 57.118056 Tz (Povidone ) Tj 2.975 0 Td 50.771605 Tz (Iodine ) Tj 2.041667 0 Td 47.530864 Tz (\(solution ) Tj 2.761111 0 Td 55.092593 Tz (or ) Tj 0.816667 0 Td 50.231481 Tz (ointment\), ) Tj 3.247222 0 Td 48.611111 Tz (Silver ) Tj 1.925 0 Td 45.37037 Tz (Nitrate, ) Tj 48.571429 0 0 48.571429 0 2499 Tm 6.65 0 Td 51.470588 Tz (Silver ) Tj 2.511765 0 Td 51.470588 Tz (Sulfadiazine, ) Tj 4.652941 0 Td 51.470588 Tz (Triclosan, ) Tj 3.767647 0 Td 59.893048 Tz (Cetalkonium ) Tj 4.632353 0 Td 53.376906 Tz (Chloride, ) Tj 51.428571 0 0 51.428571 0 2460.023669 Tm 6.261111 0 Td 55.555556 Tz (Myristalkonium ) Tj 4.938889 0 Td 50.05144 Tz (Chloride, ) Tj 2.916667 0 Td 49.96142 Tz (Tigecycline, ) Tj 3.888889 0 Td 47.530864 Tz (Lactoferrin, ) Tj 3.675 0 Td 68.055556 Tz (Quinu ) Tj 51.428571 0 0 51.428571 0 2418.561576 Tm 6.261111 0 Td 44.444444 Tz (pristin?dalfopristin, ) Tj 6.144444 0 Td 49.259259 Tz (Linezolid, ) Tj 3.5 0 Td 53.20216 Tz (Dalbavancin, ) Tj 4.394444 0 Td 56.712963 Tz (Doripenem, ) Tj 51.428571 0 0 51.428571 0 2380.167286 Tm 6.280556 0 Td 57.613169 Tz (Imipenem, ) Tj 3.363889 0 Td 61.25 Tz (Meropenem, ) Tj 3.908333 0 Td 60.493827 Tz (and ) Tj 1.341667 0 Td 47.890947 Tz (Iclaprim. ) Tj 51.428571 0 0 51.428571 0 2333.038356 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.991667 0 Td 36.296296 Tz (still ) Tj 1.516667 0 Td 51.203704 Tz (other ) Tj 1.905556 0 Td 56.712963 Tz (embodiments, ) Tj 4.530556 0 Td 50.771605 Tz (the ) Tj 1.341667 0 Td 49.826389 Tz (chitosan ) Tj 2.838889 0 Td 54.79798 Tz (composition ) Tj 51.428571 0 0 51.428571 0 2294.054121 Tm 6.261111 0 Td 54.372428 Tz (comprises ) Tj 3.227778 0 Td 55.092593 Tz (an ) Tj 0.933333 0 Td 46.450617 Tz (essential ) Tj 2.8 0 Td 41.049383 Tz (oil ) Tj 1.030556 0 Td 55.092593 Tz (having ) Tj 2.216667 0 Td 49.85755 Tz (antimicrobial ) Tj 4.141667 0 Td 46.843434 Tz (properties. ) Tj 51.428571 0 0 51.428571 0 2250.980794 Tm 6.280556 0 Td 58.693416 Tz (Exemplary ) Tj 3.461111 0 Td 46.090535 Tz (essential ) Tj 2.780556 0 Td 42.939815 Tz (oils ) Tj 1.322222 0 Td 51.388889 Tz (include ) Tj 2.430556 0 Td 59.259259 Tz (Oregano ) Tj 2.780556 0 Td 38.888889 Tz (oil, ) Tj 1.225 0 Td 47.530864 Tz (tea ) Tj 1.108333 0 Td 46.990741 Tz (tree ) Tj 1.380556 0 Td 38.888889 Tz (oil, ) Tj 51.428571 0 0 51.428571 0 2207.011378 Tm 6.261111 0 Td 55.902778 Tz (mint ) Tj 1.575 0 Td 37.268519 Tz (oil, ) Tj 1.166667 0 Td 57.685185 Tz (Sandalwood ) Tj 3.675 0 Td 38.888889 Tz (oil, ) Tj 1.166667 0 Td 52.5 Tz (clove ) Tj 1.788889 0 Td 38.888889 Tz (oil, ) Tj 1.205556 0 Td 46.296296 Tz (nigella ) Tj 2.158333 0 Td 46.990741 Tz (sativa ) Tj 1.905556 0 Td 38.888889 Tz (oil, ) Tj 1.186111 0 Td 55.740741 Tz (onion ) Tj 51.428571 0 0 51.428571 0 2165.975858 Tm 6.261111 0 Td 39.699074 Tz (oil, ) Tj 1.186111 0 Td 52.662037 Tz (leleshwa ) Tj 2.761111 0 Td 40.509259 Tz (oil, ) Tj 1.205556 0 Td 53.06713 Tz (lavender ) Tj 2.722222 0 Td 40.509259 Tz (oil, ) Tj 1.225 0 Td 59.62963 Tz (lemon ) Tj 2.041667 0 Td 38.888889 Tz (oil, ) Tj 1.186111 0 Td 60.277778 Tz (lemon ) Tj 2.1 0 Td 51.851852 Tz (myrtle ) Tj 2.080556 0 Td 38.888889 Tz (oil, ) Tj 51.428571 0 0 51.428571 0 2127.270677 Tm 6.261111 0 Td 64.814815 Tz (neem ) Tj 1.866667 0 Td 38.888889 Tz (oil, ) Tj 1.186111 0 Td 43.981481 Tz (garlic, ) Tj 2.119444 0 Td 51.851852 Tz (eucalyptus ) Tj 3.402778 0 Td 38.888889 Tz (oil, ) Tj 1.205556 0 Td 55.416667 Tz (peppermint ) Tj 3.616667 0 Td 38.078704 Tz (oil, ) Tj 1.205556 0 Td 60.358796 Tz (cinnamon ) Tj 51.428571 0 0 51.428571 0 2085.081967 Tm 6.261111 0 Td 39.699074 Tz (oil, ) Tj 1.186111 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 60.925926 Tz (thyme ) Tj 2.080556 0 Td 37.268519 Tz (oil. ) Tj 51.428571 0 0 51.428571 0 2040.685139 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.719444 0 Td 35.648148 Tz (still ) Tj 1.244444 0 Td 50.555556 Tz (other ) Tj 1.613889 0 Td 57.253086 Tz (embodiments, ) Tj 4.277778 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 49.608262 Tz (antimicrobial ) Tj 4.025 0 Td 40.509259 Tz (is ) Tj 0.622222 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 44.074074 Tz (fatty ) Tj 1.458333 0 Td 52.662037 Tz (acid ) Tj 51.428571 0 0 51.428571 0 2000.472637 Tm 6.280556 0 Td 39.969136 Tz (\(e.g., ) Tj 1.691667 0 Td 54.398148 Tz (Cis-2-Decenoic ) Tj 4.783333 0 Td 50.231481 Tz (Acid\). ) Tj 51.428571 0 0 51.428571 0 1962.205549 Tm 7 0 Td 48.287037 Tz (Antivirals ) Tj 3.091667 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 51.311728 Tz (agents ) Tj 2.061111 0 Td 52.777778 Tz (capable ) Tj 2.45 0 Td 55.092593 Tz (of ) Tj 0.797222 0 Td 46.990741 Tz (inhibiting ) Tj 2.994444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 47.727273 Tz (replication ) Tj 51.428571 0 0 51.428571 0 1917.362745 Tm 6.261111 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 45.37037 Tz (viruses. ) Tj 2.430556 0 Td 58.738426 Tz (Examples ) Tj 3.052778 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 44.722222 Tz (anti-viral ) Tj 2.858333 0 Td 51.851852 Tz (agents ) Tj 2.061111 0 Td 51.388889 Tz (include ) Tj 2.313889 0 Td 54.012346 Tz (but ) Tj 1.127778 0 Td 50.771605 Tz (are ) Tj 1.147222 0 Td 49.691358 Tz (not ) Tj 51.428571 0 0 51.428571 0 1878.865497 Tm 6.261111 0 Td 49.074074 Tz (limited ) Tj 2.294444 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 49.56427 Tz (1-D-ribofuranosyl-1,2,4-triazole-3 ) Tj 10.383333 0 Td 54.282407 Tz (carboxamide, ) Tj 51.428571 0 0 51.428571 0 1837.343434 Tm 6.280556 0 Td 54.012346 Tz (9-2-hydroxy-ethoxy ) Tj 6.883333 0 Td 53.009259 Tz (methylguanine, ) Tj 5.425 0 Td 56.820988 Tz (adamantanamine, ) Tj 51.428571 0 0 51.428571 0 1797.424242 Tm 6.280556 0 Td 49.738325 Tz (5-iodo-2'-deoxyuridine, ) Tj 7.875 0 Td 48.269981 Tz (trifluorothymidine, ) Tj 6.513889 0 Td 45.959596 Tz (interferon, ) Tj 51.428571 0 0 51.428571 0 1751.676364 Tm 6.261111 0 Td 54.166667 Tz (adenine ) Tj 2.527778 0 Td 49.421296 Tz (arabinoside, ) Tj 3.85 0 Td 50.231481 Tz (protease ) Tj 2.722222 0 Td 45.075758 Tz (inhibitors, ) Tj 3.266667 0 Td 54.73251 Tz (thymidine ) Tj 3.247222 0 Td 51.851852 Tz (kinase ) Tj 51.428571 0 0 51.428571 0 1711.932203 Tm 6.261111 0 Td 45.075758 Tz (inhibitors, ) Tj 3.208333 0 Td 53.148148 Tz (Sugar ) Tj 1.808333 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 50.771605 Tz (glycoprotein ) Tj 3.908333 0 Td 48.971193 Tz (synthesis ) Tj 2.897222 0 Td 44.486532 Tz (inhibitors, ) Tj 3.188889 0 Td 54.444444 Tz (struc ) Tj 51.428571 0 0 51.428571 0 1669.83848 Tm 6.241667 0 Td 44.722222 Tz (tural ) Tj 1.516667 0 Td 49.537037 Tz (protein ) Tj 2.294444 0 Td 48.971193 Tz (synthesis ) Tj 2.858333 0 Td 44.486532 Tz (inhibitors, ) Tj 3.130556 0 Td 53.148148 Tz (attachment ) Tj 3.383333 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 52.175926 Tz (adsorption ) Tj 52.857143 0 0 52.857143 0 1626.5 Tm 6.091892 0 Td 43.857494 Tz (inhibitors, ) Tj 3.064865 0 Td 57.807808 Tz (and ) Tj 1.22973 0 Td 50.765766 Tz (nucleoside ) Tj 3.178378 0 Td 52.552553 Tz (analogues ) Tj 3.064865 0 Td 52.815315 Tz (such ) Tj 1.437838 0 Td 50.45045 Tz (as ) Tj 0.775676 0 Td 46.666667 Tz (acyclovir, ) Tj 2.989189 0 Td 69.369369 Tz (pen ) Tj 51.428571 0 0 51.428571 0 1587.402214 Tm 6.261111 0 Td 43.930041 Tz (ciclovir, ) Tj 2.644444 0 Td 47.61396 Tz (Valacyclovir, ) Tj 3.966667 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 47.260802 Tz (ganciclovir. ) Tj 51.428571 0 0 51.428571 0 1544.676923 Tm 7 0 Td 52.175926 Tz (Antifungal ) Tj 3.344444 0 Td 51.851852 Tz (agents ) Tj 2.1 0 Td 49.691358 Tz (useful ) Tj 2.022222 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 53.742284 Tz (compositions ) Tj 4.122222 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1502.945879 Tm 6.261111 0 Td 50.771605 Tz (invention ) Tj 2.994444 0 Td 50.462963 Tz (include ) Tj 2.352778 0 Td 48.287037 Tz (fungicidal ) Tj 3.15 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 45.959596 Tz (fungistatic ) Tj 3.247222 0 Td 51.851852 Tz (agents ) Tj 2.1 0 Td 55.092593 Tz (such ) Tj 1.536111 0 Td 43.209877 Tz (as, ) Tj 51.428571 0 0 51.428571 0 1460.326316 Tm 6.261111 0 Td 48.611111 Tz (for ) Tj 1.380556 0 Td 55.092593 Tz (example, ) Tj 3.188889 0 Td 53.703704 Tz (benzoic ) Tj 2.8 0 Td 46.666667 Tz (acid, ) Tj 1.944444 0 Td 53.030303 Tz (undecylenic ) Tj 4.025 0 Td 52.599715 Tz (alkanolamide, ) Tj 51.428571 0 0 51.428571 0 1419.540541 Tm 6.261111 0 Td 49.259259 Tz (ciclopiroX ) Tj 3.286111 0 Td 52.256944 Tz (olamine, ) Tj 2.838889 0 Td 51.131687 Tz (polyenes, ) Tj 3.111111 0 Td 50.084175 Tz (imidazoles, ) Tj 3.616667 0 Td 49.494949 Tz (allylamine, ) Tj 3.577778 0 Td 57.253086 Tz (thi ) Tj 51.428571 0 0 51.428571 0 1379.917808 Tm 6.261111 0 Td 52.146465 Tz (carbamates, ) Tj 3.869444 0 Td 53.472222 Tz (amphotericin ) Tj 4.336111 0 Td 51.851852 Tz (B, ) Tj 1.069444 0 Td 50.854701 Tz (butylparaben, ) Tj 4.433333 0 Td 51.851852 Tz (clindamycin, ) Tj 51.428571 0 0 51.428571 0 1336.707581 Tm 6.261111 0 Td 52.175926 Tz (econaxole, ) Tj 3.461111 0 Td 48.881173 Tz (fluconazole, ) Tj 3.830556 0 Td 46.720679 Tz (flucytosine, ) Tj 3.655556 0 Td 47.61396 Tz (griseofulvin, ) Tj 4.063889 0 Td 45.010288 Tz (nystatin, ) Tj 51.428571 0 0 51.428571 0 1292.354759 Tm 6.261111 0 Td 51.602564 Tz (ketoconazole, ) Tj 4.297222 0 Td 60.493827 Tz (and ) Tj 1.341667 0 Td 50.106838 Tz (Voriconazole. ) Tj 4.238889 0 Td 48.611111 Tz (In ) Tj 0.894444 0 Td 58.333333 Tz (one ) Tj 1.322222 0 Td 49.331276 Tz (preferred ) Tj 2.955556 0 Td 66.975309 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1254.228464 Tm 6.261111 0 Td 54.444444 Tz (ment, ) Tj 1.886111 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 49.259259 Tz (antifungal ) Tj 3.208333 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 53.20216 Tz (amphotericin ) Tj 4.122222 0 Td 50.231481 Tz (B. ) Tj 51.428571 0 0 51.428571 0 1209.304893 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.738889 0 Td 59.41358 Tz (one ) Tj 1.225 0 Td 57.744108 Tz (embodiment, ) Tj 3.986111 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 50.771605 Tz (invention ) Tj 2.897222 0 Td 52.662037 Tz (provides ) Tj 2.722222 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 82.098765 Tz (com ) Tj 51.428571 0 0 51.428571 0 1169.002469 Tm 6.261111 0 Td 48.611111 Tz (positions ) Tj 2.838889 0 Td 54.768519 Tz (comprising ) Tj 3.5 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 54.503367 Tz (combination ) Tj 3.830556 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 57.253086 Tz (one ) Tj 1.244444 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 60.763889 Tz (more ) Tj 1.652778 0 Td 58.873457 Tz (antimi ) Tj 51.428571 0 0 51.428571 0 1126.676923 Tm 6.261111 0 Td 47.800926 Tz (crobials ) Tj 2.527778 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 45.37037 Tz (antivirals ) Tj 2.975 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 46.990741 Tz (antifungals. ) Tj 40 0 0 40 0 1091 Tm 8.05 0 Td 79.166667 Tz (Growth ) Tj 3.2 0 Td 64.285714 Tz (Factors ) Tj 51.428571 0 0 51.428571 0 1045.959371 Tm 7 0 Td 61.033951 Tz (Growth ) Tj 2.527778 0 Td 46.759259 Tz (factors ) Tj 2.294444 0 Td 49.691358 Tz (are ) Tj 1.166667 0 Td 47.530864 Tz (typically ) Tj 2.858333 0 Td 51.851852 Tz (polypeptides ) Tj 4.083333 0 Td 48.611111 Tz (or ) Tj 0.894444 0 Td 53.652263 Tz (fragments ) Tj 51.428571 0 0 51.428571 0 1002.222766 Tm 6.241667 0 Td 52.314815 Tz (thereof ) Tj 2.333333 0 Td 46.180556 Tz (that ) Tj 1.361111 0 Td 51.851852 Tz (support ) Tj 2.411111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 46.450617 Tz (survival, ) Tj 2.761111 0 Td 53.240741 Tz (growth, ) Tj 2.508333 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 46.018519 Tz (differentiation ) Tj 51.428571 0 0 51.428571 0 961.204513 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 58.333333 Tz (a ) Tj 0.719444 0 Td 39.537037 Tz (cell. ) Tj 1.594444 0 Td 59.953704 Tz (Such ) Tj 1.827778 0 Td 51.851852 Tz (agents ) Tj 2.275 0 Td 66.975309 Tz (may ) Tj 1.594444 0 Td 56.712963 Tz (be ) Tj 1.069444 0 Td 55.092593 Tz (used ) Tj 1.672222 0 Td 46.990741 Tz (to ) Tj 0.952778 0 Td 58.333333 Tz (promote ) Tj 2.8 0 Td 67.407407 Tz (wound ) Tj 51.428571 0 0 51.428571 0 920.125964 Tm 6.241667 0 Td 48.206019 Tz (healing. ) Tj 2.663889 0 Td 84.259259 Tz (A ) Tj 0.816667 0 Td 49.826389 Tz (chitosan ) Tj 2.741667 0 Td 54.503367 Tz (composition ) Tj 3.947222 0 Td 51.851852 Tz (described ) Tj 3.111111 0 Td 50.231481 Tz (herein ) Tj 2.177778 0 Td 55.092593 Tz (can ) Tj 1.322222 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 877.85 Tm 6.241667 0 Td 55.902778 Tz (used ) Tj 1.536111 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 49.537037 Tz (deliver ) Tj 2.236111 0 Td 45.010288 Tz (virtually ) Tj 2.625 0 Td 58.333333 Tz (any ) Tj 1.225 0 Td 57.253086 Tz (growth ) Tj 2.294444 0 Td 47.530864 Tz (factor ) Tj 1.886111 0 Td 64.166667 Tz (known ) Tj 2.138889 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 38.888889 Tz (art. ) Tj 51.428571 0 0 51.428571 0 835.463054 Tm 6.280556 0 Td 59.143519 Tz (Such ) Tj 1.613889 0 Td 57.253086 Tz (growth ) Tj 2.255556 0 Td 46.759259 Tz (factors ) Tj 2.158333 0 Td 51.388889 Tz (include ) Tj 2.313889 0 Td 52.932099 Tz (but ) Tj 1.127778 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 50.771605 Tz (not ) Tj 1.108333 0 Td 48.611111 Tz (limited ) Tj 2.197222 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 58.333333 Tz (angiopoi ) Tj 51.428571 0 0 51.428571 0 793.109948 Tm 6.261111 0 Td 42.12963 Tz (etin, ) Tj 1.672222 0 Td 48.070988 Tz (acidic ) Tj 2.197222 0 Td 45.694444 Tz (fibroblast ) Tj 3.15 0 Td 57.253086 Tz (growth ) Tj 2.508333 0 Td 46.296296 Tz (factors ) Tj 2.411111 0 Td 58.873457 Tz (\(aFGF\) ) Tj 2.566667 0 Td 62.384259 Tz (\(GenBank ) Tj 51.428571 0 0 51.428571 0 750 Tm 6.261111 0 Td 55.452675 Tz (Accession ) Tj 3.461111 0 Td 59.41358 Tz (No. ) Tj 1.555556 0 Td 77.777778 Tz (NP ) Tj 1.322222 0 Td 49.826389 Tz (14.9127\) ) Tj 2.838889 0 Td 59.41358 Tz (and ) Tj 1.516667 0 Td 49.259259 Tz (basic ) Tj 2.022222 0 Td 72.376543 Tz (FGF ) Tj 1.769444 0 Td 62.789352 Tz (\(GenBank ) Tj 51.428571 0 0 51.428571 0 712.123711 Tm 6.261111 0 Td 55.092593 Tz (Accession ) Tj 3.480556 0 Td 56.17284 Tz (No. ) Tj 1.477778 0 Td 63.194444 Tz (AAA52448\), ) Tj 4.277778 0 Td 59.143519 Tz (bone ) Tj 1.905556 0 Td 57.449495 Tz (morphogenic ) Tj 4.258333 0 Td 50 Tz (protein ) Tj 51.428571 0 0 51.428571 0 667 Tm 6.280556 0 Td 67.407407 Tz (\(BMP\) ) Tj 2.469444 0 Td 62.384259 Tz (\(GenBank ) Tj 3.402778 0 Td 55.092593 Tz (Accession ) Tj 3.402778 0 Td 58.333333 Tz (No. ) Tj 1.536111 0 Td 62.546296 Tz (BAD92827\), ) Tj 4.219444 0 Td 51.041667 Tz (vascular ) Tj 51.428571 0 0 51.428571 0 627.002364 Tm 6.261111 0 Td 48.905724 Tz (endothelial ) Tj 3.422222 0 Td 57.253086 Tz (growth ) Tj 2.236111 0 Td 48.070988 Tz (factor ) Tj 1.886111 0 Td 66.435185 Tz (\(VEGF\) ) Tj 2.547222 0 Td 62.789352 Tz (\(GenBank ) Tj 3.130556 0 Td 55.092593 Tz (Accession ) Tj 3.169444 0 Td 58.333333 Tz (No. ) Tj 51.428571 0 0 51.428571 0 586.589128 Tm 6.261111 0 Td 70.891204 Tz (AAA35789 ) Tj 3.752778 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 79.398148 Tz (NP ) Tj 1.283333 0 Td 55.976431 Tz (001020539\), ) Tj 4.063889 0 Td 53.652263 Tz (epidermal ) Tj 3.247222 0 Td 57.79321 Tz (growth ) Tj 2.469444 0 Td 47.530864 Tz (factor ) Tj 51.428571 0 0 51.428571 0 543.860911 Tm 6.280556 0 Td 61.574074 Tz (\(EGF\) ) Tj 2.022222 0 Td 62.789352 Tz (\(GenBank ) Tj 3.15 0 Td 55.092593 Tz (Accession ) Tj 3.169444 0 Td 58.333333 Tz (No. ) Tj 1.263889 0 Td 79.398148 Tz (NP ) Tj 1.283333 0 Td 54.282407 Tz (001954\), ) Tj 2.8 0 Td 52.391975 Tz (transforming ) Tj 51.428571 0 0 51.428571 0 502.189802 Tm 6.261111 0 Td 56.712963 Tz (growth ) Tj 2.702778 0 Td 46.990741 Tz (factor ) Tj 2.275 0 Td 38.888889 Tz (C. ) Tj 1.108333 0 Td 60.185185 Tz (\(TGF-C\) ) Tj 3.169444 0 Td 62.384259 Tz (\(GenBank ) Tj 3.538889 0 Td 54.73251 Tz (Accession ) Tj 3.597222 0 Td 58.333333 Tz (No. ) Tj 51.428571 0 0 51.428571 0 462.164021 Tm 6.261111 0 Td 79.398148 Tz (NP ) Tj 1.322222 0 Td 57.407407 Tz (003227\) ) Tj 2.761111 0 Td 59.41358 Tz (and ) Tj 1.458333 0 Td 52.121914 Tz (transforming ) Tj 4.122222 0 Td 57.253086 Tz (growth ) Tj 2.45 0 Td 47.530864 Tz (factor ) Tj 2.197222 0 Td 42.12963 Tz (B ) Tj 0.661111 0 Td 59.259259 Tz (\(TFG-B\) ) Tj 51.428571 0 0 51.428571 0 420.46554 Tm 6.280556 0 Td 62.384259 Tz (\(GenBank ) Tj 3.558333 0 Td 54.73251 Tz (Accession ) Tj 3.597222 0 Td 57.253086 Tz (No. ) Tj 1.730556 0 Td 56.064815 Tz (1109243A\), ) Tj 3.986111 0 Td 48.003472 Tz (platelet-derived ) Tj 51.428571 0 0 51.428571 0 377.003517 Tm 6.261111 0 Td 48.905724 Tz (endothelial ) Tj 3.383333 0 Td 43.75 Tz (cell ) Tj 1.186111 0 Td 57.79321 Tz (growth ) Tj 2.275 0 Td 46.990741 Tz (factor ) Tj 1.827778 0 Td 65.174897 Tz (\(PD-ECGF\) ) Tj 3.694444 0 Td 62.384259 Tz (\(GenBank ) Tj 3.072222 0 Td 67.407407 Tz (Acces ) Tj 51.428571 0 0 51.428571 0 338.763411 Tm 6.280556 0 Td 49.421296 Tz (sion ) Tj 1.808333 0 Td 57.253086 Tz (No. ) Tj 1.633333 0 Td 79.398148 Tz (NP ) Tj 1.322222 0 Td 53.877315 Tz (001944\), ) Tj 3.169444 0 Td 47.800926 Tz (platelet-derived ) Tj 5.152778 0 Td 57.253086 Tz (growth ) Tj 2.663889 0 Td 48.070988 Tz (factor ) Tj 51.428571 0 0 51.428571 0 293 Tm 6.280556 0 Td 64.814815 Tz (\(PDGF\) ) Tj 2.508333 0 Td 62.789352 Tz (\(GenBank ) Tj 3.111111 0 Td 55.092593 Tz (Accession ) Tj 3.169444 0 Td 58.333333 Tz (No. ) Tj 1.302778 0 Td 56.712963 Tz (1109245A\), ) Tj 3.597222 0 Td 58.981481 Tz (tumor ) Tj 1.925 0 Td 60.925926 Tz (necro ) Tj 51.428571 0 0 51.428571 0 251 Tm 6.280556 0 Td 41.049383 Tz (sis ) Tj 0.913889 0 Td 48.070988 Tz (factor ) Tj 1.866667 0 Td 40.509259 Tz (C. ) Tj 0.641667 0 Td 53.472222 Tz (\(TNF-C.\) ) Tj 2.722222 0 Td 62.789352 Tz (\(GenBank ) Tj 3.130556 0 Td 55.092593 Tz (Accession ) Tj 3.15 0 Td 58.333333 Tz (No. ) Tj 1.244444 0 Td 62.546296 Tz (CAA26669\), ) Tj 51.428571 0 0 51.428571 0 212.637363 Tm 6.241667 0 Td 53.148148 Tz (hepatocyte ) Tj 3.422222 0 Td 57.253086 Tz (growth ) Tj 2.352778 0 Td 47.530864 Tz (factor ) Tj 1.963889 0 Td 64.814815 Tz (\(HGF\) ) Tj 2.197222 0 Td 62.789352 Tz (\(GenBank ) Tj 3.247222 0 Td 54.73251 Tz (Accession ) Tj 3.227778 0 Td 58.333333 Tz (No. ) Tj 51.428571 0 0 51.428571 0 169.084399 Tm 6.280556 0 Td 84.259259 Tz (BAA ) Tj 1.594444 0 Td 51.388889 Tz (14348\), ) Tj 2.547222 0 Td 46.759259 Tz (insulin ) Tj 2.352778 0 Td 45.37037 Tz (like ) Tj 1.438889 0 Td 57.253086 Tz (growth ) Tj 2.430556 0 Td 48.611111 Tz (factor ) Tj 2.061111 0 Td 55.740741 Tz (\(IGF\) ) Tj 2.061111 0 Td 62.384259 Tz (\(GenBank ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.502778 0 Td 72.916667 Tz (12 ) Tj 51.428571 0 0 51.428571 0 2915.095941 Tm 25.2 0 Td 55.092593 Tz (Accession ) Tj 3.344444 0 Td 57.253086 Tz (No. ) Tj 1.419444 0 Td 54.282407 Tz (P08833\), ) Tj 2.916667 0 Td 49.305556 Tz (erythropoietin ) Tj 4.472222 0 Td 63.194444 Tz (\(GenBank ) Tj 3.286111 0 Td 67.407407 Tz (Acces ) Tj 51.428571 0 0 51.428571 0 2874.666667 Tm 25.219444 0 Td 49.421296 Tz (sion ) Tj 1.438889 0 Td 56.17284 Tz (No. ) Tj 1.302778 0 Td 54.282407 Tz (PO1588\), ) Tj 2.838889 0 Td 54.552469 Tz (colony ) Tj 2.216667 0 Td 49.494949 Tz (stimulating ) Tj 3.5 0 Td 47.530864 Tz (factor ) Tj 1.925 0 Td 53.472222 Tz (\(CSF\), ) Tj 2.197222 0 Td 67.407407 Tz (macro ) Tj 51.428571 0 0 51.428571 0 2831.581395 Tm 25.180556 0 Td 61.213992 Tz (phage-CSF ) Tj 3.441667 0 Td 63.425926 Tz (\(M-CSF\) ) Tj 2.819444 0 Td 62.789352 Tz (\(GenBank ) Tj 3.130556 0 Td 55.092593 Tz (Accession ) Tj 3.15 0 Td 57.253086 Tz (No. ) Tj 1.186111 0 Td 62.222222 Tz (AAB59527\), ) Tj 51.428571 0 0 51.428571 0 2791.44186 Tm 25.2 0 Td 54.503367 Tz (granulocyte/macrophage ) Tj 7.388889 0 Td 72.376543 Tz (CSF ) Tj 1.516667 0 Td 66.435185 Tz (\(GM-CSF\) ) Tj 3.383333 0 Td 62.789352 Tz (\(GenBank ) Tj 3.15 0 Td 67.407407 Tz (Acces ) Tj 51.428571 0 0 51.428571 0 2748.396999 Tm 25.219444 0 Td 50.231481 Tz (sion ) Tj 1.594444 0 Td 59.41358 Tz (No. ) Tj 1.497222 0 Td 77.777778 Tz (NP ) Tj 1.283333 0 Td 57.87037 Tz (000749\) ) Tj 2.8 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 42.12963 Tz (nitric ) Tj 1.925 0 Td 53.796296 Tz (oxide ) Tj 2.041667 0 Td 51.851852 Tz (synthase ) Tj 2.877778 0 Td 64.814815 Tz (\(NOS\) ) Tj 51.428571 0 0 51.428571 0 2706.428202 Tm 25.219444 0 Td 62.384259 Tz (\(GenBank ) Tj 3.344444 0 Td 54.73251 Tz (Accession ) Tj 3.383333 0 Td 56.17284 Tz (No. ) Tj 1.419444 0 Td 62.87037 Tz (AAA36365\). ) Tj 4.219444 0 Td 46.990741 Tz (In ) Tj 0.972222 0 Td 58.333333 Tz (one ) Tj 1.438889 0 Td 49.691358 Tz (preferred ) Tj 51.428571 0 0 51.428571 0 2665.576208 Tm 25.2 0 Td 57.744108 Tz (embodiment, ) Tj 4.063889 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 57.253086 Tz (growth ) Tj 2.333333 0 Td 47.530864 Tz (factor ) Tj 1.925 0 Td 40.509259 Tz (is ) Tj 0.777778 0 Td 83.179012 Tz (BMP ) Tj 51.428571 0 0 51.428571 0 2630 Tm 25.2 0 Td 53.148148 Tz (Analgesics ) Tj 51.428571 0 0 51.428571 0 2583.111406 Tm 25.919444 0 Td 53.877315 Tz (Chitosan ) Tj 2.858333 0 Td 53.742284 Tz (compositions ) Tj 4.161111 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 50.411523 Tz (invention ) Tj 2.994444 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 59.953704 Tz (be ) Tj 0.991667 0 Td 54.282407 Tz (used ) Tj 1.575 0 Td 49.691358 Tz (for ) Tj 51.428571 0 0 51.428571 0 2541.842491 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 49.016204 Tz (delivery ) Tj 2.527778 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 60.763889 Tz (more ) Tj 1.594444 0 Td 51.851852 Tz (agents ) Tj 2.041667 0 Td 46.990741 Tz (that ) Tj 1.263889 0 Td 51.203704 Tz (ameliorate ) Tj 3.227778 0 Td 47.962963 Tz (pain, ) Tj 1.613889 0 Td 55.092593 Tz (Such ) Tj 51.428571 0 0 51.428571 0 2501.115723 Tm 25.2 0 Td 51.311728 Tz (agents ) Tj 2.080556 0 Td 50.925926 Tz (include ) Tj 2.333333 0 Td 52.932099 Tz (but ) Tj 1.166667 0 Td 49.691358 Tz (are ) Tj 1.127778 0 Td 50.771605 Tz (not ) Tj 1.127778 0 Td 49.074074 Tz (limited ) Tj 2.275 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 51.851852 Tz (opioid ) Tj 2.080556 0 Td 49.583333 Tz (analgesics ) Tj 3.208333 0 Td 42.12963 Tz (\(e.g. ) Tj 51.428571 0 0 51.428571 0 2464 Tm 25.2 0 Td 54.73251 Tz (morphine, ) Tj 3.538889 0 Td 57.638889 Tz (hydromorphone, ) Tj 5.463889 0 Td 58.333333 Tz (oxymorphone, ) Tj 4.802778 0 Td 50.501543 Tz (levorphanol, ) Tj 51.428571 0 0 51.428571 0 2419.042607 Tm 25.2 0 Td 48.611111 Tz (levallorphan, ) Tj 4.316667 0 Td 55.416667 Tz (methadone, ) Tj 3.791667 0 Td 52.146465 Tz (meperidine, ) Tj 3.888889 0 Td 47.170782 Tz (fentanyl, ) Tj 3.033333 0 Td 50.231481 Tz (codeine, ) Tj 51.428571 0 0 51.428571 0 2381 Tm 25.2 0 Td 52.283951 Tz (dihydrocodeine, ) Tj 5.075 0 Td 55.740741 Tz (oxycodone, ) Tj 3.713889 0 Td 55.092593 Tz (hydrocodone, ) Tj 4.316667 0 Td 55.591168 Tz (propoxyphene, ) Tj 51.428571 0 0 51.428571 0 2334.189873 Tm 25.2 0 Td 53.472222 Tz (nalmefene, ) Tj 3.752778 0 Td 49.200337 Tz (nalorphine, ) Tj 3.772222 0 Td 51.851852 Tz (naloxone, ) Tj 3.344444 0 Td 48.905724 Tz (naltrexone, ) Tj 3.713889 0 Td 59.953704 Tz (buprenor ) Tj 51.428571 0 0 51.428571 0 2296.088411 Tm 25.2 0 Td 49.691358 Tz (phine, ) Tj 1.983333 0 Td 51.311728 Tz (butorphanol, ) Tj 3.927778 0 Td 53.472222 Tz (nalbuphine ) Tj 3.402778 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 51.311728 Tz (pentazocine; ) Tj 3.908333 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 54.012346 Tz (nonsteroi ) Tj 51.428571 0 0 51.428571 0 2253.89049 Tm 25.2 0 Td 48.611111 Tz (dal ) Tj 1.672222 0 Td 52.054398 Tz (antiinflammatory ) Tj 5.794444 0 Td 55.092593 Tz (drug ) Tj 2.119444 0 Td 63.888889 Tz (\(NSAID\) ) Tj 3.461111 0 Td 41.049383 Tz (\(e.g., ) Tj 2.255556 0 Td 44.560185 Tz (aspirin, ) Tj 51.428571 0 0 51.428571 0 2207.8 Tm 25.2 0 Td 48.611111 Tz (diclofenac, ) Tj 3.869444 0 Td 43.308081 Tz (diflusinal, ) Tj 3.519444 0 Td 48.971193 Tz (etodolac, ) Tj 3.305556 0 Td 50.771605 Tz (fenbufen, ) Tj 3.422222 0 Td 50.378788 Tz (fenoprofen, ) Tj 51.428571 0 0 51.428571 0 2169.527207 Tm 25.2 0 Td 43.602694 Tz (flufenisal, ) Tj 3.227778 0 Td 46.616809 Tz (flurbiprofen, ) Tj 3.966667 0 Td 49.907407 Tz (ibuprofen, ) Tj 3.344444 0 Td 52.599715 Tz (indomethacin, ) Tj 4.452778 0 Td 58.796296 Tz (ketopro ) Tj 48.571429 0 0 48.571429 0 2125 Tm 26.682353 0 Td 48.897059 Tz (fen, ) Tj 1.461765 0 Td 51.127451 Tz (ketorolac, ) Tj 3.397059 0 Td 60.04902 Tz (meclofenamic ) Tj 4.632353 0 Td 48.72549 Tz (acid, ) Tj 1.770588 0 Td 62.908497 Tz (mefenamic ) Tj 3.685294 0 Td 49.411765 Tz (acid, ) Tj 1.832353 0 Td 71.20098 Tz (nabu ) Tj 51.428571 0 0 51.428571 0 2088.853012 Tm 25.2 0 Td 55.092593 Tz (metone, ) Tj 2.663889 0 Td 52.932099 Tz (naproxen, ) Tj 3.188889 0 Td 51.203704 Tz (oxaprozin, ) Tj 3.383333 0 Td 52.932099 Tz (phenylbutaZone, ) Tj 5.075 0 Td 52.175926 Tz (piroxicam, ) Tj 51.428571 0 0 51.428571 0 2044.440945 Tm 25.219444 0 Td 47.890947 Tz (Sulindac, ) Tj 3.013889 0 Td 50.636574 Tz (tolmetin ) Tj 2.897222 0 Td 51.851852 Tz (or ) Tj 1.05 0 Td 53.472222 Tz (Zomepirac, ) Tj 3.675 0 Td 51.851852 Tz (or ) Tj 1.030556 0 Td 55.092593 Tz (a ) Tj 0.777778 0 Td 52.256944 Tz (pharmaceutically ) Tj 51.428571 0 0 51.428571 0 2001.071166 Tm 25.2 0 Td 51.203704 Tz (acceptable ) Tj 3.305556 0 Td 42.12963 Tz (Salt ) Tj 1.244444 0 Td 46.585648 Tz (thereof; ) Tj 2.469444 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 48.316498 Tz (barbiturate ) Tj 3.402778 0 Td 47.170782 Tz (sedative, ) Tj 2.8 0 Td 42.939815 Tz (e.g. ) Tj 1.283333 0 Td 66.975309 Tz (amobar ) Tj 51.428571 0 0 51.428571 0 1961.0489 Tm 25.180556 0 Td 41.049383 Tz (bital, ) Tj 1.847222 0 Td 47.61396 Tz (aprobarbital, ) Tj 4.102778 0 Td 46.866097 Tz (butabarbital, ) Tj 4.044444 0 Td 45.37037 Tz (butabital, ) Tj 3.130556 0 Td 51.62037 Tz (mephobarbital, ) Tj 51.428571 0 0 51.428571 0 1919.166038 Tm 25.2 0 Td 48.341049 Tz (metharbital, ) Tj 4.180556 0 Td 50.356125 Tz (methohexital, ) Tj 4.588889 0 Td 47.916667 Tz (pentobarbital, ) Tj 4.647222 0 Td 47.916667 Tz (phenobartital, ) Tj 51.428571 0 0 51.428571 0 1878.136919 Tm 25.219444 0 Td 47.115385 Tz (secobarbital, ) Tj 3.888889 0 Td 44.290123 Tz (talbutal, ) Tj 2.605556 0 Td 53.292181 Tz (theamylal ) Tj 3.130556 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 48.935185 Tz (thiopental ) Tj 3.169444 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 66.975309 Tz (pharma ) Tj 51.428571 0 0 51.428571 0 1835.727273 Tm 25.2 0 Td 46.990741 Tz (ceutically ) Tj 3.091667 0 Td 51.851852 Tz (acceptable ) Tj 3.383333 0 Td 42.939815 Tz (salt ) Tj 1.322222 0 Td 46.180556 Tz (thereof; ) Tj 2.527778 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 71.296296 Tz (COX-2 ) Tj 2.430556 0 Td 46.8107 Tz (inhibitor ) Tj 2.819444 0 Td 41.481481 Tz (\(e.g. ) Tj 48.571429 0 0 48.571429 0 1793 Tm 26.682353 0 Td 52.156863 Tz (celecoxib, ) Tj 3.417647 0 Td 54.139434 Tz (rofecoxib ) Tj 3.211765 0 Td 54.901961 Tz (or ) Tj 0.905882 0 Td 53.342246 Tz (Valdecoxib. ) Tj 40 0 0 40 0 1757 Tm 32.4 0 Td 70.833333 Tz (Anti-Thrombotic ) Tj 51.428571 0 0 51.428571 0 1709.992491 Tm 25.919444 0 Td 53.877315 Tz (Chitosan ) Tj 2.761111 0 Td 53.742284 Tz (compositions ) Tj 4.025 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 50.771605 Tz (invention ) Tj 2.897222 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 48.611111 Tz (also ) Tj 1.361111 0 Td 49.151235 Tz (useful ) Tj 1.944444 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1670.75 Tm 25.2 0 Td 45.37037 Tz (inhibiting, ) Tj 3.286111 0 Td 52.662037 Tz (reducing ) Tj 2.819444 0 Td 48.611111 Tz (or ) Tj 0.836111 0 Td 51.58179 Tz (ameliorating ) Tj 3.947222 0 Td 45.37037 Tz (clot ) Tj 1.341667 0 Td 50.555556 Tz (formation. ) Tj 3.363889 0 Td 45.37037 Tz (In ) Tj 0.816667 0 Td 59.41358 Tz (one ) Tj 52.857143 0 0 52.857143 0 1624.817284 Tm 24.518919 0 Td 56.183456 Tz (embodiment, ) Tj 3.935135 0 Td 56.756757 Tz (a ) Tj 0.567568 0 Td 48.873874 Tz (chitosan ) Tj 2.610811 0 Td 52.743653 Tz (composition ) Tj 3.727027 0 Td 49.268018 Tz (contains ) Tj 2.610811 0 Td 56.756757 Tz (one ) Tj 1.248649 0 Td 52.027027 Tz (or ) Tj 0.87027 0 Td 59.90991 Tz (more ) Tj 51.428571 0 0 51.428571 0 1585.029586 Tm 25.2 0 Td 50.028935 Tz (anti-thrombotics ) Tj 5.016667 0 Td 40.509259 Tz (\(e.g., ) Tj 1.652778 0 Td 52.572016 Tz (thrombin, ) Tj 3.072222 0 Td 47.727273 Tz (fibrinogen, ) Tj 3.344444 0 Td 53.472222 Tz (cumidin, ) Tj 2.761111 0 Td 67.24537 Tz (hepa ) Tj 51.428571 0 0 51.428571 0 1540 Tm 25.2 0 Td 44.290123 Tz (rin ) Tj 1.05 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 54.62963 Tz (calcium ) Tj 2.547222 0 Td 40.277778 Tz (salts\). ) Tj 40 0 0 40 0 1507 Tm 32.4 0 Td 66.885965 Tz (Anti-Inflammatories ) Tj 51.428571 0 0 51.428571 0 1458.91623 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 50.555556 Tz (other ) Tj 1.691667 0 Td 56.983025 Tz (embodiments, ) Tj 4.336111 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 53.914141 Tz (composition ) Tj 3.791667 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 55.902778 Tz (used ) Tj 1.536111 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1420.978648 Tm 25.2 0 Td 48.611111 Tz (deliver ) Tj 2.236111 0 Td 55.092593 Tz (an ) Tj 0.875 0 Td 51.470588 Tz (anti-inflammatory ) Tj 5.444444 0 Td 48.611111 Tz (agent. ) Tj 2.002778 0 Td 59.953704 Tz (Such ) Tj 1.652778 0 Td 51.470588 Tz (anti-inflammatory ) Tj 51.428571 0 0 51.428571 0 1374.953576 Tm 25.2 0 Td 51.311728 Tz (agents ) Tj 2.119444 0 Td 47.800926 Tz (include, ) Tj 2.547222 0 Td 52.932099 Tz (but ) Tj 1.186111 0 Td 49.691358 Tz (are ) Tj 1.166667 0 Td 50.771605 Tz (not ) Tj 1.166667 0 Td 49.074074 Tz (limited ) Tj 2.275 0 Td 42.12963 Tz (to, ) Tj 0.972222 0 Td 50.968013 Tz (Alclofenac; ) Tj 3.616667 0 Td 66.975309 Tz (Alclom ) Tj 51.428571 0 0 51.428571 0 1337.273854 Tm 25.2 0 Td 52.314815 Tz (etaSone ) Tj 2.566667 0 Td 51.103989 Tz (Dipropionate; ) Tj 4.355556 0 Td 54.012346 Tz (Algestone ) Tj 3.247222 0 Td 52.5 Tz (Acetonide; ) Tj 3.519444 0 Td 58.981481 Tz (Alpha ) Tj 2.1 0 Td 92.901235 Tz (Amy ) Tj 51.428571 0 0 51.428571 0 1292.590533 Tm 25.2 0 Td 43.425926 Tz (lase, ) Tj 1.497222 0 Td 54.12037 Tz (Amcinafal, ) Tj 3.441667 0 Td 53.914141 Tz (Amcinafide; ) Tj 3.772222 0 Td 62.962963 Tz (Amfenac ) Tj 2.877778 0 Td 57.407407 Tz (Sodium; ) Tj 2.625 0 Td 54.444444 Tz (Amiprilose ) Tj 51.428571 0 0 51.428571 0 1252.504762 Tm 25.219444 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.666667 0 Td 53.292181 Tz (Anakinra, ) Tj 3.130556 0 Td 50.411523 Tz (Anirolac, ) Tj 3.013889 0 Td 49.691358 Tz (AnitraZafen; ) Tj 3.85 0 Td 57.523148 Tz (ApaZone; ) Tj 51.428571 0 0 51.428571 0 1211.221945 Tm 25.219444 0 Td 50.673401 Tz (Balsalazide ) Tj 3.752778 0 Td 55.812757 Tz (Disodium; ) Tj 3.480556 0 Td 54.73251 Tz (Bendazac. ) Tj 3.441667 0 Td 54.344729 Tz (Benoxaprofen; ) Tj 4.725 0 Td 68.055556 Tz (Benzy ) Tj 51.428571 0 0 51.428571 0 1170.165049 Tm 25.2 0 Td 59.953704 Tz (damine ) Tj 2.469444 0 Td 52.546296 Tz (Hydrochloride; ) Tj 4.783333 0 Td 53.030303 Tz (Bromelains; ) Tj 3.888889 0 Td 54.552469 Tz (Broperamole; ) Tj 4.297222 0 Td 67.407407 Tz (Budes ) Tj 51.428571 0 0 51.428571 0 1128.887805 Tm 25.2 0 Td 49.691358 Tz (onide; ) Tj 2.1 0 Td 51.851852 Tz (Carprofen; ) Tj 3.402778 0 Td 51.041667 Tz (Cicloprofen; ) Tj 3.947222 0 Td 52.175926 Tz (Cintazone: ) Tj 3.461111 0 Td 49.259259 Tz (Cliprofen; ) Tj 3.266667 0 Td 71.296296 Tz (Clo ) Tj 51.428571 0 0 51.428571 0 1087.810884 Tm 25.180556 0 Td 49.537037 Tz (betasol ) Tj 2.877778 0 Td 49.789562 Tz (Propionate; ) Tj 4.063889 0 Td 54.79798 Tz (Clobetasone ) Tj 4.413889 0 Td 48.611111 Tz (Butyrate; ) Tj 3.422222 0 Td 49.691358 Tz (Clopirac: ) Tj 51.428571 0 0 51.428571 0 1042.617122 Tm 25.2 0 Td 52.146465 Tz (Cloticasone ) Tj 3.733333 0 Td 50.084175 Tz (Propionate; ) Tj 3.597222 0 Td 58.603395 Tz (Cormethasone ) Tj 4.472222 0 Td 49.826389 Tz (Acetate; ) Tj 2.663889 0 Td 62.384259 Tz (Cortodox ) Tj 48.571429 0 0 48.571429 0 1002 Tm 26.682353 0 Td 54.044118 Tz (one; ) Tj 1.647059 0 Td 51.470588 Tz (Deflazacort; ) Tj 4.097059 0 Td 56.427015 Tz (Desonide; ) Tj 3.397059 0 Td 58.333333 Tz (Desoximetasone; ) Tj 5.620588 0 Td 69.008715 Tz (Dexametha ) Tj 51.428571 0 0 51.428571 0 960.14531 Tm 25.219444 0 Td 55.092593 Tz (sone ) Tj 1.983333 0 Td 50.605413 Tz (Dipropionate; ) Tj 4.647222 0 Td 52.824074 Tz (Diclofenac ) Tj 3.830556 0 Td 52.175926 Tz (Potassium; ) Tj 3.830556 0 Td 52.5 Tz (Diclofenac ) Tj 48.571429 0 0 48.571429 0 919 Tm 26.702941 0 Td 60.784314 Tz (Sodium; ) Tj 3.294118 0 Td 53.966132 Tz (Diflorasone ) Tj 4.261765 0 Td 50.784314 Tz (Diacetate; ) Tj 3.767647 0 Td 58.645276 Tz (Diflumidone ) Tj 4.55 0 Td 61.27451 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 878.477833 Tm 25.219444 0 Td 45.959596 Tz (Diflunisal; ) Tj 3.441667 0 Td 49.305556 Tz (Difluprednate; ) Tj 4.569444 0 Td 48.287037 Tz (Diftalone; ) Tj 3.305556 0 Td 56.712963 Tz (Dimethyl ) Tj 3.111111 0 Td 49.907407 Tz (Sulfoxide: ) Tj 51.428571 0 0 51.428571 0 834.653465 Tm 25.219444 0 Td 52.662037 Tz (Drocinonide; ) Tj 4.219444 0 Td 54.12037 Tz (Endrysone; ) Tj 3.694444 0 Td 58.657407 Tz (Enlimomab: ) Tj 3.966667 0 Td 56.30787 Tz (Enolicam ) Tj 3.091667 0 Td 58.333333 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 793.385902 Tm 25.219444 0 Td 46.990741 Tz (Epirizole; ) Tj 3.072222 0 Td 44.722222 Tz (Etodolac.; ) Tj 2.955556 0 Td 52.662037 Tz (Etofenamate; ) Tj 4.005556 0 Td 49.331276 Tz (Felbinac; ) Tj 2.858333 0 Td 56.17284 Tz (Fenamole: ) Tj 3.266667 0 Td 71.296296 Tz (Fen ) Tj 51.428571 0 0 51.428571 0 751.828571 Tm 25.180556 0 Td 51.311728 Tz (bufen: ) Tj 2.080556 0 Td 51.311728 Tz (Fenclofenac; ) Tj 3.908333 0 Td 50.231481 Tz (Fenclorac; ) Tj 3.247222 0 Td 51.131687 Tz (Fendosal: ) Tj 2.994444 0 Td 51.851852 Tz (Fenpipalone: ) Tj 3.966667 0 Td 71.296296 Tz (Fen ) Tj 48.571429 0 0 48.571429 0 711 Tm 26.661765 0 Td 47.54902 Tz (tiazac, ) Tj 2.326471 0 Td 52.5 Tz (Flazalone; ) Tj 3.458824 0 Td 51.782531 Tz (Fluazacort; ) Tj 3.726471 0 Td 57.647059 Tz (Flufenamic ) Tj 3.685294 0 Td 56.27451 Tz (Acid, ) Tj 2.017647 0 Td 54.558824 Tz (Flumizole; ) Tj 51.428571 0 0 51.428571 0 668.795314 Tm 25.219444 0 Td 49.494949 Tz (Flunisolide ) Tj 3.538889 0 Td 49.421296 Tz (Acetate: ) Tj 2.741667 0 Td 48.251029 Tz (Flunixin: ) Tj 2.975 0 Td 50.636574 Tz (Flunixin ) Tj 2.741667 0 Td 58.981481 Tz (Meglumine: ) Tj 3.888889 0 Td 64.814815 Tz (Fluo ) Tj 51.428571 0 0 51.428571 0 628.577883 Tm 25.2 0 Td 46.990741 Tz (cortin ) Tj 1.944444 0 Td 48.070988 Tz (Butyl; ) Tj 1.963889 0 Td 55.524691 Tz (Fluorometholone ) Tj 5.152778 0 Td 49.826389 Tz (Acetate: ) Tj 2.625 0 Td 53.619529 Tz (FluquaZone: ) Tj 3.772222 0 Td 55.632716 Tz (Flurbi ) Tj 51.428571 0 0 51.428571 0 588.600509 Tm 25.2 0 Td 49.537037 Tz (profen; ) Tj 2.625 0 Td 48.021886 Tz (Fluretofen; ) Tj 3.733333 0 Td 50.378788 Tz (Fluticasone ) Tj 3.830556 0 Td 50.378788 Tz (Propionate; ) Tj 3.869444 0 Td 51.262626 Tz (Furaprofen; ) Tj 51.428571 0 0 51.428571 0 544.888087 Tm 25.219444 0 Td 53.148148 Tz (Furobufen; ) Tj 3.519444 0 Td 51.311728 Tz (Halcinonide; ) Tj 4.005556 0 Td 52.146465 Tz (Halobetasol ) Tj 3.752778 0 Td 49.789562 Tz (Propionate; ) Tj 3.616667 0 Td 60.648148 Tz (Halopre ) Tj 51.428571 0 0 51.428571 0 503.995025 Tm 25.2 0 Td 59.143519 Tz (done ) Tj 1.711111 0 Td 49.826389 Tz (Acetate; ) Tj 2.8 0 Td 49.331276 Tz (Ibufenac; ) Tj 3.052778 0 Td 50.555556 Tz (Ibuprofen; ) Tj 3.422222 0 Td 52.211934 Tz (Ibuprofen ) Tj 3.15 0 Td 61.213992 Tz (Aluminum; ) Tj 51.428571 0 0 51.428571 0 461.718826 Tm 25.219444 0 Td 52.572016 Tz (Ibuprofen ) Tj 3.227778 0 Td 49.016204 Tz (Piconol; ) Tj 2.741667 0 Td 47.530864 Tz (Ilonidap: ) Tj 2.955556 0 Td 53.347578 Tz (Indomethacin; ) Tj 4.55 0 Td 55.362654 Tz (Indomethacin ) Tj 51.428571 0 0 51.428571 0 421.867684 Tm 25.219444 0 Td 57.407407 Tz (Sodium; ) Tj 2.955556 0 Td 51.557239 Tz (Indoprofen; ) Tj 3.947222 0 Td 50.771605 Tz (Indoxole: ) Tj 3.286111 0 Td 45.694444 Tz (Intrazole; ) Tj 3.286111 0 Td 51.103989 Tz (Isoflupredone ) Tj 51.428571 0 0 51.428571 0 379.360634 Tm 25.2 0 Td 49.826389 Tz (Acetate; ) Tj 3.072222 0 Td 50.771605 Tz (Isoxepac; ) Tj 3.422222 0 Td 51.851852 Tz (Isoxicam; ) Tj 3.519444 0 Td 52.146465 Tz (Ketoprofen; ) Tj 4.122222 0 Td 55.740741 Tz (Lofemizole ) Tj 51.428571 0 0 51.428571 0 339.312583 Tm 25.219444 0 Td 52.314815 Tz (Hydrochloride; ) Tj 5.308333 0 Td 56.271044 Tz (Lornoxicam; ) Tj 4.627778 0 Td 53.324916 Tz (Loteprednol ) Tj 4.433333 0 Td 50.87963 Tz (Etabonate: ) Tj 48.571429 0 0 48.571429 0 295 Tm 26.682353 0 Td 61.500754 Tz (Meclofenamate ) Tj 5.064706 0 Td 61.764706 Tz (Sodium; ) Tj 2.902941 0 Td 61.478758 Tz (Meclofenamic ) Tj 4.694118 0 Td 55.588235 Tz (Acid, ) Tj 1.976471 0 Td 58.645276 Tz (Meclorisone ) Tj 51.428571 0 0 51.428571 0 252.653137 Tm 25.219444 0 Td 49.494949 Tz (Dibutyrate; ) Tj 3.694444 0 Td 60.853909 Tz (Mefenamic ) Tj 3.636111 0 Td 52.5 Tz (Acid; ) Tj 2.002778 0 Td 56.565657 Tz (Mesalamine; ) Tj 4.141667 0 Td 54.822531 Tz (MeseclaZone: ) Tj 51.428571 0 0 51.428571 0 214.635603 Tm 25.2 0 Td 54.372428 Tz (Methylprednisolone ) Tj 6.241667 0 Td 49.421296 Tz (Suleptanate; ) Tj 3.966667 0 Td 53.347578 Tz (Morniflumate; ) Tj 4.569444 0 Td 74.537037 Tz (Nabume ) Tj 51.428571 0 0 51.428571 0 172.447724 Tm 25.180556 0 Td 47.962963 Tz (tone; ) Tj 1.788889 0 Td 55.812757 Tz (Naproxen; ) Tj 3.363889 0 Td 59.143519 Tz (Naproxen ) Tj 3.15 0 Td 57.87037 Tz (Sodium; ) Tj 2.741667 0 Td 54.372428 Tz (Naproxol; ) Tj 3.266667 0 Td 58.333333 Tz (Nimazone: ) Tj ET Q endstream endobj 131 0 obj << /Length 1 >> stream q endstream endobj 132 0 obj << /Length 47886 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.151351 0 Td 72.522523 Tz (13 ) Tj 51.428571 0 0 51.428571 0 2918.304762 Tm 6.261111 0 Td 51.203704 Tz (Olsalazine ) Tj 3.286111 0 Td 57.87037 Tz (Sodium; ) Tj 2.663889 0 Td 51.131687 Tz (Orgotein; ) Tj 3.013889 0 Td 54.768519 Tz (Orpanoxin: ) Tj 3.5 0 Td 54.444444 Tz (Oxaprozin: ) Tj 3.480556 0 Td 84.259259 Tz (Oxy ) Tj 51.428571 0 0 51.428571 0 2878.75846 Tm 6.261111 0 Td 54.095442 Tz (phenbutazone: ) Tj 4.433333 0 Td 51.527778 Tz (Paranyline ) Tj 3.247222 0 Td 52.314815 Tz (Hydrochloride; ) Tj 4.608333 0 Td 53.877315 Tz (Pentosan ) Tj 2.8 0 Td 56.481481 Tz (Polysul ) Tj 51.428571 0 0 51.428571 0 2831.461447 Tm 6.261111 0 Td 46.180556 Tz (fate ) Tj 1.302778 0 Td 57.407407 Tz (Sodium; ) Tj 2.644444 0 Td 56.712963 Tz (Phenbutazone ) Tj 4.258333 0 Td 62.114198 Tz (Sodium ) Tj 2.45 0 Td 49.907407 Tz (Glycerate; ) Tj 3.227778 0 Td 49.421296 Tz (Pirfenidone: ) Tj 48.571429 0 0 48.571429 0 2790 Tm 6.65 0 Td 55.588235 Tz (Piroxicam, ) Tj 3.623529 0 Td 57.95207 Tz (Piroxicam ) Tj 3.376471 0 Td 59.019608 Tz (Cinnamate; ) Tj 3.829412 0 Td 57.95207 Tz (Piroxicam ) Tj 3.376471 0 Td 59.620098 Tz (Olamine; ) Tj 3.129412 0 Td 62.908497 Tz (Pir ) Tj 51.428571 0 0 51.428571 0 2749.869779 Tm 6.261111 0 Td 49.537037 Tz (profen; ) Tj 2.430556 0 Td 50.378788 Tz (Prednazate; ) Tj 3.655556 0 Td 46.990741 Tz (Prifelone; ) Tj 3.15 0 Td 50.636574 Tz (Prodolic ) Tj 2.702778 0 Td 52.5 Tz (Acid; ) Tj 1.905556 0 Td 54.503367 Tz (ProquaZone: ) Tj 48.571429 0 0 48.571429 0 2707 Tm 6.65 0 Td 54.215686 Tz (Proxazole; ) Tj 3.520588 0 Td 56.808279 Tz (Proxazole ) Tj 3.294118 0 Td 47.610294 Tz (Citrate; ) Tj 2.594118 0 Td 59.269162 Tz (Rimexolone; ) Tj 4.241176 0 Td 55.245098 Tz (Romazarit; ) Tj 3.602941 0 Td 67.48366 Tz (Sal ) Tj 51.428571 0 0 51.428571 0 2665.974026 Tm 6.261111 0 Td 48.611111 Tz (colex; ) Tj 1.963889 0 Td 50.968013 Tz (Salnacedin; ) Tj 3.558333 0 Td 46.018519 Tz (Salsalate: ) Tj 2.955556 0 Td 56.442901 Tz (Sanguinarium ) Tj 4.258333 0 Td 50.411523 Tz (Chloride: ) Tj 2.916667 0 Td 60.277778 Tz (Secla ) Tj 51.428571 0 0 51.428571 0 2623.361502 Tm 6.261111 0 Td 51.851852 Tz (Zone: ) Tj 1.730556 0 Td 52.146465 Tz (Sermetacin; ) Tj 3.616667 0 Td 57.685185 Tz (Sudoxicam; ) Tj 3.636111 0 Td 50.411523 Tz (Sulindac: ) Tj 2.916667 0 Td 52.211934 Tz (Suprofen; ) Tj 2.994444 0 Td 61.111111 Tz (Talmeta ) Tj 51.428571 0 0 51.428571 0 2583.374255 Tm 6.261111 0 Td 44.560185 Tz (cin; ) Tj 1.302778 0 Td 49.109687 Tz (Talniflumate; ) Tj 4.044444 0 Td 47.727273 Tz (Talosalate: ) Tj 3.383333 0 Td 51.851852 Tz (Tebufelone; ) Tj 3.655556 0 Td 52.256944 Tz (Tenidap: ) Tj 2.741667 0 Td 55.555556 Tz (Tenidap ) Tj 51.428571 0 0 51.428571 0 2541.043646 Tm 6.280556 0 Td 57.87037 Tz (Sodium; ) Tj 2.994444 0 Td 56.712963 Tz (Tenoxicam; ) Tj 3.986111 0 Td 54.6875 Tz (Tesicam; ) Tj 3.188889 0 Td 52.211934 Tz (Tesimide; ) Tj 3.383333 0 Td 53.742284 Tz (Tetrydamine: ) Tj 51.428571 0 0 51.428571 0 2498.357401 Tm 6.261111 0 Td 50.771605 Tz (Tiopinac; ) Tj 2.975 0 Td 51.203704 Tz (Tixocortol ) Tj 3.344444 0 Td 46.090535 Tz (Pivalate: ) Tj 2.761111 0 Td 46.666667 Tz (Tolimetin: ) Tj 3.033333 0 Td 48.611111 Tz (Tolimetin ) Tj 2.897222 0 Td 57.87037 Tz (Sodium; ) Tj 51.428571 0 0 51.428571 0 2457.666235 Tm 6.261111 0 Td 48.316498 Tz (Triclonide; ) Tj 3.772222 0 Td 48.860399 Tz (Triflumidate: ) Tj 4.433333 0 Td 53.472222 Tz (Zidometacin; ) Tj 4.472222 0 Td 58.333333 Tz (and ) Tj 1.652778 0 Td 57.973251 Tz (Zomepirac ) Tj 40 0 0 40 0 2422 Tm 8.075 0 Td 73.809524 Tz (Sodium. ) Tj 51.428571 0 0 51.428571 0 2378.345455 Tm 6.280556 0 Td 52.256944 Tz (Delivery ) Tj 2.761111 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 56.17284 Tz (Agents ) Tj 2.313889 0 Td 54.012346 Tz (Via ) Tj 1.225 0 Td 53.472222 Tz (Chitosan ) Tj 2.819444 0 Td 56.17284 Tz (Compositions ) Tj 51.428571 0 0 51.428571 0 2335.14734 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.477778 0 Td 50.411523 Tz (invention ) Tj 3.091667 0 Td 51.851852 Tz (provides ) Tj 2.838889 0 Td 51.851852 Tz (a ) Tj 0.680556 0 Td 54.012346 Tz (simple ) Tj 2.313889 0 Td 60.925926 Tz (means ) Tj 2.177778 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 49.259259 Tz (delivering ) Tj 51.428571 0 0 51.428571 0 2295.237267 Tm 6.241667 0 Td 48.341049 Tz (biologically ) Tj 3.772222 0 Td 48.611111 Tz (active ) Tj 2.022222 0 Td 51.311728 Tz (agents ) Tj 2.177778 0 Td 39.969136 Tz (\(e.g., ) Tj 1.730556 0 Td 52.5 Tz (Small ) Tj 1.886111 0 Td 58.009259 Tz (compounds, ) Tj 3.811111 0 Td 49.537037 Tz (nucleic ) Tj 51.428571 0 0 51.428571 0 2252.557807 Tm 6.261111 0 Td 51.041667 Tz (acid ) Tj 1.419444 0 Td 51.527778 Tz (molecules, ) Tj 3.266667 0 Td 50.854701 Tz (polypeptides\) ) Tj 4.141667 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 51.851852 Tz (composition. ) Tj 51.428571 0 0 51.428571 0 2208.987212 Tm 6.261111 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 50.636574 Tz (chitosan ) Tj 2.683333 0 Td 54.503367 Tz (composition ) Tj 3.85 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 49.691358 Tz (delivered ) Tj 2.975 0 Td 43.75 Tz (to ) Tj 0.797222 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 49.537037 Tz (subject ) Tj 2.313889 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2169.448878 Tm 6.241667 0 Td 48.341049 Tz (biologically ) Tj 3.733333 0 Td 48.611111 Tz (active ) Tj 1.963889 0 Td 53.796296 Tz (agent ) Tj 1.847222 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 49.691358 Tz (eluted ) Tj 2.041667 0 Td 58.333333 Tz (from ) Tj 1.633333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 2127.673575 Tm 6.280556 0 Td 40.185185 Tz (situ. ) Tj 1.497222 0 Td 64.814815 Tz (The ) Tj 1.477778 0 Td 49.826389 Tz (chitosan ) Tj 2.722222 0 Td 54.208754 Tz (composition ) Tj 3.908333 0 Td 40.509259 Tz (is ) Tj 0.797222 0 Td 53.240741 Tz (capable ) Tj 2.566667 0 Td 55.092593 Tz (of ) Tj 0.894444 0 Td 49.259259 Tz (delivering ) Tj 3.266667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2083.725289 Tm 6.241667 0 Td 49.494949 Tz (therapeutic ) Tj 3.558333 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 51.131687 Tz (treatment ) Tj 3.013889 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 50.462963 Tz (disease ) Tj 2.372222 0 Td 55.092593 Tz (or ) Tj 0.933333 0 Td 50.231481 Tz (disorder ) Tj 2.663889 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 2042.958383 Tm 6.261111 0 Td 48.611111 Tz (requires ) Tj 2.508333 0 Td 49.259259 Tz (controlled ) Tj 3.111111 0 Td 52.391975 Tz (and/or ) Tj 2.041667 0 Td 48.251029 Tz (localized ) Tj 2.780556 0 Td 55.092593 Tz (drug ) Tj 1.477778 0 Td 49.826389 Tz (delivery ) Tj 2.566667 0 Td 54.282407 Tz (over ) Tj 1.438889 0 Td 64.814815 Tz (some ) Tj 51.428571 0 0 51.428571 0 2001.825532 Tm 6.261111 0 Td 51.851852 Tz (period ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 54.282407 Tz (time ) Tj 1.555556 0 Td 40.509259 Tz (\(e.g., ) Tj 1.75 0 Td 40.509259 Tz (1, ) Tj 0.719444 0 Td 45.37037 Tz (3, ) Tj 0.797222 0 Td 45.37037 Tz (5, ) Tj 0.777778 0 Td 58.333333 Tz (7 ) Tj 0.602778 0 Td 50.555556 Tz (days; ) Tj 1.788889 0 Td 43.75 Tz (2, ) Tj 0.758333 0 Td 46.990741 Tz (3, ) Tj 0.797222 0 Td 61.574074 Tz (4 ) Tj 0.602778 0 Td 55.092593 Tz (weeks; ) Tj 2.313889 0 Td 40.509259 Tz (1, ) Tj 0.738889 0 Td 42.12963 Tz (2, ) Tj 0.777778 0 Td 43.75 Tz (3, ) Tj 51.428571 0 0 51.428571 0 1960.46875 Tm 6.280556 0 Td 43.75 Tz (6, ) Tj 0.913889 0 Td 53.472222 Tz (12 ) Tj 1.030556 0 Td 51.851852 Tz (months\). ) Tj 2.877778 0 Td 48.287037 Tz (Desirably, ) Tj 3.227778 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 49.826389 Tz (chitosan ) Tj 2.722222 0 Td 54.208754 Tz (composition ) Tj 3.908333 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 1916.622166 Tm 6.261111 0 Td 47.530864 Tz (prises ) Tj 1.944444 0 Td 55.092593 Tz (an ) Tj 0.894444 0 Td 47.170782 Tz (effective ) Tj 2.761111 0 Td 61.033951 Tz (amount ) Tj 2.411111 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 58.333333 Tz (one ) Tj 1.283333 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 61.574074 Tz (more ) Tj 1.691667 0 Td 45.959596 Tz (antibiotics ) Tj 3.305556 0 Td 39.429012 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1878.962406 Tm 6.261111 0 Td 52.572016 Tz (amikacin, ) Tj 3.247222 0 Td 54.503367 Tz (daptomycin, ) Tj 3.966667 0 Td 55.362654 Tz (Vancomycin\), ) Tj 4.375 0 Td 56.712963 Tz (growth ) Tj 2.45 0 Td 46.296296 Tz (factors ) Tj 2.333333 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 1835.230404 Tm 6.261111 0 Td 57.87037 Tz (promote ) Tj 2.625 0 Td 64.814815 Tz (wound ) Tj 2.119444 0 Td 48.206019 Tz (healing, ) Tj 2.488889 0 Td 52.5 Tz (Small ) Tj 1.788889 0 Td 51.527778 Tz (molecules, ) Tj 3.247222 0 Td 52.5 Tz (hemostatic ) Tj 3.325 0 Td 51.851852 Tz (agents ) Tj 51.428571 0 0 51.428571 0 1794.211896 Tm 6.280556 0 Td 39.969136 Tz (\(e.g., ) Tj 1.788889 0 Td 55.902778 Tz (thrombin ) Tj 3.033333 0 Td 52.932099 Tz (and/or ) Tj 2.216667 0 Td 47.260802 Tz (fibrinogen\), ) Tj 3.772222 0 Td 50.028935 Tz (anti-thrombotics ) Tj 5.152778 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1753.684685 Tm 6.241667 0 Td 48.611111 Tz (heparin\), ) Tj 2.955556 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 46.450617 Tz (cartilage ) Tj 2.819444 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 59.953704 Tz (bone ) Tj 1.769444 0 Td 46.990741 Tz (repair ) Tj 1.963889 0 Td 48.148148 Tz (agents. ) Tj 2.333333 0 Td 63.734568 Tz (The ) Tj 1.477778 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1711.031477 Tm 6.261111 0 Td 54.208754 Tz (composition ) Tj 3.772222 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 52.391975 Tz (administered ) Tj 3.947222 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 57.523148 Tz (form ) Tj 1.575 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 43.981481 Tz (solids, ) Tj 2.022222 0 Td 52.256944 Tz (sponges, ) Tj 51.428571 0 0 51.428571 0 1672.41769 Tm 6.261111 0 Td 45.37037 Tz (films, ) Tj 1.808333 0 Td 51.203704 Tz (hydrogels, ) Tj 3.286111 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 53.796296 Tz (composites ) Tj 3.441667 0 Td 40.509259 Tz (\(e.g., ) Tj 1.691667 0 Td 56.712963 Tz (sponge ) Tj 2.236111 0 Td 53.652263 Tz (fragments ) Tj 3.130556 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 52.857143 0 0 52.857143 0 1627.273092 Tm 6.072973 0 Td 52.421171 Tz (hydrogel ) Tj 2.818919 0 Td 45.720721 Tz (matrix\). ) Tj 51.428571 0 0 51.428571 0 1587.203679 Tm 7.019444 0 Td 47.43266 Tz (Preferably, ) Tj 3.441667 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 50.231481 Tz (chitosan ) Tj 2.741667 0 Td 54.208754 Tz (composition ) Tj 3.908333 0 Td 54.012346 Tz (comprises ) Tj 3.247222 0 Td 43.75 Tz (at ) Tj 0.836111 0 Td 44.722222 Tz (least ) Tj 51.428571 0 0 51.428571 0 1543.533813 Tm 6.261111 0 Td 54.444444 Tz (about ) Tj 1.925 0 Td 32.407407 Tz (1 ) Tj 0.563889 0 Td 35.648148 Tz (lug. ) Tj 1.108333 0 Td 59.953704 Tz (25 ) Tj 1.011111 0 Td 47.530864 Tz (ug, ) Tj 1.088889 0 Td 63.194444 Tz (50 ) Tj 0.991667 0 Td 36.458333 Tz (Lig, ) Tj 1.205556 0 Td 56.17284 Tz (100 ) Tj 1.283333 0 Td 46.450617 Tz (ug. ) Tj 1.127778 0 Td 59.41358 Tz (250 ) Tj 1.361111 0 Td 46.450617 Tz (ug, ) Tj 1.088889 0 Td 60.493827 Tz (500 ) Tj 1.361111 0 Td 48.611111 Tz (ug, ) Tj 1.127778 0 Td 59.41358 Tz (750 ) Tj 1.361111 0 Td 46.450617 Tz (ug, ) Tj 50 0 0 50 0 1503.271845 Tm 6.5 0 Td 36.666667 Tz (1 ) Tj 0.52 0 Td 62.222222 Tz (mg, ) Tj 1.32 0 Td 60 Tz (5 ) Tj 0.58 0 Td 62.222222 Tz (mg, ) Tj 1.4 0 Td 55 Tz (10 ) Tj 0.88 0 Td 60 Tz (mg, ) Tj 1.32 0 Td 60 Tz (25 ) Tj 0.94 0 Td 62.222222 Tz (mg, ) Tj 1.3 0 Td 63.333333 Tz (50 ) Tj 0.98 0 Td 61.111111 Tz (mg, ) Tj 1.32 0 Td 58.333333 Tz (75 ) Tj 0.94 0 Td 61.111111 Tz (mg, ) Tj 1.36 0 Td 60 Tz (100 ) Tj 1.3 0 Td 60 Tz (mg, ) Tj 1.3 0 Td 62.222222 Tz (200 ) Tj 1.34 0 Td 60 Tz (mg. ) Tj 51.428571 0 0 51.428571 0 1461.005457 Tm 6.261111 0 Td 61.574074 Tz (250 ) Tj 1.380556 0 Td 59.41358 Tz (mg, ) Tj 1.322222 0 Td 60.493827 Tz (300 ) Tj 1.361111 0 Td 58.333333 Tz (mg, ) Tj 1.322222 0 Td 61.574074 Tz (400 ) Tj 1.361111 0 Td 59.41358 Tz (mg. ) Tj 1.341667 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 59.41358 Tz (500 ) Tj 1.341667 0 Td 76.157407 Tz (mg ) Tj 1.147222 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 56.712963 Tz (an ) Tj 0.952778 0 Td 52.5 Tz (agent ) Tj 1.827778 0 Td 40.509259 Tz (\(e.g., ) Tj 1.691667 0 Td 59.953704 Tz (an ) Tj 51.428571 0 0 51.428571 0 1416.737089 Tm 6.261111 0 Td 43.75 Tz (antibiotic\). ) Tj 3.344444 0 Td 46.990741 Tz (In ) Tj 0.719444 0 Td 53.240741 Tz (another ) Tj 2.352778 0 Td 57.744108 Tz (embodiment, ) Tj 3.947222 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 54.503367 Tz (composition ) Tj 3.752778 0 Td 47.800926 Tz (releases ) Tj 51.428571 0 0 51.428571 0 1376.837333 Tm 6.261111 0 Td 45.37037 Tz (at ) Tj 0.680556 0 Td 44.722222 Tz (least ) Tj 1.497222 0 Td 55.092593 Tz (about ) Tj 1.847222 0 Td 32.407407 Tz (1 ) Tj 0.466667 0 Td 36.458333 Tz (Jug, ) Tj 1.069444 0 Td 56.712963 Tz (25 ) Tj 0.894444 0 Td 46.450617 Tz (ug. ) Tj 1.05 0 Td 59.953704 Tz (50 ) Tj 0.913889 0 Td 47.530864 Tz (ug, ) Tj 1.088889 0 Td 57.253086 Tz (100 ) Tj 1.205556 0 Td 48.611111 Tz (ug, ) Tj 1.030556 0 Td 60.493827 Tz (250 ) Tj 1.283333 0 Td 48.611111 Tz (ug, ) Tj 1.030556 0 Td 60.493827 Tz (500 ) Tj 1.302778 0 Td 47.530864 Tz (ug, ) Tj 1.030556 0 Td 59.41358 Tz (750 ) Tj 50 0 0 50 0 1336.235543 Tm 6.5 0 Td 47.777778 Tz (ug, ) Tj 1.16 0 Td 33.333333 Tz (1 ) Tj 0.54 0 Td 61.111111 Tz (mg, ) Tj 1.32 0 Td 56.666667 Tz (5 ) Tj 0.58 0 Td 62.222222 Tz (mg, ) Tj 1.38 0 Td 58.333333 Tz (10 ) Tj 0.94 0 Td 61.111111 Tz (mg, ) Tj 1.3 0 Td 61.666667 Tz (25 ) Tj 0.98 0 Td 61.111111 Tz (mg, ) Tj 1.34 0 Td 61.666667 Tz (50 ) Tj 0.96 0 Td 61.111111 Tz (mg, ) Tj 1.34 0 Td 58.333333 Tz (75 ) Tj 0.94 0 Td 62.222222 Tz (mg, ) Tj 1.38 0 Td 60 Tz (100 ) Tj 1.3 0 Td 60 Tz (mg, ) Tj 1.34 0 Td 61.111111 Tz (200 ) Tj 51.428571 0 0 51.428571 0 1295.510638 Tm 6.261111 0 Td 61.574074 Tz (mg, ) Tj 1.341667 0 Td 60.493827 Tz (250 ) Tj 1.322222 0 Td 59.41358 Tz (mg, ) Tj 1.283333 0 Td 61.574074 Tz (300 ) Tj 1.361111 0 Td 58.333333 Tz (mg, ) Tj 1.283333 0 Td 60.493827 Tz (400 ) Tj 1.341667 0 Td 59.41358 Tz (mg, ) Tj 1.302778 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 59.41358 Tz (500 ) Tj 1.322222 0 Td 74.537037 Tz (mg ) Tj 1.108333 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 58.333333 Tz (an ) Tj 0.913889 0 Td 53.148148 Tz (agent ) Tj 1.788889 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1249 Tm 6.261111 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 45.664983 Tz (antibiotic\) ) Tj 3.208333 0 Td 55.902778 Tz (over ) Tj 1.536111 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 52.932099 Tz (course ) Tj 2.1 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 45.37037 Tz (at ) Tj 0.758333 0 Td 45.37037 Tz (least ) Tj 1.536111 0 Td 54.444444 Tz (about ) Tj 1.905556 0 Td 40.509259 Tz (1, ) Tj 0.738889 0 Td 42.12963 Tz (2, ) Tj 0.738889 0 Td 43.75 Tz (3, ) Tj 0.797222 0 Td 42.12963 Tz (4, ) Tj 0.738889 0 Td 43.75 Tz (5, ) Tj 51.428571 0 0 51.428571 0 1208.974684 Tm 6.280556 0 Td 43.75 Tz (6, ) Tj 0.913889 0 Td 43.75 Tz (7, ) Tj 0.913889 0 Td 45.37037 Tz (8, ) Tj 0.933333 0 Td 43.75 Tz (9, ) Tj 0.972222 0 Td 46.450617 Tz (10, ) Tj 1.283333 0 Td 47.530864 Tz (14, ) Tj 1.244444 0 Td 49.691358 Tz (21, ) Tj 1.283333 0 Td 49.691358 Tz (28, ) Tj 1.263889 0 Td 55.092593 Tz (or ) Tj 0.972222 0 Td 59.953704 Tz (35 ) Tj 1.127778 0 Td 49.907407 Tz (days. ) Tj 1.944444 0 Td 43.75 Tz (In ) Tj 0.952778 0 Td 35.648148 Tz (still ) Tj 1.458333 0 Td 52.777778 Tz (another ) Tj 51.428571 0 0 51.428571 0 1169.748459 Tm 6.261111 0 Td 57.449495 Tz (embodiment, ) Tj 4.005556 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 53.914141 Tz (composition ) Tj 3.752778 0 Td 54.73251 Tz (comprises ) Tj 3.130556 0 Td 45.37037 Tz (at ) Tj 0.738889 0 Td 44.074074 Tz (least ) Tj 1.497222 0 Td 54.444444 Tz (about ) Tj 1.866667 0 Td 32.407407 Tz (1 ) Tj 0.486111 0 Td 36.458333 Tz (Jug, ) Tj 50 0 0 50 0 1127.758321 Tm 6.44 0 Td 61.666667 Tz (25 ) Tj 1.02 0 Td 48.888889 Tz (ug, ) Tj 1.1 0 Td 63.333333 Tz (50 ) Tj 1.02 0 Td 47.777778 Tz (ug. ) Tj 1.2 0 Td 57.777778 Tz (100 ) Tj 1.3 0 Td 47.777778 Tz (ug. ) Tj 1.14 0 Td 61.111111 Tz (250 ) Tj 1.38 0 Td 47.777778 Tz (ug, ) Tj 1.12 0 Td 61.111111 Tz (500 ) Tj 1.38 0 Td 48.888889 Tz (ug, ) Tj 1.1 0 Td 62.222222 Tz (750 ) Tj 1.38 0 Td 50 Tz (ug, ) Tj 1.2 0 Td 33.333333 Tz (1 ) Tj 0.56 0 Td 61.111111 Tz (mg, ) Tj 1.34 0 Td 56.666667 Tz (5 ) Tj 0.62 0 Td 60 Tz (mg. ) Tj 50 0 0 50 0 1086.579017 Tm 6.52 0 Td 58.333333 Tz (10 ) Tj 0.88 0 Td 61.111111 Tz (mg, ) Tj 1.3 0 Td 60 Tz (25 ) Tj 0.96 0 Td 60 Tz (mg, ) Tj 1.3 0 Td 61.666667 Tz (50 ) Tj 0.94 0 Td 61.111111 Tz (mg, ) Tj 1.3 0 Td 58.333333 Tz (75 ) Tj 0.92 0 Td 62.222222 Tz (mg, ) Tj 1.38 0 Td 60 Tz (100 ) Tj 1.24 0 Td 62.222222 Tz (mg, ) Tj 1.3 0 Td 64.444444 Tz (200 ) Tj 1.34 0 Td 61.111111 Tz (mg, ) Tj 1.3 0 Td 62.222222 Tz (250 ) Tj 1.32 0 Td 60 Tz (mg. ) Tj 1.26 0 Td 63.333333 Tz (300 ) Tj 51.428571 0 0 51.428571 0 1044.807542 Tm 6.261111 0 Td 61.574074 Tz (mg, ) Tj 1.322222 0 Td 61.574074 Tz (400 ) Tj 1.341667 0 Td 58.333333 Tz (mg. ) Tj 1.322222 0 Td 48.611111 Tz (or ) Tj 0.816667 0 Td 59.41358 Tz (500 ) Tj 1.322222 0 Td 74.537037 Tz (mg ) Tj 1.108333 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 58.333333 Tz (an ) Tj 0.913889 0 Td 53.148148 Tz (agent ) Tj 1.788889 0 Td 41.049383 Tz (\(e.g., ) Tj 1.691667 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 45.37037 Tz (antibiotic\) ) Tj 3.188889 0 Td 55.092593 Tz (per ) Tj 45.714286 0 0 45.714286 0 1008 Tm 7.04375 0 Td 82.638889 Tz (cm. ) Tj 51.428571 0 0 51.428571 0 962.015094 Tm 6.261111 0 Td 53.472222 Tz (Chitosan ) Tj 2.819444 0 Td 53.877315 Tz (Coatings ) Tj 51.428571 0 0 51.428571 0 920.977778 Tm 7 0 Td 87.5 Tz (A ) Tj 0.836111 0 Td 49.826389 Tz (chitosan ) Tj 2.761111 0 Td 54.208754 Tz (composition ) Tj 3.947222 0 Td 68.055556 Tz (may ) Tj 1.555556 0 Td 59.953704 Tz (be ) Tj 1.05 0 Td 52.662037 Tz (included ) Tj 2.858333 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 51.388889 Tz (coating ) Tj 51.428571 0 0 51.428571 0 875.746532 Tm 6.261111 0 Td 47.170782 Tz (material. ) Tj 2.741667 0 Td 53.472222 Tz (Such ) Tj 1.458333 0 Td 48.611111 Tz (as ) Tj 0.719444 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 44.722222 Tz (film, ) Tj 1.497222 0 Td 46.180556 Tz (that ) Tj 1.263889 0 Td 37.268519 Tz (is ) Tj 0.602778 0 Td 55.902778 Tz (used ) Tj 1.477778 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 51.041667 Tz (coat ) Tj 1.380556 0 Td 48.611111 Tz (or ) Tj 0.719444 0 Td 59.953704 Tz (wrap ) Tj 1.613889 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 54.166667 Tz (medical ) Tj 51.428571 0 0 51.428571 0 835.700767 Tm 6.261111 0 Td 52.932099 Tz (device ) Tj 2.197222 0 Td 39.969136 Tz (\(e.g., ) Tj 1.730556 0 Td 55.902778 Tz (drug ) Tj 1.613889 0 Td 49.016204 Tz (delivery ) Tj 2.663889 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 51.203704 Tz (other ) Tj 1.808333 0 Td 53.703704 Tz (medical ) Tj 2.566667 0 Td 47.395833 Tz (device\). ) Tj 2.566667 0 Td 61.574074 Tz (Such ) Tj 51.428571 0 0 51.428571 0 797.390213 Tm 6.261111 0 Td 50.231481 Tz (coatings ) Tj 2.644444 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 49.259259 Tz (used, ) Tj 1.711111 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 55.497685 Tz (example, ) Tj 2.916667 0 Td 47.530864 Tz (for ) Tj 1.05 0 Td 46.585648 Tz (treating ) Tj 2.469444 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 52.175926 Tz (preventing ) Tj 3.363889 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 755.46755 Tm 6.261111 0 Td 55.497685 Tz (pathogen ) Tj 3.052778 0 Td 47.530864 Tz (infection ) Tj 2.994444 0 Td 51.851852 Tz (or ) Tj 0.972222 0 Td 49.691358 Tz (for ) Tj 1.244444 0 Td 55.902778 Tz (drug ) Tj 1.75 0 Td 45.730453 Tz (delivery. ) Tj 2.916667 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 49.421296 Tz (orthopedics, ) Tj 51.428571 0 0 51.428571 0 712.880299 Tm 6.261111 0 Td 67.24537 Tz (many ) Tj 1.925 0 Td 47.863248 Tz (post-Surgical ) Tj 4.044444 0 Td 47.638889 Tz (infections ) Tj 3.169444 0 Td 50.771605 Tz (are ) Tj 1.205556 0 Td 49.907407 Tz (associated ) Tj 3.325 0 Td 52.662037 Tz (with ) Tj 1.594444 0 Td 52.777778 Tz (implant ) Tj 51.428571 0 0 51.428571 0 671.105769 Tm 6.261111 0 Td 46.990741 Tz (materials. ) Tj 3.052778 0 Td 47.395833 Tz (Patients ) Tj 2.469444 0 Td 50.05144 Tz (receiving ) Tj 2.877778 0 Td 55.092593 Tz (an ) Tj 0.875 0 Td 51.527778 Tz (orthopedic ) Tj 3.266667 0 Td 52.256944 Tz (implants ) Tj 2.683333 0 Td 57.523148 Tz (have ) Tj 1.536111 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 628.971736 Tm 6.261111 0 Td 47.530864 Tz (infection ) Tj 2.994444 0 Td 45.37037 Tz (risk ) Tj 1.458333 0 Td 59.953704 Tz (of ) Tj 0.991667 0 Td 54.444444 Tz (about ) Tj 2.022222 0 Td 77.777778 Tz (5% ) Tj 1.341667 0 Td 48.611111 Tz (for ) Tj 1.244444 0 Td 42.12963 Tz (total ) Tj 1.613889 0 Td 47.314815 Tz (joint ) Tj 1.827778 0 Td 50.605413 Tz (replacements. ) Tj 51.428571 0 0 51.428571 0 585.322314 Tm 6.280556 0 Td 49.826389 Tz (Bacteria ) Tj 2.566667 0 Td 49.691358 Tz (are ) Tj 1.011111 0 Td 50.411523 Tz (passively ) Tj 2.858333 0 Td 55.092593 Tz (adsorbed ) Tj 2.8 0 Td 59.953704 Tz (on ) Tj 0.855556 0 Td 50.378788 Tz (biomaterial ) Tj 3.480556 0 Td 49.826389 Tz (surfaces ) Tj 2.527778 0 Td 46.018519 Tz (after ) Tj 51.428571 0 0 51.428571 0 545.597516 Tm 6.261111 0 Td 49.109687 Tz (implantation. ) Tj 4.180556 0 Td 64.814815 Tz (The ) Tj 1.516667 0 Td 54.503367 Tz (fundamental ) Tj 3.966667 0 Td 53.472222 Tz (pathogenic ) Tj 3.597222 0 Td 60.493827 Tz (mechanism ) Tj 3.655556 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 501.854742 Tm 6.241667 0 Td 50.393519 Tz (biomaterial-centered ) Tj 6.261111 0 Td 48.070988 Tz (sepsis ) Tj 1.983333 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 51.131687 Tz (microbial ) Tj 2.994444 0 Td 49.691358 Tz (colonization ) Tj 3.811111 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 461.827995 Tm 6.241667 0 Td 50.231481 Tz (biomaterials ) Tj 3.811111 0 Td 53.877315 Tz (followed ) Tj 2.741667 0 Td 59.953704 Tz (by ) Tj 0.913889 0 Td 51.041667 Tz (adjacent ) Tj 2.625 0 Td 62.5 Tz (damaged ) Tj 2.761111 0 Td 44.155093 Tz (tissues. ) Tj 2.352778 0 Td 47.395833 Tz (Patients ) Tj 51.428571 0 0 51.428571 0 419.072165 Tm 6.241667 0 Td 46.990741 Tz (that ) Tj 1.4 0 Td 46.450617 Tz (suffer ) Tj 1.944444 0 Td 57.523148 Tz (from ) Tj 1.691667 0 Td 55.092593 Tz (such ) Tj 1.633333 0 Td 47.314815 Tz (infections ) Tj 3.111111 0 Td 49.907407 Tz (often ) Tj 1.847222 0 Td 48.148148 Tz (require ) Tj 2.294444 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 56.018519 Tz (removal ) Tj 51.428571 0 0 51.428571 0 379.03939 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 54.208754 Tz (replacement ) Tj 3.811111 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 51.851852 Tz (the ) Tj 1.166667 0 Td 53.240741 Tz (implant ) Tj 2.45 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 48.611111 Tz (eradicate ) Tj 2.877778 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 45.694444 Tz (infection. ) Tj 51.428571 0 0 51.428571 0 339.402235 Tm 7 0 Td 61.574074 Tz (To ) Tj 1.147222 0 Td 43.425926 Tz (treat ) Tj 1.711111 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 52.777778 Tz (prevent ) Tj 2.586111 0 Td 58.333333 Tz (an ) Tj 1.108333 0 Td 50.411523 Tz (implant-associated ) Tj 5.891667 0 Td 47.170782 Tz (infection ) Tj 2.975 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 296.182796 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.819444 0 Td 54.208754 Tz (composition ) Tj 3.986111 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 50.771605 Tz (invention ) Tj 3.130556 0 Td 40.509259 Tz (is ) Tj 0.855556 0 Td 51.851852 Tz (applied ) Tj 2.547222 0 Td 46.990741 Tz (to ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 255.005031 Tm 6.261111 0 Td 54.62963 Tz (medical ) Tj 2.663889 0 Td 52.391975 Tz (device ) Tj 2.197222 0 Td 41.049383 Tz (\(e.g., ) Tj 1.808333 0 Td 48.611111 Tz (implant\). ) Tj 2.955556 0 Td 64.814815 Tz (The ) Tj 1.497222 0 Td 49.421296 Tz (chitosan ) Tj 2.741667 0 Td 55.092593 Tz (composition ) Tj 51.428571 0 0 51.428571 0 215.641154 Tm 6.261111 0 Td 51.446759 Tz (provides ) Tj 2.780556 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 48.148148 Tz (release ) Tj 2.275 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 48.905724 Tz (therapeutic ) Tj 3.519444 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 50.231481 Tz (prophylactic ) Tj 3.888889 0 Td 53.796296 Tz (agent ) Tj 51.428571 0 0 51.428571 0 171.178744 Tm 6.261111 0 Td 58.333333 Tz (from ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 48.148148 Tz (device. ) Tj 2.216667 0 Td 59.953704 Tz (Such ) Tj 1.594444 0 Td 51.851852 Tz (agents ) Tj 2.041667 0 Td 53.935185 Tz (advantageously ) Tj 4.725 0 Td 53.472222 Tz (reduce ) Tj 2.080556 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 46.180556 Tz (risk ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.502778 0 Td 74.537037 Tz (14 ) Tj 51.428571 0 0 51.428571 0 2914.363636 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 47.530864 Tz (infection ) Tj 2.916667 0 Td 50.231481 Tz (associated ) Tj 3.363889 0 Td 52.662037 Tz (with ) Tj 1.633333 0 Td 52.121914 Tz (conventional ) Tj 4.122222 0 Td 48.611111 Tz (implants. ) Tj 3.013889 0 Td 61.574074 Tz (Such ) Tj 51.428571 0 0 51.428571 0 2874.914573 Tm 25.2 0 Td 50.231481 Tz (coatings ) Tj 2.644444 0 Td 54.012346 Tz (can ) Tj 1.166667 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 51.388889 Tz (applied ) Tj 2.333333 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 59.41358 Tz (any ) Tj 1.283333 0 Td 54.166667 Tz (medical ) Tj 2.508333 0 Td 52.391975 Tz (device ) Tj 2.041667 0 Td 66.759259 Tz (known ) Tj 2.216667 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2833.760098 Tm 25.2 0 Td 38.078704 Tz (art, ) Tj 1.127778 0 Td 48.611111 Tz (including, ) Tj 3.052778 0 Td 54.012346 Tz (but ) Tj 1.166667 0 Td 49.691358 Tz (not ) Tj 1.069444 0 Td 48.611111 Tz (limited ) Tj 2.177778 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 51.527778 Tz (orthopedic ) Tj 3.305556 0 Td 50.925926 Tz (devices ) Tj 2.333333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.633333 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 2793.661061 Tm 25.161111 0 Td 46.018519 Tz (joint ) Tj 1.769444 0 Td 49.691358 Tz (implants, ) Tj 3.111111 0 Td 46.990741 Tz (fracture ) Tj 2.663889 0 Td 44.965278 Tz (repairs, ) Tj 2.566667 0 Td 48.070988 Tz (spinal ) Tj 2.138889 0 Td 49.691358 Tz (implants, ) Tj 3.091667 0 Td 50.925926 Tz (screws, ) Tj 51.428571 0 0 51.428571 0 2751.01956 Tm 25.2 0 Td 46.666667 Tz (rods, ) Tj 1.633333 0 Td 44.155093 Tz (plates\); ) Tj 2.372222 0 Td 46.990741 Tz (Surgical ) Tj 2.469444 0 Td 51.851852 Tz (devices ) Tj 2.391667 0 Td 40.509259 Tz (\(e.g., ) Tj 1.691667 0 Td 46.180556 Tz (Sutures, ) Tj 2.430556 0 Td 44.965278 Tz (Staples, ) Tj 2.352778 0 Td 58.873457 Tz (anasto ) Tj 51.428571 0 0 51.428571 0 2705.741117 Tm 25.2 0 Td 57.037037 Tz (mosis ) Tj 2.002778 0 Td 49.016204 Tz (devices, ) Tj 2.683333 0 Td 47.170782 Tz (vertebral ) Tj 2.858333 0 Td 46.450617 Tz (disks, ) Tj 1.983333 0 Td 59.143519 Tz (bone ) Tj 1.691667 0 Td 47.314815 Tz (pins, ) Tj 1.730556 0 Td 49.151235 Tz (Suture ) Tj 2.061111 0 Td 50.636574 Tz (anchors, ) Tj 51.428571 0 0 51.428571 0 2666.854321 Tm 25.180556 0 Td 52.5 Tz (hemostatic ) Tj 3.441667 0 Td 44.290123 Tz (barriers, ) Tj 2.702778 0 Td 52.777778 Tz (clamps, ) Tj 2.488889 0 Td 51.388889 Tz (screws, ) Tj 2.45 0 Td 44.444444 Tz (plates, ) Tj 2.158333 0 Td 42.669753 Tz (clips, ) Tj 1.847222 0 Td 50.636574 Tz (vascular ) Tj 51.428571 0 0 51.428571 0 2623.395702 Tm 25.2 0 Td 49.691358 Tz (implants, ) Tj 3.013889 0 Td 46.990741 Tz (tissue ) Tj 2.022222 0 Td 52.211934 Tz (adhesives ) Tj 3.169444 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 46.090535 Tz (sealants, ) Tj 2.838889 0 Td 45.910494 Tz (tissue ) Tj 2.022222 0 Td 45.075758 Tz (scaffolds\); ) Tj 51.428571 0 0 51.428571 0 2584.953271 Tm 25.180556 0 Td 66.759259 Tz (wound ) Tj 2.197222 0 Td 61.574074 Tz (management ) Tj 3.830556 0 Td 49.016204 Tz (devices; ) Tj 2.547222 0 Td 50.339506 Tz (drug-delivering ) Tj 4.686111 0 Td 50.636574 Tz (vascular ) Tj 2.586111 0 Td 45.37037 Tz (stents ) Tj 51.428571 0 0 51.428571 0 2542.507692 Tm 25.219444 0 Td 39.429012 Tz (\(e.g., ) Tj 1.808333 0 Td 58.333333 Tz (a ) Tj 0.7 0 Td 54.484954 Tz (balloon-expanded ) Tj 5.6 0 Td 43.344907 Tz (stents\); ) Tj 2.508333 0 Td 49.907407 Tz (other ) Tj 1.866667 0 Td 50.636574 Tz (vascular ) Tj 2.8 0 Td 51.388889 Tz (devices ) Tj 51.428571 0 0 51.428571 0 2498.678887 Tm 25.219444 0 Td 39.429012 Tz (\(e.g., ) Tj 1.730556 0 Td 43.055556 Tz (grafts, ) Tj 2.119444 0 Td 46.018519 Tz (catheters, ) Tj 3.091667 0 Td 47.685185 Tz (valves, ) Tj 2.294444 0 Td 40.185185 Tz (artificial ) Tj 2.702778 0 Td 45.37037 Tz (hearts, ) Tj 2.177778 0 Td 49.259259 Tz (heart ) Tj 1.75 0 Td 44.290123 Tz (assist ) Tj 51.428571 0 0 51.428571 0 2459.628758 Tm 25.2 0 Td 48.251029 Tz (devices\); ) Tj 3.266667 0 Td 52.146465 Tz (implantable ) Tj 4.083333 0 Td 43.209877 Tz (defibrillators; ) Tj 4.55 0 Td 54.444444 Tz (blood ) Tj 2.294444 0 Td 55.092593 Tz (oxygenator ) Tj 51.428571 0 0 51.428571 0 2415.730769 Tm 25.2 0 Td 51.851852 Tz (devices ) Tj 2.430556 0 Td 39.969136 Tz (\(e.g., ) Tj 1.652778 0 Td 49.074074 Tz (tubing, ) Tj 2.333333 0 Td 56.565657 Tz (membranes\); ) Tj 4.005556 0 Td 58.657407 Tz (membranes; ) Tj 3.772222 0 Td 49.200337 Tz (biosensors; ) Tj 51.428571 0 0 51.428571 0 2377.00507 Tm 25.219444 0 Td 50.771605 Tz (shunts ) Tj 2.255556 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 52.546296 Tz (hydrocephalus; ) Tj 4.841667 0 Td 54.444444 Tz (endoscopic ) Tj 3.694444 0 Td 49.016204 Tz (devices; ) Tj 2.8 0 Td 48.251029 Tz (infection ) Tj 51.428571 0 0 51.428571 0 2333.12 Tm 25.2 0 Td 49.074074 Tz (control ) Tj 2.313889 0 Td 49.016204 Tz (devices; ) Tj 2.625 0 Td 48.611111 Tz (dental ) Tj 2.022222 0 Td 51.851852 Tz (devices ) Tj 2.45 0 Td 40.509259 Tz (\(e.g., ) Tj 1.730556 0 Td 48.611111 Tz (dental ) Tj 2.022222 0 Td 49.331276 Tz (implants, ) Tj 2.955556 0 Td 55.902778 Tz (frac ) Tj 51.428571 0 0 51.428571 0 2295.049577 Tm 25.180556 0 Td 48.611111 Tz (ture ) Tj 1.361111 0 Td 47.530864 Tz (repair ) Tj 1.886111 0 Td 47.890947 Tz (devices\), ) Tj 2.780556 0 Td 48.935185 Tz (urological ) Tj 3.130556 0 Td 51.851852 Tz (devices ) Tj 2.372222 0 Td 39.969136 Tz (\(e.g., ) Tj 1.672222 0 Td 46.296296 Tz (penile, ) Tj 2.158333 0 Td 58.873457 Tz (sphinc ) Tj 51.428571 0 0 51.428571 0 2248 Tm 25.180556 0 Td 38.888889 Tz (ter, ) Tj 1.361111 0 Td 45.010288 Tz (urethral, ) Tj 2.858333 0 Td 52.777778 Tz (bladder ) Tj 2.625 0 Td 58.333333 Tz (and ) Tj 1.497222 0 Td 47.314815 Tz (renal ) Tj 1.866667 0 Td 48.611111 Tz (devices, ) Tj 2.761111 0 Td 59.41358 Tz (and ) Tj 1.477778 0 Td 45.664983 Tz (catheters\); ) Tj 51.428571 0 0 51.428571 0 2210.199525 Tm 25.2 0 Td 55.812757 Tz (colostomy ) Tj 3.208333 0 Td 58.333333 Tz (bag ) Tj 1.205556 0 Td 53.796296 Tz (attachment ) Tj 3.383333 0 Td 49.421296 Tz (devices; ) Tj 2.566667 0 Td 54.444444 Tz (ophthalmic ) Tj 3.441667 0 Td 51.851852 Tz (devices ) Tj 2.372222 0 Td 42.12963 Tz (\(e.g. ) Tj 51.428571 0 0 51.428571 0 2167.698795 Tm 25.2 0 Td 48.316498 Tz (intraocular ) Tj 3.402778 0 Td 47.453704 Tz (coils/screws\); ) Tj 4.277778 0 Td 58.738426 Tz (glaucoma ) Tj 3.072222 0 Td 49.907407 Tz (drain ) Tj 1.769444 0 Td 48.148148 Tz (shunts; ) Tj 2.313889 0 Td 48.611111 Tz (synthetic ) Tj 51.428571 0 0 51.428571 0 2127.103627 Tm 25.2 0 Td 49.907407 Tz (prostheses ) Tj 3.519444 0 Td 40.509259 Tz (\(e.g., ) Tj 1.905556 0 Td 45.37037 Tz (breast\); ) Tj 2.683333 0 Td 48.021886 Tz (intraocular ) Tj 3.616667 0 Td 46.759259 Tz (lenses; ) Tj 2.469444 0 Td 45.100309 Tz (respiratory, ) Tj 51.428571 0 0 51.428571 0 2086.300971 Tm 25.2 0 Td 48.935185 Tz (peripheral ) Tj 3.227778 0 Td 48.611111 Tz (cardiovascular, ) Tj 4.666667 0 Td 44.907407 Tz (spinal, ) Tj 2.197222 0 Td 48.611111 Tz (neurological, ) Tj 4.083333 0 Td 45.833333 Tz (dental, ) Tj 2.197222 0 Td 46.180556 Tz (ear/ ) Tj 51.428571 0 0 51.428571 0 2042.125 Tm 25.2 0 Td 49.200337 Tz (nose/throat ) Tj 3.597222 0 Td 40.509259 Tz (\(e.g., ) Tj 1.808333 0 Td 51.851852 Tz (ear ) Tj 1.263889 0 Td 52.256944 Tz (drainage ) Tj 2.858333 0 Td 46.296296 Tz (tubes\); ) Tj 2.352778 0 Td 47.314815 Tz (renal ) Tj 1.808333 0 Td 48.611111 Tz (devices; ) Tj 2.702778 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2003.904474 Tm 25.2 0 Td 46.180556 Tz (dialysis ) Tj 2.45 0 Td 39.969136 Tz (\(e.g., ) Tj 1.633333 0 Td 49.074074 Tz (tubing, ) Tj 2.313889 0 Td 58.333333 Tz (membranes, ) Tj 3.713889 0 Td 42.939815 Tz (grafts\), ) Tj 2.294444 0 Td 49.537037 Tz (urinary ) Tj 2.313889 0 Td 45.37037 Tz (catheters, ) Tj 51.428571 0 0 51.428571 0 1958.786223 Tm 25.2 0 Td 51.262626 Tz (intravenous ) Tj 3.577778 0 Td 46.018519 Tz (catheters, ) Tj 2.936111 0 Td 52.5 Tz (Small ) Tj 1.769444 0 Td 53.472222 Tz (diameter ) Tj 2.702778 0 Td 43.981481 Tz (grafts, ) Tj 2.061111 0 Td 50.636574 Tz (vascular ) Tj 2.586111 0 Td 43.055556 Tz (grafts, ) Tj 51.428571 0 0 51.428571 0 1916.451923 Tm 25.2 0 Td 40.185185 Tz (artificial ) Tj 2.605556 0 Td 53.472222 Tz (lung ) Tj 1.458333 0 Td 46.018519 Tz (catheters, ) Tj 2.916667 0 Td 42.12963 Tz (atrial ) Tj 1.711111 0 Td 45.910494 Tz (septal ) Tj 1.886111 0 Td 49.151235 Tz (defect ) Tj 1.925 0 Td 47.530864 Tz (closures, ) Tj 2.741667 0 Td 52.777778 Tz (electro ) Tj 51.428571 0 0 51.428571 0 1877.880052 Tm 25.219444 0 Td 49.200337 Tz (stimulation ) Tj 3.655556 0 Td 49.907407 Tz (leads ) Tj 1.925 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 49.074074 Tz (cardiac ) Tj 2.488889 0 Td 57.79321 Tz (rhythm ) Tj 2.547222 0 Td 61.574074 Tz (management ) Tj 4.083333 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1835.581337 Tm 25.2 0 Td 53.148148 Tz (pacer ) Tj 1.925 0 Td 44.907407 Tz (leads\), ) Tj 2.216667 0 Td 53.240741 Tz (glucose ) Tj 2.566667 0 Td 50.925926 Tz (sensors ) Tj 2.488889 0 Td 51.203704 Tz (\(long-term ) Tj 3.422222 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 47.530864 Tz (short-term\), ) Tj 51.428571 0 0 51.428571 0 1798.168317 Tm 25.2 0 Td 53.148148 Tz (degradable ) Tj 3.538889 0 Td 53.06713 Tz (coronary ) Tj 2.897222 0 Td 45.37037 Tz (Stents ) Tj 1.983333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.788889 0 Td 50.968013 Tz (degradable, ) Tj 3.733333 0 Td 58.657407 Tz (non-degrad ) Tj 51.428571 0 0 51.428571 0 1752.738035 Tm 25.2 0 Td 46.018519 Tz (able, ) Tj 1.691667 0 Td 46.720679 Tz (peripheral\), ) Tj 3.655556 0 Td 55.740741 Tz (blood ) Tj 1.944444 0 Td 51.041667 Tz (pressure ) Tj 2.722222 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 46.018519 Tz (stent ) Tj 1.633333 0 Td 46.666667 Tz (graft ) Tj 1.711111 0 Td 45.37037 Tz (catheters, ) Tj 51.428571 0 0 51.428571 0 1711.439708 Tm 25.180556 0 Td 46.018519 Tz (birth ) Tj 1.613889 0 Td 48.611111 Tz (control ) Tj 2.255556 0 Td 49.016204 Tz (devices, ) Tj 2.566667 0 Td 48.206019 Tz (prostate ) Tj 2.547222 0 Td 52.932099 Tz (cancer ) Tj 2.1 0 Td 49.331276 Tz (implants, ) Tj 2.877778 0 Td 59.143519 Tz (bone ) Tj 1.652778 0 Td 44.907407 Tz (repair/ ) Tj 51.428571 0 0 51.428571 0 1671.804941 Tm 25.2 0 Td 54.822531 Tz (augmentation ) Tj 4.491667 0 Td 48.611111 Tz (devices, ) Tj 2.819444 0 Td 49.151235 Tz (breast ) Tj 2.275 0 Td 49.331276 Tz (implants, ) Tj 3.169444 0 Td 46.8107 Tz (cartilage ) Tj 3.033333 0 Td 47.530864 Tz (repair ) Tj 52.857143 0 0 52.857143 0 1626.658031 Tm 24.518919 0 Td 47.691441 Tz (devices, ) Tj 2.686486 0 Td 46.771772 Tz (dental ) Tj 2.1 0 Td 47.997998 Tz (implants, ) Tj 2.989189 0 Td 52.202202 Tz (implanted ) Tj 3.197297 0 Td 52.815315 Tz (drug ) Tj 1.683784 0 Td 47.691441 Tz (infusion ) Tj 2.648649 0 Td 46.246246 Tz (tubes, ) Tj 51.428571 0 0 51.428571 0 1585.71358 Tm 25.2 0 Td 44.290123 Tz (intravitreal ) Tj 3.480556 0 Td 55.092593 Tz (drug ) Tj 1.613889 0 Td 49.016204 Tz (delivery ) Tj 2.644444 0 Td 49.016204 Tz (devices, ) Tj 2.644444 0 Td 53.796296 Tz (nerve ) Tj 1.886111 0 Td 50.501543 Tz (regeneration ) Tj 3.908333 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 1543.710429 Tm 25.2 0 Td 44.290123 Tz (duits, ) Tj 1.944444 0 Td 50.968013 Tz (oncological ) Tj 3.694444 0 Td 49.691358 Tz (implants, ) Tj 2.975 0 Td 48.791152 Tz (electrostimulation ) Tj 5.619444 0 Td 45.37037 Tz (leads, ) Tj 1.963889 0 Td 54.282407 Tz (pain ) Tj 51.428571 0 0 51.428571 0 1505.79397 Tm 25.2 0 Td 62.222222 Tz (management ) Tj 4.219444 0 Td 49.331276 Tz (implants, ) Tj 3.169444 0 Td 49.373638 Tz (spinal/orthopedic ) Tj 5.541667 0 Td 47.530864 Tz (repair ) Tj 2.177778 0 Td 48.611111 Tz (devices, ) Tj 51.428571 0 0 51.428571 0 1459.874251 Tm 25.180556 0 Td 66.759259 Tz (wound ) Tj 2.216667 0 Td 47.962963 Tz (dressings, ) Tj 3.091667 0 Td 55.555556 Tz (embolic ) Tj 2.527778 0 Td 49.259259 Tz (protection ) Tj 3.169444 0 Td 38.078704 Tz (filters, ) Tj 2.022222 0 Td 57.253086 Tz (abdominal ) Tj 3.305556 0 Td 63.734568 Tz (aor ) Tj 51.428571 0 0 51.428571 0 1419.05168 Tm 25.180556 0 Td 41.049383 Tz (tic ) Tj 1.069444 0 Td 58.333333 Tz (aneurysm ) Tj 3.15 0 Td 43.518519 Tz (grafts, ) Tj 2.158333 0 Td 48.611111 Tz (heart ) Tj 1.808333 0 Td 50.231481 Tz (valves ) Tj 2.177778 0 Td 39.969136 Tz (\(e.g., ) Tj 1.808333 0 Td 51.851852 Tz (mechanical, ) Tj 3.752778 0 Td 64.814815 Tz (poly ) Tj 51.428571 0 0 51.428571 0 1377.245774 Tm 25.2 0 Td 50.771605 Tz (meric, ) Tj 2.216667 0 Td 43.518519 Tz (tissue, ) Tj 2.275 0 Td 51.353276 Tz (percutaneous, ) Tj 4.433333 0 Td 50.925926 Tz (carbon, ) Tj 2.547222 0 Td 57.253086 Tz (sewing ) Tj 2.488889 0 Td 42.12963 Tz (cuff\), ) Tj 1.944444 0 Td 52.5 Tz (valve ) Tj 51.428571 0 0 51.428571 0 1334.745679 Tm 25.2 0 Td 51.311728 Tz (annuloplasty ) Tj 4.005556 0 Td 48.611111 Tz (devices, ) Tj 2.644444 0 Td 46.990741 Tz (mitral ) Tj 1.983333 0 Td 51.851852 Tz (valve ) Tj 1.827778 0 Td 47.530864 Tz (repair ) Tj 1.963889 0 Td 49.016204 Tz (devices, ) Tj 2.663889 0 Td 50.231481 Tz (vascular ) Tj 48.571429 0 0 48.571429 0 1293 Tm 26.682353 0 Td 51.470588 Tz (intervention ) Tj 4.158824 0 Td 51.89951 Tz (devices, ) Tj 2.944118 0 Td 42.892157 Tz (left ) Tj 1.482353 0 Td 49.56427 Tz (ventricle ) Tj 3.108824 0 Td 46.895425 Tz (assist ) Tj 2.120588 0 Td 51.041667 Tz (devices, ) Tj 2.944118 0 Td 56.960784 Tz (neuro ) Tj 51.428571 0 0 51.428571 0 1252.209756 Tm 25.2 0 Td 58.333333 Tz (aneurysm ) Tj 3.052778 0 Td 51.49177 Tz (treatment ) Tj 3.033333 0 Td 42.669753 Tz (coils, ) Tj 1.808333 0 Td 49.96142 Tz (neurological ) Tj 3.85 0 Td 46.018519 Tz (catheters, ) Tj 3.033333 0 Td 39.699074 Tz (left ) Tj 1.166667 0 Td 42.12963 Tz (atrial ) Tj 51.428571 0 0 51.428571 0 1211.406699 Tm 25.2 0 Td 57.613169 Tz (appendage ) Tj 3.305556 0 Td 37.673611 Tz (filters, ) Tj 2.041667 0 Td 52.932099 Tz (hemodialysis ) Tj 4.025 0 Td 49.016204 Tz (devices, ) Tj 2.566667 0 Td 48.611111 Tz (catheter ) Tj 2.488889 0 Td 42.777778 Tz (cuff, ) Tj 1.477778 0 Td 64.814815 Tz (anas ) Tj 48.571429 0 0 48.571429 0 1168 Tm 26.661765 0 Td 56.862745 Tz (tomotic ) Tj 2.614706 0 Td 49.56427 Tz (closures, ) Tj 2.923529 0 Td 53.615196 Tz (vascular ) Tj 2.738235 0 Td 54.901961 Tz (access ) Tj 2.202941 0 Td 48.72549 Tz (catheters, ) Tj 3.129412 0 Td 52.941176 Tz (cardiac ) Tj 2.45 0 Td 50.612745 Tz (sensors, ) Tj 51.428571 0 0 51.428571 0 1128.05 Tm 25.180556 0 Td 48.611111 Tz (uterine ) Tj 2.508333 0 Td 52.662037 Tz (bleeding ) Tj 2.994444 0 Td 49.826389 Tz (patches, ) Tj 2.877778 0 Td 49.259259 Tz (urological ) Tj 3.461111 0 Td 49.463938 Tz (catheters/stents/im ) Tj 51.428571 0 0 51.428571 0 1087.009569 Tm 25.2 0 Td 45.37037 Tz (plants, ) Tj 2.1 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 44.722222 Tz (vitro ) Tj 1.516667 0 Td 47.800926 Tz (diagnostics, ) Tj 3.616667 0 Td 58.333333 Tz (aneurysm ) Tj 2.975 0 Td 51.49177 Tz (exclusion ) Tj 2.955556 0 Td 49.421296 Tz (devices, ) Tj 2.508333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1049 Tm 25.2 0 Td 51.103989 Tz (neuropatches. ) Tj 51.428571 0 0 51.428571 0 1001.559413 Tm 25.938889 0 Td 59.143519 Tz (Examples ) Tj 3.111111 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 50.555556 Tz (other ) Tj 1.769444 0 Td 47.395833 Tz (suitable ) Tj 2.547222 0 Td 51.388889 Tz (devices ) Tj 2.488889 0 Td 47.800926 Tz (include, ) Tj 2.566667 0 Td 52.932099 Tz (but ) Tj 1.225 0 Td 49.691358 Tz (are ) Tj 1.205556 0 Td 50.771605 Tz (not ) Tj 51.428571 0 0 51.428571 0 960.78481 Tm 25.2 0 Td 49.074074 Tz (limited ) Tj 2.333333 0 Td 42.12963 Tz (to, ) Tj 1.069444 0 Td 57.523148 Tz (Vena ) Tj 1.672222 0 Td 55.092593 Tz (cava ) Tj 1.613889 0 Td 38.078704 Tz (filters, ) Tj 2.119444 0 Td 49.537037 Tz (urinary ) Tj 2.411111 0 Td 44.398148 Tz (dialators, ) Tj 2.975 0 Td 54.444444 Tz (endoscopic ) Tj 51.428571 0 0 51.428571 0 919.846336 Tm 25.219444 0 Td 46.990741 Tz (Surgical ) Tj 2.430556 0 Td 46.450617 Tz (tissue ) Tj 1.827778 0 Td 46.254209 Tz (extractors, ) Tj 3.208333 0 Td 54.503367 Tz (atherectomy ) Tj 3.772222 0 Td 46.018519 Tz (catheters, ) Tj 2.955556 0 Td 44.560185 Tz (clot ) Tj 1.205556 0 Td 56.712963 Tz (extrac ) Tj 51.428571 0 0 51.428571 0 878.576923 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.361111 0 Td 45.694444 Tz (catheters, ) Tj 2.955556 0 Td 53.06713 Tz (coronary ) Tj 2.722222 0 Td 51.262626 Tz (guidewires, ) Tj 3.597222 0 Td 54.282407 Tz (drug ) Tj 1.536111 0 Td 49.016204 Tz (infusion ) Tj 2.566667 0 Td 45.37037 Tz (catheters, ) Tj 51.428571 0 0 51.428571 0 840.119438 Tm 25.2 0 Td 53.796296 Tz (esophageal ) Tj 3.383333 0 Td 43.518519 Tz (stents, ) Tj 2.002778 0 Td 47.43266 Tz (circulatory ) Tj 3.325 0 Td 51.851852 Tz (Support ) Tj 2.333333 0 Td 51.041667 Tz (systems, ) Tj 2.625 0 Td 52.662037 Tz (angiographic ) Tj 51.428571 0 0 51.428571 0 798.153121 Tm 25.2 0 Td 45.694444 Tz (catheters, ) Tj 2.975 0 Td 53.06713 Tz (coronary ) Tj 2.722222 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 48.935185 Tz (peripheral ) Tj 3.130556 0 Td 50.968013 Tz (guidewires, ) Tj 3.538889 0 Td 53.472222 Tz (hemodialysis ) Tj 51.428571 0 0 51.428571 0 752.157195 Tm 25.2 0 Td 45.694444 Tz (catheters, ) Tj 3.130556 0 Td 52.350427 Tz (neurovascular ) Tj 4.375 0 Td 51.851852 Tz (balloon ) Tj 2.547222 0 Td 45.694444 Tz (catheters, ) Tj 3.091667 0 Td 60.223765 Tz (tympanostomy ) Tj 51.428571 0 0 51.428571 0 711.147316 Tm 25.2 0 Td 52.662037 Tz (vent ) Tj 1.575 0 Td 46.990741 Tz (tubes, ) Tj 1.983333 0 Td 49.768519 Tz (cerebro-spinal ) Tj 4.511111 0 Td 44.074074 Tz (fluid ) Tj 1.652778 0 Td 47.685185 Tz (shunts, ) Tj 2.333333 0 Td 44.373219 Tz (defibrillator ) Tj 3.733333 0 Td 45.910494 Tz (leads, ) Tj 51.428571 0 0 51.428571 0 670.1477 Tm 25.2 0 Td 53.20216 Tz (percutaneous ) Tj 4.063889 0 Td 49.537037 Tz (closure ) Tj 2.333333 0 Td 49.016204 Tz (devices, ) Tj 2.605556 0 Td 51.851852 Tz (drainage ) Tj 2.683333 0 Td 48.070988 Tz (tubes, ) Tj 1.963889 0 Td 48.611111 Tz (thoracic ) Tj 2.566667 0 Td 69.135802 Tz (cav ) Tj 51.428571 0 0 51.428571 0 630.22276 Tm 25.2 0 Td 42.12963 Tz (ity ) Tj 1.030556 0 Td 50 Tz (Suction ) Tj 2.372222 0 Td 52.662037 Tz (drainage ) Tj 2.780556 0 Td 46.018519 Tz (catheters, ) Tj 3.033333 0 Td 50.898693 Tz (electrophysiology ) Tj 5.502778 0 Td 45.37037 Tz (catheters, ) Tj 51.428571 0 0 51.428571 0 587.287273 Tm 25.219444 0 Td 49.151235 Tz (stroke ) Tj 1.963889 0 Td 52.314815 Tz (therapy ) Tj 2.430556 0 Td 46.018519 Tz (catheters, ) Tj 3.013889 0 Td 51.388889 Tz (abscess ) Tj 2.430556 0 Td 51.851852 Tz (drainage ) Tj 2.702778 0 Td 46.018519 Tz (catheters, ) Tj 3.013889 0 Td 45.37037 Tz (biliary ) Tj 51.428571 0 0 51.428571 0 545.688564 Tm 25.2 0 Td 51.851852 Tz (drainage ) Tj 2.741667 0 Td 49.331276 Tz (products, ) Tj 2.916667 0 Td 46.180556 Tz (dialysis ) Tj 2.45 0 Td 46.018519 Tz (catheters, ) Tj 3.013889 0 Td 46.759259 Tz (central ) Tj 2.216667 0 Td 56.712963 Tz (venous ) Tj 2.275 0 Td 51.311728 Tz (access ) Tj 51.428571 0 0 51.428571 0 504.267606 Tm 25.2 0 Td 45.694444 Tz (catheters, ) Tj 3.013889 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 48.611111 Tz (parental ) Tj 2.605556 0 Td 51.851852 Tz (feeding ) Tj 2.411111 0 Td 45.694444 Tz (catheters. ) Tj 51.428571 0 0 51.428571 0 460.267442 Tm 25.938889 0 Td 37.268519 Tz (It ) Tj 0.836111 0 Td 38.888889 Tz (is ) Tj 0.875 0 Td 53.796296 Tz (noted ) Tj 2.002778 0 Td 45.37037 Tz (that ) Tj 1.477778 0 Td 45.37037 Tz (in ) Tj 0.933333 0 Td 51.851852 Tz (other ) Tj 1.886111 0 Td 59.806397 Tz (embodiments ) Tj 4.336111 0 Td 59.953704 Tz (of ) Tj 1.011111 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 50.462963 Tz (present ) Tj 51.428571 0 0 51.428571 0 420.807186 Tm 25.2 0 Td 48.611111 Tz (invention, ) Tj 3.091667 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 54.208754 Tz (composition ) Tj 3.811111 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.462963 Tz (present ) Tj 2.313889 0 Td 50.771605 Tz (invention ) Tj 51.428571 0 0 51.428571 0 377.282443 Tm 25.2 0 Td 69.135802 Tz (may ) Tj 1.458333 0 Td 46.990741 Tz (self ) Tj 1.244444 0 Td 54.012346 Tz (adhere ) Tj 2.119444 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 53.703704 Tz (medical ) Tj 2.488889 0 Td 52.391975 Tz (device ) Tj 2.061111 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 66.975309 Tz (may ) Tj 1.419444 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 54.166667 Tz (adhered ) Tj 2.488889 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 336.539662 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 52.391975 Tz (device ) Tj 2.138889 0 Td 61.574074 Tz (by ) Tj 1.030556 0 Td 60.277778 Tz (means ) Tj 2.1 0 Td 51.203704 Tz (other ) Tj 1.769444 0 Td 51.851852 Tz (than ) Tj 1.536111 0 Td 50.925926 Tz (coating ) Tj 2.430556 0 Td 46.666667 Tz (materials, ) Tj 3.111111 0 Td 53.472222 Tz (such ) Tj 1.575 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 295.632783 Tm 25.2 0 Td 49.907407 Tz (adhesives, ) Tj 3.363889 0 Td 46.585648 Tz (Sutures, ) Tj 2.586111 0 Td 53.472222 Tz (or ) Tj 0.972222 0 Td 52.932099 Tz (compression. ) Tj 4.161111 0 Td 68.055556 Tz (Any ) Tj 1.613889 0 Td 46.585648 Tz (Suitable ) Tj 2.625 0 Td 59.953704 Tz (method ) Tj 51.428571 0 0 51.428571 0 251.723164 Tm 25.2 0 Td 65.625 Tz (know ) Tj 1.983333 0 Td 45.37037 Tz (in ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 43.209877 Tz (art ) Tj 1.147222 0 Td 69.135802 Tz (may ) Tj 1.594444 0 Td 58.333333 Tz (be ) Tj 1.069444 0 Td 45.37037 Tz (utilized ) Tj 2.547222 0 Td 45.37037 Tz (to ) Tj 0.913889 0 Td 54.552469 Tz (adhere ) Tj 2.352778 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 213.273657 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.85 0 Td 48.611111 Tz (to ) Tj 0.855556 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 46.585648 Tz (Surface. ) Tj 2.566667 0 Td 56.17284 Tz (For ) Tj 1.244444 0 Td 55.092593 Tz (example, ) Tj 2.936111 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 171.78022 Tm 25.2 0 Td 48.611111 Tz (position ) Tj 2.741667 0 Td 66.975309 Tz (may ) Tj 1.575 0 Td 58.333333 Tz (be ) Tj 1.05 0 Td 55.092593 Tz (adhered ) Tj 2.663889 0 Td 46.990741 Tz (to ) Tj 0.952778 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 49.537037 Tz (Surface ) Tj 2.45 0 Td 58.333333 Tz (by ) Tj 1.069444 0 Td 51.041667 Tz (pressing ) Tj 2.8 0 Td 50.771605 Tz (the ) Tj ET Q endstream endobj 133 0 obj << /Length 1 >> stream q endstream endobj 134 0 obj << /Length 51230 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.151351 0 Td 74.099099 Tz (15 ) Tj 51.428571 0 0 51.428571 0 2916.198032 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 53.914141 Tz (composition ) Tj 3.811111 0 Td 53.472222 Tz (onto ) Tj 1.516667 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 49.537037 Tz (device, ) Tj 2.313889 0 Td 57.523148 Tz (wrapping ) Tj 2.975 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 52.391975 Tz (device ) Tj 51.428571 0 0 51.428571 0 2875.016867 Tm 6.241667 0 Td 54.282407 Tz (with ) Tj 1.438889 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 44.074074 Tz (film, ) Tj 1.477778 0 Td 51.851852 Tz (or ) Tj 0.738889 0 Td 52.662037 Tz (spraying ) Tj 2.644444 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 53.914141 Tz (composition ) Tj 3.733333 0 Td 53.472222 Tz (onto ) Tj 40 0 0 40 0 2838 Tm 8.025 0 Td 65.277778 Tz (the ) Tj 1.5 0 Td 62.5 Tz (device. ) Tj 51.428571 0 0 51.428571 0 2792.21374 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 50.636574 Tz (chitosan ) Tj 2.702778 0 Td 54.012346 Tz (compositions ) Tj 4.2 0 Td 54.282407 Tz (with ) Tj 1.594444 0 Td 53.347578 Tz (biocompatible ) Tj 4.452778 0 Td 49.421296 Tz (surfaces ) Tj 51.428571 0 0 51.428571 0 2750.881773 Tm 6.261111 0 Td 69.135802 Tz (may ) Tj 1.458333 0 Td 59.953704 Tz (be ) Tj 0.952778 0 Td 44.965278 Tz (utilized ) Tj 2.411111 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 50 Tz (various ) Tj 2.372222 0 Td 54.166667 Tz (medical ) Tj 2.508333 0 Td 48.881173 Tz (applications ) Tj 3.752778 0 Td 48.287037 Tz (including, ) Tj 51.428571 0 0 51.428571 0 2706.939086 Tm 6.241667 0 Td 54.012346 Tz (but ) Tj 1.225 0 Td 51.851852 Tz (not ) Tj 1.166667 0 Td 48.611111 Tz (limited ) Tj 2.294444 0 Td 41.049383 Tz (to, ) Tj 0.991667 0 Td 55.902778 Tz (drug ) Tj 1.575 0 Td 49.421296 Tz (delivery ) Tj 2.644444 0 Td 51.388889 Tz (devices ) Tj 2.411111 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 49.907407 Tz (controlled ) Tj 51.428571 0 0 51.428571 0 2668.910152 Tm 6.261111 0 Td 48.148148 Tz (release ) Tj 2.197222 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 52.995643 Tz (pharmacologically ) Tj 5.561111 0 Td 48.611111 Tz (active ) Tj 1.866667 0 Td 49.074074 Tz (agents, ) Tj 2.236111 0 Td 51.131687 Tz (including ) Tj 2.897222 0 Td 66.759259 Tz (wound ) Tj 51.428571 0 0 51.428571 0 2626.026008 Tm 6.241667 0 Td 51.851852 Tz (healing ) Tj 2.566667 0 Td 49.016204 Tz (devices, ) Tj 2.8 0 Td 54.282407 Tz (such ) Tj 1.691667 0 Td 51.851852 Tz (as ) Tj 1.030556 0 Td 52.5 Tz (hemostatic ) Tj 3.597222 0 Td 51.851852 Tz (sponges, ) Tj 2.916667 0 Td 47.638889 Tz (dressings, ) Tj 51.428571 0 0 51.428571 0 2583.071517 Tm 6.280556 0 Td 49.151235 Tz (Suture ) Tj 2.061111 0 Td 49.016204 Tz (material ) Tj 2.605556 0 Td 60.493827 Tz (and ) Tj 1.361111 0 Td 55.092593 Tz (meshes, ) Tj 2.605556 0 Td 53.703704 Tz (medical ) Tj 2.566667 0 Td 52.932099 Tz (device ) Tj 2.158333 0 Td 48.611111 Tz (coatings/films ) Tj 51.428571 0 0 51.428571 0 2542.748999 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.477778 0 Td 51.203704 Tz (other ) Tj 1.925 0 Td 53.347578 Tz (biocompatible ) Tj 4.588889 0 Td 49.331276 Tz (implants. ) Tj 3.111111 0 Td 62.654321 Tz (The ) Tj 1.594444 0 Td 57.407407 Tz (methods ) Tj 2.838889 0 Td 59.953704 Tz (of ) Tj 1.05 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2499.909953 Tm 6.261111 0 Td 50.771605 Tz (invention ) Tj 2.936111 0 Td 59.62963 Tz (would ) Tj 1.925 0 Td 49.421296 Tz (also ) Tj 1.341667 0 Td 52.256944 Tz (provides ) Tj 2.683333 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 48.611111 Tz (the ) Tj 1.011111 0 Td 49.583333 Tz (controlled ) Tj 3.130556 0 Td 52.441077 Tz (degradation ) Tj 51.428571 0 0 51.428571 0 2457.13555 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 51.388889 Tz (coating ) Tj 2.391667 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 46.990741 Tz (suitable ) Tj 2.527778 0 Td 55.092593 Tz (timeframe ) Tj 3.208333 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 47.685185 Tz (release ) Tj 2.216667 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (active ) Tj 45.714286 0 0 45.714286 0 2421 Tm 7.04375 0 Td 62.642045 Tz (components. ) Tj 40 0 0 40 0 2381 Tm 8.05 0 Td 68.75 Tz (Chitosan ) Tj 3.675 0 Td 63.888889 Tz (Fibers ) Tj 51.428571 0 0 51.428571 0 2332.647059 Tm 7.019444 0 Td 62.384259 Tz (Randomly ) Tj 3.247222 0 Td 50.231481 Tz (oriented ) Tj 2.663889 0 Td 48.148148 Tz (fibrous ) Tj 2.333333 0 Td 55.902778 Tz (mats ) Tj 1.594444 0 Td 56.17284 Tz (can ) Tj 1.263889 0 Td 58.333333 Tz (be ) Tj 0.991667 0 Td 64.814815 Tz (made ) Tj 1.808333 0 Td 57.523148 Tz (from ) Tj 1.672222 0 Td 62.654321 Tz (chi ) Tj 51.428571 0 0 51.428571 0 2292.608273 Tm 6.241667 0 Td 51.203704 Tz (tosan ) Tj 1.769444 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 49.907407 Tz (electrospinning ) Tj 4.744444 0 Td 53.148148 Tz (\(Schiffman ) Tj 3.422222 0 Td 60.493827 Tz (and ) Tj 1.322222 0 Td 51.851852 Tz (Schauer, ) Tj 2.761111 0 Td 68.595679 Tz (Biomac ) Tj 51.428571 0 0 51.428571 0 2248.973384 Tm 6.261111 0 Td 51.851852 Tz (romolecules, ) Tj 3.986111 0 Td 54.444444 Tz (2007. ) Tj 1.905556 0 Td 45.37037 Tz (8\(9\): ) Tj 1.652778 0 Td 43.75 Tz (p. ) Tj 0.797222 0 Td 51.851852 Tz (2665-7\). ) Tj 2.702778 0 Td 59.62963 Tz (These ) Tj 2.061111 0 Td 43.75 Tz (fibers ) Tj 1.847222 0 Td 49.691358 Tz (are ) Tj 1.166667 0 Td 55.902778 Tz (typi ) Tj 51.428571 0 0 51.428571 0 2206.763926 Tm 6.261111 0 Td 46.666667 Tz (cally ) Tj 1.672222 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 64.00463 Tz (mean ) Tj 1.847222 0 Td 53.06713 Tz (diameter ) Tj 2.761111 0 Td 61.574074 Tz (of ) Tj 0.952778 0 Td 59.41358 Tz (100 ) Tj 1.341667 0 Td 59.41358 Tz (nm, ) Tj 1.341667 0 Td 51.851852 Tz (but ) Tj 1.225 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 53.472222 Tz (diameter ) Tj 2.8 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2168.920596 Tm 6.261111 0 Td 44.830247 Tz (fibers ) Tj 1.808333 0 Td 56.17284 Tz (can ) Tj 1.225 0 Td 52.662037 Tz (vary ) Tj 1.497222 0 Td 54.012346 Tz (widely ) Tj 2.158333 0 Td 56.17284 Tz (depending ) Tj 3.227778 0 Td 59.953704 Tz (upon ) Tj 1.652778 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 61.574074 Tz (number ) Tj 2.411111 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 44.155093 Tz (factors. ) Tj 51.428571 0 0 51.428571 0 2123.766839 Tm 6.280556 0 Td 68.865741 Tz (Some ) Tj 1.788889 0 Td 44.830247 Tz (fibers ) Tj 1.788889 0 Td 55.092593 Tz (can ) Tj 1.166667 0 Td 56.712963 Tz (be ) Tj 0.836111 0 Td 48.611111 Tz (as ) Tj 0.777778 0 Td 47.962963 Tz (large ) Tj 1.594444 0 Td 50.231481 Tz (as ) Tj 0.836111 0 Td 32.407407 Tz (1 ) Tj 0.505556 0 Td 69.675926 Tz (um ) Tj 1.05 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 49.331276 Tz (diameter, ) Tj 2.819444 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 50.231481 Tz (as ) Tj 0.797222 0 Td 51.851852 Tz (Small ) Tj 51.428571 0 0 51.428571 0 2083.59354 Tm 6.261111 0 Td 50.231481 Tz (as ) Tj 0.933333 0 Td 59.953704 Tz (28 ) Tj 1.069444 0 Td 59.41358 Tz (nm. ) Tj 1.4 0 Td 47.962963 Tz (Typically, ) Tj 3.227778 0 Td 47.685185 Tz (fibrous ) Tj 2.372222 0 Td 55.092593 Tz (mats ) Tj 1.652778 0 Td 58.333333 Tz (have ) Tj 1.711111 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 64.00463 Tz (mean ) Tj 1.886111 0 Td 53.877315 Tz (diameter ) Tj 40 0 0 40 0 2048 Tm 8.025 0 Td 74.404762 Tz (between ) Tj 3.55 0 Td 72.02381 Tz (100-200 ) Tj 3.4 0 Td 73.611111 Tz (nm. ) Tj 51.428571 0 0 51.428571 0 2000.572193 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 60.493827 Tz (one ) Tj 1.263889 0 Td 52.932099 Tz (approach, ) Tj 3.072222 0 Td 53.796296 Tz (about ) Tj 1.827778 0 Td 52.932099 Tz (7-9 ) Tj 1.205556 0 Td 59.953704 Tz (wt ) Tj 0.913889 0 Td 97.222222 Tz (% ) Tj 0.816667 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 50.771605 Tz (dissolved ) Tj 2.955556 0 Td 46.990741 Tz (in ) Tj 40 0 0 40 0 1965 Tm 8.075 0 Td 80.357143 Tz (99-100% ) Tj 3.7 0 Td 58.055556 Tz (trifluoroacetic ) Tj 5.525 0 Td 58.333333 Tz (acid. ) Tj 2.025 0 Td 83.333333 Tz (The ) Tj 1.8 0 Td 64.285714 Tz (solvent ) Tj 2.975 0 Td 61.979167 Tz (solution ) Tj 3.3 0 Td 64.583333 Tz (contains ) Tj 51.428571 0 0 51.428571 0 1918.345818 Tm 6.261111 0 Td 54.444444 Tz (about ) Tj 1.847222 0 Td 63.518519 Tz (0-30% ) Tj 2.197222 0 Td 55.452675 Tz (methylene ) Tj 3.188889 0 Td 50.231481 Tz (chloride ) Tj 2.644444 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 49.691358 Tz (aid ) Tj 1.127778 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 45.121083 Tz (spinnability. ) Tj 3.752778 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1875.699379 Tm 6.280556 0 Td 48.206019 Tz (Solution ) Tj 2.508333 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 50.231481 Tz (gently ) Tj 2.002778 0 Td 60.277778 Tz (mixed ) Tj 2.002778 0 Td 47.530864 Tz (for ) Tj 1.030556 0 Td 58.333333 Tz (24 ) Tj 0.855556 0 Td 49.691358 Tz (hours. ) Tj 1.983333 0 Td 59.953704 Tz (At ) Tj 0.875 0 Td 43.75 Tz (this ) Tj 1.225 0 Td 50.555556 Tz (point ) Tj 1.672222 0 Td 48.611111 Tz (additives ) Tj 51.428571 0 0 51.428571 0 1835.865979 Tm 6.280556 0 Td 54.282407 Tz (Such ) Tj 1.613889 0 Td 50.231481 Tz (as ) Tj 0.894444 0 Td 49.691358 Tz (drugs, ) Tj 2.080556 0 Td 47.170782 Tz (proteins, ) Tj 2.858333 0 Td 54.166667 Tz (calcium ) Tj 2.586111 0 Td 54.73251 Tz (phosphate ) Tj 3.247222 0 Td 40.509259 Tz (salts, ) Tj 1.788889 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 51.203704 Tz (other ) Tj 51.428571 0 0 51.428571 0 1792.712919 Tm 6.241667 0 Td 48.341049 Tz (biologically ) Tj 3.636111 0 Td 49.151235 Tz (active ) Tj 1.925 0 Td 47.800926 Tz (constituents ) Tj 3.597222 0 Td 56.17284 Tz (can ) Tj 1.166667 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 52.932099 Tz (added. ) Tj 2.061111 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 48.206019 Tz (solution ) Tj 2.469444 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1751.232558 Tm 6.261111 0 Td 54.012346 Tz (loaded ) Tj 2.197222 0 Td 46.180556 Tz (into ) Tj 1.341667 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 45.37037 Tz (plastic ) Tj 2.197222 0 Td 58.333333 Tz (10 ) Tj 0.933333 0 Td 81.018519 Tz (mL ) Tj 1.205556 0 Td 47.800926 Tz (syringe. ) Tj 2.566667 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 59.41358 Tz (one ) Tj 1.263889 0 Td 58.038721 Tz (embodiment, ) Tj 4.083333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1708.930719 Tm 6.241667 0 Td 51.203704 Tz (blunt ) Tj 1.788889 0 Td 51.851852 Tz (21 ) Tj 0.952778 0 Td 57.685185 Tz (gauge ) Tj 1.983333 0 Td 56.17284 Tz (\(G\) ) Tj 1.263889 0 Td 53.148148 Tz (metal ) Tj 1.866667 0 Td 52.932099 Tz (needle ) Tj 2.138889 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 49.259259 Tz (used. ) Tj 1.769444 0 Td 50.231481 Tz (In ) Tj 0.836111 0 Td 50.555556 Tz (other ) Tj 1.75 0 Td 66.975309 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1667.967047 Tm 6.261111 0 Td 52.932099 Tz (ments, ) Tj 2.197222 0 Td 51.311728 Tz (needle ) Tj 2.119444 0 Td 46.018519 Tz (sizes ) Tj 1.633333 0 Td 54.444444 Tz (range ) Tj 1.866667 0 Td 57.523148 Tz (from ) Tj 1.652778 0 Td 54.444444 Tz (about ) Tj 1.925 0 Td 55.092593 Tz (16-23G. ) Tj 2.566667 0 Td 61.574074 Tz (The ) Tj 1.380556 0 Td 50.925926 Tz (Syringe ) Tj 52.857143 0 0 52.857143 0 1625.14069 Tm 6.091892 0 Td 37.837838 Tz (is ) Tj 0.794595 0 Td 52.027027 Tz (loaded ) Tj 2.175676 0 Td 44.144144 Tz (into ) Tj 1.381081 0 Td 53.603604 Tz (a ) Tj 0.624324 0 Td 49.099099 Tz (syringe ) Tj 2.345946 0 Td 67.004505 Tz (pump ) Tj 1.891892 0 Td 56.756757 Tz (and ) Tj 1.324324 0 Td 49.399399 Tz (the ) Tj 1.154054 0 Td 48.873874 Tz (flowrate ) Tj 2.648649 0 Td 36.261261 Tz (is ) Tj 0.775676 0 Td 43.093093 Tz (set ) Tj 1.040541 0 Td 48.348348 Tz (for ) Tj 51.428571 0 0 51.428571 0 1583.175592 Tm 6.261111 0 Td 57.685185 Tz (20-30 ) Tj 1.963889 0 Td 58.333333 Tz (uL/min ) Tj 2.333333 0 Td 47.800926 Tz (\(usually ) Tj 2.547222 0 Td 61.574074 Tz (20 ) Tj 0.991667 0 Td 55.555556 Tz (uL/min\) ) Tj 2.527778 0 Td 61.574074 Tz (The ) Tj 1.380556 0 Td 51.851852 Tz (needle ) Tj 2.1 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 55.452675 Tz (connected ) Tj 51.428571 0 0 51.428571 0 1542.905569 Tm 6.241667 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 48.206019 Tz (positive ) Tj 2.45 0 Td 49.331276 Tz (electrode ) Tj 2.819444 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 62.87037 Tz (power ) Tj 2.002778 0 Td 49.074074 Tz (source, ) Tj 2.236111 0 Td 52.5 Tz (while ) Tj 1.730556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 45.37037 Tz (target ) Tj 51.428571 0 0 51.428571 0 1501.971985 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 54.372428 Tz (connected ) Tj 3.072222 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 53.240741 Tz (ground. ) Tj 2.372222 0 Td 64.814815 Tz (The ) Tj 1.283333 0 Td 46.450617 Tz (target ) Tj 1.808333 0 Td 56.17284 Tz (can ) Tj 1.186111 0 Td 47.685185 Tz (consist ) Tj 2.158333 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 56.17284 Tz (copper ) Tj 51.428571 0 0 51.428571 0 1458.997516 Tm 6.261111 0 Td 47.314815 Tz (plate ) Tj 1.633333 0 Td 59.259259 Tz (wrapped ) Tj 2.683333 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 61.168981 Tz (aluminum ) Tj 3.15 0 Td 39.537037 Tz (foil, ) Tj 1.380556 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 60.358796 Tz (aluminum ) Tj 3.15 0 Td 82.098765 Tz (SEM ) Tj 1.672222 0 Td 46.018519 Tz (stub, ) Tj 1.575 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 1416.69509 Tm 6.261111 0 Td 58.333333 Tz (any ) Tj 1.361111 0 Td 50.555556 Tz (other ) Tj 1.788889 0 Td 53.472222 Tz (conductive ) Tj 3.538889 0 Td 46.585648 Tz (surface. ) Tj 2.547222 0 Td 62.654321 Tz (The ) Tj 1.458333 0 Td 50.925926 Tz (voltage ) Tj 2.430556 0 Td 40.509259 Tz (is ) Tj 0.797222 0 Td 45.37037 Tz (set ) Tj 1.108333 0 Td 58.796296 Tz (between ) Tj 51.428571 0 0 51.428571 0 1375.358904 Tm 6.338889 0 Td 53.796296 Tz (15-26 ) Tj 1.963889 0 Td 50.771605 Tz (kV. ) Tj 1.244444 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 49.826389 Tz (distance ) Tj 2.683333 0 Td 57.407407 Tz (between ) Tj 2.741667 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 42.12963 Tz (tip ) Tj 1.088889 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 47.530864 Tz (the ) Tj 1.186111 0 Td 45.910494 Tz (target ) Tj 1.944444 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1333.448819 Tm 6.241667 0 Td 57.87037 Tz (between ) Tj 2.780556 0 Td 55.092593 Tz (about ) Tj 2.061111 0 Td 53.796296 Tz (12-25 ) Tj 2.002778 0 Td 57.253086 Tz (cm. ) Tj 1.458333 0 Td 46.990741 Tz (In ) Tj 0.933333 0 Td 58.333333 Tz (one ) Tj 1.4 0 Td 49.691358 Tz (preferred ) Tj 3.033333 0 Td 57.449495 Tz (embodiment, ) Tj 51.428571 0 0 51.428571 0 1294.03125 Tm 6.319444 0 Td 54.444444 Tz (15-16 ) Tj 1.905556 0 Td 72.916667 Tz (cm ) Tj 1.108333 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 49.259259 Tz (used. ) Tj 1.711111 0 Td 47.962963 Tz (Typically, ) Tj 3.111111 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 51.49177 Tz (apparatus ) Tj 3.033333 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 55.902778 Tz (used ) Tj 1.594444 0 Td 48.070988 Tz (inside ) Tj 1.983333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1250.156744 Tm 6.261111 0 Td 47.962963 Tz (ventilated ) Tj 3.033333 0 Td 61.574074 Tz (box ) Tj 1.283333 0 Td 50.771605 Tz (within ) Tj 2.022222 0 Td 61.574074 Tz (fume ) Tj 1.633333 0 Td 53.796296 Tz (hood. ) Tj 1.769444 0 Td 64.814815 Tz (The ) Tj 1.302778 0 Td 62.654321 Tz (box ) Tj 1.263889 0 Td 48.206019 Tz (protects ) Tj 2.488889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 44.290123 Tz (fibers ) Tj 51.428571 0 0 51.428571 0 1211.107097 Tm 6.261111 0 Td 58.333333 Tz (from ) Tj 1.652778 0 Td 44.290123 Tz (air ) Tj 1.030556 0 Td 48.206019 Tz (currents ) Tj 2.547222 0 Td 51.851852 Tz (as ) Tj 0.875 0 Td 51.851852 Tz (they ) Tj 1.477778 0 Td 50.771605 Tz (are ) Tj 1.166667 0 Td 51.49177 Tz (deposited ) Tj 3.013889 0 Td 58.333333 Tz (on ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 43.518519 Tz (target. ) Tj 2.061111 0 Td 65.625 Tz (Once ) Tj 51.428571 0 0 51.428571 0 1167.471154 Tm 6.261111 0 Td 49.583333 Tz (deposited, ) Tj 3.111111 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 53.06713 Tz (fibermat ) Tj 2.702778 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 60.185185 Tz (removed ) Tj 2.683333 0 Td 57.523148 Tz (from ) Tj 1.536111 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 50 Tz (surface ) Tj 2.216667 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 1125.549738 Tm 6.241667 0 Td 47.685185 Tz (treated ) Tj 2.313889 0 Td 50.231481 Tz (as ) Tj 0.952778 0 Td 48.611111 Tz (follows. ) Tj 2.663889 0 Td 47.962963 Tz (Typically, ) Tj 3.208333 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 45.37037 Tz (fiber ) Tj 1.691667 0 Td 59.41358 Tz (mat ) Tj 1.380556 0 Td 40.509259 Tz (is ) Tj 0.855556 0 Td 53.796296 Tz (maintained ) Tj 48.571429 0 0 48.571429 0 1085 Tm 6.608824 0 Td 60.392157 Tz (under ) Tj 2.017647 0 Td 66.911765 Tz (vacuum ) Tj 2.676471 0 Td 50.326797 Tz (for ) Tj 1.091176 0 Td 58.333333 Tz (about ) Tj 1.976471 0 Td 63.480392 Tz (24 ) Tj 0.988235 0 Td 52.614379 Tz (hours, ) Tj 2.141176 0 Td 61.764706 Tz (and ) Tj 1.338235 0 Td 54.901961 Tz (then ) Tj 1.585294 0 Td 51.470588 Tz (the ) Tj 1.173529 0 Td 47.352941 Tz (fiber ) Tj 1.647059 0 Td 64.052288 Tz (mat ) Tj 1.379412 0 Td 41.176471 Tz (is ) Tj 51.428571 0 0 51.428571 0 1042.607891 Tm 6.261111 0 Td 49.200337 Tz (neutralized ) Tj 3.402778 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 82.638889 Tz (5M ) Tj 1.166667 0 Td 85.555556 Tz (NaCO. ) Tj 2.741667 0 Td 51.851852 Tz (After ) Tj 1.691667 0 Td 49.537037 Tz (drying, ) Tj 2.294444 0 Td 54.282407 Tz (mats ) Tj 1.477778 0 Td 51.851852 Tz (are ) Tj 1.088889 0 Td 49.691358 Tz (cut ) Tj 1.069444 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 60.493827 Tz (any ) Tj 51.428571 0 0 51.428571 0 1001.674653 Tm 6.261111 0 Td 50 Tz (desired ) Tj 2.411111 0 Td 46.990741 Tz (size ) Tj 1.4 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 42.718855 Tz (sterilized. ) Tj 3.111111 0 Td 56.944444 Tz (Another ) Tj 2.702778 0 Td 59.41358 Tz (method ) Tj 2.430556 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 48.905724 Tz (electrospin ) Tj 51.428571 0 0 51.428571 0 963.637011 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 50.636574 Tz (involves ) Tj 2.780556 0 Td 52.5 Tz (using ) Tj 1.944444 0 Td 50.378788 Tz (1,1,1,3,3,3-Hexafluoroisopropanol ) Tj 51.428571 0 0 51.428571 0 917 Tm 6.280556 0 Td 56.712963 Tz (\(HFIP\) ) Tj 2.197222 0 Td 51.851852 Tz (as ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 49.537037 Tz (solvent ) Tj 2.255556 0 Td 52.5 Tz (\(Shin ) Tj 1.75 0 Td 43.75 Tz (et ) Tj 0.7 0 Td 36.458333 Tz (al., ) Tj 1.05 0 Td 51.851852 Tz (J ) Tj 0.466667 0 Td 49.691358 Tz (Periodontol, ) Tj 3.752778 0 Td 54.282407 Tz (2005.76\(10\): ) Tj 51.428571 0 0 51.428571 0 877.068966 Tm 6.261111 0 Td 43.75 Tz (p. ) Tj 0.991667 0 Td 50.771605 Tz (1778-84\). ) Tj 3.15 0 Td 68.055556 Tz (One ) Tj 1.575 0 Td 55.092593 Tz (advantage ) Tj 3.344444 0 Td 38.888889 Tz (is ) Tj 0.836111 0 Td 46.180556 Tz (that ) Tj 1.497222 0 Td 47.962963 Tz (there ) Tj 1.808333 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 55.092593 Tz (no ) Tj 1.069444 0 Td 57.523148 Tz (need ) Tj 1.730556 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 834.031208 Tm 6.261111 0 Td 47.962963 Tz (neutralize ) Tj 3.227778 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 51.041667 Tz (mat. ) Tj 1.594444 0 Td 63.734568 Tz (The ) Tj 1.536111 0 Td 46.585648 Tz (residual ) Tj 2.625 0 Td 50.462963 Tz (solvent ) Tj 2.469444 0 Td 38.888889 Tz (is ) Tj 0.816667 0 Td 51.311728 Tz (pulled ) Tj 2.197222 0 Td 50.771605 Tz (off ) Tj 1.166667 0 Td 50.231481 Tz (in ) Tj 51.428571 0 0 51.428571 0 793.653333 Tm 6.261111 0 Td 58.796296 Tz (vacuum. ) Tj 2.877778 0 Td 64.814815 Tz (HFIP ) Tj 1.886111 0 Td 49.537037 Tz (solvent ) Tj 2.430556 0 Td 55.092593 Tz (can ) Tj 1.361111 0 Td 47.800926 Tz (also ) Tj 1.497222 0 Td 59.953704 Tz (be ) Tj 1.069444 0 Td 55.092593 Tz (used ) Tj 1.672222 0 Td 53.472222 Tz (with ) Tj 1.672222 0 Td 55.812757 Tz (methylene ) Tj 51.428571 0 0 51.428571 0 753.002597 Tm 6.261111 0 Td 49.826389 Tz (chloride ) Tj 2.702778 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 50.771605 Tz (aid ) Tj 1.244444 0 Td 43.75 Tz (in ) Tj 0.855556 0 Td 52.256944 Tz (spinning ) Tj 2.819444 0 Td 56.388889 Tz (Other ) Tj 2.002778 0 Td 57.87037 Tz (methods ) Tj 2.780556 0 Td 47.530864 Tz (for ) Tj 1.108333 0 Td 51.851852 Tz (generating ) Tj 51.428571 0 0 51.428571 0 712.424204 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 44.290123 Tz (fibers ) Tj 1.886111 0 Td 50.771605 Tz (are ) Tj 1.244444 0 Td 48.935185 Tz (described, ) Tj 3.266667 0 Td 48.611111 Tz (for ) Tj 1.147222 0 Td 55.092593 Tz (example, ) Tj 2.955556 0 Td 59.953704 Tz (by ) Tj 1.05 0 Td 58.693416 Tz (Sangsanoh ) Tj 51.428571 0 0 51.428571 0 668.72973 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 53.652263 Tz (Supaphol, ) Tj 3.188889 0 Td 55.092593 Tz (Biomacromolecules, ) Tj 6.202778 0 Td 53.796296 Tz (2006. ) Tj 1.886111 0 Td 48.611111 Tz (7\(10\): ) Tj 2.022222 0 Td 43.75 Tz (p. ) Tj 0.797222 0 Td 56.712963 Tz (2710-4 ) Tj 51.428571 0 0 51.428571 0 626 Tm 6.261111 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 54.73251 Tz (Schiffman ) Tj 3.188889 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 51.446759 Tz (Schauer, ) Tj 2.722222 0 Td 55.092593 Tz (Biomacromolecules, ) Tj 6.163889 0 Td 53.796296 Tz (2007. ) Tj 1.866667 0 Td 45.37037 Tz (8\(2\): ) Tj 51.428571 0 0 51.428571 0 585.471503 Tm 6.261111 0 Td 43.75 Tz (p. ) Tj 0.855556 0 Td 52.662037 Tz (594-601. ) Tj 2.838889 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 57.87037 Tz (methods ) Tj 2.702778 0 Td 61.574074 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 50.771605 Tz (invention ) Tj 3.013889 0 Td 53.240741 Tz (provide ) Tj 2.508333 0 Td 49.691358 Tz (for ) Tj 1.147222 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 543.730532 Tm 6.261111 0 Td 49.259259 Tz (controlled ) Tj 3.188889 0 Td 51.557239 Tz (degradation ) Tj 3.636111 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.259259 Tz (these ) Tj 1.711111 0 Td 44.290123 Tz (fibers ) Tj 1.808333 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 55.092593 Tz (mats ) Tj 1.555556 0 Td 45.37037 Tz (after ) Tj 1.575 0 Td 53.240741 Tz (fabrica ) Tj 51.428571 0 0 51.428571 0 505.971014 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.419444 0 Td 51.446759 Tz (\(through ) Tj 2.702778 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 54.012346 Tz (use ) Tj 1.205556 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 49.331276 Tz (buffering ) Tj 2.936111 0 Td 42.669753 Tz (step\). ) Tj 51.428571 0 0 51.428571 0 460.429363 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 51.203704 Tz (other ) Tj 1.866667 0 Td 56.983025 Tz (embodiments, ) Tj 4.511111 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 50.05144 Tz (invention ) Tj 3.091667 0 Td 52.256944 Tz (provides ) Tj 2.916667 0 Td 48.611111 Tz (for ) Tj 1.244444 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 423.607619 Tm 6.261111 0 Td 52.5 Tz (production ) Tj 3.422222 0 Td 55.092593 Tz (of ) Tj 0.836111 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 51.353276 Tz (microspheres. ) Tj 51.428571 0 0 51.428571 0 378.728863 Tm 6.261111 0 Td 70 Tz (Wound ) Tj 2.352778 0 Td 54.166667 Tz (Healing ) Tj 2.566667 0 Td 54.62963 Tz (Devices ) Tj 51.428571 0 0 51.428571 0 338.667984 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.438889 0 Td 50 Tz (present ) Tj 2.430556 0 Td 50.771605 Tz (invention ) Tj 3.072222 0 Td 51.851852 Tz (provides ) Tj 2.858333 0 Td 65.462963 Tz (wound ) Tj 2.255556 0 Td 51.851852 Tz (healing ) Tj 2.508333 0 Td 51.388889 Tz (devices ) Tj 51.428571 0 0 51.428571 0 297.278351 Tm 6.241667 0 Td 46.990741 Tz (that ) Tj 1.458333 0 Td 60.493827 Tz (employ ) Tj 2.527778 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 50.231481 Tz (chitosan ) Tj 2.8 0 Td 51.851852 Tz (composition. ) Tj 4.083333 0 Td 63.734568 Tz (The ) Tj 1.477778 0 Td 66.759259 Tz (wound ) Tj 2.333333 0 Td 51.388889 Tz (healing ) Tj 51.428571 0 0 51.428571 0 255.859259 Tm 6.261111 0 Td 51.851852 Tz (devices ) Tj 2.430556 0 Td 65.895062 Tz (may ) Tj 1.4 0 Td 58.333333 Tz (be ) Tj 0.913889 0 Td 51.851852 Tz (configured ) Tj 3.286111 0 Td 61.574074 Tz (by ) Tj 0.972222 0 Td 55.555556 Tz (forming ) Tj 2.508333 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 49.826389 Tz (chitosan ) Tj 2.625 0 Td 73.240741 Tz (compo ) Tj 51.428571 0 0 51.428571 0 210.885457 Tm 6.280556 0 Td 44.290123 Tz (sition ) Tj 1.886111 0 Td 46.180556 Tz (into ) Tj 1.380556 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 55.740741 Tz (shape ) Tj 1.905556 0 Td 60.493827 Tz (and ) Tj 1.361111 0 Td 46.990741 Tz (size ) Tj 1.4 0 Td 44.398148 Tz (Sufficient ) Tj 2.897222 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 61.574074 Tz (accommodate ) Tj 4.336111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 169.947302 Tm 6.241667 0 Td 66.759259 Tz (wound ) Tj 2.255556 0 Td 53.796296 Tz (being ) Tj 1.886111 0 Td 44.560185 Tz (treated. ) Tj 2.430556 0 Td 46.990741 Tz (If ) Tj 0.7 0 Td 47.395833 Tz (desired, ) Tj 2.566667 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 65.462963 Tz (wound ) Tj 2.197222 0 Td 51.388889 Tz (healing ) Tj 2.411111 0 Td 52.932099 Tz (device ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.597297 0 Td 72.522523 Tz (16 ) Tj 51.428571 0 0 51.428571 0 2915.540606 Tm 25.2 0 Td 54.73251 Tz (comprises ) Tj 3.130556 0 Td 50.636574 Tz (chitosan ) Tj 2.644444 0 Td 42.12963 Tz (fibers. ) Tj 1.963889 0 Td 70 Tz (Wound ) Tj 2.294444 0 Td 50.925926 Tz (healing ) Tj 2.352778 0 Td 50.925926 Tz (devices ) Tj 2.352778 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 53.796296 Tz (desir ) Tj 51.428571 0 0 51.428571 0 2876.544503 Tm 25.2 0 Td 51.851852 Tz (ably ) Tj 1.516667 0 Td 56.712963 Tz (produced ) Tj 3.033333 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 55.902778 Tz (whatever ) Tj 2.936111 0 Td 55.740741 Tz (shape ) Tj 1.944444 0 Td 58.333333 Tz (and ) Tj 1.361111 0 Td 46.990741 Tz (size ) Tj 1.380556 0 Td 40.509259 Tz (is ) Tj 0.797222 0 Td 51.851852 Tz (necessary ) Tj 3.091667 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 2832.384615 Tm 25.2 0 Td 53.240741 Tz (provide ) Tj 2.411111 0 Td 61.574074 Tz (optimum ) Tj 2.761111 0 Td 51.131687 Tz (treatment ) Tj 2.897222 0 Td 48.611111 Tz (to ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 59.41358 Tz (wound. ) Tj 2.313889 0 Td 58.333333 Tz (These ) Tj 1.905556 0 Td 51.851852 Tz (devices ) Tj 2.352778 0 Td 57.253086 Tz (can ) Tj 51.428571 0 0 51.428571 0 2789.484646 Tm 25.180556 0 Td 61.574074 Tz (be ) Tj 0.991667 0 Td 56.30787 Tz (produced ) Tj 3.013889 0 Td 42.12963 Tz (in ) Tj 0.816667 0 Td 56.388889 Tz (forms ) Tj 2.002778 0 Td 45.37037 Tz (that ) Tj 1.361111 0 Td 48.206019 Tz (include, ) Tj 2.605556 0 Td 51.851852 Tz (but ) Tj 1.186111 0 Td 50.771605 Tz (are ) Tj 1.244444 0 Td 49.691358 Tz (not ) Tj 1.166667 0 Td 49.074074 Tz (limited ) Tj 2.352778 0 Td 39.969136 Tz (to, ) Tj 51.428571 0 0 51.428571 0 2750.838791 Tm 25.2 0 Td 48.611111 Tz (plugs, ) Tj 2.022222 0 Td 54.166667 Tz (meshes, ) Tj 2.547222 0 Td 41.666667 Tz (strips, ) Tj 2.002778 0 Td 45.775463 Tz (Sutures, ) Tj 2.469444 0 Td 47.638889 Tz (dressings, ) Tj 3.15 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 58.333333 Tz (any ) Tj 1.302778 0 Td 51.203704 Tz (other ) Tj 1.75 0 Td 58.333333 Tz (form ) Tj 51.428571 0 0 51.428571 0 2705.867235 Tm 25.2 0 Td 51.041667 Tz (able ) Tj 1.361111 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 61.574074 Tz (accommodate ) Tj 4.180556 0 Td 60.493827 Tz (and ) Tj 1.225 0 Td 43.75 Tz (assist ) Tj 1.75 0 Td 43.75 Tz (in ) Tj 0.680556 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 48.070988 Tz (repair ) Tj 1.847222 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 59.41358 Tz (wound. ) Tj 2.294444 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 2668.385417 Tm 25.2 0 Td 62.5 Tz (damaged ) Tj 2.916667 0 Td 49.421296 Tz (portions ) Tj 2.702778 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 47.222222 Tz (patient ) Tj 2.255556 0 Td 46.990741 Tz (that ) Tj 1.438889 0 Td 66.975309 Tz (may ) Tj 1.516667 0 Td 58.333333 Tz (be ) Tj 0.972222 0 Td 48.148148 Tz (treated ) Tj 2.294444 0 Td 54.282407 Tz (with ) Tj 51.428571 0 0 51.428571 0 2625.033766 Tm 25.2 0 Td 51.851852 Tz (devices ) Tj 2.527778 0 Td 64.00463 Tz (made ) Tj 1.886111 0 Td 56.712963 Tz (of ) Tj 0.913889 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 53.914141 Tz (composition ) Tj 3.927778 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 50.462963 Tz (present ) Tj 51.428571 0 0 51.428571 0 2582.422222 Tm 25.2 0 Td 50.771605 Tz (invention ) Tj 3.072222 0 Td 47.800926 Tz (include, ) Tj 2.625 0 Td 52.932099 Tz (but ) Tj 1.263889 0 Td 49.691358 Tz (are ) Tj 1.244444 0 Td 49.691358 Tz (not ) Tj 1.205556 0 Td 49.537037 Tz (limited ) Tj 2.372222 0 Td 42.12963 Tz (to, ) Tj 1.05 0 Td 53.796296 Tz (bone, ) Tj 1.963889 0 Td 44.074074 Tz (cartilage, ) Tj 51.428571 0 0 51.428571 0 2539.926316 Tm 25.219444 0 Td 45.37037 Tz (skin, ) Tj 1.711111 0 Td 57.253086 Tz (muscle ) Tj 2.352778 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 50.555556 Tz (other ) Tj 1.788889 0 Td 46.296296 Tz (tissues ) Tj 2.313889 0 Td 47.685185 Tz (\(nerve, ) Tj 2.333333 0 Td 46.450617 Tz (brain, ) Tj 2.002778 0 Td 47.530864 Tz (spinal ) Tj 2.061111 0 Td 48.611111 Tz (cord, ) Tj 51.428571 0 0 51.428571 0 2497.84058 Tm 25.180556 0 Td 45.910494 Tz (heart, ) Tj 1.827778 0 Td 46.990741 Tz (lung\). ) Tj 1.905556 0 Td 56.388889 Tz (Other ) Tj 1.866667 0 Td 48.148148 Tz (similar ) Tj 2.177778 0 Td 51.851852 Tz (devices ) Tj 2.352778 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 52.391975 Tz (administered ) Tj 3.947222 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 44.830247 Tz (assist ) Tj 51.428571 0 0 51.428571 0 2459.881773 Tm 25.2 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 51.131687 Tz (treatment ) Tj 2.994444 0 Td 47.530864 Tz (repair ) Tj 1.866667 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 55.092593 Tz (remodeling ) Tj 3.5 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 62.962963 Tz (damaged ) Tj 2.819444 0 Td 43.518519 Tz (tissue, ) Tj 51.428571 0 0 51.428571 0 2417.26408 Tm 25.180556 0 Td 53.796296 Tz (bone, ) Tj 1.827778 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 44.074074 Tz (cartilage. ) Tj 2.916667 0 Td 56.17284 Tz (For ) Tj 1.186111 0 Td 64.814815 Tz (some ) Tj 1.75 0 Td 47.364672 Tz (applications, ) Tj 3.927778 0 Td 34.027778 Tz (it ) Tj 0.622222 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 48.971193 Tz (desirable ) Tj 2.877778 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 2376.398621 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.283333 0 Td 52.932099 Tz (device ) Tj 2.255556 0 Td 48.611111 Tz (to ) Tj 0.972222 0 Td 56.712963 Tz (be ) Tj 1.069444 0 Td 51.041667 Tz (incorporated ) Tj 4.044444 0 Td 46.990741 Tz (into ) Tj 1.516667 0 Td 55.092593 Tz (an ) Tj 1.05 0 Td 48.206019 Tz (existing ) Tj 2.663889 0 Td 46.990741 Tz (tissue ) Tj 2.061111 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 2333.727932 Tm 25.2 0 Td 42.453704 Tz (facilitate ) Tj 2.741667 0 Td 65.462963 Tz (wound ) Tj 2.138889 0 Td 43.055556 Tz (repair. ) Tj 2.022222 0 Td 56.17284 Tz (For ) Tj 1.147222 0 Td 51.851852 Tz (other ) Tj 1.691667 0 Td 47.115385 Tz (applications, ) Tj 3.888889 0 Td 34.027778 Tz (it ) Tj 0.544444 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 48.971193 Tz (desirable ) Tj 51.428571 0 0 51.428571 0 2291.97 Tm 25.2 0 Td 49.691358 Tz (for ) Tj 1.05 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 52.391975 Tz (device ) Tj 2.080556 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 55.092593 Tz (degrade ) Tj 2.508333 0 Td 55.092593 Tz (over ) Tj 1.477778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 53.472222 Tz (course ) Tj 2.080556 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 50.555556 Tz (days, ) Tj 1.711111 0 Td 55.092593 Tz (weeks, ) Tj 2.197222 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 2252.628993 Tm 25.2 0 Td 54.62963 Tz (months. ) Tj 2.586111 0 Td 59.953704 Tz (Such ) Tj 1.730556 0 Td 51.557239 Tz (degradation ) Tj 3.694444 0 Td 68.055556 Tz (may ) Tj 1.497222 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 53.935185 Tz (advantageously ) Tj 4.802778 0 Td 46.585648 Tz (tailored ) Tj 51.428571 0 0 51.428571 0 2209.443433 Tm 25.180556 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 43.75 Tz (Suit ) Tj 1.302778 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 53.796296 Tz (needs ) Tj 1.886111 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 46.990741 Tz (particular ) Tj 3.072222 0 Td 48.611111 Tz (Subject ) Tj 2.294444 0 Td 52.5 Tz (using ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 57.87037 Tz (methods ) Tj 51.428571 0 0 51.428571 0 2167.631453 Tm 25.2 0 Td 51.851852 Tz (described ) Tj 2.936111 0 Td 47.685185 Tz (herein. ) Tj 2.197222 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 47.685185 Tz (elution ) Tj 2.197222 0 Td 52.391975 Tz (and/or ) Tj 2.061111 0 Td 51.557239 Tz (degradation ) Tj 3.577778 0 Td 45.833333 Tz (profile ) Tj 2.080556 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2126.817259 Tm 25.2 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 53.914141 Tz (composition ) Tj 3.830556 0 Td 40.509259 Tz (\(e.g., ) Tj 1.730556 0 Td 44.722222 Tz (film, ) Tj 1.594444 0 Td 54.62963 Tz (Sponge\) ) Tj 2.586111 0 Td 54.012346 Tz (can ) Tj 1.244444 0 Td 56.712963 Tz (be ) Tj 0.913889 0 Td 47.685185 Tz (altered ) Tj 2.255556 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 2085.612903 Tm 25.2 0 Td 51.851852 Tz (described ) Tj 3.15 0 Td 50.771605 Tz (herein ) Tj 2.197222 0 Td 59.953704 Tz (by ) Tj 1.166667 0 Td 54.444444 Tz (modulating ) Tj 3.675 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 52.211934 Tz (following ) Tj 3.208333 0 Td 46.018519 Tz (variables: ) Tj 51.428571 0 0 51.428571 0 2043.134443 Tm 25.2 0 Td 54.012346 Tz (degree ) Tj 2.411111 0 Td 55.092593 Tz (of ) Tj 1.05 0 Td 47.685185 Tz (deacetylation, ) Tj 4.530556 0 Td 46.990741 Tz (neutralization ) Tj 4.413889 0 Td 46.450617 Tz (solution, ) Tj 2.955556 0 Td 50.462963 Tz (Solvent ) Tj 51.428571 0 0 51.428571 0 2002.442543 Tm 25.2 0 Td 56.712963 Tz (make-up, ) Tj 2.955556 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 55.092593 Tz (weight ) Tj 2.177778 0 Td 44.290123 Tz ('%, ) Tj 1.05 0 Td 54.012346 Tz (molecular ) Tj 3.130556 0 Td 50.925926 Tz (weight, ) Tj 2.352778 0 Td 52.932099 Tz (and/or ) Tj 51.428571 0 0 51.428571 0 1961.107817 Tm 25.2 0 Td 42.592593 Tz (crystallinity. ) Tj 4.063889 0 Td 46.990741 Tz (In ) Tj 1.030556 0 Td 49.907407 Tz (other ) Tj 1.886111 0 Td 57.253086 Tz (embodiments, ) Tj 4.530556 0 Td 58.333333 Tz (a ) Tj 0.758333 0 Td 49.691358 Tz (buffering ) Tj 3.111111 0 Td 47.800926 Tz (step ) Tj 1.594444 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1917.935687 Tm 25.2 0 Td 51.851852 Tz (included ) Tj 2.761111 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 57.407407 Tz (methods ) Tj 2.702778 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 55.092593 Tz (producing ) Tj 3.208333 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 63.888889 Tz (composi ) Tj 40 0 0 40 0 1882 Tm 32.375 0 Td 55.833333 Tz (tion. ) Tj 51.428571 0 0 51.428571 0 1834.985696 Tm 25.919444 0 Td 46.616809 Tz (Crystallinity ) Tj 3.888889 0 Td 47.530864 Tz (indicates ) Tj 2.838889 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 54.012346 Tz (degree ) Tj 2.177778 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 45.694444 Tz (structural ) Tj 2.994444 0 Td 51.851852 Tz (order ) Tj 1.769444 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 1795.557576 Tm 25.2 0 Td 59.773663 Tz (compound. ) Tj 3.480556 0 Td 55.902778 Tz (Polymers ) Tj 2.916667 0 Td 54.282407 Tz (such ) Tj 1.497222 0 Td 50.231481 Tz (as ) Tj 0.816667 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 46.990741 Tz (either ) Tj 1.847222 0 Td 59.773663 Tz (amorphous ) Tj 51.428571 0 0 51.428571 0 1753.836759 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 47.395833 Tz (semicrystalline. ) Tj 4.802778 0 Td 57.613169 Tz (Chitosans ) Tj 3.344444 0 Td 43.055556 Tz (crystallinity, ) Tj 3.888889 0 Td 44.560185 Tz (like ) Tj 1.302778 0 Td 51.203704 Tz (other ) Tj 1.711111 0 Td 64.814815 Tz (poly ) Tj 51.428571 0 0 51.428571 0 1712.280255 Tm 25.2 0 Td 53.148148 Tz (mers, ) Tj 1.866667 0 Td 56.018519 Tz (depends ) Tj 2.625 0 Td 58.333333 Tz (on ) Tj 0.952778 0 Td 37.808642 Tz (its ) Tj 0.952778 0 Td 47.314815 Tz (type, ) Tj 1.691667 0 Td 56.018519 Tz (number, ) Tj 2.586111 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 47.314815 Tz (regularity ) Tj 3.072222 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 64.814815 Tz (poly ) Tj 51.428571 0 0 51.428571 0 1670.116788 Tm 25.2 0 Td 51.851852 Tz (mer-chain, ) Tj 3.305556 0 Td 49.421296 Tz (side ) Tj 1.341667 0 Td 57.037037 Tz (group ) Tj 1.925 0 Td 49.583333 Tz (chemistry, ) Tj 3.188889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 53.472222 Tz (degree ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 52.391975 Tz (matrix ) Tj 2.061111 0 Td 67.24537 Tz (pack ) Tj 52.857143 0 0 52.857143 0 1628.064133 Tm 24.518919 0 Td 50.45045 Tz (ing ) Tj 1.040541 0 Td 53.603604 Tz (or ) Tj 0.756757 0 Td 45.326577 Tz (density, ) Tj 2.327027 0 Td 58.858859 Tz (and ) Tj 1.191892 0 Td 46.327096 Tz (crosslinking. ) Tj 3.783784 0 Td 60.960961 Tz (The ) Tj 1.248649 0 Td 43.416493 Tz (crystallinity ) Tj 3.537838 0 Td 53.603604 Tz (of ) Tj 0.718919 0 Td 50.056306 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1584.233251 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 36.728395 Tz (its ) Tj 0.875 0 Td 51.851852 Tz (products ) Tj 2.702778 0 Td 56.17284 Tz (can ) Tj 1.205556 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 49.259259 Tz (controlled ) Tj 3.15 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 47.685185 Tz (altered ) Tj 2.216667 0 Td 52.391975 Tz (during ) Tj 2.119444 0 Td 64.351852 Tz (manufac ) Tj 51.428571 0 0 51.428571 0 1545.241379 Tm 25.180556 0 Td 48.611111 Tz (ture ) Tj 1.4 0 Td 53.240741 Tz (through ) Tj 2.508333 0 Td 36.728395 Tz (its ) Tj 0.952778 0 Td 54.012346 Tz (molecular ) Tj 3.15 0 Td 50.925926 Tz (weight, ) Tj 2.372222 0 Td 54.012346 Tz (degree ) Tj 2.197222 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 47.916667 Tz (deacetylation, ) Tj 51.428571 0 0 51.428571 0 1503.349701 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 49.421296 Tz (crosslinking ) Tj 3.675 0 Td 48.611111 Tz (to ) Tj 0.738889 0 Td 45.37037 Tz (affect ) Tj 1.769444 0 Td 52.777778 Tz (thermal ) Tj 2.372222 0 Td 46.548822 Tz (properties. ) Tj 3.247222 0 Td 55.092593 Tz (Such ) Tj 1.477778 0 Td 50.231481 Tz (as ) Tj 0.797222 0 Td 52.314815 Tz (melting ) Tj 51.428571 0 0 51.428571 0 1462.485714 Tm 25.2 0 Td 46.450617 Tz (point, ) Tj 1.963889 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 52.363548 Tz (physical-mechanical ) Tj 6.280556 0 Td 46.843434 Tz (properties, ) Tj 3.402778 0 Td 55.092593 Tz (such ) Tj 1.633333 0 Td 50.231481 Tz (as ) Tj 0.913889 0 Td 45.833333 Tz (tensile ) Tj 51.428571 0 0 51.428571 0 1420.970938 Tm 25.219444 0 Td 46.090535 Tz (strength, ) Tj 2.722222 0 Td 57.87037 Tz (Young's ) Tj 2.702778 0 Td 55.092593 Tz (modulus, ) Tj 2.897222 0 Td 51.446759 Tz (Swelling ) Tj 2.683333 0 Td 60.493827 Tz (and ) Tj 1.322222 0 Td 49.96142 Tz (degradation. ) Tj 51.428571 0 0 51.428571 0 1378.542819 Tm 25.919444 0 Td 51.851852 Tz (Crosslinking ) Tj 4.025 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 52.314815 Tz (process ) Tj 2.508333 0 Td 58.333333 Tz (which ) Tj 2.041667 0 Td 46.666667 Tz (links ) Tj 1.691667 0 Td 58.333333 Tz (polymer ) Tj 2.702778 0 Td 51.851852 Tz (chains ) Tj 51.428571 0 0 51.428571 0 1335.133917 Tm 25.180556 0 Td 46.8107 Tz (together. ) Tj 2.877778 0 Td 46.990741 Tz (In ) Tj 0.913889 0 Td 47.890947 Tz (chitosan, ) Tj 2.897222 0 Td 49.421296 Tz (crosslinking ) Tj 3.888889 0 Td 52.314815 Tz (induces ) Tj 2.488889 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 56.860269 Tz (three-dimen ) Tj 51.428571 0 0 51.428571 0 1292.521411 Tm 25.219444 0 Td 46.990741 Tz (sional ) Tj 2.061111 0 Td 52.391975 Tz (matrix ) Tj 2.236111 0 Td 55.092593 Tz (of ) Tj 0.913889 0 Td 49.475309 Tz (interconnected, ) Tj 4.802778 0 Td 42.592593 Tz (linear, ) Tj 2.119444 0 Td 54.372428 Tz (polymeric ) Tj 3.266667 0 Td 48.148148 Tz (chains. ) Tj 51.428571 0 0 51.428571 0 1253.065574 Tm 25.2 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 53.472222 Tz (degree ) Tj 2.158333 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 50.231481 Tz (extent ) Tj 2.061111 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 49.421296 Tz (crosslinking ) Tj 3.811111 0 Td 56.018519 Tz (depends ) Tj 2.625 0 Td 56.712963 Tz (on ) Tj 0.913889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 57.685185 Tz (cross ) Tj 51.428571 0 0 51.428571 0 1214.815612 Tm 25.2 0 Td 49.074074 Tz (linking ) Tj 2.644444 0 Td 48.070988 Tz (agent. ) Tj 2.372222 0 Td 57.973251 Tz (Exemplary ) Tj 3.752778 0 Td 49.151235 Tz (crosslinking ) Tj 4.122222 0 Td 51.311728 Tz (agents ) Tj 2.45 0 Td 50.925926 Tz (include ) Tj 51.428571 0 0 51.428571 0 1172.150852 Tm 25.219444 0 Td 58.333333 Tz (Sodium ) Tj 2.411111 0 Td 49.56427 Tz (tripolyphosphate, ) Tj 5.347222 0 Td 51.446759 Tz (ethylene ) Tj 2.722222 0 Td 50.771605 Tz (glycol ) Tj 2.138889 0 Td 48.935185 Tz (diglycidyl ) Tj 3.208333 0 Td 44.290123 Tz (ether, ) Tj 51.428571 0 0 51.428571 0 1131.118563 Tm 25.2 0 Td 51.446759 Tz (ethylene ) Tj 2.761111 0 Td 49.691358 Tz (oxide, ) Tj 2.1 0 Td 49.907407 Tz (glutaraldehyde, ) Tj 4.783333 0 Td 50.434028 Tz (epichlorohydrin, ) Tj 5.172222 0 Td 55.092593 Tz (diisocya ) Tj 51.428571 0 0 51.428571 0 1088.242767 Tm 25.2 0 Td 46.018519 Tz (nate, ) Tj 1.691667 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 49.421296 Tz (genipin. ) Tj 2.663889 0 Td 51.851852 Tz (Crosslinking ) Tj 4.044444 0 Td 54.012346 Tz (can ) Tj 1.263889 0 Td 49.421296 Tz (also ) Tj 1.477778 0 Td 59.953704 Tz (be ) Tj 0.991667 0 Td 55.902778 Tz (accomplished ) Tj 51.428571 0 0 51.428571 0 1044.133449 Tm 25.180556 0 Td 53.148148 Tz (using ) Tj 1.866667 0 Td 59.41358 Tz (microwave ) Tj 3.461111 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 45.37037 Tz (ultraviolet ) Tj 3.208333 0 Td 51.851852 Tz (exposure. ) Tj 51.428571 0 0 51.428571 0 1003.707572 Tm 25.919444 0 Td 51.851852 Tz (Chitosans ) Tj 3.363889 0 Td 48.611111 Tz (properties ) Tj 3.188889 0 Td 55.092593 Tz (can ) Tj 1.244444 0 Td 49.421296 Tz (also ) Tj 1.458333 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 47.685185 Tz (altered ) Tj 2.255556 0 Td 59.953704 Tz (by ) Tj 1.030556 0 Td 54.444444 Tz (modulating ) Tj 51.428571 0 0 51.428571 0 961.97552 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 53.472222 Tz (degree ) Tj 2.158333 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 47.916667 Tz (deacetylation. ) Tj 4.277778 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 58.038721 Tz (embodiment, ) Tj 4.025 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 54.012346 Tz (degree ) Tj 51.428571 0 0 51.428571 0 920.5 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 1.147222 0 Td 49.109687 Tz (deacetylation ) Tj 4.413889 0 Td 38.888889 Tz (is ) Tj 0.991667 0 Td 50.636574 Tz (adjusted ) Tj 2.936111 0 Td 57.87037 Tz (between ) Tj 2.955556 0 Td 55.092593 Tz (about ) Tj 2.197222 0 Td 58.333333 Tz (50-100%, ) Tj 51.428571 0 0 51.428571 0 877.478149 Tm 25.180556 0 Td 56.018519 Tz (wherein ) Tj 2.605556 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 56.712963 Tz (bottom ) Tj 2.313889 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 53.148148 Tz (range ) Tj 1.847222 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 58.333333 Tz (any ) Tj 1.302778 0 Td 48.611111 Tz (integer ) Tj 2.236111 0 Td 57.87037 Tz (between ) Tj 2.683333 0 Td 59.953704 Tz (50 ) Tj 51.428571 0 0 51.428571 0 835.92112 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 50.771605 Tz (99, ) Tj 1.108333 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.771605 Tz (top ) Tj 1.108333 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 52.5 Tz (range ) Tj 1.75 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 58.333333 Tz (any ) Tj 1.244444 0 Td 48.611111 Tz (integer ) Tj 2.197222 0 Td 56.944444 Tz (between ) Tj 2.625 0 Td 73.45679 Tz (51% ) Tj 51.428571 0 0 51.428571 0 794.756681 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.633333 0 Td 58.981481 Tz (100%. ) Tj 2.372222 0 Td 45.37037 Tz (In ) Tj 1.05 0 Td 47.314815 Tz (particular ) Tj 3.305556 0 Td 57.253086 Tz (embodiments, ) Tj 4.666667 0 Td 48.611111 Tz (the ) Tj 1.4 0 Td 53.472222 Tz (degree ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 752.094241 Tm 25.2 0 Td 49.85755 Tz (deacetylation ) Tj 4.180556 0 Td 40.509259 Tz (is ) Tj 0.797222 0 Td 62.384259 Tz (51%, ) Tj 1.847222 0 Td 62.384259 Tz (55%, ) Tj 1.827778 0 Td 62.384259 Tz (60%, ) Tj 1.808333 0 Td 62.384259 Tz (61%. ) Tj 1.847222 0 Td 62.384259 Tz (65%, ) Tj 1.827778 0 Td 62.384259 Tz (70%, ) Tj 1.808333 0 Td 62.384259 Tz (71%, ) Tj 47.142857 0 0 47.142857 0 711 Tm 27.490909 0 Td 68.939394 Tz (73%, ) Tj 1.951515 0 Td 68.055556 Tz (74%, ) Tj 1.930303 0 Td 68.055556 Tz (75%, ) Tj 1.909091 0 Td 68.055556 Tz (76%, ) Tj 1.930303 0 Td 68.055556 Tz (77%, ) Tj 1.972727 0 Td 67.171717 Tz (78%, ) Tj 1.930303 0 Td 67.171717 Tz (79%, ) Tj 1.909091 0 Td 68.055556 Tz (80%, ) Tj 1.930303 0 Td 68.055556 Tz (85%, ) Tj 1.930303 0 Td 68.055556 Tz (90%, ) Tj 51.428571 0 0 51.428571 0 672.168927 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 62.384259 Tz (95%. ) Tj 1.75 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 48.611111 Tz (general, ) Tj 2.527778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 52.391975 Tz (higher ) Tj 2.061111 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 53.472222 Tz (degree ) Tj 2.1 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 48.148148 Tz (deacetylation, ) Tj 51.428571 0 0 51.428571 0 629.848761 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 54.012346 Tz (slower ) Tj 2.138889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 51.851852 Tz (degradation ) Tj 3.713889 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 52.121914 Tz (composition. ) Tj 48.571429 0 0 48.571429 0 586 Tm 27.464706 0 Td 49.754902 Tz (If ) Tj 0.864706 0 Td 50.183824 Tz (desired, ) Tj 2.758824 0 Td 53.186275 Tz (chitosan ) Tj 2.944118 0 Td 41.176471 Tz (is ) Tj 0.905882 0 Td 51.158645 Tz (neutralized ) Tj 3.705882 0 Td 48.72549 Tz (after ) Tj 1.791176 0 Td 54.044118 Tz (acid ) Tj 1.647059 0 Td 51.127451 Tz (treatment. ) Tj 51.428571 0 0 51.428571 0 543.50134 Tm 25.2 0 Td 69.135802 Tz (Any ) Tj 1.575 0 Td 53.472222 Tz (base ) Tj 1.613889 0 Td 65.462963 Tz (known ) Tj 2.275 0 Td 46.990741 Tz (in ) Tj 0.913889 0 Td 48.611111 Tz (the ) Tj 1.166667 0 Td 44.290123 Tz (art ) Tj 1.088889 0 Td 41.049383 Tz (\(e.g., ) Tj 1.808333 0 Td 68.703704 Tz (NaOH, ) Tj 2.430556 0 Td 71.296296 Tz (KOH, ) Tj 2.041667 0 Td 70.216049 Tz (NH-OH, ) Tj 51.428571 0 0 51.428571 0 503.110429 Tm 25.2 0 Td 66.666667 Tz (Ca\(OH\), ) Tj 3.052778 0 Td 70.833333 Tz (Mg\(OH\), ) Tj 3.208333 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 54.552469 Tz (combinations ) Tj 4.161111 0 Td 47.800926 Tz (thereof\) ) Tj 2.566667 0 Td 66.975309 Tz (may ) Tj 1.438889 0 Td 56.712963 Tz (be ) Tj 0.913889 0 Td 55.902778 Tz (used ) Tj 51.428571 0 0 51.428571 0 460.920398 Tm 25.180556 0 Td 46.990741 Tz (to ) Tj 0.913889 0 Td 47.314815 Tz (neutralize ) Tj 3.111111 0 Td 55.092593 Tz (an ) Tj 0.952778 0 Td 48.070988 Tz (acid-treated ) Tj 3.752778 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 52.121914 Tz (composition. ) Tj 4.102778 0 Td 54.552469 Tz (Prefer ) Tj 51.428571 0 0 51.428571 0 420.911765 Tm 25.2 0 Td 46.018519 Tz (ably, ) Tj 1.516667 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 47.222222 Tz (neutralization ) Tj 4.141667 0 Td 48.611111 Tz (Solution ) Tj 2.508333 0 Td 52.932099 Tz (has ) Tj 1.127778 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 74.537037 Tz (pH ) Tj 1.05 0 Td 48.611111 Tz (greater ) Tj 2.177778 0 Td 51.851852 Tz (than ) Tj 1.419444 0 Td 50.771605 Tz (7.4 ) Tj 1.05 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 376 Tm 25.2 0 Td 45.37037 Tz (7.8, ) Tj 1.458333 0 Td 43.75 Tz (8.0, ) Tj 1.419444 0 Td 46.180556 Tz (8.5, ) Tj 1.477778 0 Td 44.560185 Tz (9.0, ) Tj 1.536111 0 Td 44.290123 Tz (10, ) Tj 1.263889 0 Td 44.290123 Tz (11, ) Tj 1.166667 0 Td 59.41358 Tz (and ) Tj 1.497222 0 Td 45.37037 Tz (12, ) Tj 1.244444 0 Td 47.530864 Tz (13, ) Tj 1.283333 0 Td 46.450617 Tz (14, ) Tj 1.263889 0 Td 47.530864 Tz (15, ) Tj 1.283333 0 Td 44.560185 Tz (16\). ) Tj 1.419444 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 339.336735 Tm 25.2 0 Td 47.453704 Tz (neutralization ) Tj 4.297222 0 Td 46.990741 Tz (step ) Tj 1.419444 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 47.530864 Tz (optional, ) Tj 2.838889 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 50.771605 Tz (not ) Tj 1.205556 0 Td 41.319444 Tz (strictly ) Tj 2.255556 0 Td 47.890947 Tz (required. ) Tj 2.897222 0 Td 46.990741 Tz (If ) Tj 48.571429 0 0 48.571429 0 295 Tm 26.682353 0 Td 50.183824 Tz (desired, ) Tj 2.717647 0 Td 52.614379 Tz (the ) Tj 1.194118 0 Td 53.615196 Tz (chitosan ) Tj 2.902941 0 Td 41.176471 Tz (is ) Tj 0.802941 0 Td 50 Tz (treated ) Tj 2.367647 0 Td 56.617647 Tz (with ) Tj 1.688235 0 Td 51.470588 Tz (water, ) Tj 2.161765 0 Td 64.338235 Tz (PBS, ) Tj 1.832353 0 Td 56.617647 Tz (or ) Tj 0.947059 0 Td 45.098039 Tz (sterile ) Tj 51.428571 0 0 51.428571 0 254.698113 Tm 25.219444 0 Td 46.990741 Tz (saline ) Tj 2.119444 0 Td 51.851852 Tz (following ) Tj 3.227778 0 Td 50.231481 Tz (acid ) Tj 1.613889 0 Td 48.611111 Tz (treatment. ) Tj 3.383333 0 Td 35.648148 Tz (It ) Tj 0.855556 0 Td 66.975309 Tz (may ) Tj 1.652778 0 Td 55.497685 Tz (comprise ) Tj 3.072222 0 Td 63.194444 Tz (0.01 ) Tj 51.428571 0 0 51.428571 0 210.770218 Tm 25.258333 0 Td 61.574074 Tz (10.0M ) Tj 2.061111 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 53.472222 Tz (base ) Tj 1.516667 0 Td 40.509259 Tz (\(e.g., ) Tj 1.711111 0 Td 47.314815 Tz (0.01, ) Tj 1.672222 0 Td 49.691358 Tz (0.025, ) Tj 2.002778 0 Td 51.131687 Tz (0.5,0.75, ) Tj 3.013889 0 Td 42.939815 Tz (0.1, ) Tj 1.283333 0 Td 47.962963 Tz (0.25, ) Tj 1.672222 0 Td 44.560185 Tz (0.5, ) Tj 51.428571 0 0 51.428571 0 168.744186 Tm 25.2 0 Td 47.962963 Tz (0.75, ) Tj 1.691667 0 Td 42.12963 Tz (1.0, ) Tj 1.244444 0 Td 42.12963 Tz (1.5, ) Tj 1.186111 0 Td 44.560185 Tz (2.0, ) Tj 1.225 0 Td 46.180556 Tz (2.5, ) Tj 1.263889 0 Td 56.712963 Tz (3,4,5,6,7,8,9, ) Tj 5.016667 0 Td 71.296296 Tz (10M\) ) Tj 1.866667 0 Td 41.049383 Tz (\(e.g., ) Tj 1.652778 0 Td 63.734568 Tz (NaOH\). ) Tj ET Q endstream endobj 135 0 obj << /Length 1 >> stream q endstream endobj 136 0 obj << /Length 51621 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.17027 0 Td 74.099099 Tz (17 ) Tj 51.428571 0 0 51.428571 0 2916.034134 Tm 6.261111 0 Td 53.472222 Tz (Chitosan ) Tj 2.936111 0 Td 53.472222 Tz (compositions ) Tj 4.238889 0 Td 48.316498 Tz (neutralized ) Tj 3.519444 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 52.5 Tz (bases ) Tj 1.905556 0 Td 55.092593 Tz (having ) Tj 2.333333 0 Td 55.740741 Tz (lower ) Tj 51.428571 0 0 51.428571 0 2877.365385 Tm 6.261111 0 Td 51.041667 Tz (molarity ) Tj 2.683333 0 Td 54.166667 Tz (degrade ) Tj 2.488889 0 Td 61.574074 Tz (more ) Tj 1.672222 0 Td 47.395833 Tz (quickly. ) Tj 2.469444 0 Td 53.877315 Tz (Chitosan ) Tj 2.819444 0 Td 53.472222 Tz (compositions ) Tj 4.063889 0 Td 70.216049 Tz (neu ) Tj 51.428571 0 0 51.428571 0 2833.334963 Tm 6.241667 0 Td 46.180556 Tz (tralized ) Tj 2.430556 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 51.851852 Tz (bases ) Tj 1.769444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 51.49177 Tz (increased ) Tj 3.013889 0 Td 50.231481 Tz (molarity ) Tj 2.644444 0 Td 54.62963 Tz (degrade ) Tj 2.508333 0 Td 62.384259 Tz (more ) Tj 1.691667 0 Td 53.472222 Tz (slowly ) Tj 51.428571 0 0 51.428571 0 2788.942928 Tm 6.241667 0 Td 52.662037 Tz (than ) Tj 1.477778 0 Td 51.203704 Tz (those ) Tj 1.808333 0 Td 48.611111 Tz (neutralized ) Tj 3.402778 0 Td 46.990741 Tz (at ) Tj 0.797222 0 Td 46.450617 Tz (lesser ) Tj 1.886111 0 Td 46.254209 Tz (molarities. ) Tj 3.286111 0 Td 54.444444 Tz (Thus, ) Tj 1.866667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 61.574074 Tz (degra ) Tj 51.428571 0 0 51.428571 0 2750.031368 Tm 6.261111 0 Td 50.231481 Tz (dation ) Tj 2.041667 0 Td 48.611111 Tz (properties ) Tj 3.188889 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 54.012346 Tz (can ) Tj 1.244444 0 Td 58.333333 Tz (be ) Tj 0.952778 0 Td 56.532922 Tz (modulated ) Tj 3.305556 0 Td 59.953704 Tz (by ) Tj 0.972222 0 Td 46.585648 Tz (altering ) Tj 51.428571 0 0 51.428571 0 2709.777778 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 50.231481 Tz (molarity ) Tj 2.683333 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 47.800926 Tz (neutralizing ) Tj 3.694444 0 Td 47.962963 Tz (base. ) Tj 48.571429 0 0 48.571429 0 2666 Tm 7.432353 0 Td 49.754902 Tz (In ) Tj 0.988235 0 Td 53.529412 Tz (other ) Tj 1.935294 0 Td 60.334967 Tz (embodiments, ) Tj 4.755882 0 Td 51.470588 Tz (the ) Tj 1.255882 0 Td 53.846154 Tz (concentration ) Tj 4.591176 0 Td 61.764706 Tz (of ) Tj 1.008824 0 Td 52.614379 Tz (the ) Tj 1.317647 0 Td 50.898693 Tz (acidic ) Tj 51.428571 0 0 51.428571 0 2623.267427 Tm 6.280556 0 Td 50 Tz (solvent ) Tj 2.294444 0 Td 55.902778 Tz (used ) Tj 1.555556 0 Td 43.75 Tz (to ) Tj 0.777778 0 Td 49.421296 Tz (dissolve ) Tj 2.566667 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.636574 Tz (chitosan ) Tj 2.663889 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 50.636574 Tz (adjusted ) Tj 2.625 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 53.472222 Tz (time ) Tj 51.428571 0 0 51.428571 0 2583.308458 Tm 6.261111 0 Td 51.851852 Tz (period ) Tj 2.061111 0 Td 55.092593 Tz (used ) Tj 1.516667 0 Td 45.37037 Tz (to ) Tj 0.758333 0 Td 49.421296 Tz (dissolve ) Tj 2.566667 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 44.155093 Tz (altered. ) Tj 2.372222 0 Td 56.17284 Tz (For ) Tj 1.147222 0 Td 55.092593 Tz (example, ) Tj 48.571429 0 0 48.571429 0 2541 Tm 6.629412 0 Td 58.333333 Tz (a ) Tj 0.597059 0 Td 58.333333 Tz (0.1%, ) Tj 2.038235 0 Td 59.019608 Tz (0.5%, ) Tj 2.058824 0 Td 65.196078 Tz (1%, ) Tj 1.4 0 Td 68.627451 Tz (2%, ) Tj 1.482353 0 Td 85.784314 Tz (3% ) Tj 1.276471 0 Td 56.617647 Tz (or ) Tj 0.905882 0 Td 84.068627 Tz (5% ) Tj 1.235294 0 Td 54.044118 Tz (acid ) Tj 1.544118 0 Td 51.041667 Tz (solution ) Tj 2.717647 0 Td 41.176471 Tz (is ) Tj 0.741176 0 Td 53.529412 Tz (used. ) Tj 1.873529 0 Td 53.186275 Tz (In ) Tj 51.428571 0 0 51.428571 0 2498.510417 Tm 6.261111 0 Td 46.990741 Tz (particular ) Tj 3.208333 0 Td 56.712963 Tz (embodiments, ) Tj 4.511111 0 Td 50.231481 Tz (chitosan ) Tj 2.858333 0 Td 37.268519 Tz (is ) Tj 0.875 0 Td 51.131687 Tz (dissolved ) Tj 3.15 0 Td 46.990741 Tz (in ) Tj 0.991667 0 Td 43.981481 Tz (acetic, ) Tj 51.428571 0 0 51.428571 0 2459.347518 Tm 6.261111 0 Td 39.814815 Tz (citric, ) Tj 1.866667 0 Td 45.833333 Tz (oxalic, ) Tj 2.1 0 Td 49.259259 Tz (propionic, ) Tj 3.111111 0 Td 48.611111 Tz (ascorbic, ) Tj 2.761111 0 Td 50.356125 Tz (hydrochloric, ) Tj 4.102778 0 Td 50 Tz (formic, ) Tj 2.275 0 Td 51.851852 Tz (Sali ) Tj 51.428571 0 0 51.428571 0 2414.794483 Tm 6.261111 0 Td 46.666667 Tz (cylic ) Tj 1.769444 0 Td 53.472222 Tz (and/or ) Tj 2.294444 0 Td 42.669753 Tz (lactic ) Tj 1.905556 0 Td 46.990741 Tz (acids, ) Tj 2.080556 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 0.738889 0 Td 54.503367 Tz (combination ) Tj 4.005556 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 46.990741 Tz (those. ) Tj 2.138889 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 2375.726841 Tm 6.261111 0 Td 48.206019 Tz (general, ) Tj 2.488889 0 Td 48.070988 Tz (acidic ) Tj 1.886111 0 Td 49.421296 Tz (solvents ) Tj 2.566667 0 Td 54.444444 Tz (comprising ) Tj 3.422222 0 Td 50.771605 Tz (increased ) Tj 2.897222 0 Td 46.990741 Tz (levels ) Tj 1.866667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 43.209877 Tz (lactic ) Tj 51.428571 0 0 51.428571 0 2335.180268 Tm 6.261111 0 Td 51.041667 Tz (acid ) Tj 1.438889 0 Td 57.523148 Tz (form ) Tj 1.613889 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 53.742284 Tz (compositions ) Tj 4.083333 0 Td 46.180556 Tz (that ) Tj 1.322222 0 Td 54.62963 Tz (degrade ) Tj 2.508333 0 Td 62.384259 Tz (more ) Tj 1.711111 0 Td 51.851852 Tz (quickly ) Tj 51.428571 0 0 51.428571 0 2292.820446 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.361111 0 Td 46.990741 Tz (also ) Tj 1.458333 0 Td 58.333333 Tz (have ) Tj 1.711111 0 Td 54.62963 Tz (reduced ) Tj 2.625 0 Td 48.206019 Tz (strength ) Tj 2.625 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 44.191919 Tz (durability. ) Tj 3.266667 0 Td 48.611111 Tz (In ) Tj 0.933333 0 Td 50 Tz (various ) Tj 48.571429 0 0 48.571429 0 2250 Tm 6.629412 0 Td 60.334967 Tz (embodiments, ) Tj 4.673529 0 Td 57.47549 Tz (combinations ) Tj 4.467647 0 Td 60.04902 Tz (of ) Tj 0.967647 0 Td 49.183007 Tz (acetic ) Tj 2.1 0 Td 62.908497 Tz (and ) Tj 1.461765 0 Td 45.751634 Tz (lactic ) Tj 1.976471 0 Td 52.156863 Tz (acids ) Tj 1.914706 0 Td 52.614379 Tz (are ) Tj 51.428571 0 0 51.428571 0 2210.13859 Tm 6.241667 0 Td 50.555556 Tz (used. ) Tj 1.672222 0 Td 51.851852 Tz (Acetic ) Tj 2.041667 0 Td 52.256944 Tz (provides ) Tj 2.722222 0 Td 60.763889 Tz (more ) Tj 1.613889 0 Td 48.206019 Tz (strength ) Tj 2.508333 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 54.552469 Tz (slower ) Tj 2.1 0 Td 49.96142 Tz (degradation. ) Tj 51.428571 0 0 51.428571 0 2168.012146 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.952778 0 Td 46.090535 Tz (contrast, ) Tj 2.877778 0 Td 43.209877 Tz (lactic ) Tj 1.925 0 Td 51.041667 Tz (acid ) Tj 1.594444 0 Td 51.851852 Tz (provides ) Tj 2.897222 0 Td 61.574074 Tz (more ) Tj 1.847222 0 Td 40.779321 Tz (flexibility. ) Tj 3.344444 0 Td 48.611111 Tz (In ) Tj 0.952778 0 Td 59.41358 Tz (one ) Tj 51.428571 0 0 51.428571 0 2124.471033 Tm 6.261111 0 Td 52.572016 Tz (approach, ) Tj 3.013889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 44.074074 Tz (ratio ) Tj 1.536111 0 Td 55.092593 Tz (of ) Tj 0.777778 0 Td 42.669753 Tz (lactic ) Tj 1.711111 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 46.990741 Tz (acetic ) Tj 1.866667 0 Td 51.041667 Tz (acid ) Tj 1.419444 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 50.231481 Tz (varied ) Tj 2.002778 0 Td 55.902778 Tz (from ) Tj 1.575 0 Td 44.560185 Tz (5:1, ) Tj 48.571429 0 0 48.571429 0 2084 Tm 6.629412 0 Td 48.897059 Tz (4:1, ) Tj 1.420588 0 Td 48.897059 Tz (3:1, ) Tj 1.4 0 Td 49.754902 Tz (2:1, ) Tj 1.523529 0 Td 45.465686 Tz (1:1, ) Tj 1.420588 0 Td 45.465686 Tz (1:2, ) Tj 1.4 0 Td 46.323529 Tz (1:3, ) Tj 1.441176 0 Td 45.465686 Tz (1:4, ) Tj 1.358824 0 Td 46.323529 Tz (to ) Tj 0.905882 0 Td 44.607843 Tz (1:5. ) Tj 1.358824 0 Td 49.754902 Tz (In ) Tj 0.885294 0 Td 60.620915 Tz (one ) Tj 1.317647 0 Td 61.14082 Tz (embodiment, ) Tj 51.428571 0 0 51.428571 0 2041.533417 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 55.092593 Tz (blended ) Tj 2.663889 0 Td 51.041667 Tz (acid ) Tj 1.555556 0 Td 50.462963 Tz (solvent ) Tj 2.430556 0 Td 54.73251 Tz (comprises ) Tj 3.325 0 Td 63.194444 Tz (90%/10%, ) Tj 3.402778 0 Td 68.055556 Tz (80%/20% ) Tj 48.571429 0 0 48.571429 0 2001 Tm 6.629412 0 Td 67.340686 Tz (75%/25%, ) Tj 3.623529 0 Td 66.482843 Tz (70%/30%, ) Tj 3.582353 0 Td 66.911765 Tz (60%/40%, ) Tj 3.602941 0 Td 66.482843 Tz (50%/50%. ) Tj 3.582353 0 Td 51.470588 Tz (In ) Tj 0.988235 0 Td 37.058824 Tz (still ) Tj 1.523529 0 Td 54.215686 Tz (other ) Tj 51.428571 0 0 51.428571 0 1958.04436 Tm 6.261111 0 Td 56.983025 Tz (embodiments, ) Tj 4.355556 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 50.636574 Tz (chitosan ) Tj 2.702778 0 Td 55.632716 Tz (weight ) Tj 2.313889 0 Td 90.740741 Tz (% ) Tj 0.816667 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 48.148148 Tz (altered ) Tj 2.275 0 Td 57.523148 Tz (from ) Tj 1.652778 0 Td 63.194444 Tz (0.25 ) Tj 51.428571 0 0 51.428571 0 1915.815013 Tm 6.319444 0 Td 60.277778 Tz (10.0% ) Tj 2.061111 0 Td 41.049383 Tz (\(e.g., ) Tj 1.730556 0 Td 43.75 Tz (0.1, ) Tj 1.322222 0 Td 45.37037 Tz (0.2, ) Tj 1.341667 0 Td 47.314815 Tz (0.25, ) Tj 1.691667 0 Td 44.560185 Tz (0.3, ) Tj 1.341667 0 Td 49.826389 Tz (0.4,0.5, ) Tj 2.702778 0 Td 38.888889 Tz (1, ) Tj 0.816667 0 Td 45.37037 Tz (1.25, ) Tj 1.672222 0 Td 42.12963 Tz (1.5, ) Tj 1.341667 0 Td 45.37037 Tz (1.75, ) Tj 51.428571 0 0 51.428571 0 1874 Tm 6.261111 0 Td 45.37037 Tz (2.0, ) Tj 1.263889 0 Td 46.180556 Tz (2.5, ) Tj 1.322222 0 Td 44.560185 Tz (3.0, ) Tj 1.283333 0 Td 44.560185 Tz (3.5, ) Tj 1.302778 0 Td 43.75 Tz (4, ) Tj 0.738889 0 Td 45.37037 Tz (5, ) Tj 0.758333 0 Td 42.12963 Tz (6, ) Tj 0.738889 0 Td 43.75 Tz (7, ) Tj 0.719444 0 Td 45.37037 Tz (8, ) Tj 0.758333 0 Td 45.37037 Tz (9, ) Tj 0.816667 0 Td 55.092593 Tz (10%\). ) Tj 1.905556 0 Td 48.611111 Tz (In ) Tj 0.777778 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 57.744108 Tz (embodiment, ) Tj 51.428571 0 0 51.428571 0 1833.678161 Tm 6.261111 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 35.648148 Tz (1 ) Tj 0.602778 0 Td 59.953704 Tz (wt ) Tj 0.991667 0 Td 97.222222 Tz (% ) Tj 0.913889 0 Td 50.231481 Tz (chitosan ) Tj 2.722222 0 Td 48.611111 Tz (solution ) Tj 2.644444 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 47.314815 Tz (preferred, ) Tj 3.130556 0 Td 59.62963 Tz (where ) Tj 2.061111 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 35.648148 Tz (1 ) Tj 0.602778 0 Td 59.953704 Tz (wt ) Tj 0.991667 0 Td 100.462963 Tz (% ) Tj 51.428571 0 0 51.428571 0 1792.351064 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.741667 0 Td 48.206019 Tz (Solution ) Tj 2.625 0 Td 49.421296 Tz (contains ) Tj 2.761111 0 Td 35.648148 Tz (1 ) Tj 0.583333 0 Td 61.574074 Tz (gram ) Tj 1.808333 0 Td 55.092593 Tz (of ) Tj 0.894444 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 55.092593 Tz (per ) Tj 1.302778 0 Td 58.333333 Tz (100 ) Tj 1.341667 0 Td 61.574074 Tz (ml ) Tj 51.428571 0 0 51.428571 0 1751.663043 Tm 6.280556 0 Td 46.090535 Tz (solution. ) Tj 2.838889 0 Td 47.962963 Tz (Typically, ) Tj 3.247222 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 52.391975 Tz (higher ) Tj 2.236111 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 59.953704 Tz (wt ) Tj 1.05 0 Td 66.435185 Tz (%, ) Tj 1.166667 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 55.092593 Tz (slower ) Tj 2.294444 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1716 Tm 6.261111 0 Td 49.96142 Tz (degradation. ) Tj 51.428571 0 0 51.428571 0 1668.886598 Tm 7.019444 0 Td 45.37037 Tz (If ) Tj 0.661111 0 Td 50 Tz (desired ) Tj 2.313889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 54.208754 Tz (composition ) Tj 3.811111 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 54.012346 Tz (loaded ) Tj 2.138889 0 Td 53.472222 Tz (with ) Tj 1.497222 0 Td 51.851852 Tz (agents ) Tj 52.857143 0 0 52.857143 0 1624.790754 Tm 6.091892 0 Td 56.756757 Tz (and ) Tj 1.154054 0 Td 49.399399 Tz (the ) Tj 1.021622 0 Td 48.873874 Tz (chitosan ) Tj 2.497297 0 Td 52.743653 Tz (composition ) Tj 3.67027 0 Td 36.261261 Tz (is ) Tj 0.605405 0 Td 48.698699 Tz (delivered ) Tj 2.724324 0 Td 47.297297 Tz (to ) Tj 0.718919 0 Td 50.45045 Tz (a ) Tj 0.472973 0 Td 64.324324 Tz (wound ) Tj 2.024324 0 Td 47.297297 Tz (to ) Tj 0.737838 0 Td 57.545045 Tz (form ) Tj 51.428571 0 0 51.428571 0 1587.049268 Tm 6.261111 0 Td 51.851852 Tz (a ) Tj 0.680556 0 Td 49.016204 Tz (delivery ) Tj 2.722222 0 Td 55.632716 Tz (system ) Tj 2.372222 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 47.530864 Tz (the ) Tj 1.186111 0 Td 48.611111 Tz (agent. ) Tj 2.177778 0 Td 47.138047 Tz (Preferably, ) Tj 3.480556 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1541.826303 Tm 6.261111 0 Td 54.208754 Tz (composition ) Tj 3.830556 0 Td 50.636574 Tz (contains ) Tj 2.644444 0 Td 58.333333 Tz (an ) Tj 0.952778 0 Td 46.450617 Tz (effective ) Tj 2.722222 0 Td 61.574074 Tz (amount ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 53.877315 Tz (chemical ) Tj 2.858333 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1503.070838 Tm 6.261111 0 Td 52.054398 Tz (pharmaceutically ) Tj 5.152778 0 Td 49.151235 Tz (active ) Tj 1.905556 0 Td 56.388889 Tz (component. ) Tj 3.597222 0 Td 46.990741 Tz (In ) Tj 0.738889 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 57.744108 Tz (embodiment, ) Tj 3.986111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1459.973366 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 54.208754 Tz (composition ) Tj 3.791667 0 Td 48.070988 Tz (self-adheres ) Tj 3.655556 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 42.939815 Tz (site ) Tj 1.186111 0 Td 45.37037 Tz (at ) Tj 0.719444 0 Td 57.685185 Tz (which ) Tj 1.925 0 Td 49.826389 Tz (delivery ) Tj 48.571429 0 0 48.571429 0 1417 Tm 6.629412 0 Td 41.176471 Tz (is ) Tj 0.885294 0 Td 49.754902 Tz (desired. ) Tj 2.8 0 Td 49.754902 Tz (In ) Tj 0.988235 0 Td 55.882353 Tz (another ) Tj 2.655882 0 Td 61.452763 Tz (embodiment, ) Tj 4.426471 0 Td 58.333333 Tz (an ) Tj 1.091176 0 Td 56.188725 Tz (adhesive ) Tj 3.088235 0 Td 53.186275 Tz (or ) Tj 0.988235 0 Td 53.529412 Tz (other ) Tj 51.428571 0 0 51.428571 0 1378.10582 Tm 6.261111 0 Td 53.06713 Tz (adhering ) Tj 2.858333 0 Td 60.925926 Tz (means ) Tj 2.158333 0 Td 66.975309 Tz (may ) Tj 1.477778 0 Td 59.953704 Tz (be ) Tj 0.991667 0 Td 51.388889 Tz (applied ) Tj 2.411111 0 Td 48.611111 Tz (to ) Tj 0.855556 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 50.555556 Tz (outer ) Tj 1.788889 0 Td 54.444444 Tz (edges ) Tj 1.944444 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1337 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 53.914141 Tz (composition ) Tj 3.888889 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 55.092593 Tz (hold ) Tj 1.613889 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 54.208754 Tz (composition ) Tj 3.927778 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 49.826389 Tz (position ) Tj 51.428571 0 0 51.428571 0 1295.940568 Tm 6.261111 0 Td 52.932099 Tz (during ) Tj 2.294444 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 49.016204 Tz (delivery ) Tj 2.722222 0 Td 59.953704 Tz (of ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 54.6875 Tz (chemical ) Tj 2.994444 0 Td 53.472222 Tz (or ) Tj 0.952778 0 Td 52.459491 Tz (pharmaceutically ) Tj 51.428571 0 0 51.428571 0 1251.330864 Tm 6.261111 0 Td 48.611111 Tz (active ) Tj 1.963889 0 Td 56.064815 Tz (component. ) Tj 3.616667 0 Td 59.143519 Tz (Such ) Tj 1.633333 0 Td 52.662037 Tz (adherent ) Tj 2.741667 0 Td 60.925926 Tz (means ) Tj 2.061111 0 Td 68.055556 Tz (may ) Tj 1.438889 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 55.902778 Tz (used ) Tj 1.536111 0 Td 53.148148 Tz (alone ) Tj 51.428571 0 0 51.428571 0 1211.46433 Tm 6.261111 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 54.79798 Tz (combination ) Tj 3.908333 0 Td 52.662037 Tz (with ) Tj 1.516667 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 48.860399 Tz (self-adhering ) Tj 4.044444 0 Td 48.611111 Tz (properties ) Tj 3.15 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 62.654321 Tz (chi ) Tj 51.428571 0 0 51.428571 0 1169.110559 Tm 6.241667 0 Td 48.070988 Tz (tosan. ) Tj 1.983333 0 Td 53.877315 Tz (Chitosan ) Tj 2.877778 0 Td 53.742284 Tz (compositions ) Tj 4.141667 0 Td 52.777778 Tz (provide ) Tj 2.488889 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 46.018519 Tz (local ) Tj 1.633333 0 Td 69.351852 Tz (admin ) Tj 51.428571 0 0 51.428571 0 1126.913229 Tm 6.261111 0 Td 43.930041 Tz (istration ) Tj 2.644444 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 49.537037 Tz (desired ) Tj 2.313889 0 Td 61.033951 Tz (amount ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 48.905724 Tz (therapeutic ) Tj 3.480556 0 Td 48.611111 Tz (agent. ) Tj 51.428571 0 0 51.428571 0 1084.207133 Tm 7 0 Td 55.092593 Tz (Other ) Tj 2.1 0 Td 59.217172 Tz (embodiments ) Tj 4.336111 0 Td 61.574074 Tz (of ) Tj 1.088889 0 Td 48.611111 Tz (the ) Tj 1.302778 0 Td 50.925926 Tz (present ) Tj 2.586111 0 Td 50.411523 Tz (invention ) Tj 3.188889 0 Td 50.925926 Tz (include ) Tj 51.428571 0 0 51.428571 0 1047.128266 Tm 6.241667 0 Td 56.339031 Tz (wound-healing ) Tj 4.588889 0 Td 51.388889 Tz (devices ) Tj 2.372222 0 Td 51.851852 Tz (configured ) Tj 3.266667 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 56.712963 Tz (produced ) Tj 2.897222 0 Td 50.231481 Tz (as ) Tj 0.797222 0 Td 55.092593 Tz (biologi ) Tj 48.571429 0 0 48.571429 0 1002 Tm 6.629412 0 Td 49.183007 Tz (cal ) Tj 1.255882 0 Td 48.382353 Tz (fasteners. ) Tj 3.294118 0 Td 57.47549 Tz (Such ) Tj 1.708824 0 Td 54.901961 Tz (as ) Tj 1.008824 0 Td 50.183824 Tz (threads, ) Tj 2.779412 0 Td 51.470588 Tz (Sutures ) Tj 2.511765 0 Td 61.764706 Tz (and ) Tj 1.482353 0 Td 67.254902 Tz (woven ) Tj 2.388235 0 Td 48.529412 Tz (sheets. ) Tj 51.428571 0 0 51.428571 0 959.605735 Tm 6.261111 0 Td 55.555556 Tz (Threads ) Tj 2.488889 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 48.148148 Tz (Sutures ) Tj 2.216667 0 Td 54.444444 Tz (comprising ) Tj 3.461111 0 Td 50 Tz (various ) Tj 2.275 0 Td 59.217172 Tz (embodiments ) Tj 4.122222 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 923.139315 Tm 6.261111 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 53.914141 Tz (composition ) Tj 3.752778 0 Td 53.240741 Tz (provide ) Tj 2.391667 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 53.347578 Tz (biocompatible ) Tj 4.316667 0 Td 49.691358 Tz (fastening ) Tj 2.838889 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 880.32991 Tm 6.280556 0 Td 49.421296 Tz (Suturing ) Tj 2.722222 0 Td 49.826389 Tz (function ) Tj 2.761111 0 Td 48.611111 Tz (for ) Tj 1.186111 0 Td 51.262626 Tz (temporarily ) Tj 3.713889 0 Td 46.990741 Tz (treating ) Tj 2.586111 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 49.537037 Tz (sealing ) Tj 2.391667 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 838.007792 Tm 6.261111 0 Td 58.333333 Tz (open ) Tj 1.827778 0 Td 59.41358 Tz (wound. ) Tj 2.527778 0 Td 48.860399 Tz (Additionally, ) Tj 4.219444 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 48.611111 Tz (biological ) Tj 3.363889 0 Td 47.170782 Tz (fasteners ) Tj 2.994444 0 Td 69.135802 Tz (may ) Tj 51.428571 0 0 51.428571 0 796.328358 Tm 6.261111 0 Td 51.388889 Tz (include ) Tj 2.411111 0 Td 52.805011 Tz (pharmacologically ) Tj 5.658333 0 Td 48.611111 Tz (active ) Tj 2.002778 0 Td 51.311728 Tz (agents ) Tj 2.119444 0 Td 46.180556 Tz (that ) Tj 1.380556 0 Td 68.055556 Tz (may ) Tj 1.497222 0 Td 43.75 Tz (assist ) Tj 1.847222 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 752.788628 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 51.851852 Tz (healing ) Tj 2.372222 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 55.092593 Tz (remodeling ) Tj 3.519444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 46.990741 Tz (tissue ) Tj 1.925 0 Td 50.771605 Tz (within ) Tj 2.061111 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 57.79321 Tz (around ) Tj 51.428571 0 0 51.428571 0 714.177665 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 59.41358 Tz (wound. ) Tj 2.508333 0 Td 53.796296 Tz (Advantageously, ) Tj 5.211111 0 Td 54.282407 Tz (such ) Tj 1.672222 0 Td 49.691358 Tz (fastening ) Tj 3.033333 0 Td 58.333333 Tz (and ) Tj 1.419444 0 Td 49.826389 Tz (Suturing ) Tj 51.428571 0 0 51.428571 0 668.865285 Tm 6.261111 0 Td 51.851852 Tz (devices ) Tj 2.45 0 Td 65.895062 Tz (may ) Tj 1.4 0 Td 59.953704 Tz (be ) Tj 0.933333 0 Td 47.222222 Tz (treated ) Tj 2.177778 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 55.092593 Tz (degrade ) Tj 2.547222 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 52.662037 Tz (Vivo ) Tj 1.477778 0 Td 46.990741 Tz (at ) Tj 0.758333 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 50.462963 Tz (desired ) Tj 2.333333 0 Td 41.481481 Tz (rate. ) Tj 51.428571 0 0 51.428571 0 627.823163 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.875 0 Td 49.907407 Tz (other ) Tj 1.711111 0 Td 56.712963 Tz (embodiments, ) Tj 4.355556 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 53.914141 Tz (composition ) Tj 3.830556 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 69.351852 Tz (admin ) Tj 51.428571 0 0 51.428571 0 587.907655 Tm 6.261111 0 Td 46.296296 Tz (istered ) Tj 2.138889 0 Td 45.37037 Tz (directly ) Tj 2.372222 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 59.953704 Tz (an ) Tj 0.894444 0 Td 49.074074 Tz (injured ) Tj 2.197222 0 Td 46.018519 Tz (area. ) Tj 1.536111 0 Td 87.5 Tz (A ) Tj 0.680556 0 Td 49.826389 Tz (chitosan ) Tj 2.566667 0 Td 54.208754 Tz (composition ) Tj 3.791667 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 545.549451 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.458333 0 Td 50.411523 Tz (invention ) Tj 3.305556 0 Td 37.268519 Tz (is ) Tj 0.972222 0 Td 52.662037 Tz (administered ) Tj 4.316667 0 Td 59.953704 Tz (by ) Tj 1.302778 0 Td 46.843434 Tz (sprinkling, ) Tj 3.636111 0 Td 51.446759 Tz (packing, ) Tj 51.428571 0 0 51.428571 0 506.263158 Tm 6.261111 0 Td 50.378788 Tz (implanting, ) Tj 3.597222 0 Td 47.170782 Tz (inserting ) Tj 2.8 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 53.877315 Tz (applying ) Tj 2.838889 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 57.253086 Tz (any ) Tj 1.322222 0 Td 49.907407 Tz (other ) Tj 1.691667 0 Td 61.111111 Tz (adminis ) Tj 51.428571 0 0 51.428571 0 461.312746 Tm 6.241667 0 Td 45.37037 Tz (tration ) Tj 2.236111 0 Td 60.277778 Tz (means ) Tj 2.080556 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 42.12963 Tz (site ) Tj 1.283333 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 56.17284 Tz (trauma ) Tj 2.294444 0 Td 40.509259 Tz (\(e.g., ) Tj 1.75 0 Td 58.333333 Tz (open ) Tj 1.672222 0 Td 59.953704 Tz (wound, ) Tj 2.469444 0 Td 59.143519 Tz (open ) Tj 51.428571 0 0 51.428571 0 420.730667 Tm 6.261111 0 Td 45.010288 Tz (fracture, ) Tj 2.702778 0 Td 59.259259 Tz (complex ) Tj 2.741667 0 Td 56.481481 Tz (wound\). ) Tj 51.428571 0 0 51.428571 0 379.269155 Tm 6.280556 0 Td 54.768519 Tz (Hemostatic ) Tj 3.538889 0 Td 53.472222 Tz (Chitosan ) Tj 2.819444 0 Td 56.17284 Tz (Compositions ) Tj 51.428571 0 0 51.428571 0 338.351213 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 50.05144 Tz (invention ) Tj 2.975 0 Td 47.685185 Tz (further ) Tj 2.216667 0 Td 52.256944 Tz (provides ) Tj 2.761111 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 53.742284 Tz (compositions ) Tj 4.122222 0 Td 50.231481 Tz (in ) Tj 51.428571 0 0 51.428571 0 295.13597 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 57.523148 Tz (form ) Tj 1.633333 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 52.824074 Tz (hemostatic ) Tj 3.422222 0 Td 52.391975 Tz (matrix ) Tj 2.1 0 Td 41.049383 Tz (\(e.g., ) Tj 1.691667 0 Td 52.5 Tz (hemostatic ) Tj 3.402778 0 Td 50.411523 Tz (sponges\). ) Tj 51.428571 0 0 51.428571 0 253.676923 Tm 6.280556 0 Td 59.143519 Tz (Such ) Tj 1.672222 0 Td 53.742284 Tz (compositions ) Tj 4.102778 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 49.151235 Tz (useful ) Tj 2.002778 0 Td 53.148148 Tz (alone ) Tj 1.808333 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 66.975309 Tz (may ) Tj 1.438889 0 Td 56.712963 Tz (be ) Tj 0.913889 0 Td 55.902778 Tz (used ) Tj 1.555556 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 215.60401 Tm 6.261111 0 Td 49.421296 Tz (delivery ) Tj 2.702778 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 48.905724 Tz (therapeutic ) Tj 3.538889 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 50.771605 Tz (prophylactic ) Tj 3.947222 0 Td 53.796296 Tz (agent ) Tj 1.925 0 Td 49.907407 Tz (delineated ) Tj 51.428571 0 0 51.428571 0 173.04902 Tm 6.241667 0 Td 47.685185 Tz (herein. ) Tj 2.275 0 Td 59.953704 Tz (Such ) Tj 1.730556 0 Td 50.231481 Tz (matrices ) Tj 2.683333 0 Td 49.691358 Tz (generally ) Tj 2.955556 0 Td 55.497685 Tz (comprise ) Tj 2.897222 0 Td 55.092593 Tz (porous ) Tj 2.255556 0 Td 63.888889 Tz (composi ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.578378 0 Td 74.099099 Tz (18 ) Tj 51.428571 0 0 51.428571 0 2915.583446 Tm 25.180556 0 Td 47.314815 Tz (tions ) Tj 1.808333 0 Td 58.333333 Tz (formed ) Tj 2.488889 0 Td 55.902778 Tz (from ) Tj 1.788889 0 Td 47.170782 Tz (chitosan. ) Tj 2.975 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 48.206019 Tz (general, ) Tj 2.702778 0 Td 55.092593 Tz (sponges ) Tj 2.702778 0 Td 56.17284 Tz (can ) Tj 1.361111 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 2875.727494 Tm 25.2 0 Td 58.333333 Tz (formed ) Tj 2.255556 0 Td 61.574074 Tz (by ) Tj 0.913889 0 Td 52.572016 Tz (providing ) Tj 2.994444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.990741 Tz (liquid ) Tj 1.866667 0 Td 48.611111 Tz (solution ) Tj 2.547222 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 51.851852 Tz (capable ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 2835.245902 Tm 25.2 0 Td 56.018519 Tz (forming ) Tj 2.663889 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 55.092593 Tz (porous ) Tj 2.333333 0 Td 50.657895 Tz (three-dimensionally ) Tj 6.144444 0 Td 46.990741 Tz (stable ) Tj 2.022222 0 Td 45.046296 Tz (structure. ) Tj 3.091667 0 Td 48.611111 Tz (In ) Tj 51.428571 0 0 51.428571 0 2789.64277 Tm 25.2 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 58.038721 Tz (embodiment, ) Tj 4.005556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 48.611111 Tz (Solution ) Tj 2.547222 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 53.472222 Tz (prepared ) Tj 2.741667 0 Td 59.953704 Tz (by ) Tj 0.913889 0 Td 54.62963 Tz (dissolv ) Tj 51.428571 0 0 51.428571 0 2750.482714 Tm 25.2 0 Td 50.771605 Tz (ing ) Tj 1.186111 0 Td 50.501543 Tz (deacetylated ) Tj 3.888889 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 48.070988 Tz (acidic ) Tj 1.983333 0 Td 46.990741 Tz (solvent. ) Tj 2.508333 0 Td 84.259259 Tz (A ) Tj 0.719444 0 Td 57.253086 Tz (sponge ) Tj 2.294444 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2706.402469 Tm 25.2 0 Td 58.333333 Tz (formed ) Tj 2.255556 0 Td 59.953704 Tz (by ) Tj 0.913889 0 Td 48.611111 Tz (casting ) Tj 2.197222 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 48.206019 Tz (Solution ) Tj 2.469444 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 61.574074 Tz (mold ) Tj 1.613889 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 53.703704 Tz (achieve ) Tj 2.372222 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 50.462963 Tz (desired ) Tj 51.428571 0 0 51.428571 0 2666.646914 Tm 25.219444 0 Td 49.691358 Tz (shape. ) Tj 1.983333 0 Td 64.814815 Tz (The ) Tj 1.361111 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 48.611111 Tz (Solution ) Tj 2.566667 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 51.851852 Tz (then ) Tj 1.458333 0 Td 51.311728 Tz (frozen ) Tj 2.061111 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 47.530864 Tz (lyophilized, ) Tj 51.428571 0 0 51.428571 0 2627.669609 Tm 25.180556 0 Td 51.851852 Tz (thereby ) Tj 2.488889 0 Td 55.555556 Tz (forming ) Tj 2.605556 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (chitosan ) Tj 2.722222 0 Td 52.314815 Tz (sponge. ) Tj 2.508333 0 Td 50.231481 Tz (Lyophilization ) Tj 4.511111 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 2582.511111 Tm 25.2 0 Td 54.012346 Tz (ducted ) Tj 2.119444 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 54.012346 Tz (reduce ) Tj 2.080556 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 47.530864 Tz (liquid ) Tj 1.886111 0 Td 42.12963 Tz (\(e.g. ) Tj 1.458333 0 Td 51.311728 Tz (water\) ) Tj 2.041667 0 Td 50.925926 Tz (content ) Tj 2.333333 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 51.851852 Tz (matrix ) Tj 48.571429 0 0 48.571429 0 2541 Tm 26.661765 0 Td 49.754902 Tz (to ) Tj 0.926471 0 Td 46.323529 Tz (less ) Tj 1.441176 0 Td 54.044118 Tz (than ) Tj 1.585294 0 Td 57.647059 Tz (about ) Tj 2.017647 0 Td 66.339869 Tz (5%, ) Tj 1.523529 0 Td 65.196078 Tz (10%, ) Tj 1.852941 0 Td 66.911765 Tz (20%, ) Tj 1.894118 0 Td 66.053922 Tz (25%, ) Tj 1.894118 0 Td 66.053922 Tz (30%, ) Tj 1.852941 0 Td 67.769608 Tz (40%, ) Tj 1.914706 0 Td 66.053922 Tz (50%, ) Tj 51.428571 0 0 51.428571 0 2498.630435 Tm 25.2 0 Td 63.194444 Tz (75%, ) Tj 1.827778 0 Td 61.574074 Tz (80%, ) Tj 1.827778 0 Td 62.384259 Tz (90%, ) Tj 1.808333 0 Td 63.194444 Tz (95%, ) Tj 1.847222 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 67.24537 Tz (100% ) Tj 1.905556 0 Td 63.194444 Tz (by ) Tj 1.069444 0 Td 51.388889 Tz (weight. ) Tj 2.508333 0 Td 42.12963 Tz (If ) Tj 0.758333 0 Td 47.395833 Tz (desired, ) Tj 2.566667 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2460.254047 Tm 25.219444 0 Td 55.632716 Tz (second ) Tj 2.197222 0 Td 47.685185 Tz (lyophilization ) Tj 4.238889 0 Td 46.990741 Tz (step ) Tj 1.322222 0 Td 40.509259 Tz (is ) Tj 0.7 0 Td 47.685185 Tz (carried ) Tj 2.177778 0 Td 45.37037 Tz (out. ) Tj 1.283333 0 Td 53.472222 Tz (This ) Tj 1.497222 0 Td 47.800926 Tz (step ) Tj 1.361111 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 42.12963 Tz (strictly ) Tj 51.428571 0 0 51.428571 0 2419.080148 Tm 25.2 0 Td 47.170782 Tz (optional. ) Tj 2.819444 0 Td 55.092593 Tz (Following ) Tj 3.208333 0 Td 59.41358 Tz (one ) Tj 1.283333 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 60.763889 Tz (more ) Tj 1.691667 0 Td 46.788194 Tz (lyophilizations, ) Tj 4.725 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 55.740741 Tz (chito ) Tj 51.428571 0 0 51.428571 0 2375.546392 Tm 25.219444 0 Td 50.771605 Tz (San ) Tj 1.244444 0 Td 54.208754 Tz (composition ) Tj 3.908333 0 Td 68.055556 Tz (may ) Tj 1.536111 0 Td 35 Tz (still ) Tj 1.361111 0 Td 51.388889 Tz (include ) Tj 2.430556 0 Td 64.814815 Tz (some ) Tj 1.808333 0 Td 61.574074 Tz (amount ) Tj 2.527778 0 Td 55.092593 Tz (of ) Tj 0.875 0 Td 48.070988 Tz (water. ) Tj 51.428571 0 0 51.428571 0 2334.405941 Tm 25.2 0 Td 47.638889 Tz (Typically, ) Tj 3.130556 0 Td 49.109687 Tz (lypholization ) Tj 4.102778 0 Td 58.333333 Tz (removes ) Tj 2.683333 0 Td 46.990741 Tz (at ) Tj 0.797222 0 Td 44.722222 Tz (least ) Tj 1.575 0 Td 55.092593 Tz (about ) Tj 1.886111 0 Td 63.194444 Tz (70%, ) Tj 1.769444 0 Td 62.384259 Tz (75%, ) Tj 51.428571 0 0 51.428571 0 2291.171717 Tm 25.219444 0 Td 62.384259 Tz (80%, ) Tj 1.691667 0 Td 62.384259 Tz (90%, ) Tj 1.711111 0 Td 50.771605 Tz (95, ) Tj 1.108333 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 67.24537 Tz (100% ) Tj 1.808333 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 46.990741 Tz (original ) Tj 2.469444 0 Td 55.092593 Tz (water ) Tj 1.788889 0 Td 51.851852 Tz (content ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2251.954488 Tm 25.2 0 Td 50.231481 Tz (chitosan ) Tj 2.838889 0 Td 52.121914 Tz (composition. ) Tj 4.161111 0 Td 54.282407 Tz (Chitosan ) Tj 3.033333 0 Td 53.472222 Tz (compositions ) Tj 4.277778 0 Td 46.180556 Tz (that ) Tj 1.516667 0 Td 45.910494 Tz (retain ) Tj 51.428571 0 0 51.428571 0 2208.100386 Tm 25.219444 0 Td 63.194444 Tz (Some ) Tj 1.788889 0 Td 52.662037 Tz (moisture ) Tj 2.8 0 Td 66.975309 Tz (may ) Tj 1.477778 0 Td 56.712963 Tz (be ) Tj 0.913889 0 Td 57.523148 Tz (packaged ) Tj 3.033333 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 42.12963 Tz (sterile ) Tj 2.022222 0 Td 41.319444 Tz (foil ) Tj 1.225 0 Td 48.611111 Tz (to ) Tj 0.855556 0 Td 53.06713 Tz (maintain ) Tj 40 0 0 40 0 2173 Tm 32.425 0 Td 69.791667 Tz (Such ) Tj 2.05 0 Td 63.425926 Tz (moisture. ) Tj 51.428571 0 0 51.428571 0 2127.068152 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 57.253086 Tz (one ) Tj 1.263889 0 Td 52.572016 Tz (approach, ) Tj 3.052778 0 Td 51.851852 Tz (the ) Tj 1.166667 0 Td 57.253086 Tz (sponge ) Tj 2.275 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 46.990741 Tz (neutralized, ) Tj 3.616667 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 55.092593 Tz (example, ) Tj 51.428571 0 0 51.428571 0 2084.546816 Tm 25.180556 0 Td 61.574074 Tz (by ) Tj 0.991667 0 Td 50.411523 Tz (treatment ) Tj 2.955556 0 Td 52.662037 Tz (with ) Tj 1.516667 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.907407 Tz (basic ) Tj 1.730556 0 Td 46.8107 Tz (solution, ) Tj 2.741667 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 51.041667 Tz (then ) Tj 1.477778 0 Td 46.882716 Tz (re-lyophilized. ) Tj 51.428571 0 0 51.428571 0 2042.760351 Tm 25.2 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 57.253086 Tz (sponge ) Tj 2.313889 0 Td 51.851852 Tz (matrix ) Tj 2.119444 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 46.342593 Tz (stabilized ) Tj 3.033333 0 Td 45.640432 Tz (structurally ) Tj 3.519444 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 54.166667 Tz (remains ) Tj 2.547222 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 2001.659794 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 51.311728 Tz (highly ) Tj 2.138889 0 Td 55.092593 Tz (dense ) Tj 1.886111 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 58.693416 Tz (compacted ) Tj 3.422222 0 Td 44.722222 Tz (State ) Tj 1.594444 0 Td 44.074074 Tz (until ) Tj 1.594444 0 Td 51.49177 Tz (contacted ) Tj 3.072222 0 Td 51.851852 Tz (with ) Tj 1.536111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1962.770654 Tm 25.2 0 Td 48.070988 Tz (liquid ) Tj 1.925 0 Td 48.905724 Tz (Susceptible ) Tj 3.422222 0 Td 48.611111 Tz (to ) Tj 0.797222 0 Td 50.87963 Tz (absorption ) Tj 3.247222 0 Td 61.574074 Tz (by ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 48.611111 Tz (matrix, ) Tj 2.294444 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 54.6875 Tz (example, ) Tj 51.428571 0 0 51.428571 0 1919.09901 Tm 25.180556 0 Td 59.953704 Tz (body ) Tj 1.691667 0 Td 42.12963 Tz (fluids. ) Tj 2.041667 0 Td 55.092593 Tz (For ) Tj 1.186111 0 Td 54.166667 Tz (medical ) Tj 2.527778 0 Td 46.180556 Tz (use, ) Tj 1.322222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 58.333333 Tz (compacted ) Tj 3.383333 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 57.685185 Tz (compressed ) Tj 51.428571 0 0 51.428571 0 1877.256177 Tm 25.219444 0 Td 56.712963 Tz (sponge ) Tj 2.333333 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 44.398148 Tz (sterilized ) Tj 2.975 0 Td 51.851852 Tz (using ) Tj 1.847222 0 Td 57.253086 Tz (any ) Tj 1.361111 0 Td 46.990741 Tz (suitable ) Tj 2.586111 0 Td 60.277778 Tz (means ) Tj 2.119444 0 Td 40.509259 Tz (\(e.g., ) Tj 1.769444 0 Td 55.740741 Tz (radia ) Tj 51.428571 0 0 51.428571 0 1835.295423 Tm 25.180556 0 Td 43.209877 Tz (tion\). ) Tj 1.983333 0 Td 63.734568 Tz (The ) Tj 1.575 0 Td 52.932099 Tz (device ) Tj 2.352778 0 Td 38.888889 Tz (is ) Tj 0.875 0 Td 57.928241 Tz (packaged ) Tj 3.227778 0 Td 45.37037 Tz (in ) Tj 0.991667 0 Td 42.12963 Tz (sterile ) Tj 2.197222 0 Td 55.452675 Tz (packaging ) Tj 3.461111 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 1792.250346 Tm 25.2 0 Td 54.62963 Tz (medical ) Tj 2.741667 0 Td 46.990741 Tz (use. ) Tj 1.575 0 Td 61.033951 Tz (Sponge ) Tj 2.625 0 Td 53.472222 Tz (elements ) Tj 3.033333 0 Td 51.851852 Tz (or ) Tj 1.011111 0 Td 51.203704 Tz (other ) Tj 1.944444 0 Td 50.925926 Tz (devices ) Tj 2.625 0 Td 56.712963 Tz (of ) Tj 1.011111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1751.316056 Tm 25.2 0 Td 50.771605 Tz (invention ) Tj 3.013889 0 Td 68.055556 Tz (may ) Tj 1.497222 0 Td 46.990741 Tz (also ) Tj 1.419444 0 Td 50.925926 Tz (contain ) Tj 2.391667 0 Td 59.41358 Tz (one ) Tj 1.302778 0 Td 53.472222 Tz (or ) Tj 0.913889 0 Td 60.763889 Tz (more ) Tj 1.691667 0 Td 48.611111 Tz (active ) Tj 2.002778 0 Td 48.905724 Tz (therapeutic ) Tj 51.428571 0 0 51.428571 0 1713.647059 Tm 25.2 0 Td 48.148148 Tz (agents. ) Tj 2.488889 0 Td 56.17284 Tz (For ) Tj 1.4 0 Td 55.497685 Tz (example, ) Tj 3.072222 0 Td 52.662037 Tz (they ) Tj 1.691667 0 Td 51.388889 Tz (include ) Tj 2.566667 0 Td 51.851852 Tz (agents ) Tj 2.294444 0 Td 46.180556 Tz (that ) Tj 1.516667 0 Td 58.333333 Tz (promote ) Tj 51.428571 0 0 51.428571 0 1671.416867 Tm 25.2 0 Td 46.990741 Tz (clotting ) Tj 2.469444 0 Td 40.509259 Tz (\(e.g., ) Tj 1.672222 0 Td 55.902778 Tz (thrombin ) Tj 2.916667 0 Td 52.932099 Tz (and/or ) Tj 2.119444 0 Td 46.990741 Tz (fibrinogen\). ) Tj 3.597222 0 Td 49.109687 Tz (Alternatively ) Tj 4.102778 0 Td 51.851852 Tz (or ) Tj 52.857143 0 0 52.857143 0 1624.066002 Tm 24.518919 0 Td 44.144144 Tz (in ) Tj 0.756757 0 Td 46.246246 Tz (addition, ) Tj 2.724324 0 Td 56.231231 Tz (sponge ) Tj 2.232432 0 Td 52.421171 Tz (elements ) Tj 2.724324 0 Td 53.603604 Tz (or ) Tj 0.832432 0 Td 49.189189 Tz (other ) Tj 1.683784 0 Td 50 Tz (devices ) Tj 2.327027 0 Td 58.333333 Tz (of ) Tj 0.794595 0 Td 49.399399 Tz (the ) Tj 1.097297 0 Td 60.540541 Tz (inven ) Tj 51.428571 0 0 51.428571 0 1584.29419 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.419444 0 Td 50.462963 Tz (include ) Tj 2.372222 0 Td 45.664983 Tz (antibiotics ) Tj 3.266667 0 Td 52.932099 Tz (and/or ) Tj 2.1 0 Td 57.253086 Tz (growth ) Tj 2.333333 0 Td 46.759259 Tz (factors ) Tj 2.236111 0 Td 45.37037 Tz (that ) Tj 1.322222 0 Td 58.333333 Tz (promote ) Tj 51.428571 0 0 51.428571 0 1544.909589 Tm 25.180556 0 Td 46.990741 Tz (tissue ) Tj 1.925 0 Td 56.712963 Tz (growth ) Tj 2.294444 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 48.206019 Tz (healing. ) Tj 51.428571 0 0 51.428571 0 1502.739015 Tm 25.919444 0 Td 87.5 Tz (A ) Tj 0.797222 0 Td 50.231481 Tz (chitosan ) Tj 2.722222 0 Td 54.208754 Tz (composition ) Tj 3.908333 0 Td 37.268519 Tz (is ) Tj 0.777778 0 Td 51.851852 Tz (incubated ) Tj 3.111111 0 Td 52.662037 Tz (with ) Tj 1.575 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 49.200337 Tz (therapeutic ) Tj 51.428571 0 0 51.428571 0 1460.611253 Tm 25.2 0 Td 53.148148 Tz (agent ) Tj 1.827778 0 Td 54.282407 Tz (Such ) Tj 1.555556 0 Td 46.990741 Tz (that ) Tj 1.361111 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 53.148148 Tz (agent ) Tj 1.847222 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 51.041667 Tz (incorporated ) Tj 3.927778 0 Td 45.37037 Tz (into ) Tj 1.361111 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 47.890947 Tz (chitosan. ) Tj 51.428571 0 0 51.428571 0 1420.208597 Tm 25.2 0 Td 47.222222 Tz (Alternatively, ) Tj 4.258333 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 47.890947 Tz (addition, ) Tj 2.858333 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 49.200337 Tz (therapeutic ) Tj 3.519444 0 Td 53.148148 Tz (agent ) Tj 1.886111 0 Td 66.975309 Tz (may ) Tj 1.458333 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 1378.48038 Tm 25.2 0 Td 51.041667 Tz (incorporated ) Tj 3.85 0 Td 46.990741 Tz (in ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 54.208754 Tz (composition ) Tj 3.772222 0 Td 52.932099 Tz (during ) Tj 2.080556 0 Td 45.910494 Tz (fabrication. ) Tj 51.428571 0 0 51.428571 0 1334.343226 Tm 25.2 0 Td 53.472222 Tz (This ) Tj 1.555556 0 Td 51.203704 Tz (incubation ) Tj 3.363889 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 46.8107 Tz (typically ) Tj 2.819444 0 Td 48.148148 Tz (carried ) Tj 2.275 0 Td 52.932099 Tz (out ) Tj 1.205556 0 Td 51.851852 Tz (before ) Tj 2.119444 0 Td 55.092593 Tz (or ) Tj 0.894444 0 Td 52.391975 Tz (during ) Tj 2.177778 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1294.27582 Tm 25.2 0 Td 54.012346 Tz (procedure ) Tj 3.072222 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 44.074074 Tz (treat ) Tj 1.497222 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 48.611111 Tz (Subject ) Tj 2.216667 0 Td 53.148148 Tz (using ) Tj 1.788889 0 Td 57.87037 Tz (methods ) Tj 2.625 0 Td 51.851852 Tz (described ) Tj 2.955556 0 Td 47.685185 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 1252.461635 Tm 25.219444 0 Td 60.493827 Tz (Sponge ) Tj 2.488889 0 Td 48.611111 Tz (materials ) Tj 2.916667 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 50.411523 Tz (invention ) Tj 3.052778 0 Td 46.180556 Tz (will ) Tj 1.4 0 Td 53.703704 Tz (advantageously ) Tj 4.802778 0 Td 58.333333 Tz (be ) Tj 51.428571 0 0 51.428571 0 1212.575916 Tm 25.2 0 Td 55.416667 Tz (expandable ) Tj 3.694444 0 Td 64.00463 Tz (when ) Tj 1.925 0 Td 49.537037 Tz (wetted. ) Tj 2.488889 0 Td 47.43266 Tz (Preferably, ) Tj 3.5 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 56.712963 Tz (sponge ) Tj 2.391667 0 Td 54.012346 Tz (has ) Tj 1.322222 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1168.322904 Tm 25.2 0 Td 50.231481 Tz (capacity ) Tj 2.605556 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 58.333333 Tz (expand ) Tj 2.275 0 Td 43.75 Tz (at ) Tj 0.7 0 Td 44.722222 Tz (least ) Tj 1.497222 0 Td 54.444444 Tz (about ) Tj 1.866667 0 Td 66.030093 Tz (10%-100% ) Tj 3.402778 0 Td 46.990741 Tz (\(10, ) Tj 1.302778 0 Td 48.611111 Tz (20, ) Tj 1.069444 0 Td 50.771605 Tz (30, ) Tj 1.088889 0 Td 49.691358 Tz (40, ) Tj 51.428571 0 0 51.428571 0 1126.846361 Tm 25.219444 0 Td 46.180556 Tz (50\). ) Tj 1.516667 0 Td 48.611111 Tz (In ) Tj 0.972222 0 Td 50.555556 Tz (other ) Tj 1.866667 0 Td 56.983025 Tz (embodiments, ) Tj 4.452778 0 Td 58.333333 Tz (a ) Tj 0.738889 0 Td 56.712963 Tz (sponge ) Tj 2.411111 0 Td 56.481481 Tz (expands ) Tj 2.761111 0 Td 59.953704 Tz (by ) Tj 1.108333 0 Td 54.444444 Tz (about ) Tj 51.428571 0 0 51.428571 0 1083.352201 Tm 25.2 0 Td 70.486111 Tz (200% ) Tj 1.925 0 Td 56.712963 Tz (by ) Tj 0.991667 0 Td 59.41358 Tz (volume ) Tj 2.372222 0 Td 64.814815 Tz (when ) Tj 1.788889 0 Td 54.012346 Tz (wetted ) Tj 2.177778 0 Td 43.75 Tz (to ) Tj 0.797222 0 Td 46.990741 Tz (saturation ) Tj 3.072222 0 Td 52.662037 Tz (with ) Tj 1.516667 0 Td 52.572016 Tz (deionized ) Tj 51.428571 0 0 51.428571 0 1042.849938 Tm 25.180556 0 Td 49.691358 Tz (water, ) Tj 1.983333 0 Td 44.444444 Tz (buffer, ) Tj 2.080556 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 53.148148 Tz (agent ) Tj 1.769444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 48.287037 Tz (invention. ) Tj 3.15 0 Td 49.331276 Tz (Preferred ) Tj 2.877778 0 Td 57.253086 Tz (sponge ) Tj 51.428571 0 0 51.428571 0 1003.317585 Tm 25.2 0 Td 49.331276 Tz (materials ) Tj 3.091667 0 Td 53.240741 Tz (achieve ) Tj 2.683333 0 Td 49.259259 Tz (rapid ) Tj 1.925 0 Td 60.493827 Tz (Volume ) Tj 2.605556 0 Td 53.796296 Tz (expansions ) Tj 3.694444 0 Td 39.969136 Tz (\(e.g., ) Tj 1.886111 0 Td 66.435185 Tz (when ) Tj 51.428571 0 0 51.428571 0 960.501292 Tm 25.2 0 Td 59.953704 Tz (immersed ) Tj 3.266667 0 Td 46.990741 Tz (in ) Tj 0.952778 0 Td 56.481481 Tz (aqueous ) Tj 2.761111 0 Td 45.694444 Tz (solution\). ) Tj 3.208333 0 Td 54.12037 Tz (Hemostatic ) Tj 3.655556 0 Td 55.555556 Tz (sponges ) Tj 2.722222 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 921.85 Tm 25.2 0 Td 56.30787 Tz (produced ) Tj 2.916667 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 59.41358 Tz (any ) Tj 1.263889 0 Td 46.990741 Tz (size ) Tj 1.302778 0 Td 50.636574 Tz (required ) Tj 2.625 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 48.905724 Tz (application ) Tj 3.422222 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 58.873457 Tz (wound. ) Tj 2.372222 0 Td 48.611111 Tz (In ) Tj 51.428571 0 0 51.428571 0 879.261501 Tm 25.2 0 Td 58.333333 Tz (one ) Tj 1.263889 0 Td 58.038721 Tz (embodiment, ) Tj 4.083333 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 58.738426 Tz (expanded ) Tj 3.072222 0 Td 56.712963 Tz (sponge ) Tj 2.255556 0 Td 48.070988 Tz (exerts ) Tj 2.002778 0 Td 55.976431 Tz (compression ) Tj 51.428571 0 0 51.428571 0 836.211679 Tm 25.2 0 Td 59.953704 Tz (on ) Tj 0.913889 0 Td 53.324916 Tz (Surrounding ) Tj 3.675 0 Td 46.296296 Tz (tissues ) Tj 2.138889 0 Td 64.00463 Tz (when ) Tj 1.788889 0 Td 53.652263 Tz (implanted ) Tj 3.091667 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 47.395833 Tz (delivers ) Tj 2.45 0 Td 58.333333 Tz (an ) Tj 0.875 0 Td 49.151235 Tz (active ) Tj 51.428571 0 0 51.428571 0 796.295943 Tm 25.2 0 Td 53.148148 Tz (agent ) Tj 1.711111 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 50.501543 Tz (implantation ) Tj 3.811111 0 Td 42.12963 Tz (site ) Tj 1.147222 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 53.324916 Tz (Surrounding ) Tj 3.655556 0 Td 43.518519 Tz (tissue. ) Tj 1.983333 0 Td 71.944444 Tz (Advan ) Tj 51.428571 0 0 51.428571 0 754.769231 Tm 25.180556 0 Td 48.935185 Tz (tageously, ) Tj 3.169444 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 53.472222 Tz (compositions ) Tj 4.044444 0 Td 52.932099 Tz (generated ) Tj 3.072222 0 Td 52.662037 Tz (with ) Tj 1.477778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 54.552469 Tz (buffer ) Tj 51.428571 0 0 51.428571 0 712.19598 Tm 25.2 0 Td 51.851852 Tz (ing ) Tj 1.186111 0 Td 47.800926 Tz (step ) Tj 1.419444 0 Td 51.49177 Tz (described ) Tj 3.013889 0 Td 50.771605 Tz (herein ) Tj 2.061111 0 Td 53.703704 Tz (provide ) Tj 2.508333 0 Td 47.530864 Tz (for ) Tj 1.108333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 49.259259 Tz (controlled ) Tj 3.208333 0 Td 61.574074 Tz (degra ) Tj 51.428571 0 0 51.428571 0 668.443758 Tm 25.2 0 Td 50.231481 Tz (dation ) Tj 2.041667 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 52.5 Tz (hemostatic ) Tj 3.402778 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 49.016204 Tz (devices, ) Tj 2.566667 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 51.851852 Tz (well ) Tj 1.458333 0 Td 50.231481 Tz (as ) Tj 0.836111 0 Td 52.572016 Tz (providing ) Tj 51.428571 0 0 51.428571 0 627.277519 Tm 25.2 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 48.935185 Tz (controlled ) Tj 3.169444 0 Td 48.611111 Tz (release ) Tj 2.294444 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 52.5 Tz (hemostatic ) Tj 3.402778 0 Td 47.685185 Tz (agents. ) Tj 51.428571 0 0 51.428571 0 589.322835 Tm 25.219444 0 Td 52.256944 Tz (Delivery ) Tj 2.761111 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 53.877315 Tz (Chitosan ) Tj 2.819444 0 Td 56.442901 Tz (Compositions ) Tj 51.428571 0 0 51.428571 0 545.059133 Tm 25.919444 0 Td 53.877315 Tz (Chitosan ) Tj 2.838889 0 Td 54.012346 Tz (compositions ) Tj 4.180556 0 Td 54.012346 Tz (can ) Tj 1.283333 0 Td 58.333333 Tz (be ) Tj 0.952778 0 Td 50.411523 Tz (delivered ) Tj 2.975 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 58.333333 Tz (any ) Tj 1.380556 0 Td 59.953704 Tz (method ) Tj 51.428571 0 0 51.428571 0 502.553501 Tm 25.2 0 Td 64.814815 Tz (known ) Tj 2.255556 0 Td 48.611111 Tz (to ) Tj 0.894444 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 46.296296 Tz (skilled ) Tj 2.236111 0 Td 43.75 Tz (artisan. ) Tj 2.469444 0 Td 46.990741 Tz (In ) Tj 0.875 0 Td 58.333333 Tz (one ) Tj 1.322222 0 Td 52.932099 Tz (approach, ) Tj 3.15 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 461.980392 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.869444 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 46.759259 Tz (locally ) Tj 2.275 0 Td 50.05144 Tz (delivered ) Tj 2.936111 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 42.939815 Tz (site ) Tj 1.283333 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 56.17284 Tz (trauma ) Tj 2.275 0 Td 46.990741 Tz (in ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 420.332481 Tm 25.2 0 Td 58.333333 Tz (form ) Tj 1.633333 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 46.990741 Tz (film ) Tj 1.361111 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 52.777778 Tz (sponge. ) Tj 2.411111 0 Td 64.814815 Tz (The ) Tj 1.380556 0 Td 44.074074 Tz (film, ) Tj 1.575 0 Td 52.777778 Tz (sponge, ) Tj 2.45 0 Td 50.231481 Tz (or ) Tj 0.797222 0 Td 50.555556 Tz (other ) Tj 1.691667 0 Td 66.759259 Tz (wound ) Tj 51.428571 0 0 51.428571 0 379.749667 Tm 25.2 0 Td 62.222222 Tz (management ) Tj 4.044444 0 Td 52.932099 Tz (device ) Tj 2.255556 0 Td 54.012346 Tz (can ) Tj 1.283333 0 Td 59.953704 Tz (be ) Tj 1.05 0 Td 51.851852 Tz (configured ) Tj 3.441667 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 33.487654 Tz (fit ) Tj 0.913889 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 66.111111 Tz (wound ) Tj 2.333333 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 338.324808 Tm 25.2 0 Td 45.37037 Tz (virtually ) Tj 2.741667 0 Td 57.253086 Tz (any ) Tj 1.322222 0 Td 42.777778 Tz (size. ) Tj 1.613889 0 Td 46.990741 Tz (In ) Tj 0.836111 0 Td 53.240741 Tz (another ) Tj 2.469444 0 Td 52.572016 Tz (approach, ) Tj 3.130556 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 298.585276 Tm 25.2 0 Td 48.611111 Tz (position ) Tj 2.527778 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 46.990741 Tz (Surgically ) Tj 3.013889 0 Td 54.012346 Tz (implanted ) Tj 3.072222 0 Td 43.75 Tz (at ) Tj 0.719444 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 42.12963 Tz (site ) Tj 1.166667 0 Td 59.62963 Tz (where ) Tj 1.963889 0 Td 55.452675 Tz (promotion ) Tj 3.227778 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 253.946794 Tm 25.180556 0 Td 51.388889 Tz (healing ) Tj 2.644444 0 Td 52.391975 Tz (and/or ) Tj 2.313889 0 Td 51.131687 Tz (treatment ) Tj 3.247222 0 Td 51.851852 Tz (or ) Tj 1.069444 0 Td 51.527778 Tz (prevention ) Tj 3.577778 0 Td 58.333333 Tz (of ) Tj 1.108333 0 Td 47.170782 Tz (infection ) Tj 3.033333 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 213.070218 Tm 25.2 0 Td 47.890947 Tz (required. ) Tj 2.8 0 Td 46.990741 Tz (If ) Tj 0.661111 0 Td 47.395833 Tz (desired, ) Tj 2.430556 0 Td 51.851852 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 54.208754 Tz (composition ) Tj 3.791667 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 54.552469 Tz (loaded ) Tj 2.138889 0 Td 53.472222 Tz (with ) Tj 51.428571 0 0 51.428571 0 171.00361 Tm 25.2 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 61.574074 Tz (more ) Tj 1.613889 0 Td 45.959596 Tz (antibiotics ) Tj 3.208333 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 50.555556 Tz (other ) Tj 1.613889 0 Td 48.341049 Tz (biologically ) Tj 3.636111 0 Td 48.611111 Tz (active ) Tj 1.905556 0 Td 51.311728 Tz (agents ) Tj 2.002778 0 Td 61.574074 Tz (by ) Tj ET Q endstream endobj 137 0 obj << /Length 1 >> stream q endstream endobj 138 0 obj << /Length 52141 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.151351 0 Td 74.099099 Tz (19 ) Tj 51.428571 0 0 51.428571 0 2914.175879 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 45.730453 Tz (clinician ) Tj 2.702778 0 Td 50.771605 Tz (within ) Tj 2.022222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 47.395833 Tz (Surgical ) Tj 2.469444 0 Td 46.018519 Tz (Suite ) Tj 1.575 0 Td 60.277778 Tz (where ) Tj 1.963889 0 Td 51.131687 Tz (treatment ) Tj 2.975 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 2876.749392 Tm 6.261111 0 Td 51.131687 Tz (provided. ) Tj 2.994444 0 Td 53.472222 Tz (This ) Tj 1.536111 0 Td 53.935185 Tz (advantageously ) Tj 4.763889 0 Td 52.932099 Tz (allows ) Tj 2.138889 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 73.240741 Tz (compo ) Tj 51.428571 0 0 51.428571 0 2832.015424 Tm 6.280556 0 Td 44.290123 Tz (sition ) Tj 1.827778 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 54.012346 Tz (loaded ) Tj 2.177778 0 Td 52.662037 Tz (with ) Tj 1.497222 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 46.180556 Tz (specific ) Tj 2.469444 0 Td 53.148148 Tz (agent ) Tj 1.827778 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 54.503367 Tz (combination ) Tj 3.869444 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 2792.101818 Tm 6.261111 0 Td 51.311728 Tz (agents ) Tj 1.983333 0 Td 46.990741 Tz (tailored ) Tj 2.391667 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 54.444444 Tz (needs ) Tj 1.808333 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.447222 0 Td 47.314815 Tz (particular ) Tj 2.955556 0 Td 47.685185 Tz (patient ) Tj 2.138889 0 Td 45.37037 Tz (at ) Tj 0.661111 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 51.203704 Tz (point ) Tj 51.428571 0 0 51.428571 0 2749.744526 Tm 6.261111 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 58.333333 Tz (which ) Tj 2.002778 0 Td 51.041667 Tz (care ) Tj 1.458333 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 50.771605 Tz (provided. ) Tj 51.428571 0 0 51.428571 0 2713 Tm 6.280556 0 Td 53.652263 Tz (Screening ) Tj 3.091667 0 Td 57.253086 Tz (Assays ) Tj 51.428571 0 0 51.428571 0 2666.515192 Tm 7 0 Td 66.435185 Tz (As ) Tj 1.108333 0 Td 51.49177 Tz (described ) Tj 3.072222 0 Td 47.222222 Tz (herein, ) Tj 2.275 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 50.462963 Tz (present ) Tj 2.391667 0 Td 50.771605 Tz (invention ) Tj 3.033333 0 Td 52.256944 Tz (provides ) Tj 2.819444 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 2627.500603 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 49.016204 Tz (delivery ) Tj 2.547222 0 Td 58.333333 Tz (of ) Tj 0.758333 0 Td 49.200337 Tz (therapeutic ) Tj 3.422222 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 50.501543 Tz (prophylactic ) Tj 3.830556 0 Td 51.311728 Tz (agents ) Tj 2.041667 0 Td 45.37037 Tz (to ) Tj 0.758333 0 Td 62.114198 Tz (wounds ) Tj 51.428571 0 0 51.428571 0 2583.077121 Tm 6.261111 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 47.962963 Tz (vivo. ) Tj 1.652778 0 Td 62.654321 Tz (The ) Tj 1.322222 0 Td 50.771605 Tz (invention ) Tj 2.975 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 55.092593 Tz (based ) Tj 1.866667 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 46.990741 Tz (part ) Tj 1.322222 0 Td 59.953704 Tz (on ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 51.851852 Tz (discovery ) Tj 3.033333 0 Td 45.37037 Tz (that ) Tj 51.428571 0 0 51.428571 0 2542.480916 Tm 6.241667 0 Td 49.200337 Tz (therapeutic ) Tj 3.519444 0 Td 51.311728 Tz (agents ) Tj 2.138889 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 58.333333 Tz (be ) Tj 0.972222 0 Td 50.05144 Tz (delivered ) Tj 2.994444 0 Td 51.851852 Tz (using ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2502.254027 Tm 6.261111 0 Td 48.611111 Tz (position ) Tj 2.586111 0 Td 59.62963 Tz (where ) Tj 2.002778 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 51.851852 Tz (agents ) Tj 2.080556 0 Td 60.493827 Tz (and ) Tj 1.322222 0 Td 51.851852 Tz (degradation ) Tj 3.675 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 63.888889 Tz (composi ) Tj 51.428571 0 0 51.428571 0 2458.698539 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.438889 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 46.180556 Tz (tailored ) Tj 2.488889 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 43.75 Tz (suit ) Tj 1.302778 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 53.796296 Tz (needs ) Tj 1.886111 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 46.990741 Tz (particular ) Tj 3.052778 0 Td 44.155093 Tz (patient. ) Tj 2.372222 0 Td 64.814815 Tz (To ) Tj 51.428571 0 0 51.428571 0 2419.307506 Tm 6.261111 0 Td 46.990741 Tz (identify ) Tj 2.488889 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 53.742284 Tz (compositions ) Tj 4.102778 0 Td 55.092593 Tz (having ) Tj 2.197222 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 49.537037 Tz (desired ) Tj 2.294444 0 Td 60.648148 Tz (degrada ) Tj 51.428571 0 0 51.428571 0 2377.034356 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.341667 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 48.148148 Tz (elution ) Tj 2.216667 0 Td 43.930041 Tz (profiles, ) Tj 2.547222 0 Td 52.211934 Tz (screening ) Tj 3.013889 0 Td 66.975309 Tz (may ) Tj 1.380556 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 47.685185 Tz (carried ) Tj 2.197222 0 Td 50.771605 Tz (out ) Tj 1.088889 0 Td 53.148148 Tz (using ) Tj 40 0 0 40 0 2339 Tm 8.05 0 Td 77.083333 Tz (no ) Tj 1.575 0 Td 79.166667 Tz (more ) Tj 2.475 0 Td 66.666667 Tz (than ) Tj 2.225 0 Td 63.690476 Tz (routine ) Tj 3.3 0 Td 73.809524 Tz (methods ) Tj 3.725 0 Td 84.166667 Tz (known ) Tj 3.15 0 Td 58.333333 Tz (in ) Tj 1.3 0 Td 65.277778 Tz (the ) Tj 1.75 0 Td 56.944444 Tz (art ) Tj 1.575 0 Td 79.166667 Tz (and ) Tj 51.428571 0 0 51.428571 0 2293.323383 Tm 6.261111 0 Td 51.851852 Tz (described ) Tj 3.072222 0 Td 47.685185 Tz (herein. ) Tj 2.352778 0 Td 57.253086 Tz (For ) Tj 1.283333 0 Td 55.092593 Tz (example, ) Tj 2.955556 0 Td 50.231481 Tz (chitosan ) Tj 2.741667 0 Td 53.472222 Tz (compositions ) Tj 4.180556 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 2250.663278 Tm 6.261111 0 Td 54.012346 Tz (loaded ) Tj 2.197222 0 Td 52.662037 Tz (with ) Tj 1.516667 0 Td 58.333333 Tz (one ) Tj 1.302778 0 Td 50.231481 Tz (or ) Tj 0.855556 0 Td 60.763889 Tz (more ) Tj 1.672222 0 Td 48.905724 Tz (therapeutic ) Tj 3.461111 0 Td 51.851852 Tz (agents ) Tj 2.1 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 55.092593 Tz (Such ) Tj 1.555556 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2210.797992 Tm 6.261111 0 Td 48.611111 Tz (positions ) Tj 2.955556 0 Td 49.691358 Tz (are ) Tj 1.205556 0 Td 52.662037 Tz (subsequently ) Tj 4.122222 0 Td 59.953704 Tz (compared ) Tj 3.188889 0 Td 46.990741 Tz (to ) Tj 0.913889 0 Td 49.691358 Tz (untreated ) Tj 3.013889 0 Td 49.074074 Tz (control ) Tj 51.428571 0 0 51.428571 0 2171.021302 Tm 6.261111 0 Td 53.742284 Tz (compositions ) Tj 4.044444 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 46.180556 Tz (identify ) Tj 2.411111 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 53.472222 Tz (compositions ) Tj 4.005556 0 Td 46.180556 Tz (that ) Tj 1.263889 0 Td 57.87037 Tz (promote ) Tj 51.428571 0 0 51.428571 0 2125.987342 Tm 6.241667 0 Td 48.206019 Tz (healing. ) Tj 2.644444 0 Td 46.990741 Tz (In ) Tj 0.836111 0 Td 52.777778 Tz (another ) Tj 2.45 0 Td 58.038721 Tz (embodiment, ) Tj 4.102778 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 51.851852 Tz (degradation ) Tj 3.713889 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 61.574074 Tz (chi ) Tj 51.428571 0 0 51.428571 0 2085.223561 Tm 6.241667 0 Td 51.203704 Tz (tosan ) Tj 1.905556 0 Td 53.914141 Tz (composition ) Tj 3.908333 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 50.05144 Tz (invention ) Tj 3.072222 0 Td 37.268519 Tz (is ) Tj 0.758333 0 Td 54.62963 Tz (assayed ) Tj 2.605556 0 Td 46.990741 Tz (in ) Tj 0.913889 0 Td 52.662037 Tz (Vivo ) Tj 1.594444 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 2045.788063 Tm 6.261111 0 Td 46.990741 Tz (identify ) Tj 2.45 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 54.012346 Tz (degree ) Tj 2.1 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 48.860399 Tz (deacetylation ) Tj 4.025 0 Td 45.37037 Tz (that ) Tj 1.225 0 Td 53.619529 Tz (corresponds ) Tj 3.733333 0 Td 43.75 Tz (to ) Tj 0.680556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2002.580854 Tm 6.261111 0 Td 50 Tz (desired ) Tj 2.469444 0 Td 51.557239 Tz (degradation ) Tj 3.752778 0 Td 43.344907 Tz (profile. ) Tj 2.411111 0 Td 69.135802 Tz (Any ) Tj 1.633333 0 Td 61.033951 Tz (number ) Tj 2.547222 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 57.87037 Tz (methods ) Tj 2.8 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 1961.764268 Tm 6.261111 0 Td 48.971193 Tz (available ) Tj 2.858333 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 50.636574 Tz (carrying ) Tj 2.683333 0 Td 50.771605 Tz (out ) Tj 1.127778 0 Td 51.851852 Tz (Screening ) Tj 2.994444 0 Td 51.851852 Tz (assays ) Tj 2.1 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 46.585648 Tz (identify ) Tj 2.469444 0 Td 55.902778 Tz (Such ) Tj 51.428571 0 0 51.428571 0 1923 Tm 6.261111 0 Td 51.851852 Tz (compositions. ) Tj 51.428571 0 0 51.428571 0 1878.346299 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 57.87037 Tz (working ) Tj 2.605556 0 Td 55.092593 Tz (example, ) Tj 2.838889 0 Td 51.49177 Tz (candidate ) Tj 2.936111 0 Td 61.934156 Tz (compounds ) Tj 3.519444 0 Td 50.771605 Tz (are ) Tj 1.088889 0 Td 58.981481 Tz (added ) Tj 51.428571 0 0 51.428571 0 1835.132221 Tm 6.261111 0 Td 45.37037 Tz (at ) Tj 0.894444 0 Td 51.851852 Tz (varying ) Tj 2.508333 0 Td 50.231481 Tz (concentrations ) Tj 4.55 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 49.826389 Tz (chitosan ) Tj 2.741667 0 Td 52.121914 Tz (composition. ) Tj 4.083333 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1793.848117 Tm 6.261111 0 Td 54.012346 Tz (degree ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 47.530864 Tz (infection ) Tj 2.761111 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 65.462963 Tz (wound ) Tj 2.1 0 Td 51.388889 Tz (healing ) Tj 2.352778 0 Td 37.268519 Tz (is ) Tj 0.602778 0 Td 52.662037 Tz (then ) Tj 1.477778 0 Td 57.523148 Tz (measured ) Tj 2.916667 0 Td 53.148148 Tz (using ) Tj 51.428571 0 0 51.428571 0 1749.991326 Tm 6.280556 0 Td 51.041667 Tz (standard ) Tj 2.702778 0 Td 57.87037 Tz (methods ) Tj 2.644444 0 Td 48.611111 Tz (as ) Tj 0.855556 0 Td 51.49177 Tz (described ) Tj 2.994444 0 Td 46.759259 Tz (herein. ) Tj 2.216667 0 Td 62.654321 Tz (The ) Tj 1.341667 0 Td 54.012346 Tz (degree ) Tj 2.158333 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 56.388889 Tz (infec ) Tj 51.428571 0 0 51.428571 0 1710.02449 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.516667 0 Td 41.049383 Tz (\(e.g., ) Tj 1.866667 0 Td 62.114198 Tz (number ) Tj 2.566667 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 47.170782 Tz (bacteria\) ) Tj 2.916667 0 Td 53.472222 Tz (or ) Tj 0.991667 0 Td 65.462963 Tz (wound ) Tj 2.333333 0 Td 50.925926 Tz (healing ) Tj 2.508333 0 Td 45.37037 Tz (in ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1670.20241 Tm 6.261111 0 Td 53.06713 Tz (presence ) Tj 2.722222 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 63.599537 Tz (compound ) Tj 3.208333 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 59.953704 Tz (compared ) Tj 3.013889 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 46.666667 Tz (level ) Tj 1.594444 0 Td 57.928241 Tz (measured ) Tj 52.857143 0 0 52.857143 0 1627.853933 Tm 6.091892 0 Td 44.144144 Tz (in ) Tj 0.983784 0 Td 50.45045 Tz (a ) Tj 0.756757 0 Td 47.747748 Tz (control ) Tj 2.478378 0 Td 49.099099 Tz (lacking ) Tj 2.478378 0 Td 49.399399 Tz (the ) Tj 1.324324 0 Td 58.158158 Tz (compound. ) Tj 3.594595 0 Td 78.828829 Tz (A ) Tj 0.889189 0 Td 61.880631 Tz (compound ) Tj 3.405405 0 Td 45.720721 Tz (that ) Tj 51.428571 0 0 51.428571 0 1583.085575 Tm 6.261111 0 Td 55.497685 Tz (enhances ) Tj 2.838889 0 Td 51.388889 Tz (healing ) Tj 2.352778 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 52.5 Tz (considered ) Tj 3.344444 0 Td 48.611111 Tz (useful ) Tj 1.944444 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 48.935185 Tz (invention. ) Tj 3.15 0 Td 55.902778 Tz (Such ) Tj 51.428571 0 0 51.428571 0 1545.388387 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 63.599537 Tz (compound ) Tj 3.305556 0 Td 68.055556 Tz (may ) Tj 1.477778 0 Td 58.333333 Tz (be ) Tj 0.952778 0 Td 49.259259 Tz (used, ) Tj 1.730556 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 55.497685 Tz (example, ) Tj 2.877778 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 48.611111 Tz (therapeutic ) Tj 3.461111 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1501.27483 Tm 6.261111 0 Td 49.016204 Tz (prevent, ) Tj 2.819444 0 Td 47.530864 Tz (delay, ) Tj 2.177778 0 Td 48.905724 Tz (ameliorate, ) Tj 3.733333 0 Td 42.777778 Tz (stabilize, ) Tj 3.033333 0 Td 53.472222 Tz (or ) Tj 1.05 0 Td 44.074074 Tz (treat ) Tj 1.75 0 Td 58.333333 Tz (a ) Tj 0.797222 0 Td 50.462963 Tz (disease ) Tj 51.428571 0 0 51.428571 0 1459.203655 Tm 6.261111 0 Td 51.851852 Tz (described ) Tj 3.130556 0 Td 50.771605 Tz (herein ) Tj 2.216667 0 Td 39.969136 Tz (\(e.g., ) Tj 1.808333 0 Td 46.450617 Tz (tissue ) Tj 2.022222 0 Td 55.497685 Tz (damage\). ) Tj 3.072222 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 50.555556 Tz (other ) Tj 1.847222 0 Td 66.975309 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1418.960494 Tm 6.261111 0 Td 52.932099 Tz (ments, ) Tj 2.216667 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 64.409722 Tz (compound ) Tj 3.344444 0 Td 49.331276 Tz (prevents, ) Tj 2.955556 0 Td 48.611111 Tz (delays, ) Tj 2.313889 0 Td 49.421296 Tz (ameliorates, ) Tj 3.869444 0 Td 53.148148 Tz (stabi ) Tj 48.571429 0 0 48.571429 0 1376 Tm 6.629412 0 Td 44.607843 Tz (lizes, ) Tj 1.852941 0 Td 56.617647 Tz (or ) Tj 0.885294 0 Td 46.323529 Tz (treats ) Tj 1.914706 0 Td 58.333333 Tz (a ) Tj 0.617647 0 Td 52.941176 Tz (disease ) Tj 2.470588 0 Td 54.901961 Tz (or ) Tj 0.885294 0 Td 53.186275 Tz (disorder ) Tj 2.758824 0 Td 54.901961 Tz (described ) Tj 3.191176 0 Td 50 Tz (herein. ) Tj 2.388235 0 Td 64.338235 Tz (Such ) Tj 51.428571 0 0 51.428571 0 1336.702609 Tm 6.241667 0 Td 49.200337 Tz (therapeutic ) Tj 3.519444 0 Td 61.574074 Tz (compounds ) Tj 3.558333 0 Td 50.771605 Tz (are ) Tj 1.166667 0 Td 48.611111 Tz (useful ) Tj 2.022222 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 47.314815 Tz (vivo. ) Tj 51.428571 0 0 51.428571 0 1296.313131 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.797222 0 Td 52.314815 Tz (another ) Tj 2.391667 0 Td 52.572016 Tz (approach, ) Tj 3.052778 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 53.742284 Tz (compositions ) Tj 4.083333 0 Td 55.632716 Tz (having ) Tj 2.216667 0 Td 63.194444 Tz (vary ) Tj 51.428571 0 0 51.428571 0 1252.55335 Tm 6.261111 0 Td 50.771605 Tz (ing ) Tj 1.147222 0 Td 52.314815 Tz (degrees ) Tj 2.391667 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 49.358974 Tz (deacetylation ) Tj 4.063889 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 52.211934 Tz (incubated ) Tj 3.013889 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 47.962963 Tz (vivo, ) Tj 1.633333 0 Td 58.333333 Tz (added ) Tj 1.944444 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1211.421628 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 59.953704 Tz (wound, ) Tj 2.333333 0 Td 53.472222 Tz (or ) Tj 0.758333 0 Td 50.771605 Tz (are ) Tj 1.088889 0 Td 51.49177 Tz (contacted ) Tj 2.975 0 Td 51.851852 Tz (with ) Tj 1.419444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 53.914141 Tz (composition ) Tj 3.752778 0 Td 54.768519 Tz (comprising ) Tj 3.422222 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 1173.071605 Tm 6.261111 0 Td 63.194444 Tz (enzyme ) Tj 2.547222 0 Td 55.632716 Tz (having ) Tj 2.313889 0 Td 51.49177 Tz (chitosan-degrading ) Tj 5.833333 0 Td 42.489712 Tz (activity. ) Tj 2.605556 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 49.691358 Tz (length ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1127.108214 Tm 6.241667 0 Td 55.092593 Tz (time ) Tj 1.691667 0 Td 50.231481 Tz (required ) Tj 2.761111 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 50.231481 Tz (chitosan ) Tj 2.819444 0 Td 51.262626 Tz (degradation ) Tj 3.772222 0 Td 38.888889 Tz (is ) Tj 0.816667 0 Td 52.662037 Tz (then ) Tj 1.672222 0 Td 57.928241 Tz (measured ) Tj 51.428571 0 0 51.428571 0 1083.863158 Tm 6.241667 0 Td 53.148148 Tz (using ) Tj 1.983333 0 Td 51.446759 Tz (standard ) Tj 2.877778 0 Td 57.87037 Tz (methods ) Tj 2.819444 0 Td 48.611111 Tz (as ) Tj 1.011111 0 Td 51.49177 Tz (described ) Tj 3.15 0 Td 47.222222 Tz (herein. ) Tj 2.372222 0 Td 84.259259 Tz (A ) Tj 0.875 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1047.424242 Tm 6.261111 0 Td 54.208754 Tz (composition ) Tj 3.927778 0 Td 55.632716 Tz (having ) Tj 2.333333 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 50.462963 Tz (desired ) Tj 2.45 0 Td 51.851852 Tz (degradation ) Tj 3.791667 0 Td 45.37037 Tz (profile ) Tj 2.236111 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1003.41573 Tm 6.261111 0 Td 54.012346 Tz (degrading ) Tj 3.188889 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (3 ) Tj 0.622222 0 Td 49.907407 Tz (days, ) Tj 1.788889 0 Td 55.092593 Tz (5 ) Tj 0.602778 0 Td 49.907407 Tz (days, ) Tj 1.827778 0 Td 35.648148 Tz (1 ) Tj 0.563889 0 Td 56.388889 Tz (week, ) Tj 1.983333 0 Td 55.092593 Tz (2 ) Tj 0.602778 0 Td 55.092593 Tz (weeks, ) Tj 2.255556 0 Td 55.092593 Tz (3 ) Tj 0.622222 0 Td 55.092593 Tz (weeks, ) Tj 2.313889 0 Td 35.648148 Tz (1 ) Tj 51.428571 0 0 51.428571 0 958 Tm 6.261111 0 Td 56.712963 Tz (month, ) Tj 2.411111 0 Td 58.333333 Tz (2 ) Tj 0.7 0 Td 55.092593 Tz (months, ) Tj 2.663889 0 Td 55.092593 Tz (3 ) Tj 0.719444 0 Td 56.018519 Tz (months\) ) Tj 2.741667 0 Td 37.268519 Tz (is ) Tj 0.816667 0 Td 52.5 Tz (considered ) Tj 3.480556 0 Td 49.151235 Tz (useful ) Tj 2.138889 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 920.786865 Tm 6.261111 0 Td 48.611111 Tz (invention; ) Tj 3.169444 0 Td 53.472222 Tz (Such ) Tj 1.477778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 54.503367 Tz (composition ) Tj 3.830556 0 Td 66.975309 Tz (may ) Tj 1.380556 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 50.555556 Tz (used, ) Tj 1.711111 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 54.6875 Tz (example, ) Tj 2.838889 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 878.641646 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 49.200337 Tz (therapeutic ) Tj 3.422222 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 49.421296 Tz (prevent, ) Tj 2.586111 0 Td 46.990741 Tz (delay, ) Tj 1.866667 0 Td 49.494949 Tz (ameliorate, ) Tj 3.461111 0 Td 43.425926 Tz (stabilize, ) Tj 2.8 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 44.074074 Tz (treat ) Tj 51.428571 0 0 51.428571 0 835.221643 Tm 6.261111 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 49.537037 Tz (disease ) Tj 2.391667 0 Td 51.851852 Tz (described ) Tj 3.111111 0 Td 49.691358 Tz (herein ) Tj 2.119444 0 Td 41.049383 Tz (\(e.g., ) Tj 1.788889 0 Td 46.450617 Tz (tissue ) Tj 1.983333 0 Td 55.497685 Tz (damage\). ) Tj 3.033333 0 Td 46.990741 Tz (In ) Tj 0.875 0 Td 51.203704 Tz (other ) Tj 51.428571 0 0 51.428571 0 796.251889 Tm 6.261111 0 Td 56.983025 Tz (embodiments, ) Tj 4.491667 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 54.208754 Tz (composition ) Tj 3.986111 0 Td 48.611111 Tz (prevents, ) Tj 3.033333 0 Td 47.685185 Tz (delays, ) Tj 2.430556 0 Td 61.574074 Tz (amelio ) Tj 48.571429 0 0 48.571429 0 752 Tm 6.629412 0 Td 45.751634 Tz (rates, ) Tj 1.997059 0 Td 46.167558 Tz (stabilizes, ) Tj 3.438235 0 Td 53.186275 Tz (or ) Tj 0.988235 0 Td 45.179739 Tz (treats ) Tj 1.997059 0 Td 58.333333 Tz (a ) Tj 0.679412 0 Td 53.431373 Tz (disease ) Tj 2.594118 0 Td 54.901961 Tz (or ) Tj 0.988235 0 Td 53.186275 Tz (disorder ) Tj 2.861765 0 Td 55.283224 Tz (described ) Tj 51.428571 0 0 51.428571 0 712.727856 Tm 6.241667 0 Td 47.685185 Tz (herein. ) Tj 2.255556 0 Td 60.763889 Tz (Such ) Tj 1.711111 0 Td 48.611111 Tz (therapeutic ) Tj 3.480556 0 Td 53.472222 Tz (compositions ) Tj 4.083333 0 Td 50.771605 Tz (are ) Tj 1.186111 0 Td 48.611111 Tz (useful ) Tj 2.002778 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 47.314815 Tz (vivo. ) Tj 51.428571 0 0 51.428571 0 671.440049 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.263889 0 Td 50.462963 Tz (present ) Tj 2.275 0 Td 50.771605 Tz (invention ) Tj 2.897222 0 Td 52.256944 Tz (provides ) Tj 2.683333 0 Td 58.333333 Tz (methods ) Tj 2.605556 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 46.585648 Tz (treating ) Tj 2.372222 0 Td 62.222222 Tz (patho ) Tj 51.428571 0 0 51.428571 0 630.076087 Tm 6.261111 0 Td 57.253086 Tz (gen ) Tj 1.594444 0 Td 47.314815 Tz (infections ) Tj 3.344444 0 Td 41.049383 Tz (\(e.g., ) Tj 2.002778 0 Td 44.722222 Tz (bacterial, ) Tj 3.208333 0 Td 41.589506 Tz (viral, ) Tj 2.041667 0 Td 46.990741 Tz (fungal\), ) Tj 2.761111 0 Td 60.185185 Tz (complex ) Tj 51.428571 0 0 51.428571 0 584.735632 Tm 6.241667 0 Td 58.333333 Tz (wounds, ) Tj 2.838889 0 Td 58.333333 Tz (open ) Tj 1.788889 0 Td 45.37037 Tz (fractures, ) Tj 3.111111 0 Td 52.314815 Tz (trauma, ) Tj 2.566667 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 50.231481 Tz (associated ) Tj 3.383333 0 Td 49.421296 Tz (diseases ) Tj 51.428571 0 0 51.428571 0 545.052632 Tm 6.261111 0 Td 52.391975 Tz (and/or ) Tj 2.333333 0 Td 49.331276 Tz (disorders ) Tj 3.130556 0 Td 53.472222 Tz (or ) Tj 1.088889 0 Td 61.979167 Tz (symptoms ) Tj 3.461111 0 Td 51.388889 Tz (thereof ) Tj 2.527778 0 Td 59.62963 Tz (which ) Tj 2.275 0 Td 55.497685 Tz (comprise ) Tj 51.428571 0 0 51.428571 0 505.191411 Tm 6.261111 0 Td 51.353276 Tz (administering ) Tj 4.238889 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 47.746914 Tz (therapeutically ) Tj 4.55 0 Td 46.450617 Tz (effective ) Tj 2.761111 0 Td 61.033951 Tz (amount ) Tj 2.430556 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 82.098765 Tz (com ) Tj 51.428571 0 0 51.428571 0 464.715711 Tm 6.261111 0 Td 48.611111 Tz (position ) Tj 2.644444 0 Td 54.444444 Tz (comprising ) Tj 3.519444 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 48.905724 Tz (therapeutic ) Tj 3.519444 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 64.274691 Tz (prophy ) Tj 51.428571 0 0 51.428571 0 421.06087 Tm 6.261111 0 Td 43.75 Tz (lactic ) Tj 1.983333 0 Td 53.148148 Tz (agent ) Tj 2.022222 0 Td 56.712963 Tz (of ) Tj 1.011111 0 Td 55.092593 Tz (a ) Tj 0.738889 0 Td 55.092593 Tz (formulae ) Tj 3.033333 0 Td 50.771605 Tz (herein ) Tj 2.255556 0 Td 45.37037 Tz (to ) Tj 0.972222 0 Td 58.333333 Tz (a ) Tj 0.758333 0 Td 49.537037 Tz (Subject ) Tj 2.488889 0 Td 40.509259 Tz (\(e.g., ) Tj 1.886111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 376 Tm 6.261111 0 Td 64.814815 Tz (mammal, ) Tj 3.052778 0 Td 55.092593 Tz (such ) Tj 1.672222 0 Td 48.611111 Tz (as ) Tj 0.913889 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 56.481481 Tz (human\). ) Tj 2.722222 0 Td 54.444444 Tz (Thus, ) Tj 1.963889 0 Td 58.333333 Tz (one ) Tj 1.380556 0 Td 60.925926 Tz (embodiment ) Tj 3.986111 0 Td 37.268519 Tz (is ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 340.097171 Tm 6.261111 0 Td 61.033951 Tz (method ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 46.180556 Tz (treating ) Tj 2.391667 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 48.611111 Tz (Subject ) Tj 2.216667 0 Td 47.890947 Tz (suffering ) Tj 2.780556 0 Td 57.523148 Tz (from ) Tj 1.613889 0 Td 50.231481 Tz (or ) Tj 0.777778 0 Td 48.905724 Tz (Susceptible ) Tj 3.402778 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 293.733758 Tm 6.261111 0 Td 56.712963 Tz (an ) Tj 0.952778 0 Td 46.018519 Tz (infection, ) Tj 3.033333 0 Td 51.851852 Tz (trauma, ) Tj 2.469444 0 Td 59.953704 Tz (wound, ) Tj 2.430556 0 Td 58.333333 Tz (open ) Tj 1.691667 0 Td 44.290123 Tz (fracture, ) Tj 2.683333 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 47.222222 Tz (related ) Tj 2.255556 0 Td 59.41358 Tz (dis ) Tj 51.428571 0 0 51.428571 0 255.464619 Tm 6.261111 0 Td 52.662037 Tz (ease ) Tj 1.652778 0 Td 51.851852 Tz (or ) Tj 0.991667 0 Td 49.826389 Tz (disorder ) Tj 2.741667 0 Td 46.180556 Tz (that ) Tj 1.497222 0 Td 48.206019 Tz (requires ) Tj 2.702778 0 Td 47.890947 Tz (targeting ) Tj 2.955556 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 58.333333 Tz (a ) Tj 0.719444 0 Td 48.905724 Tz (therapeutic ) Tj 51.428571 0 0 51.428571 0 212.707521 Tm 6.261111 0 Td 53.914141 Tz (composition ) Tj 4.005556 0 Td 42.12963 Tz (to ) Tj 0.913889 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 38.888889 Tz (site. ) Tj 1.555556 0 Td 62.654321 Tz (The ) Tj 1.555556 0 Td 59.41358 Tz (method ) Tj 2.527778 0 Td 49.826389 Tz (includes ) Tj 2.780556 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 48.611111 Tz (step ) Tj 1.555556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 171.915789 Tm 6.261111 0 Td 51.353276 Tz (administering ) Tj 4.336111 0 Td 46.990741 Tz (to ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 69.675926 Tz (mammal ) Tj 2.858333 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 48.905724 Tz (therapeutic ) Tj 3.558333 0 Td 61.574074 Tz (amount ) Tj 2.566667 0 Td 56.712963 Tz (of ) Tj 0.952778 0 Td 55.092593 Tz (a ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.540541 0 Td 77.252252 Tz (20 ) Tj 51.428571 0 0 51.428571 0 2914.532121 Tm 25.2 0 Td 64.00463 Tz (compound ) Tj 3.227778 0 Td 50.231481 Tz (herein ) Tj 1.983333 0 Td 44.722222 Tz (sufficient ) Tj 2.819444 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 42.12963 Tz (treat ) Tj 1.438889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 49.537037 Tz (disease ) Tj 2.236111 0 Td 55.092593 Tz (or ) Tj 0.797222 0 Td 49.421296 Tz (disorder ) Tj 2.527778 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 2873.359801 Tm 25.219444 0 Td 63.425926 Tz (symptom ) Tj 2.916667 0 Td 46.585648 Tz (thereof, ) Tj 2.469444 0 Td 56.388889 Tz (under ) Tj 1.886111 0 Td 50.231481 Tz (conditions ) Tj 3.266667 0 Td 54.282407 Tz (such ) Tj 1.516667 0 Td 46.990741 Tz (that ) Tj 1.322222 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 50 Tz (disease ) Tj 2.333333 0 Td 51.851852 Tz (or ) Tj 40 0 0 40 0 2838 Tm 32.4 0 Td 64.583333 Tz (disorder ) Tj 3.375 0 Td 50 Tz (is ) Tj 0.95 0 Td 56.770833 Tz (treated. ) Tj 51.428571 0 0 51.428571 0 2791.232947 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 57.87037 Tz (methods ) Tj 2.663889 0 Td 50.771605 Tz (herein ) Tj 2.061111 0 Td 51.388889 Tz (include ) Tj 2.372222 0 Td 51.602564 Tz (administering ) Tj 4.258333 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 49.537037 Tz (subject ) Tj 51.428571 0 0 51.428571 0 2749.570361 Tm 25.219444 0 Td 49.583333 Tz (\(including ) Tj 3.169444 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 48.611111 Tz (Subject ) Tj 2.236111 0 Td 46.018519 Tz (identified ) Tj 2.936111 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 55.902778 Tz (need ) Tj 1.555556 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 54.282407 Tz (Such ) Tj 1.497222 0 Td 50.231481 Tz (treatment\) ) Tj 51.428571 0 0 51.428571 0 2706.602041 Tm 25.2 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 46.8107 Tz (effective ) Tj 2.780556 0 Td 61.574074 Tz (amount ) Tj 2.45 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 63.599537 Tz (compound ) Tj 3.305556 0 Td 51.851852 Tz (described ) Tj 3.052778 0 Td 47.685185 Tz (herein, ) Tj 2.294444 0 Td 50.231481 Tz (or ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2667.021118 Tm 25.2 0 Td 53.914141 Tz (composition ) Tj 3.85 0 Td 51.49177 Tz (described ) Tj 3.013889 0 Td 50.231481 Tz (herein ) Tj 2.080556 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 56.018519 Tz (produce ) Tj 2.586111 0 Td 55.092593 Tz (such ) Tj 1.555556 0 Td 42.12963 Tz (effect. ) Tj 2.061111 0 Td 63.194444 Tz (Iden ) Tj 51.428571 0 0 51.428571 0 2624.279391 Tm 25.180556 0 Td 46.759259 Tz (tifying ) Tj 2.236111 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 48.611111 Tz (Subject ) Tj 2.352778 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 55.902778 Tz (need ) Tj 1.652778 0 Td 56.712963 Tz (of ) Tj 0.933333 0 Td 53.472222 Tz (Such ) Tj 1.613889 0 Td 51.131687 Tz (treatment ) Tj 3.072222 0 Td 54.012346 Tz (can ) Tj 1.302778 0 Td 56.712963 Tz (be ) Tj 0.991667 0 Td 45.37037 Tz (in ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2585.340852 Tm 25.161111 0 Td 58.333333 Tz (judgment ) Tj 3.013889 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 49.074074 Tz (Subject ) Tj 2.275 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.691358 Tz (health ) Tj 2.041667 0 Td 50.231481 Tz (care ) Tj 1.4 0 Td 49.421296 Tz (professional ) Tj 3.791667 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 57.253086 Tz (can ) Tj 51.428571 0 0 51.428571 0 2544.668293 Tm 25.180556 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 48.935185 Tz (subjective ) Tj 3.130556 0 Td 41.481481 Tz (\(e.g. ) Tj 1.458333 0 Td 51.041667 Tz (opinion\) ) Tj 2.663889 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 49.331276 Tz (objective ) Tj 2.838889 0 Td 42.12963 Tz (\(e.g. ) Tj 1.497222 0 Td 55.092593 Tz (measurable ) Tj 3.461111 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 2500.142119 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 42.939815 Tz (test ) Tj 1.244444 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 49.259259 Tz (diagnostic ) Tj 3.227778 0 Td 53.472222 Tz (method\). ) Tj 51.428571 0 0 51.428571 0 2457.685824 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 48.611111 Tz (therapeutic ) Tj 3.461111 0 Td 57.87037 Tz (methods ) Tj 2.663889 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 50.411523 Tz (invention ) Tj 2.975 0 Td 55.092593 Tz (\(which ) Tj 2.236111 0 Td 50.925926 Tz (include ) Tj 51.428571 0 0 51.428571 0 2418.153846 Tm 25.2 0 Td 50.231481 Tz (prophylactic ) Tj 3.869444 0 Td 49.907407 Tz (treatment\) ) Tj 3.286111 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 50.462963 Tz (general ) Tj 2.391667 0 Td 55.497685 Tz (comprise ) Tj 2.897222 0 Td 50.694444 Tz (administration ) Tj 51.428571 0 0 51.428571 0 2377.082902 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.991667 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 47.962963 Tz (therapeutically ) Tj 4.705556 0 Td 46.450617 Tz (effective ) Tj 2.858333 0 Td 61.574074 Tz (amount ) Tj 2.566667 0 Td 61.574074 Tz (of ) Tj 1.030556 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 61.934156 Tz (compounds ) Tj 51.428571 0 0 51.428571 0 2332.708844 Tm 25.180556 0 Td 47.685185 Tz (herein, ) Tj 2.352778 0 Td 55.092593 Tz (Such ) Tj 1.652778 0 Td 48.611111 Tz (as ) Tj 0.913889 0 Td 58.333333 Tz (a ) Tj 0.7 0 Td 63.599537 Tz (compound ) Tj 3.402778 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 55.092593 Tz (formulae ) Tj 2.936111 0 Td 50.771605 Tz (herein ) Tj 2.138889 0 Td 48.611111 Tz (to ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2293.312821 Tm 25.219444 0 Td 49.074074 Tz (Subject ) Tj 2.333333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.730556 0 Td 51.851852 Tz (animal, ) Tj 2.45 0 Td 62.114198 Tz (human\) ) Tj 2.547222 0 Td 45.37037 Tz (in ) Tj 0.855556 0 Td 56.712963 Tz (need ) Tj 1.613889 0 Td 46.585648 Tz (thereof, ) Tj 2.547222 0 Td 51.131687 Tz (including ) Tj 3.052778 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2249.847797 Tm 25.2 0 Td 64.814815 Tz (mammal, ) Tj 3.111111 0 Td 46.720679 Tz (particularly ) Tj 3.791667 0 Td 55.092593 Tz (a ) Tj 0.738889 0 Td 59.41358 Tz (human. ) Tj 2.566667 0 Td 59.953704 Tz (Such ) Tj 1.866667 0 Td 51.131687 Tz (treatment ) Tj 3.188889 0 Td 45.37037 Tz (will ) Tj 1.497222 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 2210.048309 Tm 25.219444 0 Td 47.395833 Tz (Suitably ) Tj 2.488889 0 Td 52.662037 Tz (administered ) Tj 3.986111 0 Td 48.611111 Tz (to ) Tj 0.816667 0 Td 46.8107 Tz (subjects, ) Tj 2.761111 0 Td 46.450617 Tz (particularly ) Tj 3.558333 0 Td 58.796296 Tz (humans, ) Tj 2.722222 0 Td 61.574074 Tz (Suf ) Tj 51.428571 0 0 51.428571 0 2168.57385 Tm 25.2 0 Td 48.611111 Tz (fering ) Tj 1.905556 0 Td 52.5 Tz (from, ) Tj 1.691667 0 Td 51.851852 Tz (having, ) Tj 2.333333 0 Td 49.200337 Tz (Susceptible ) Tj 3.383333 0 Td 41.049383 Tz (to, ) Tj 0.894444 0 Td 53.472222 Tz (or ) Tj 0.738889 0 Td 45.37037 Tz (at ) Tj 0.7 0 Td 46.180556 Tz (risk ) Tj 1.244444 0 Td 47.530864 Tz (for ) Tj 0.952778 0 Td 58.333333 Tz (an ) Tj 0.875 0 Td 45.37037 Tz (infection, ) Tj 51.428571 0 0 51.428571 0 2125.963338 Tm 25.2 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 55.902778 Tz (need ) Tj 1.575 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 48.206019 Tz (healing, ) Tj 2.566667 0 Td 55.092593 Tz (having ) Tj 2.197222 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 52.777778 Tz (trauma, ) Tj 2.45 0 Td 59.953704 Tz (wound, ) Tj 2.391667 0 Td 58.333333 Tz (open ) Tj 1.652778 0 Td 44.650206 Tz (fracture, ) Tj 51.428571 0 0 51.428571 0 2083.371715 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 46.759259 Tz (related ) Tj 2.216667 0 Td 47.800926 Tz (disease, ) Tj 2.566667 0 Td 46.8107 Tz (disorder, ) Tj 2.8 0 Td 51.851852 Tz (or ) Tj 0.894444 0 Td 63.425926 Tz (symptom ) Tj 2.955556 0 Td 46.180556 Tz (thereof. ) Tj 2.527778 0 Td 62.037037 Tz (Determi ) Tj 51.428571 0 0 51.428571 0 2042.398868 Tm 25.2 0 Td 50.771605 Tz (nation ) Tj 2.177778 0 Td 59.953704 Tz (of ) Tj 1.030556 0 Td 51.203704 Tz (those ) Tj 1.925 0 Td 48.206019 Tz (subjects ) Tj 2.702778 0 Td 48.611111 Tz (at ) Tj 1.263889 0 Td 46.018519 Tz (risk ) Tj 1.75 0 Td 56.17284 Tz (can ) Tj 1.419444 0 Td 58.333333 Tz (be ) Tj 1.088889 0 Td 65.625 Tz (made ) Tj 1.925 0 Td 61.574074 Tz (by ) Tj 1.108333 0 Td 59.41358 Tz (any ) Tj 51.428571 0 0 51.428571 0 2003.665857 Tm 25.2 0 Td 49.691358 Tz (objective ) Tj 2.858333 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 49.259259 Tz (subjective ) Tj 3.15 0 Td 51.602564 Tz (determination ) Tj 4.238889 0 Td 58.333333 Tz (by ) Tj 0.894444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.907407 Tz (diagnostic ) Tj 3.169444 0 Td 42.939815 Tz (test ) Tj 1.244444 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1962.502591 Tm 25.2 0 Td 52.777778 Tz (opinion ) Tj 2.508333 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 58.333333 Tz (a ) Tj 0.661111 0 Td 48.611111 Tz (Subject ) Tj 2.352778 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 49.691358 Tz (health ) Tj 2.080556 0 Td 51.041667 Tz (care ) Tj 1.516667 0 Td 51.851852 Tz (provider ) Tj 2.741667 0 Td 41.049383 Tz (\(e.g., ) Tj 1.769444 0 Td 50 Tz (genetic ) Tj 51.428571 0 0 51.428571 0 1917.196273 Tm 25.180556 0 Td 40.185185 Tz (test, ) Tj 1.438889 0 Td 62.654321 Tz (enzyme ) Tj 2.469444 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 48.611111 Tz (protein ) Tj 2.294444 0 Td 51.851852 Tz (marker, ) Tj 2.430556 0 Td 59.953704 Tz (Marker ) Tj 2.372222 0 Td 45.37037 Tz (\(as ) Tj 1.05 0 Td 50.925926 Tz (defined ) Tj 2.352778 0 Td 46.180556 Tz (herein\), ) Tj 51.428571 0 0 51.428571 0 1877.697733 Tm 25.2 0 Td 52.391975 Tz (family ) Tj 2.080556 0 Td 45.37037 Tz (history, ) Tj 2.372222 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 41.589506 Tz (like\). ) Tj 1.711111 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 51.851852 Tz (agents ) Tj 2.080556 0 Td 50.231481 Tz (herein ) Tj 2.061111 0 Td 66.975309 Tz (may ) Tj 1.4 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 47.800926 Tz (also ) Tj 51.428571 0 0 51.428571 0 1832.564581 Tm 25.180556 0 Td 55.902778 Tz (used ) Tj 1.633333 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 51.131687 Tz (treatment ) Tj 2.994444 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 57.253086 Tz (any ) Tj 1.322222 0 Td 50.555556 Tz (other ) Tj 1.75 0 Td 48.971193 Tz (disorders ) Tj 2.936111 0 Td 46.990741 Tz (in ) Tj 0.836111 0 Td 58.333333 Tz (which ) Tj 2.041667 0 Td 32.407407 Tz (it ) Tj 0.661111 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 1794.403423 Tm 25.2 0 Td 48.611111 Tz (desirable ) Tj 2.780556 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 57.87037 Tz (promote ) Tj 2.605556 0 Td 50.462963 Tz (healing ) Tj 2.333333 0 Td 50.231481 Tz (or ) Tj 0.758333 0 Td 43.425926 Tz (treat ) Tj 1.458333 0 Td 53.472222 Tz (or ) Tj 0.758333 0 Td 52.777778 Tz (prevent ) Tj 2.372222 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 45.37037 Tz (infection. ) Tj 51.428571 0 0 51.428571 0 1750.35611 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 59.41358 Tz (one ) Tj 1.302778 0 Td 57.744108 Tz (embodiment, ) Tj 4.102778 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 50.771605 Tz (invention ) Tj 2.994444 0 Td 52.256944 Tz (provides ) Tj 2.741667 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 59.953704 Tz (method ) Tj 2.391667 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 1711.421801 Tm 25.2 0 Td 54.12037 Tz (monitoring ) Tj 3.363889 0 Td 51.131687 Tz (treatment ) Tj 2.897222 0 Td 48.971193 Tz (progress. ) Tj 2.780556 0 Td 64.814815 Tz (The ) Tj 1.322222 0 Td 60.493827 Tz (method ) Tj 2.333333 0 Td 49.421296 Tz (includes ) Tj 2.547222 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 46.990741 Tz (step ) Tj 51.428571 0 0 51.428571 0 1670.024722 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 53.030303 Tz (determining ) Tj 3.733333 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 47.314815 Tz (level ) Tj 1.652778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.259259 Tz (diagnostic ) Tj 3.247222 0 Td 56.712963 Tz (marker ) Tj 2.255556 0 Td 54.282407 Tz (\(Marker\) ) Tj 2.838889 0 Td 40.509259 Tz (\(e.g., ) Tj 52.857143 0 0 52.857143 0 1626.265306 Tm 24.5 0 Td 64.954955 Tz (wound ) Tj 2.1 0 Td 50.45045 Tz (healing ) Tj 2.289189 0 Td 49.5905 Tz (parameters, ) Tj 3.5 0 Td 59.90991 Tz (number ) Tj 2.289189 0 Td 56.756757 Tz (of ) Tj 0.775676 0 Td 44.844845 Tz (bacterial ) Tj 2.591892 0 Td 41.516517 Tz (cells, ) Tj 1.664865 0 Td 52.027027 Tz (or ) Tj 0.756757 0 Td 57.807808 Tz (any ) Tj 51.428571 0 0 51.428571 0 1584.78607 Tm 25.180556 0 Td 46.450617 Tz (target ) Tj 1.944444 0 Td 49.583333 Tz (delineated ) Tj 3.208333 0 Td 50.771605 Tz (herein ) Tj 2.119444 0 Td 56.532922 Tz (modulated ) Tj 3.305556 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 63.599537 Tz (compound ) Tj 3.286111 0 Td 47.685185 Tz (herein, ) Tj 51.428571 0 0 51.428571 0 1542.322275 Tm 25.2 0 Td 50.555556 Tz (C-reactive ) Tj 3.188889 0 Td 46.585648 Tz (protein, ) Tj 2.391667 0 Td 52.662037 Tz (cytokine ) Tj 2.683333 0 Td 44.444444 Tz (levels, ) Tj 2.002778 0 Td 55.092593 Tz (or ) Tj 0.777778 0 Td 48.611111 Tz (indicator ) Tj 2.761111 0 Td 45.775463 Tz (thereof, ) Tj 2.391667 0 Td 42.12963 Tz (etc.\) ) Tj 51.428571 0 0 51.428571 0 1503.232386 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 49.259259 Tz (diagnostic ) Tj 3.227778 0 Td 58.333333 Tz (measurement ) Tj 4.044444 0 Td 40.509259 Tz (\(e.g., ) Tj 1.711111 0 Td 48.148148 Tz (screen, ) Tj 2.216667 0 Td 50.771605 Tz (assay\) ) Tj 2.061111 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 49.537037 Tz (subject ) Tj 51.428571 0 0 51.428571 0 1460.114024 Tm 25.219444 0 Td 47.530864 Tz (Suffering ) Tj 2.877778 0 Td 58.333333 Tz (from ) Tj 1.75 0 Td 53.472222 Tz (or ) Tj 0.952778 0 Td 48.611111 Tz (Susceptible ) Tj 3.519444 0 Td 48.611111 Tz (to ) Tj 0.913889 0 Td 56.712963 Tz (an ) Tj 1.030556 0 Td 45.37037 Tz (infection, ) Tj 3.091667 0 Td 50.231481 Tz (disorder ) Tj 2.722222 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1417.612658 Tm 25.219444 0 Td 61.574074 Tz (symptoms ) Tj 3.227778 0 Td 46.180556 Tz (thereof, ) Tj 2.488889 0 Td 46.990741 Tz (in ) Tj 0.836111 0 Td 58.333333 Tz (which ) Tj 2.002778 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 49.074074 Tz (Subject ) Tj 2.275 0 Td 54.012346 Tz (has ) Tj 1.244444 0 Td 56.712963 Tz (been ) Tj 1.613889 0 Td 61.111111 Tz (adminis ) Tj 51.428571 0 0 51.428571 0 1378.212608 Tm 25.180556 0 Td 49.259259 Tz (tered ) Tj 1.711111 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 49.200337 Tz (therapeutic ) Tj 3.461111 0 Td 61.574074 Tz (amount ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 54.208754 Tz (composition ) Tj 3.811111 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1338.152358 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 49.826389 Tz (chitosan ) Tj 2.625 0 Td 53.914141 Tz (composition ) Tj 3.791667 0 Td 54.12037 Tz (comprising ) Tj 3.422222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.200337 Tz (therapeutic ) Tj 3.441667 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 64.274691 Tz (prophy ) Tj 51.428571 0 0 51.428571 0 1292.915493 Tm 25.2 0 Td 43.209877 Tz (lactic ) Tj 1.808333 0 Td 50.771605 Tz (agent\) ) Tj 2.080556 0 Td 50.771605 Tz (herein ) Tj 2.1 0 Td 44.398148 Tz (Sufficient ) Tj 2.897222 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 44.074074 Tz (treat ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 49.537037 Tz (disease ) Tj 2.352778 0 Td 51.851852 Tz (or ) Tj 0.855556 0 Td 75.347222 Tz (symp ) Tj 40 0 0 40 0 1257 Tm 32.375 0 Td 76.041667 Tz (toms ) Tj 2.075 0 Td 59.375 Tz (thereof. ) Tj 3.1 0 Td 80.555556 Tz (The ) Tj 1.7 0 Td 60 Tz (level ) Tj 2.025 0 Td 75 Tz (of ) Tj 1 0 Td 77.777778 Tz (Marker ) Tj 3.025 0 Td 70 Tz (determined ) Tj 4.425 0 Td 58.333333 Tz (in ) Tj 0.975 0 Td 62.5 Tz (the ) Tj 1.4 0 Td 77.083333 Tz (method ) Tj 51.428571 0 0 51.428571 0 1210.523752 Tm 25.2 0 Td 55.092593 Tz (can ) Tj 1.166667 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 59.953704 Tz (compared ) Tj 3.033333 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 64.814815 Tz (known ) Tj 2.1 0 Td 46.990741 Tz (levels ) Tj 1.866667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 59.41358 Tz (Marker ) Tj 2.275 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 46.990741 Tz (either ) Tj 1.788889 0 Td 51.388889 Tz (healthy ) Tj 51.428571 0 0 51.428571 0 1167.135802 Tm 25.2 0 Td 57.253086 Tz (normal ) Tj 2.255556 0 Td 48.611111 Tz (controls ) Tj 2.547222 0 Td 55.092593 Tz (or ) Tj 0.797222 0 Td 46.990741 Tz (in ) Tj 0.777778 0 Td 50.555556 Tz (other ) Tj 1.691667 0 Td 43.569959 Tz (afflicted ) Tj 2.547222 0 Td 46.585648 Tz (patients ) Tj 2.45 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 47.530864 Tz (establish ) Tj 2.761111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1126.589651 Tm 25.219444 0 Td 47.170782 Tz (Subject's ) Tj 2.761111 0 Td 49.537037 Tz (disease ) Tj 2.275 0 Td 42.592593 Tz (status. ) Tj 2.022222 0 Td 46.990741 Tz (In ) Tj 0.738889 0 Td 49.691358 Tz (preferred ) Tj 2.858333 0 Td 56.712963 Tz (embodiments, ) Tj 4.258333 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 57.253086 Tz (second ) Tj 51.428571 0 0 51.428571 0 1084.892031 Tm 25.2 0 Td 46.666667 Tz (level ) Tj 1.633333 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 60.493827 Tz (Marker ) Tj 2.372222 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 48.611111 Tz (subject ) Tj 2.255556 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 54.444444 Tz (determined ) Tj 3.480556 0 Td 42.12963 Tz (at ) Tj 0.719444 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 52.662037 Tz (time ) Tj 1.458333 0 Td 51.203704 Tz (point ) Tj 48.571429 0 0 48.571429 0 1043 Tm 26.682353 0 Td 46.666667 Tz (later ) Tj 1.667647 0 Td 54.044118 Tz (than ) Tj 1.626471 0 Td 51.470588 Tz (the ) Tj 1.235294 0 Td 54.374057 Tz (determination ) Tj 4.55 0 Td 60.04902 Tz (of ) Tj 0.926471 0 Td 52.614379 Tz (the ) Tj 1.235294 0 Td 40.490196 Tz (first ) Tj 1.502941 0 Td 46.323529 Tz (level, ) Tj 1.935294 0 Td 64.052288 Tz (and ) Tj 1.441176 0 Td 51.470588 Tz (the ) Tj 1.214706 0 Td 62.908497 Tz (two ) Tj 51.428571 0 0 51.428571 0 1001.493064 Tm 25.2 0 Td 46.990741 Tz (levels ) Tj 1.905556 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 59.953704 Tz (compared ) Tj 3.091667 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 54.62963 Tz (monitor ) Tj 2.45 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 52.391975 Tz (course ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 50 Tz (disease ) Tj 2.313889 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 961.642595 Tm 25.2 0 Td 46.585648 Tz (efficacy ) Tj 2.469444 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 47.800926 Tz (therapy. ) Tj 2.547222 0 Td 50.231481 Tz (In ) Tj 0.777778 0 Td 47.685185 Tz (certain ) Tj 2.197222 0 Td 50.05144 Tz (preferred ) Tj 2.897222 0 Td 56.983025 Tz (embodiments, ) Tj 4.336111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 920.089308 Tm 25.2 0 Td 50.356125 Tz (pre-treatment ) Tj 4.180556 0 Td 46.666667 Tz (level ) Tj 1.672222 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 60.493827 Tz (Marker ) Tj 2.411111 0 Td 45.37037 Tz (in ) Tj 0.855556 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 48.611111 Tz (subject ) Tj 2.313889 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 55.092593 Tz (determined ) Tj 51.428571 0 0 51.428571 0 878.582233 Tm 25.2 0 Td 47.314815 Tz (prior ) Tj 1.575 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 54.372428 Tz (beginning ) Tj 3.072222 0 Td 51.49177 Tz (treatment ) Tj 2.916667 0 Td 53.652263 Tz (according ) Tj 3.052778 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 43.75 Tz (this ) Tj 1.225 0 Td 48.611111 Tz (invention; ) Tj 3.091667 0 Td 44.560185 Tz (this ) Tj 51.428571 0 0 51.428571 0 836.526448 Tm 25.2 0 Td 50.356125 Tz (pre-treatment ) Tj 4.180556 0 Td 46.018519 Tz (level ) Tj 1.594444 0 Td 61.574074 Tz (of ) Tj 0.894444 0 Td 59.41358 Tz (Marker ) Tj 2.352778 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 51.041667 Tz (then ) Tj 1.458333 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 59.953704 Tz (compared ) Tj 3.091667 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 793.152263 Tm 25.2 0 Td 46.666667 Tz (level ) Tj 1.788889 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 59.953704 Tz (Marker ) Tj 2.527778 0 Td 43.75 Tz (in ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 48.611111 Tz (subject ) Tj 2.411111 0 Td 45.37037 Tz (after ) Tj 1.711111 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 50.411523 Tz (treatment ) Tj 3.072222 0 Td 84.259259 Tz (com ) Tj 51.428571 0 0 51.428571 0 751.339105 Tm 25.2 0 Td 56.018519 Tz (mences, ) Tj 2.605556 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 54.012346 Tz (determine ) Tj 3.15 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 46.990741 Tz (efficacy ) Tj 2.508333 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 47.962963 Tz (treatment. ) Tj 51.428571 0 0 51.428571 0 712.472422 Tm 25.2 0 Td 49.421296 Tz (Test ) Tj 1.438889 0 Td 65.174897 Tz (Compounds ) Tj 3.752778 0 Td 60.493827 Tz (and ) Tj 1.361111 0 Td 48.206019 Tz (Extracts 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6.261111 0 Td 55.092593 Tz (example, ) Tj 2.8 0 Td 52.5 Tz (those ) Tj 1.769444 0 Td 54.282407 Tz (Such ) Tj 1.497222 0 Td 48.611111 Tz (as ) Tj 0.797222 0 Td 51.49177 Tz (described ) Tj 2.975 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 48.611111 Tz (R. ) Tj 0.816667 0 Td 52.777778 Tz (Larock, ) Tj 2.372222 0 Td 67.695473 Tz (Comprehen ) Tj 51.428571 0 0 51.428571 0 2083.191067 Tm 6.280556 0 Td 48.611111 Tz (sive ) Tj 1.438889 0 Td 55.555556 Tz (Organic ) Tj 2.605556 0 Td 51.851852 Tz (Transformations, ) Tj 5.25 0 Td 85.339506 Tz (VCH ) Tj 1.866667 0 Td 49.907407 Tz (Publishers ) Tj 3.305556 0 Td 50 Tz (\(1989\); ) Tj 2.391667 0 Td 46.990741 Tz (T. ) Tj 51.428571 0 0 51.428571 0 2042.295739 Tm 6.261111 0 Td 64.814815 Tz (W. ) Tj 0.991667 0 Td 58.873457 Tz (Greene ) Tj 2.255556 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 38.888889 Tz (P. ) Tj 0.661111 0 Td 58.333333 Tz (G. ) Tj 0.913889 0 Td 64.814815 Tz (M. ) Tj 0.991667 0 Td 55.740741 Tz (Wuts, ) Tj 1.886111 0 Td 48.935185 Tz (Protective ) Tj 3.111111 0 Td 58.873457 Tz (Groups ) Tj 2.313889 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 55.555556 Tz (Organic ) Tj 51.428571 0 0 51.428571 0 2001.471042 Tm 6.280556 0 Td 49.259259 Tz (Synthesis, ) Tj 3.227778 0 Td 59.41358 Tz (2nd ) Tj 1.302778 0 Td 43.75 Tz (ed., ) Tj 1.283333 0 Td 57.523148 Tz (John ) Tj 1.652778 0 Td 57.037037 Tz (Wiley ) Tj 1.963889 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 59.143519 Tz (Sons ) Tj 1.691667 0 Td 50 Tz (\(1991\); ) Tj 2.391667 0 Td 48.611111 Tz (L. ) Tj 0.894444 0 Td 49.151235 Tz (Fieser ) Tj 51.428571 0 0 51.428571 0 1959.691391 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 68.055556 Tz (M. ) Tj 1.205556 0 Td 44.907407 Tz (Fieser, ) Tj 2.255556 0 Td 49.691358 Tz (Fieser ) Tj 2.061111 0 Td 60.493827 Tz (and ) Tj 1.438889 0 Td 46.990741 Tz (Fiesers ) Tj 2.663889 0 Td 54.282407 Tz (Reagents ) Tj 2.975 0 Td 47.530864 Tz (for ) Tj 1.147222 0 Td 55.555556 Tz (Organic ) Tj 51.428571 0 0 51.428571 0 1918.68254 Tm 6.280556 0 Td 49.259259 Tz (Synthesis, ) Tj 3.111111 0 Td 56.712963 Tz (John ) Tj 1.516667 0 Td 57.685185 Tz (Wiley ) Tj 1.886111 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 57.523148 Tz (Sons ) Tj 1.575 0 Td 50 Tz (\(1994\); ) Tj 2.275 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 48.611111 Tz (L. ) Tj 0.777778 0 Td 48.971193 Tz (Paquette, ) Tj 2.819444 0 Td 42.939815 Tz (ed., ) Tj 51.428571 0 0 51.428571 0 1880.393701 Tm 6.280556 0 Td 54.822531 Tz (Encyclopedia ) Tj 4.394444 0 Td 58.333333 Tz (of ) Tj 1.088889 0 Td 54.6875 Tz (Reagents ) Tj 3.091667 0 Td 48.611111 Tz (for ) Tj 1.283333 0 Td 56.018519 Tz (Organic ) Tj 2.819444 0 Td 48.611111 Tz (Synthesis, ) Tj 3.402778 0 Td 58.333333 Tz (John ) Tj 51.428571 0 0 51.428571 0 1834.639069 Tm 6.261111 0 Td 57.685185 Tz (Wiley ) Tj 1.983333 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 57.523148 Tz (Sons ) Tj 1.672222 0 Td 49.537037 Tz (\(1995\), ) Tj 2.352778 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 53.796296 Tz (subsequent ) Tj 3.461111 0 Td 47.800926 Tz (editions ) Tj 2.566667 0 Td 45.775463 Tz (thereof. ) Tj 51.428571 0 0 51.428571 0 1794.821656 Tm 7 0 Td 47.222222 Tz (Alternatively, ) Tj 4.180556 0 Td 44.290123 Tz (libraries ) Tj 2.586111 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 47.222222 Tz (natural ) Tj 2.216667 0 Td 61.574074 Tz (compounds ) Tj 3.558333 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 58.333333 Tz (form ) Tj 51.428571 0 0 51.428571 0 1750.848411 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 44.722222 Tz (bacterial, ) Tj 2.916667 0 Td 48.148148 Tz (fungal, ) Tj 2.216667 0 Td 45.910494 Tz (plant, ) Tj 1.847222 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 55.632716 Tz (animal ) Tj 2.197222 0 Td 46.990741 Tz (extracts ) Tj 2.488889 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 72.376543 Tz (commer ) Tj 51.428571 0 0 51.428571 0 1710.173913 Tm 6.261111 0 Td 44.830247 Tz (cially ) Tj 1.788889 0 Td 48.971193 Tz (available ) Tj 2.819444 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 62.114198 Tz (number ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 49.421296 Tz (Sources, ) Tj 2.547222 0 Td 51.131687 Tz (including ) Tj 2.955556 0 Td 48.611111 Tz (Biotics ) Tj 51.428571 0 0 51.428571 0 1667.215311 Tm 6.280556 0 Td 50.231481 Tz (\(Sussex, ) Tj 2.605556 0 Td 59.143519 Tz (UK\), ) Tj 1.594444 0 Td 62.654321 Tz (Xenova ) Tj 2.411111 0 Td 51.446759 Tz (\(Slough, ) Tj 2.663889 0 Td 60.763889 Tz (UK\), ) Tj 1.633333 0 Td 57.253086 Tz (Harbor ) Tj 2.216667 0 Td 57.253086 Tz (Branch ) Tj 2.197222 0 Td 70.648148 Tz (Ocean ) Tj 52.857143 0 0 52.857143 0 1624.23681 Tm 6.091892 0 Td 49.662162 Tz (graphics ) Tj 2.62973 0 Td 42.392392 Tz (Institute ) Tj 2.497297 0 Td 40.990991 Tz (\(Ft. ) Tj 1.191892 0 Td 45.495495 Tz (Pierce, ) Tj 2.156757 0 Td 39.93994 Tz (Fla.\), ) Tj 1.664865 0 Td 56.756757 Tz (and ) Tj 1.248649 0 Td 57.702703 Tz (PharmaMar, ) Tj 3.651351 0 Td 53.603604 Tz (U.S.A. ) Tj 51.428571 0 0 51.428571 0 1585.756522 Tm 6.280556 0 Td 55.092593 Tz (\(Cambridge, ) Tj 3.927778 0 Td 50.462963 Tz (Mass.\). ) Tj 2.469444 0 Td 45.37037 Tz (In ) Tj 0.816667 0 Td 47.890947 Tz (addition, ) Tj 2.897222 0 Td 47.222222 Tz (natural ) Tj 2.275 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 47.61396 Tz (synthetically ) Tj 51.428571 0 0 51.428571 0 1544.509653 Tm 6.261111 0 Td 56.712963 Tz (produced ) Tj 3.052778 0 Td 43.930041 Tz (libraries ) Tj 2.741667 0 Td 48.611111 Tz (are ) Tj 1.205556 0 Td 54.012346 Tz (produced, ) Tj 3.286111 0 Td 42.12963 Tz (if ) Tj 0.777778 0 Td 47.395833 Tz (desired, ) Tj 2.625 0 Td 53.292181 Tz (according ) Tj 3.208333 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1500.021711 Tm 6.261111 0 Td 58.333333 Tz (methods ) Tj 2.722222 0 Td 65.462963 Tz (known ) Tj 2.216667 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 38.888889 Tz (art, ) Tj 1.166667 0 Td 40.833333 Tz (e.g., ) Tj 1.497222 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 51.041667 Tz (standard ) Tj 2.702778 0 Td 48.287037 Tz (extraction ) Tj 3.130556 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 1459.458583 Tm 6.261111 0 Td 47.61396 Tz (fractionation ) Tj 3.927778 0 Td 54.282407 Tz (methods. ) Tj 2.838889 0 Td 59.143519 Tz (Examples ) Tj 2.994444 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 57.87037 Tz (methods ) Tj 2.625 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 59.41358 Tz (synthe ) Tj 51.428571 0 0 51.428571 0 1416.256442 Tm 6.280556 0 Td 41.049383 Tz (sis ) Tj 0.894444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 54.372428 Tz (molecular ) Tj 3.052778 0 Td 43.930041 Tz (libraries ) Tj 2.527778 0 Td 56.17284 Tz (can ) Tj 1.166667 0 Td 56.712963 Tz (be ) Tj 0.855556 0 Td 56.388889 Tz (found ) Tj 1.866667 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 39.699074 Tz (art, ) Tj 1.127778 0 Td 47.530864 Tz (for ) Tj 0.972222 0 Td 59.259259 Tz (example ) Tj 48.571429 0 0 48.571429 0 1376 Tm 6.629412 0 Td 43.464052 Tz (in: ) Tj 1.214706 0 Td 61.19281 Tz (DeWitt ) Tj 2.532353 0 Td 46.323529 Tz (et ) Tj 0.885294 0 Td 40.318627 Tz (al., ) Tj 1.358824 0 Td 52.843137 Tz (Proc. ) Tj 1.997059 0 Td 48.039216 Tz (Natl. ) Tj 1.811765 0 Td 57.647059 Tz (Acad. ) Tj 2.120588 0 Td 46.323529 Tz (Sci. ) Tj 1.585294 0 Td 52.042484 Tz (U.S.A. ) Tj 2.244118 0 Td 56.617647 Tz (90:6909, ) Tj 48.571429 0 0 48.571429 0 1334 Tm 6.691176 0 Td 55.588235 Tz (1993: ) Tj 1.894118 0 Td 59.477124 Tz (Erb ) Tj 1.276471 0 Td 48.039216 Tz (et ) Tj 0.741176 0 Td 38.602941 Tz (al., ) Tj 1.173529 0 Td 52.156863 Tz (Proc. ) Tj 1.811765 0 Td 48.72549 Tz (Natl. ) Tj 1.626471 0 Td 59.019608 Tz (Acad. ) Tj 1.976471 0 Td 46.323529 Tz (Sci. ) Tj 1.4 0 Td 72.058824 Tz (USA ) Tj 1.523529 0 Td 56.808279 Tz (91:11422, ) Tj 3.314706 0 Td 55.588235 Tz (1994; ) Tj 48.571429 0 0 48.571429 0 1293 Tm 6.629412 0 Td 64.509804 Tz (Zuckermann ) Tj 4.055882 0 Td 48.039216 Tz (et ) Tj 0.720588 0 Td 40.318627 Tz (al., ) Tj 1.091176 0 Td 44.607843 Tz (J. ) Tj 0.802941 0 Td 60.906863 Tz (Med. ) Tj 1.75 0 Td 62.45098 Tz (Chem. ) Tj 2.120588 0 Td 56.188725 Tz (37:2678, ) Tj 2.944118 0 Td 55.588235 Tz (1994; ) Tj 1.852941 0 Td 72.058824 Tz (Cho ) Tj 1.482353 0 Td 48.039216 Tz (et ) Tj 0.720588 0 Td 38.602941 Tz (al., ) Tj 51.428571 0 0 51.428571 0 1250.105606 Tm 6.241667 0 Td 53.703704 Tz (Science ) Tj 2.527778 0 Td 53.652263 Tz (261:1303, ) Tj 3.266667 0 Td 52.5 Tz (1993: ) Tj 1.866667 0 Td 48.148148 Tz (Carrell ) Tj 2.313889 0 Td 43.75 Tz (et ) Tj 0.797222 0 Td 37.268519 Tz (al., ) Tj 1.166667 0 Td 57.253086 Tz (Angew. ) Tj 2.430556 0 Td 59.62963 Tz (Chem. ) Tj 2.158333 0 Td 37.268519 Tz (Int. ) Tj 51.428571 0 0 51.428571 0 1209.838384 Tm 6.280556 0 Td 50.771605 Tz (Ed. ) Tj 1.166667 0 Td 49.259259 Tz (Engl. ) Tj 1.652778 0 Td 53.06713 Tz (33:2059, ) Tj 2.8 0 Td 53.148148 Tz (1994; ) Tj 1.730556 0 Td 49.691358 Tz (Carell ) Tj 1.944444 0 Td 45.37037 Tz (et ) Tj 0.661111 0 Td 36.458333 Tz (al., ) Tj 1.05 0 Td 57.253086 Tz (Angew. ) Tj 2.294444 0 Td 60.277778 Tz (Chem. ) Tj 2.061111 0 Td 37.268519 Tz (Int. ) Tj 1.127778 0 Td 49.691358 Tz (Ed. ) Tj 51.428571 0 0 51.428571 0 1168.008511 Tm 6.3 0 Td 48.611111 Tz (Engl. ) Tj 1.886111 0 Td 53.06713 Tz (33:2061, ) Tj 3.013889 0 Td 52.5 Tz (1994; ) Tj 1.944444 0 Td 59.41358 Tz (and ) Tj 1.438889 0 Td 55.092593 Tz (Gallop ) Tj 2.352778 0 Td 45.37037 Tz (et ) Tj 0.913889 0 Td 36.458333 Tz (al., ) Tj 1.225 0 Td 40.509259 Tz (J. ) Tj 0.952778 0 Td 57.523148 Tz (Med. ) Tj 1.847222 0 Td 59.62963 Tz (Chem. ) Tj 51.428571 0 0 51.428571 0 1125.496902 Tm 6.261111 0 Td 50.771605 Tz (37: ) Tj 1.011111 0 Td 51.851852 Tz (1233, ) Tj 1.827778 0 Td 51.203704 Tz (1994. ) Tj 1.808333 0 Td 52.391975 Tz (Furthermore, ) Tj 3.986111 0 Td 45.37037 Tz (if ) Tj 0.641667 0 Td 47.395833 Tz (desired, ) Tj 2.488889 0 Td 57.253086 Tz (any ) Tj 1.283333 0 Td 45.37037 Tz (library ) Tj 2.1 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 84.259259 Tz (com ) Tj 51.428571 0 0 51.428571 0 1086.937725 Tm 6.261111 0 Td 60.925926 Tz (pound ) Tj 1.983333 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 47.222222 Tz (readily ) Tj 2.197222 0 Td 53.06713 Tz (modified ) Tj 2.702778 0 Td 52.5 Tz (using ) Tj 1.75 0 Td 51.041667 Tz (standard ) Tj 2.625 0 Td 51.49177 Tz (chemical, ) Tj 2.916667 0 Td 48.251029 Tz (physical, ) Tj 40 0 0 40 0 1049 Tm 8.05 0 Td 68.75 Tz (or ) Tj 1.075 0 Td 69.318182 Tz (biochemical ) Tj 4.925 0 Td 69.791667 Tz (methods. ) Tj 51.428571 0 0 51.428571 0 1004.1262 Tm 7.019444 0 Td 47.890947 Tz (Libraries ) Tj 2.975 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 61.574074 Tz (compounds ) Tj 3.733333 0 Td 65.895062 Tz (may ) Tj 1.575 0 Td 56.712963 Tz (be ) Tj 1.030556 0 Td 51.851852 Tz (presented ) Tj 3.169444 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 49.421296 Tz (Solution ) Tj 51.428571 0 0 51.428571 0 962.502564 Tm 6.280556 0 Td 40.509259 Tz (\(e.g., ) Tj 1.827778 0 Td 55.452675 Tz (Houghten, ) Tj 3.422222 0 Td 52.350427 Tz (Biotechniques ) Tj 4.491667 0 Td 52.441077 Tz (13:412-421, ) Tj 3.888889 0 Td 49.691358 Tz (1992\), ) Tj 2.138889 0 Td 53.472222 Tz (or ) Tj 0.952778 0 Td 61.574074 Tz (on ) Tj 51.428571 0 0 51.428571 0 917.770732 Tm 6.241667 0 Td 55.092593 Tz (beads ) Tj 1.866667 0 Td 58.333333 Tz (\(Lam, ) Tj 1.983333 0 Td 54.552469 Tz (Nature ) Tj 2.138889 0 Td 53.148148 Tz (354:82-84, ) Tj 3.441667 0 Td 50.231481 Tz (1991\), ) Tj 2.002778 0 Td 51.203704 Tz (chips ) Tj 1.75 0 Td 49.537037 Tz (\(Fodor, ) Tj 2.352778 0 Td 54.552469 Tz (Nature ) Tj 51.428571 0 0 51.428571 0 875 Tm 6.261111 0 Td 54.012346 Tz (364:555-556, ) Tj 4.219444 0 Td 49.151235 Tz (1993\), ) Tj 2.022222 0 Td 48.206019 Tz (bacteria ) Tj 2.566667 0 Td 50.636574 Tz (\(Ladner, ) Tj 2.683333 0 Td 52.662037 Tz (U.S. ) Tj 1.516667 0 Td 45.37037 Tz (Pat. ) Tj 1.361111 0 Td 57.253086 Tz (No. ) Tj 1.302778 0 Td 49.151235 Tz (5,223, ) Tj 51.428571 0 0 51.428571 0 835.385417 Tm 6.261111 0 Td 49.907407 Tz (409\), ) Tj 1.866667 0 Td 51.311728 Tz (spores ) Tj 2.197222 0 Td 55.555556 Tz (\(Ladner ) Tj 2.663889 0 Td 51.851852 Tz (U.S. ) Tj 1.633333 0 Td 43.75 Tz (Pat. ) Tj 1.438889 0 Td 57.253086 Tz (No. ) Tj 1.4 0 Td 50.378788 Tz (5,223,409\), ) Tj 3.655556 0 Td 54.282407 Tz (plasmids ) Tj 51.428571 0 0 51.428571 0 792 Tm 6.280556 0 Td 51.388889 Tz (\(Cullet ) Tj 2.313889 0 Td 36.458333 Tz (al., ) Tj 1.108333 0 Td 56.712963 Tz (Proc ) Tj 1.536111 0 Td 51.041667 Tz (Natl ) Tj 1.380556 0 Td 61.111111 Tz (AcadSci ) Tj 2.780556 0 Td 69.135802 Tz (USA ) Tj 1.419444 0 Td 54.594017 Tz (89:1865-1869, ) Tj 4.491667 0 Td 55.092593 Tz (1992\) ) Tj 1.808333 0 Td 53.472222 Tz (or ) Tj 51.428571 0 0 51.428571 0 750.941176 Tm 6.261111 0 Td 61.574074 Tz (on ) Tj 1.088889 0 Td 58.333333 Tz (phage ) Tj 2.119444 0 Td 48.070988 Tz (\(Scott ) Tj 2.080556 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 52.391975 Tz (Smith, ) Tj 2.255556 0 Td 53.703704 Tz (Science ) Tj 2.586111 0 Td 54.282407 Tz (249:386-390, ) Tj 4.355556 0 Td 51.851852 Tz (1990; ) Tj 48.571429 0 0 48.571429 0 711 Tm 6.65 0 Td 53.921569 Tz (Devlin, ) Tj 2.429412 0 Td 56.372549 Tz (Science ) Tj 2.511765 0 Td 57.761438 Tz (249:404406, ) Tj 4.385294 0 Td 55.588235 Tz (1990; ) Tj 1.894118 0 Td 57.761438 Tz (Cwirla ) Tj 2.244118 0 Td 48.039216 Tz (et ) Tj 0.741176 0 Td 41.176471 Tz (al. ) Tj 0.947059 0 Td 52.843137 Tz (Proc. ) Tj 1.832353 0 Td 47.352941 Tz (Natl. ) Tj 48.571429 0 0 48.571429 0 669 Tm 6.588235 0 Td 59.019608 Tz (Acad. ) Tj 2.120588 0 Td 46.323529 Tz (Sci. ) Tj 1.441176 0 Td 58.069382 Tz (87:6378-6382, ) Tj 4.920588 0 Td 55.588235 Tz (1990; ) Tj 2.038235 0 Td 45.588235 Tz (Felici, ) Tj 2.182353 0 Td 46.323529 Tz (J. ) Tj 0.947059 0 Td 56.617647 Tz (Mol. ) Tj 1.75 0 Td 45.980392 Tz (Biol. ) Tj 1.75 0 Td 55.759804 Tz (222: ) Tj 51.428571 0 0 51.428571 0 628.065116 Tm 6.261111 0 Td 54.282407 Tz (301-310, ) Tj 2.936111 0 Td 51.203704 Tz (1991; ) Tj 1.827778 0 Td 57.253086 Tz (Ladner ) Tj 2.294444 0 Td 44.965278 Tz (supra.\). ) Tj 51.428571 0 0 51.428571 0 586.234519 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 47.890947 Tz (addition, ) Tj 2.8 0 Td 51.203704 Tz (those ) Tj 1.730556 0 Td 46.296296 Tz (skilled ) Tj 2.177778 0 Td 42.12963 Tz (in ) Tj 0.758333 0 Td 47.530864 Tz (the ) Tj 1.05 0 Td 45.37037 Tz (art ) Tj 0.972222 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 54.282407 Tz (drug ) Tj 1.516667 0 Td 52.211934 Tz (discovery ) Tj 3.013889 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 546.264741 Tm 6.261111 0 Td 57.154882 Tz (development ) Tj 4.005556 0 Td 46.759259 Tz (readily ) Tj 2.197222 0 Td 52.824074 Tz (understand ) Tj 3.383333 0 Td 45.37037 Tz (that ) Tj 1.283333 0 Td 57.87037 Tz (methods ) Tj 2.663889 0 Td 47.530864 Tz (for ) Tj 1.05 0 Td 53.292181 Tz (dereplica ) Tj 51.428571 0 0 51.428571 0 506.962264 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.361111 0 Td 39.969136 Tz (\(e.g., ) Tj 1.633333 0 Td 56.532922 Tz (taxonomic ) Tj 3.247222 0 Td 47.453704 Tz (dereplication, ) Tj 4.161111 0 Td 48.611111 Tz (biological ) Tj 3.111111 0 Td 46.990741 Tz (dereplication, ) Tj 51.428571 0 0 51.428571 0 461.533007 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 54.6875 Tz (chemical ) Tj 2.858333 0 Td 47.222222 Tz (dereplication, ) Tj 4.2 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 59.41358 Tz (any ) Tj 1.302778 0 Td 54.79798 Tz (combination ) Tj 3.85 0 Td 48.206019 Tz (thereof\) ) Tj 2.566667 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 421.532595 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 50.084175 Tz (elimination ) Tj 3.538889 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 46.018519 Tz (replicates ) Tj 3.033333 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 49.074074 Tz (repeats ) Tj 2.313889 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 48.251029 Tz (materials ) Tj 2.858333 0 Td 51.388889 Tz (already ) Tj 51.428571 0 0 51.428571 0 378.747368 Tm 6.261111 0 Td 66.111111 Tz (known ) Tj 2.391667 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 44.722222 Tz (their ) Tj 1.691667 0 Td 45.37037 Tz (activity ) Tj 2.625 0 Td 53.472222 Tz (should ) Tj 2.313889 0 Td 59.953704 Tz (be ) Tj 1.069444 0 Td 60.358796 Tz (employed ) Tj 3.286111 0 Td 59.548611 Tz (whenever ) Tj 51.428571 0 0 51.428571 0 343 Tm 6.261111 0 Td 47.170782 Tz (possible. ) Tj 51.428571 0 0 51.428571 0 296.087379 Tm 6.261111 0 Td 72.106481 Tz (When ) Tj 1.905556 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 53.796296 Tz (crude ) Tj 1.75 0 Td 47.685185 Tz (extract ) Tj 2.177778 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 46.018519 Tz (identified ) Tj 2.897222 0 Td 50.231481 Tz (as ) Tj 0.797222 0 Td 51.203704 Tz (containing ) Tj 3.208333 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 64.814815 Tz (compound ) Tj 51.428571 0 0 51.428571 0 252.176471 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 42.489712 Tz (interest, ) Tj 2.547222 0 Td 47.685185 Tz (further ) Tj 2.216667 0 Td 47.364672 Tz (fractionation ) Tj 3.927778 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 48.611111 Tz (positive ) Tj 2.547222 0 Td 51.041667 Tz (lead ) Tj 1.438889 0 Td 47.685185 Tz (extract ) Tj 51.428571 0 0 51.428571 0 213.063415 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 51.49177 Tz (necessary ) Tj 2.994444 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 44.907407 Tz (isolate ) Tj 2.1 0 Td 54.282407 Tz (chemical ) Tj 2.819444 0 Td 48.070988 Tz (constituents ) Tj 3.675 0 Td 50.378788 Tz (responsible ) Tj 3.538889 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 168.658098 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 54.6875 Tz (observed ) Tj 2.877778 0 Td 42.12963 Tz (effect. ) Tj 2.041667 0 Td 55.092593 Tz (Thus, ) Tj 1.925 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 51.851852 Tz (goal ) Tj 1.516667 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 46.548822 Tz (extraction, ) Tj 3.363889 0 Td 56.712963 Tz (frac ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.444444 0 Td 77.777778 Tz (22 ) Tj 51.428571 0 0 51.428571 0 2915.828784 Tm 25.180556 0 Td 46.342593 Tz (tionation, ) Tj 3.033333 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 46.720679 Tz (purification ) Tj 3.636111 0 Td 51.851852 Tz (process ) Tj 2.45 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 48.148148 Tz (careful ) Tj 2.275 0 Td 53.652263 Tz (character ) Tj 51.428571 0 0 51.428571 0 2870.877285 Tm 25.2 0 Td 46.759259 Tz (ization ) Tj 2.294444 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 45.138889 Tz (identification ) Tj 4.141667 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 51.851852 Tz (a ) Tj 0.641667 0 Td 54.6875 Tz (chemical ) Tj 2.975 0 Td 45.37037 Tz (entity ) Tj 1.983333 0 Td 51.851852 Tz (within ) Tj 2.177778 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2827.437877 Tm 25.2 0 Td 53.796296 Tz (crude ) Tj 1.788889 0 Td 47.222222 Tz (extract ) Tj 2.138889 0 Td 46.180556 Tz (that ) Tj 1.244444 0 Td 52.662037 Tz (achieves ) Tj 2.683333 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 50.462963 Tz (desired ) Tj 2.275 0 Td 48.287037 Tz (biological ) Tj 3.072222 0 Td 42.592593 Tz (effect. ) Tj 2.002778 0 Td 72.916667 Tz (Meth ) Tj 51.428571 0 0 51.428571 0 2785.692308 Tm 25.2 0 Td 55.092593 Tz (ods ) Tj 1.283333 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 47.364672 Tz (fractionation ) Tj 3.966667 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 46.450617 Tz (purification ) Tj 3.655556 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 55.092593 Tz (Such ) Tj 1.594444 0 Td 54.012346 Tz (heterogenous ) Tj 40 0 0 40 0 2747 Tm 32.4 0 Td 60.416667 Tz (extracts ) Tj 3.2 0 Td 65.277778 Tz (are ) Tj 1.45 0 Td 85 Tz (known ) Tj 2.9 0 Td 58.333333 Tz (in ) Tj 1.025 0 Td 63.888889 Tz (the ) Tj 1.425 0 Td 50 Tz (art. ) Tj 51.428571 0 0 51.428571 0 2696.748571 Tm 25.938889 0 Td 55.092593 Tz (Small ) Tj 2.158333 0 Td 54.012346 Tz (molecules ) Tj 3.363889 0 Td 59.953704 Tz (of ) Tj 1.069444 0 Td 49.691358 Tz (the ) Tj 1.361111 0 Td 50.411523 Tz (invention ) Tj 3.188889 0 Td 49.583333 Tz (preferably ) Tj 3.441667 0 Td 57.523148 Tz (have ) Tj 1.808333 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2653.635779 Tm 25.2 0 Td 54.372428 Tz (molecular ) Tj 3.325 0 Td 55.092593 Tz (weight ) Tj 2.333333 0 Td 58.981481 Tz (below ) Tj 2.197222 0 Td 55.740741 Tz (2,000 ) Tj 2.041667 0 Td 47.395833 Tz (daltons, ) Tj 2.702778 0 Td 61.574074 Tz (more ) Tj 1.866667 0 Td 49.907407 Tz (preferably ) Tj 51.428571 0 0 51.428571 0 2609.715877 Tm 25.180556 0 Td 57.87037 Tz (between ) Tj 2.936111 0 Td 62.654321 Tz (300 ) Tj 1.594444 0 Td 59.41358 Tz (and ) Tj 1.613889 0 Td 53.796296 Tz (1,000 ) Tj 2.1 0 Td 46.990741 Tz (daltons, ) Tj 2.761111 0 Td 59.41358 Tz (and ) Tj 1.594444 0 Td 58.333333 Tz (most ) Tj 1.886111 0 Td 49.907407 Tz (preferably ) Tj 51.428571 0 0 51.428571 0 2565.369727 Tm 25.180556 0 Td 57.87037 Tz (between ) Tj 2.625 0 Td 60.493827 Tz (400 ) Tj 1.244444 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 60.493827 Tz (700 ) Tj 1.263889 0 Td 46.990741 Tz (daltons. ) Tj 2.488889 0 Td 34.027778 Tz (It ) Tj 0.583333 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 49.691358 Tz (preferred ) Tj 2.858333 0 Td 46.180556 Tz (that ) Tj 1.263889 0 Td 49.907407 Tz (these ) Tj 1.672222 0 Td 52.5 Tz (small ) Tj 51.428571 0 0 51.428571 0 2521.901499 Tm 25.2 0 Td 54.372428 Tz (molecules ) Tj 3.188889 0 Td 49.691358 Tz (are ) Tj 1.127778 0 Td 51.388889 Tz (organic ) Tj 2.430556 0 Td 51.527778 Tz (molecules. ) Tj 40 0 0 40 0 2485 Tm 32.425 0 Td 63.541667 Tz (Kits ) Tj 51.428571 0 0 51.428571 0 2435.459184 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 50.05144 Tz (invention ) Tj 2.936111 0 Td 51.851852 Tz (provides ) Tj 2.683333 0 Td 44.560185 Tz (kits ) Tj 1.283333 0 Td 45.37037 Tz (that ) Tj 1.302778 0 Td 50.925926 Tz (include ) Tj 2.352778 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 73.240741 Tz (compo ) Tj 48.571429 0 0 48.571429 0 2391 Tm 26.702941 0 Td 45.036765 Tz (sitions. ) Tj 2.635294 0 Td 46.323529 Tz (In ) Tj 1.029412 0 Td 60.620915 Tz (one ) Tj 1.502941 0 Td 61.14082 Tz (embodiment, ) Tj 4.426471 0 Td 53.75817 Tz (the ) Tj 1.358824 0 Td 45.751634 Tz (kit ) Tj 1.235294 0 Td 53.186275 Tz (includes ) Tj 2.964706 0 Td 58.333333 Tz (a ) Tj 0.761765 0 Td 53.615196 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2353.524848 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 3.830556 0 Td 51.203704 Tz (containing ) Tj 3.305556 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 48.905724 Tz (therapeutic ) Tj 3.480556 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 50.231481 Tz (prophylactic ) Tj 3.888889 0 Td 53.148148 Tz (agent ) Tj 51.428571 0 0 51.428571 0 2304.020101 Tm 25.180556 0 Td 46.990741 Tz (that ) Tj 1.361111 0 Td 46.180556 Tz (that ) Tj 1.341667 0 Td 51.041667 Tz (prevents ) Tj 2.722222 0 Td 51.851852 Tz (or ) Tj 0.836111 0 Td 43.75 Tz (treats ) Tj 1.847222 0 Td 47.530864 Tz (infection ) Tj 2.838889 0 Td 40.509259 Tz (\(e.g., ) Tj 1.711111 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 49.85755 Tz (antimicrobial ) Tj 51.428571 0 0 51.428571 0 2263.412678 Tm 25.2 0 Td 50.231481 Tz (agent\) ) Tj 2.138889 0 Td 50.231481 Tz (or ) Tj 0.875 0 Td 46.180556 Tz (that ) Tj 1.380556 0 Td 56.30787 Tz (promotes ) Tj 3.013889 0 Td 51.388889 Tz (healing ) Tj 2.45 0 Td 40.509259 Tz (\(e.g., ) Tj 1.769444 0 Td 56.712963 Tz (growth ) Tj 2.372222 0 Td 43.518519 Tz (factor, ) Tj 2.138889 0 Td 55.092593 Tz (anti ) Tj 51.428571 0 0 51.428571 0 2219.571429 Tm 25.2 0 Td 51.851852 Tz (inflammatory, ) Tj 4.452778 0 Td 46.180556 Tz (clot ) Tj 1.458333 0 Td 56.532922 Tz (promoting ) Tj 3.422222 0 Td 49.151235 Tz (agent, ) Tj 2.158333 0 Td 48.420479 Tz (anti-thrombotic\). ) Tj 5.405556 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 2172.681013 Tm 25.2 0 Td 50.555556 Tz (other ) Tj 1.788889 0 Td 56.983025 Tz (embodiments, ) Tj 4.394444 0 Td 51.851852 Tz (the ) Tj 1.225 0 Td 43.209877 Tz (kit ) Tj 1.088889 0 Td 49.826389 Tz (contains ) Tj 2.702778 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 48.905724 Tz (therapeutic ) Tj 3.538889 0 Td 49.074074 Tz (device, ) Tj 51.428571 0 0 51.428571 0 2128.259843 Tm 25.219444 0 Td 54.282407 Tz (Such ) Tj 1.594444 0 Td 50.231481 Tz (as ) Tj 0.894444 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (chitosan ) Tj 2.722222 0 Td 46.990741 Tz (film ) Tj 1.438889 0 Td 49.151235 Tz (useful ) Tj 2.061111 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 66.111111 Tz (wound ) Tj 2.255556 0 Td 48.611111 Tz (healing, ) Tj 2.625 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2090.611177 Tm 25.219444 0 Td 52.777778 Tz (sponge, ) Tj 2.391667 0 Td 51.131687 Tz (hydrogel, ) Tj 2.975 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 48.791152 Tz (implant/prosthetic ) Tj 5.463889 0 Td 52.391975 Tz (device ) Tj 2.080556 0 Td 54.444444 Tz (comprising ) Tj 3.441667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2041.773494 Tm 25.2 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 54.208754 Tz (composition ) Tj 3.791667 0 Td 51.49177 Tz (described ) Tj 2.955556 0 Td 46.759259 Tz (herein. ) Tj 2.216667 0 Td 43.75 Tz (If ) Tj 0.641667 0 Td 46.990741 Tz (desired, ) Tj 2.45 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 57.685185 Tz (afore ) Tj 51.428571 0 0 51.428571 0 2000.009547 Tm 25.2 0 Td 56.893004 Tz (mentioned ) Tj 3.266667 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 53.742284 Tz (compositions ) Tj 4.102778 0 Td 47.222222 Tz (further ) Tj 2.158333 0 Td 55.902778 Tz (comprise ) Tj 2.858333 0 Td 55.092593 Tz (an ) Tj 0.855556 0 Td 53.796296 Tz (agent ) Tj 40 0 0 40 0 1961 Tm 32.4 0 Td 66.666667 Tz (described ) Tj 3.9 0 Td 60.119048 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 1910.641587 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.913889 0 Td 64.00463 Tz (some ) Tj 1.847222 0 Td 56.712963 Tz (embodiments, ) Tj 4.413889 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 44.290123 Tz (kit ) Tj 1.127778 0 Td 54.012346 Tz (comprises ) Tj 3.247222 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 42.592593 Tz (sterile ) Tj 2.1 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 1867.872135 Tm 25.180556 0 Td 48.070988 Tz (tainer ) Tj 1.886111 0 Td 58.333333 Tz (which ) Tj 1.944444 0 Td 50.231481 Tz (contains ) Tj 2.605556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 50.231481 Tz (chitosan ) Tj 2.625 0 Td 52.391975 Tz (composition; ) Tj 3.986111 0 Td 55.092593 Tz (such ) Tj 1.536111 0 Td 56.481481 Tz (contain ) Tj 51.428571 0 0 51.428571 0 1824.514286 Tm 25.2 0 Td 46.450617 Tz (ers ) Tj 1.244444 0 Td 56.17284 Tz (can ) Tj 1.4 0 Td 58.333333 Tz (be ) Tj 1.088889 0 Td 51.851852 Tz (boxes, ) Tj 2.255556 0 Td 55.092593 Tz (ampoules, ) Tj 3.363889 0 Td 44.560185 Tz (bottles, ) Tj 2.566667 0 Td 42.12963 Tz (vials, ) Tj 1.905556 0 Td 48.070988 Tz (tubes, ) Tj 2.1 0 Td 50.555556 Tz (bags, ) Tj 51.428571 0 0 51.428571 0 1781.387755 Tm 25.2 0 Td 53.472222 Tz (pouches, ) Tj 2.936111 0 Td 46.296296 Tz (blister-packs, ) Tj 4.258333 0 Td 53.472222 Tz (or ) Tj 1.011111 0 Td 49.907407 Tz (other ) Tj 1.866667 0 Td 46.990741 Tz (Suitable ) Tj 2.625 0 Td 50.411523 Tz (container ) Tj 3.091667 0 Td 55.740741 Tz (forms ) Tj 51.428571 0 0 51.428571 0 1736.126316 Tm 25.2 0 Td 64.814815 Tz (known ) Tj 2.255556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 51.851852 Tz (the ) Tj 1.186111 0 Td 38.078704 Tz (art. ) Tj 1.205556 0 Td 60.763889 Tz (Such ) Tj 1.75 0 Td 49.259259 Tz (containers ) Tj 3.247222 0 Td 55.092593 Tz (can ) Tj 1.244444 0 Td 59.953704 Tz (be ) Tj 1.011111 0 Td 64.814815 Tz (made ) Tj 1.827778 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 43.344907 Tz (plastic, ) Tj 51.428571 0 0 51.428571 0 1692.690821 Tm 25.2 0 Td 45.37037 Tz (glass, ) Tj 1.808333 0 Td 53.292181 Tz (laminated ) Tj 3.033333 0 Td 49.151235 Tz (paper, ) Tj 1.963889 0 Td 52.5 Tz (metal ) Tj 1.769444 0 Td 39.537037 Tz (foil, ) Tj 1.361111 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 51.203704 Tz (other ) Tj 1.711111 0 Td 48.611111 Tz (materials ) Tj 2.8 0 Td 47.395833 Tz (Suitable ) Tj 52.857143 0 0 52.857143 0 1648.550409 Tm 24.518919 0 Td 48.348348 Tz (for ) Tj 1.040541 0 Td 52.702703 Tz (holding ) Tj 2.440541 0 Td 53.603604 Tz (medicaments. ) Tj 51.428571 0 0 51.428571 0 1605.073654 Tm 25.938889 0 Td 46.990741 Tz (If ) Tj 0.875 0 Td 49.537037 Tz (desired ) Tj 2.45 0 Td 58.333333 Tz (a ) Tj 0.719444 0 Td 50.231481 Tz (chitosan ) Tj 2.838889 0 Td 53.914141 Tz (composition ) Tj 3.986111 0 Td 55.092593 Tz (of ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.283333 0 Td 50.411523 Tz (invention ) Tj 3.111111 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1563.533333 Tm 25.2 0 Td 53.877315 Tz (provided ) Tj 2.761111 0 Td 50.636574 Tz (together ) Tj 2.605556 0 Td 53.472222 Tz (with ) Tj 1.516667 0 Td 46.720679 Tz (instructions ) Tj 3.577778 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 53.148148 Tz (using ) Tj 1.788889 0 Td 34.027778 Tz (it ) Tj 0.602778 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 64.274691 Tz (prophy ) Tj 51.428571 0 0 51.428571 0 1516.637953 Tm 25.2 0 Td 43.209877 Tz (lactic ) Tj 1.827778 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 48.316498 Tz (therapeutic ) Tj 3.5 0 Td 59.41358 Tz (method ) Tj 2.411111 0 Td 51.131687 Tz (described ) Tj 3.013889 0 Td 46.759259 Tz (herein. ) Tj 2.216667 0 Td 63.734568 Tz (The ) Tj 1.419444 0 Td 52.314815 Tz (instruc ) Tj 51.428571 0 0 51.428571 0 1473.351285 Tm 25.180556 0 Td 47.314815 Tz (tions ) Tj 1.633333 0 Td 46.180556 Tz (will ) Tj 1.302778 0 Td 49.691358 Tz (generally ) Tj 2.897222 0 Td 50.925926 Tz (include ) Tj 2.313889 0 Td 51.851852 Tz (information ) Tj 3.636111 0 Td 53.148148 Tz (about ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 55.092593 Tz (use ) Tj 1.147222 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1429.960053 Tm 25.2 0 Td 54.208754 Tz (composition ) Tj 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3.052778 0 Td 44.290123 Tz (steps: ) Tj 51.428571 0 0 51.428571 0 2639.599721 Tm 7.019444 0 Td 45.37037 Tz (\(1\) ) Tj 1.186111 0 Td 52.662037 Tz (Dissolve ) Tj 2.877778 0 Td 49.826389 Tz (chitosan ) Tj 2.741667 0 Td 46.990741 Tz (in ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 64.814815 Tz (weak ) Tj 1.905556 0 Td 50.925926 Tz (organic ) Tj 2.469444 0 Td 51.041667 Tz (acid ) Tj 1.555556 0 Td 56.944444 Tz (aqueous ) Tj 40 0 0 40 0 2605 Tm 9.95 0 Td 59.259259 Tz (Solution. ) Tj 51.428571 0 0 51.428571 0 2559.527697 Tm 7.019444 0 Td 45.37037 Tz (\(2\) ) Tj 1.108333 0 Td 52.932099 Tz (Freeze ) Tj 2.138889 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 47.170782 Tz (resulting ) Tj 2.8 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 51.041667 Tz (acid ) Tj 1.458333 0 Td 46.090535 Tz (solution. ) Tj 51.428571 0 0 51.428571 0 2519.632653 Tm 7.019444 0 Td 46.450617 Tz (\(3\) ) Tj 1.030556 0 Td 51.851852 Tz (Lyophilize ) Tj 3.305556 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 48.148148 Tz (frozen, ) Tj 2.236111 0 Td 46.666667 Tz (solid ) Tj 1.594444 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 46.450617 Tz (solution, ) Tj 2.741667 0 Td 68.703704 Tz (remov ) Tj 51.428571 0 0 51.428571 0 2481.065934 Tm 7.719444 0 Td 50.771605 Tz (ing ) Tj 1.166667 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 48.070988 Tz (water. ) Tj 51.428571 0 0 51.428571 0 2443.764045 Tm 7.019444 0 Td 46.450617 Tz (\(4\) ) Tj 0.991667 0 Td 56.388889 Tz (Completely ) Tj 3.616667 0 Td 47.314815 Tz (neutralize ) Tj 3.013889 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 46.8107 Tz (resulting ) Tj 2.722222 0 Td 50.968013 Tz (dehydrated, ) Tj 3.538889 0 Td 48.611111 Tz (acidic ) Tj 51.428571 0 0 51.428571 0 2403.451613 Tm 7.719444 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 56.30787 Tz (sponge' ) Tj 2.877778 0 Td 61.574074 Tz (by ) Tj 0.933333 0 Td 51.851852 Tz (hydrating ) Tj 2.975 0 Td 35.648148 Tz (it ) Tj 0.622222 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 56.712963 Tz (an ) Tj 0.875 0 Td 52.932099 Tz (excess ) Tj 2.119444 0 Td 63.194444 Tz (concen ) Tj 51.428571 0 0 51.428571 0 2362.900524 Tm 7.7 0 Td 45.37037 Tz (tration ) Tj 2.080556 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 61.033951 Tz (Volume ) Tj 2.372222 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 58.873457 Tz (sodium ) Tj 2.313889 0 Td 55.452675 Tz (hydroxide ) Tj 3.15 0 Td 56.944444 Tz (aqueous ) Tj 2.586111 0 Td 60.763889 Tz (solu ) Tj 51.428571 0 0 51.428571 0 2321 Tm 7.7 0 Td 44.074074 Tz (tion. ) Tj 1.575 0 Td 53.472222 Tz (\(See ) Tj 1.555556 0 Td 55.092593 Tz (FIG. ) Tj 1.594444 0 Td 48.611111 Tz (1\) ) Tj 51.428571 0 0 51.428571 0 2283.338462 Tm 7.019444 0 Td 46.450617 Tz (\(5\) ) Tj 1.166667 0 Td 65.625 Tz (Wash ) Tj 1.925 0 Td 64.00463 Tz (away ) Tj 1.886111 0 Td 49.691358 Tz (the ) Tj 1.283333 0 Td 46.990741 Tz (residual ) Tj 2.586111 0 Td 48.611111 Tz (acidic ) Tj 2.119444 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 49.259259 Tz (basic ) Tj 1.808333 0 Td 52.662037 Tz (products ) Tj 51.428571 0 0 51.428571 0 2246.802893 Tm 7.7 0 Td 53.148148 Tz (using ) Tj 1.808333 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 52.777778 Tz (copious ) Tj 2.45 0 Td 61.574074 Tz (amount ) Tj 2.45 0 Td 48.971193 Tz (ultrapure ) Tj 2.877778 0 Td 48.070988 Tz (water. ) Tj 51.428571 0 0 51.428571 0 2204.919481 Tm 7.019444 0 Td 46.450617 Tz (\(6\) ) Tj 1.05 0 Td 51.311728 Tz (Buffer ) Tj 2.041667 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 50.05144 Tz (hydrated, ) Tj 2.975 0 Td 46.296296 Tz (neutral ) Tj 2.158333 0 Td 50.636574 Tz (chitosan ) Tj 2.663889 0 Td 56.712963 Tz (sponge ) Tj 2.236111 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 65.625 Tz (soak ) Tj 51.428571 0 0 51.428571 0 2162.094614 Tm 7.719444 0 Td 51.851852 Tz (ing ) Tj 1.186111 0 Td 32.407407 Tz (it ) Tj 0.641667 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 62.87037 Tz (0.25M ) Tj 2.119444 0 Td 48.611111 Tz (acetate ) Tj 2.255556 0 Td 49.151235 Tz (buffer ) Tj 2.002778 0 Td 48.206019 Tz (solution ) Tj 2.547222 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 74.537037 Tz (pH ) Tj 1.147222 0 Td 48.611111 Tz (5.6 ) Tj 1.127778 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 2122.145631 Tm 7.7 0 Td 43.75 Tz (thirty ) Tj 1.866667 0 Td 50.636574 Tz (minutes. ) Tj 51.428571 0 0 51.428571 0 2080.759099 Tm 7.019444 0 Td 45.37037 Tz (\(7\) ) Tj 1.127778 0 Td 65.895062 Tz (Remove ) Tj 2.605556 0 Td 52.391975 Tz (excess ) Tj 2.158333 0 Td 46.450617 Tz (liquid ) Tj 1.925 0 Td 57.523148 Tz (from ) Tj 1.652778 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 52.314815 Tz (sponge. ) Tj 51.428571 0 0 51.428571 0 2039.049226 Tm 7.019444 0 Td 46.450617 Tz (\(8\) ) Tj 1.341667 0 Td 53.472222 Tz (Freeze ) Tj 2.391667 0 Td 49.691358 Tz (the ) Tj 1.419444 0 Td 47.170782 Tz (resulting ) Tj 2.994444 0 Td 50.411523 Tz (hydrated, ) Tj 3.208333 0 Td 51.041667 Tz (buffered ) Tj 2.936111 0 Td 51.041667 Tz (chitosan ) Tj 38.571429 0 0 38.571429 0 2000 Tm 10.318519 0 Td 69.753086 Tz (Sponge. ) Tj 51.428571 0 0 51.428571 0 1955.840052 Tm 7.019444 0 Td 45.37037 Tz (\(9\) ) Tj 1.088889 0 Td 51.527778 Tz (Lyophilize ) Tj 3.305556 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 47.685185 Tz (frozen, ) Tj 2.255556 0 Td 47.314815 Tz (Solid ) Tj 1.672222 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 52.777778 Tz (Sponge, ) Tj 2.45 0 Td 70 Tz (remov ) Tj 51.428571 0 0 51.428571 0 1913.065934 Tm 7.719444 0 Td 50.771605 Tz (ing ) Tj 1.166667 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 48.070988 Tz (water. ) Tj 51.428571 0 0 51.428571 0 1872.229508 Tm 7.019444 0 Td 48.611111 Tz (\(10\) ) Tj 1.361111 0 Td 51.851852 Tz (Store ) Tj 1.730556 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 44.398148 Tz (finalized, ) Tj 2.858333 0 Td 50.231481 Tz (buffered ) Tj 2.566667 0 Td 50.636574 Tz (chitosan ) Tj 2.644444 0 Td 57.253086 Tz (sponge ) Tj 2.236111 0 Td 53.240741 Tz (product ) Tj 51.428571 0 0 51.428571 0 1830.5058 Tm 7.719444 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 57.253086 Tz (low ) Tj 1.302778 0 Td 54.6875 Tz (humidity ) Tj 2.877778 0 Td 53.20216 Tz (environment. ) Tj 51.428571 0 0 51.428571 0 1792.74212 Tm 7.019444 0 Td 57.87037 Tz (Sponges ) Tj 2.955556 0 Td 55.092593 Tz (having ) Tj 2.488889 0 Td 58.333333 Tz (a ) Tj 0.875 0 Td 49.537037 Tz (desired ) Tj 2.625 0 Td 51.557239 Tz (degradation ) Tj 3.908333 0 Td 45.833333 Tz (profile ) Tj 2.469444 0 Td 58.333333 Tz (were ) Tj 51.428571 0 0 51.428571 0 1748.076115 Tm 6.261111 0 Td 52.256944 Tz (obtained ) Tj 2.819444 0 Td 61.574074 Tz (by ) Tj 1.069444 0 Td 49.907407 Tz (dissolving ) Tj 3.383333 0 Td 76.157407 Tz (1% ) Tj 1.244444 0 Td 58.333333 Tz (w/v ) Tj 1.4 0 Td 50.636574 Tz (chitosan ) Tj 2.8 0 Td 63.194444 Tz (\(61% ) Tj 1.886111 0 Td 54.552469 Tz (degree ) Tj 2.255556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 1705.224543 Tm 6.261111 0 Td 49.305556 Tz (deacetylation\) ) Tj 4.355556 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 72.916667 Tz (1% ) Tj 1.186111 0 Td 47.530864 Tz (v/v ) Tj 1.127778 0 Td 51.041667 Tz (acid ) Tj 1.477778 0 Td 47.800926 Tz (solution ) Tj 2.547222 0 Td 57.253086 Tz (\(where ) Tj 2.294444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (acid ) Tj 1.458333 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 1664.053915 Tm 6.261111 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 55.555556 Tz (blended ) Tj 2.566667 0 Td 48.611111 Tz (3:1 ) Tj 1.225 0 Td 43.425926 Tz (ratio ) Tj 1.555556 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 43.209877 Tz (lactic ) Tj 1.827778 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 47.530864 Tz (acetic ) Tj 1.963889 0 Td 46.666667 Tz (acid, ) Tj 1.691667 0 Td 46.296296 Tz (respectively\). ) Tj 52.857143 0 0 52.857143 0 1621.755187 Tm 6.091892 0 Td 62.012012 Tz (The ) Tj 1.456757 0 Td 55.705706 Tz (sponge ) Tj 2.327027 0 Td 60.960961 Tz (was ) Tj 1.418919 0 Td 47.297297 Tz (cast ) Tj 1.456757 0 Td 58.333333 Tz (by ) Tj 1.059459 0 Td 47.747748 Tz (putting ) Tj 2.345946 0 Td 56.756757 Tz (75 ) Tj 1.078378 0 Td 58.333333 Tz (ml ) Tj 1.040541 0 Td 58.333333 Tz (of ) Tj 0.945946 0 Td 47.297297 Tz (the ) Tj 1.210811 0 Td 49.74975 Tz (dissolved ) Tj 40 0 0 40 0 1586 Tm 8.05 0 Td 64.583333 Tz (chitosan ) Tj 3.4 0 Td 61.979167 Tz (Solution ) Tj 3.275 0 Td 59.375 Tz (into ) Tj 1.7 0 Td 75 Tz (a ) Tj 0.8 0 Td 70.833333 Tz (10 ) Tj 1.125 0 Td 89.583333 Tz (cm ) Tj 1.375 0 Td 69.270833 Tz (diameter ) Tj 3.55 0 Td 78.125 Tz (aluminum ) Tj 4.075 0 Td 63.541667 Tz (dish ) Tj 1.8 0 Td 77.777778 Tz (and ) Tj 51.428571 0 0 51.428571 0 1538.609929 Tm 6.261111 0 Td 49.826389 Tz (freezing ) Tj 2.780556 0 Td 50.771605 Tz (the ) Tj 1.341667 0 Td 48.611111 Tz (Solution ) Tj 2.761111 0 Td 45.37037 Tz (at ) Tj 0.952778 0 Td 58.333333 Tz (-20 ) Tj 1.808333 0 Td 55.092593 Tz (C. ) Tj 1.088889 0 Td 63.734568 Tz (The ) Tj 1.575 0 Td 46.990741 Tz (cast ) Tj 1.536111 0 Td 57.79321 Tz (sponge ) Tj 2.508333 0 Td 61.574074 Tz (was ) Tj 51.428571 0 0 51.428571 0 1496.899263 Tm 6.261111 0 Td 49.789562 Tz (lyophilized ) Tj 3.441667 0 Td 45.37037 Tz (to ) Tj 0.758333 0 Td 53.472222 Tz (reduce ) Tj 2.080556 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 54.444444 Tz (water ) Tj 1.769444 0 Td 51.388889 Tz (content ) Tj 2.313889 0 Td 58.333333 Tz (by ) Tj 0.933333 0 Td 48.611111 Tz (nearly ) Tj 2.002778 0 Td 59.62963 Tz (100%. ) Tj 1.963889 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1457.121212 Tm 6.261111 0 Td 49.789562 Tz (lyophilized ) Tj 3.538889 0 Td 57.253086 Tz (sponge ) Tj 2.294444 0 Td 62.654321 Tz (was ) Tj 1.380556 0 Td 51.851852 Tz (then ) Tj 1.477778 0 Td 53.877315 Tz (hydrated ) Tj 2.819444 0 Td 46.990741 Tz (in ) Tj 0.816667 0 Td 62.654321 Tz (500 ) Tj 1.361111 0 Td 61.574074 Tz (ml ) Tj 0.972222 0 Td 61.574074 Tz (of ) Tj 0.894444 0 Td 64.166667 Tz (0.60M ) Tj 51.428571 0 0 51.428571 0 1415.612702 Tm 6.280556 0 Td 58.333333 Tz (Sodium ) Tj 2.352778 0 Td 55.452675 Tz (hydroxide ) Tj 3.247222 0 Td 47.530864 Tz (for ) Tj 1.088889 0 Td 53.596866 Tz (approximately ) Tj 4.452778 0 Td 55.092593 Tz (3 ) Tj 0.641667 0 Td 53.703704 Tz (minutes ) Tj 2.527778 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 60.925926 Tz (physi ) Tj 51.428571 0 0 51.428571 0 1376.338535 Tm 6.261111 0 Td 46.666667 Tz (cally ) Tj 1.613889 0 Td 52.932099 Tz (manipulating ) Tj 3.966667 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 56.712963 Tz (sponge ) Tj 2.177778 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 52.932099 Tz (ensure ) Tj 2.080556 0 Td 55.092593 Tz (complete ) Tj 2.819444 0 Td 48.935185 Tz (hydration. ) Tj 51.428571 0 0 51.428571 0 1330.15873 Tm 6.261111 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 57.253086 Tz (Sponge ) Tj 2.236111 0 Td 60.493827 Tz (was ) Tj 1.263889 0 Td 51.041667 Tz (then ) Tj 1.419444 0 Td 60.493827 Tz (washed ) Tj 2.333333 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 53.240741 Tz (copious ) Tj 2.391667 0 Td 58.796296 Tz (amounts ) Tj 2.644444 0 Td 48.611111 Tz (\(6 ) Tj 51.428571 0 0 51.428571 0 1290.53715 Tm 6.280556 0 Td 55.092593 Tz (L\) ) Tj 0.875 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 47.395833 Tz (purified ) Tj 2.45 0 Td 48.070988 Tz (water. ) Tj 1.925 0 Td 58.796296 Tz (Sponges ) Tj 2.683333 0 Td 48.611111 Tz (neutralized ) Tj 3.402778 0 Td 43.75 Tz (in ) Tj 0.719444 0 Td 58.873457 Tz (Sodium ) Tj 2.313889 0 Td 64.274691 Tz (hydrox ) Tj 40 0 0 40 0 1253 Tm 8.05 0 Td 63.888889 Tz (ide ) Tj 1.45 0 Td 76.388889 Tz (and ) Tj 1.7 0 Td 77.083333 Tz (washed ) Tj 3.075 0 Td 60.416667 Tz (in ) Tj 1.05 0 Td 56.018519 Tz (distilled ) Tj 3.35 0 Td 70 Tz (water ) Tj 2.375 0 Td 63.888889 Tz (are ) Tj 1.475 0 Td 80 Tz (shown ) Tj 2.725 0 Td 56.25 Tz (at ) Tj 1.025 0 Td 69.791667 Tz (FIG. ) Tj 2.025 0 Td 54.166667 Tz (1. ) Tj 51.428571 0 0 51.428571 0 1205.523077 Tm 7 0 Td 61.574074 Tz (To ) Tj 1.147222 0 Td 52.932099 Tz (ensure ) Tj 2.313889 0 Td 49.691358 Tz (the ) Tj 1.302778 0 Td 57.253086 Tz (sponge ) Tj 2.45 0 Td 62.654321 Tz (was ) Tj 1.536111 0 Td 43.75 Tz (at ) Tj 0.913889 0 Td 58.333333 Tz (a ) Tj 0.758333 0 Td 47.685185 Tz (neutral ) Tj 2.391667 0 Td 58.333333 Tz (pH. ) Tj 1.497222 0 Td 72.916667 Tz (pH ) Tj 1.302778 0 Td 61.574074 Tz (was ) Tj 51.428571 0 0 51.428571 0 1163.240537 Tm 6.261111 0 Td 54.372428 Tz (measured. ) Tj 3.15 0 Td 59.143519 Tz (Such ) Tj 1.633333 0 Td 57.253086 Tz (measurements ) Tj 4.277778 0 Td 56.17284 Tz (can ) Tj 1.186111 0 Td 56.712963 Tz (be ) Tj 0.855556 0 Td 47.685185 Tz (carried ) Tj 2.158333 0 Td 52.932099 Tz (out ) Tj 1.088889 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 72.916667 Tz (pH ) Tj 51.428571 0 0 51.428571 0 1122.783505 Tm 6.261111 0 Td 57.037037 Tz (meter ) Tj 1.925 0 Td 50.231481 Tz (or ) Tj 0.816667 0 Td 74.537037 Tz (pH ) Tj 1.147222 0 Td 48.251029 Tz (indicator ) Tj 2.819444 0 Td 41.203704 Tz (Strips. ) Tj 40 0 0 40 0 1087 Tm 9 0 Td 66.666667 Tz (Buffer ) Tj 2.725 0 Td 69.444444 Tz (Procedure ) Tj 51.428571 0 0 51.428571 0 1039.871795 Tm 7 0 Td 64.00463 Tz (Once ) Tj 1.730556 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 57.253086 Tz (sponge ) Tj 2.294444 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 45.37037 Tz (at ) Tj 0.797222 0 Td 47.222222 Tz (neutral ) Tj 2.197222 0 Td 59.41358 Tz (pH, ) Tj 1.302778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 56.712963 Tz (Sponge ) Tj 2.255556 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1002.717633 Tm 6.261111 0 Td 57.361111 Tz (compressed ) Tj 3.636111 0 Td 48.611111 Tz (to ) Tj 0.797222 0 Td 49.907407 Tz (physically ) Tj 3.247222 0 Td 52.5 Tz (expel ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 49.826389 Tz (majority ) Tj 2.663889 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 51.851852 Tz (the ) Tj 1.127778 0 Td 52.572016 Tz (hydration ) Tj 51.428571 0 0 51.428571 0 958.468557 Tm 6.280556 0 Td 46.090535 Tz (solution. ) Tj 2.663889 0 Td 64.814815 Tz (The ) Tj 1.361111 0 Td 57.361111 Tz (compressed ) Tj 3.655556 0 Td 56.712963 Tz (sponge ) Tj 2.236111 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 51.041667 Tz (then ) Tj 1.477778 0 Td 50.378788 Tz (re-hydrated ) Tj 3.519444 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 60.493827 Tz (500 ) Tj 51.428571 0 0 51.428571 0 912.467598 Tm 6.261111 0 Td 63.194444 Tz (ml ) Tj 0.972222 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 58.333333 Tz (0.25M, ) Tj 2.333333 0 Td 48.611111 Tz (5.6 ) Tj 1.088889 0 Td 74.537037 Tz (pH ) Tj 1.088889 0 Td 48.148148 Tz (acetate ) Tj 2.216667 0 Td 49.151235 Tz (buffer ) Tj 1.963889 0 Td 48.206019 Tz (solution ) Tj 2.527778 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.691358 Tz (freezable ) Tj 51.428571 0 0 51.428571 0 872.181598 Tm 6.280556 0 Td 43.930041 Tz (\(plastic\) ) Tj 2.566667 0 Td 50.411523 Tz (container ) Tj 2.897222 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 64.814815 Tz (30 ) Tj 0.952778 0 Td 51.041667 Tz (minutes. ) Tj 2.625 0 Td 64.814815 Tz (The ) Tj 1.361111 0 Td 63.518519 Tz (0.25M ) Tj 2.1 0 Td 48.148148 Tz (acetate ) Tj 2.197222 0 Td 49.151235 Tz (buffer ) Tj 51.428571 0 0 51.428571 0 830.445293 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 64.00463 Tz (made ) Tj 1.730556 0 Td 59.953704 Tz (by ) Tj 0.952778 0 Td 56.712963 Tz (mixing ) Tj 2.216667 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.016204 Tz (solution ) Tj 2.527778 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 63.518519 Tz (0.25M ) Tj 2.1 0 Td 46.990741 Tz (acetic ) Tj 1.905556 0 Td 50.231481 Tz (acid ) Tj 1.419444 0 Td 57.523148 Tz (\(-90 ) Tj 1.575 0 Td 54.012346 Tz (ml\) ) Tj 51.428571 0 0 51.428571 0 788.463625 Tm 6.261111 0 Td 46.990741 Tz (into ) Tj 1.283333 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 48.206019 Tz (solution ) Tj 2.45 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 64.166667 Tz (0.25M ) Tj 2.080556 0 Td 58.873457 Tz (sodium ) Tj 2.294444 0 Td 48.148148 Tz (acetate ) Tj 2.197222 0 Td 57.685185 Tz (\(-910 ) Tj 1.905556 0 Td 54.012346 Tz (ml\) ) Tj 1.147222 0 Td 43.425926 Tz (until ) Tj 1.438889 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 76.157407 Tz (pH ) Tj 40 0 0 40 0 754 Tm 8.05 0 Td 75 Tz (of ) Tj 1 0 Td 63.888889 Tz (5.6 ) Tj 1.375 0 Td 50 Tz (is ) Tj 0.825 0 Td 63.425926 Tz (obtained. ) Tj 3.65 0 Td 79.166667 Tz (The ) Tj 1.625 0 Td 68.055556 Tz (excess ) Tj 2.65 0 Td 62.5 Tz (buffer ) Tj 2.45 0 Td 62.5 Tz (solution ) Tj 3.25 0 Td 47.916667 Tz (is ) Tj 0.8 0 Td 77.97619 Tz (removed ) Tj 3.45 0 Td 79.166667 Tz (and ) Tj 51.428571 0 0 51.428571 0 706.020656 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 50.636574 Tz (buffered ) Tj 2.566667 0 Td 50.636574 Tz (chitosan ) Tj 2.625 0 Td 56.712963 Tz (sponge ) Tj 2.216667 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 50.771605 Tz (frozen ) Tj 1.963889 0 Td 46.990741 Tz (at ) Tj 0.738889 0 Td 60.493827 Tz (-20C. ) Tj 2.352778 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 48.148148 Tz (frozen, ) Tj 51.428571 0 0 51.428571 0 665.739454 Tm 6.241667 0 Td 51.041667 Tz (buffered ) Tj 2.644444 0 Td 50.636574 Tz (chitosan ) Tj 2.663889 0 Td 57.79321 Tz (sponge ) Tj 2.313889 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 49.789562 Tz (lyophilized ) Tj 3.5 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 53.472222 Tz (reduce ) Tj 2.158333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 54.444444 Tz (water ) Tj 51.428571 0 0 51.428571 0 625.514436 Tm 6.261111 0 Td 51.388889 Tz (content ) Tj 2.508333 0 Td 59.953704 Tz (by ) Tj 1.147222 0 Td 49.151235 Tz (nearly ) Tj 2.236111 0 Td 60.277778 Tz (100%. ) Tj 2.138889 0 Td 52.5 Tz (After ) Tj 1.905556 0 Td 46.882716 Tz (lyophilization, ) Tj 4.608333 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 68.865741 Tz (dehy ) Tj 51.428571 0 0 51.428571 0 581.013269 Tm 6.261111 0 Td 47.685185 Tz (drated, ) Tj 2.177778 0 Td 50.231481 Tz (buffered ) Tj 2.586111 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 56.712963 Tz (sponge ) Tj 2.216667 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 48.021886 Tz (transferred ) Tj 3.305556 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 50.411523 Tz (container ) Tj 51.428571 0 0 51.428571 0 539.870647 Tm 6.241667 0 Td 59.62963 Tz (which ) Tj 2.061111 0 Td 55.452675 Tz (minimizes ) Tj 3.247222 0 Td 53.846154 Tz (environmental ) Tj 4.452778 0 Td 50.771605 Tz (humidity. ) Tj 51.428571 0 0 51.428571 0 466.04 Tm 13.416667 0 Td 61.111111 Tz (Example ) Tj 2.8 0 Td 58.333333 Tz (2 ) Tj 51.428571 0 0 51.428571 0 380.843305 Tm 7.563889 0 Td 52.662037 Tz (Buffered ) Tj 2.761111 0 Td 58.333333 Tz (Sponges ) Tj 2.722222 0 Td 58.333333 Tz (Degrade ) Tj 2.683333 0 Td 66.435185 Tz (More ) Tj 1.827778 0 Td 56.064815 Tz (Completely ) Tj 3.655556 0 Td 52.662037 Tz (than ) Tj 51.428571 0 0 51.428571 0 338.393939 Tm 11.977778 0 Td 55.416667 Tz (Unbuffered ) Tj 3.558333 0 Td 58.333333 Tz (Sponges ) Tj 51.428571 0 0 51.428571 0 252.432032 Tm 7 0 Td 66.435185 Tz (As ) Tj 1.030556 0 Td 63.518519 Tz (shown ) Tj 2.138889 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 56.388889 Tz (FIGS. ) Tj 1.944444 0 Td 58.333333 Tz (2 ) Tj 0.583333 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 45.37037 Tz (3, ) Tj 0.738889 0 Td 50.636574 Tz (chitosan ) Tj 2.663889 0 Td 61.574074 Tz (sponges ) Tj 2.819444 0 Td 46.990741 Tz (that ) Tj 1.322222 0 Td 59.143519 Tz (were ) Tj 51.428571 0 0 51.428571 0 214.411483 Tm 6.241667 0 Td 51.041667 Tz (buffered ) Tj 2.605556 0 Td 60.493827 Tz (had ) Tj 1.244444 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 45.868946 Tz (significantly ) Tj 3.811111 0 Td 50.411523 Tz (increased ) Tj 2.936111 0 Td 53.472222 Tz (degree ) Tj 2.119444 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 52.441077 Tz (degradation ) Tj 51.428571 0 0 51.428571 0 176 Tm 6.261111 0 Td 42.939815 Tz (profile. ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.444444 0 Td 79.398148 Tz (24 ) Tj 51.428571 0 0 51.428571 0 2919.460733 Tm 25.938889 0 Td 58.333333 Tz (Sponges ) Tj 2.722222 0 Td 46.180556 Tz (that ) Tj 1.361111 0 Td 58.333333 Tz (have ) Tj 1.652778 0 Td 56.532922 Tz (undergone ) Tj 3.325 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 49.691358 Tz (buffering ) Tj 2.975 0 Td 46.990741 Tz (step ) Tj 1.419444 0 Td 55.902778 Tz (degraded ) Tj 51.428571 0 0 51.428571 0 2872.876074 Tm 25.2 0 Td 62.384259 Tz (more ) Tj 1.711111 0 Td 53.796296 Tz (completely ) Tj 3.441667 0 Td 51.851852 Tz (than ) Tj 1.516667 0 Td 52.175926 Tz (unbuffered ) Tj 3.363889 0 Td 51.446759 Tz (sponges. ) Tj 2.683333 0 Td 54.282407 Tz (This ) Tj 1.555556 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 60.185185 Tz (advanta ) Tj 51.428571 0 0 51.428571 0 2828.686131 Tm 25.2 0 Td 56.388889 Tz (geous ) Tj 1.866667 0 Td 55.092593 Tz (because ) Tj 2.469444 0 Td 48.611111 Tz (as ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 55.092593 Tz (drug ) Tj 1.497222 0 Td 49.016204 Tz (delivery ) Tj 2.527778 0 Td 52.932099 Tz (device ) Tj 2.061111 0 Td 49.691358 Tz (for ) Tj 1.030556 0 Td 66.111111 Tz (wound ) Tj 2.138889 0 Td 48.251029 Tz (infection ) Tj 51.428571 0 0 51.428571 0 2788.134228 Tm 25.2 0 Td 51.527778 Tz (prevention ) Tj 3.5 0 Td 50.231481 Tz (or ) Tj 0.913889 0 Td 48.611111 Tz (therapy, ) Tj 2.702778 0 Td 49.691358 Tz (the ) Tj 1.283333 0 Td 49.826389 Tz (chitosan ) Tj 2.761111 0 Td 57.253086 Tz (Sponge ) Tj 2.430556 0 Td 38.888889 Tz (is ) Tj 0.855556 0 Td 50 Tz (desired ) Tj 2.45 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 2748.306431 Tm 25.2 0 Td 55.092593 Tz (degrade ) Tj 2.508333 0 Td 64.00463 Tz (away ) Tj 1.788889 0 Td 44.722222 Tz (after ) Tj 1.575 0 Td 36.728395 Tz (its ) Tj 0.913889 0 Td 55.092593 Tz (drug ) Tj 1.555556 0 Td 49.421296 Tz (delivery ) Tj 2.586111 0 Td 51.041667 Tz (task ) Tj 1.438889 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 55.902778 Tz (complete ) Tj 2.897222 0 Td 62.384259 Tz (\(usu ) Tj 51.428571 0 0 51.428571 0 2706.186207 Tm 25.2 0 Td 44.560185 Tz (ally ) Tj 1.4 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 55.092593 Tz (4 ) Tj 0.661111 0 Td 46.990741 Tz (to ) Tj 0.933333 0 Td 58.333333 Tz (10 ) Tj 0.991667 0 Td 48.070988 Tz (days\). ) Tj 2.080556 0 Td 48.935185 Tz (Desirably, ) Tj 3.266667 0 Td 51.557239 Tz (degradation ) Tj 3.752778 0 Td 43.75 Tz (in ) Tj 0.855556 0 Td 42.939815 Tz (this ) Tj 1.380556 0 Td 52.662037 Tz (time ) Tj 51.428571 0 0 51.428571 0 2662.608273 Tm 25.2 0 Td 57.685185 Tz (frame ) Tj 1.944444 0 Td 60.277778 Tz (makes ) Tj 2.022222 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 50.87963 Tz (secondary, ) Tj 3.266667 0 Td 52.932099 Tz (device ) Tj 2.1 0 Td 44.650206 Tz (retrieval ) Tj 2.625 0 Td 51.388889 Tz (Surgery ) Tj 2.372222 0 Td 61.574074 Tz (unneces ) Tj 51.428571 0 0 51.428571 0 2621.923372 Tm 25.219444 0 Td 43.425926 Tz (sary. ) Tj 1.652778 0 Td 66.435185 Tz (By ) Tj 1.108333 0 Td 50.378788 Tz (eliminating ) Tj 3.616667 0 Td 47.395833 Tz (residual ) Tj 2.605556 0 Td 56.712963 Tz (sponge ) Tj 2.372222 0 Td 46.450617 Tz (material, ) Tj 2.838889 0 Td 61.574074 Tz (more ) Tj 1.75 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2579.946276 Tm 25.2 0 Td 47.314815 Tz (plete ) Tj 1.613889 0 Td 51.557239 Tz (degradation ) Tj 3.577778 0 Td 49.421296 Tz (also ) Tj 1.380556 0 Td 50.231481 Tz (obviates ) Tj 2.625 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 45.959596 Tz (possibility ) Tj 3.247222 0 Td 45.37037 Tz (that ) Tj 1.283333 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 68.055556 Tz (unde ) Tj 51.428571 0 0 51.428571 0 2537.039604 Tm 25.2 0 Td 54.552469 Tz (graded ) Tj 2.197222 0 Td 56.712963 Tz (sponge ) Tj 2.216667 0 Td 46.990741 Tz (will ) Tj 1.302778 0 Td 64.274691 Tz (become ) Tj 2.488889 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 41.319444 Tz (site ) Tj 1.186111 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 48.611111 Tz (future ) Tj 1.944444 0 Td 45.37037 Tz (infection. ) Tj 2.936111 0 Td 53.796296 Tz (Thus, ) Tj 51.428571 0 0 51.428571 0 2497.490667 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 49.691358 Tz (buffer ) Tj 2.119444 0 Td 48.611111 Tz (step ) Tj 1.555556 0 Td 50.231481 Tz (solves ) Tj 2.197222 0 Td 49.691358 Tz (the ) Tj 1.283333 0 Td 51.49177 Tz (challenge ) Tj 3.169444 0 Td 55.092593 Tz (of ) Tj 0.972222 0 Td 54.344729 Tz (manufacturing ) Tj 4.608333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2458.198742 Tm 25.2 0 Td 51.311728 Tz (reproducibly ) Tj 4.083333 0 Td 59.41358 Tz (and ) Tj 1.477778 0 Td 53.292181 Tz (uniformly ) Tj 3.266667 0 Td 53.472222 Tz (degradable ) Tj 3.597222 0 Td 50.231481 Tz (chitosan ) Tj 2.819444 0 Td 52.314815 Tz (sponge. ) Tj 51.428571 0 0 51.428571 0 2415.121693 Tm 25.2 0 Td 48.860399 Tz (Additionally, ) Tj 4.180556 0 Td 32.407407 Tz (it ) Tj 0.719444 0 Td 52.391975 Tz (allows ) Tj 2.255556 0 Td 48.611111 Tz (for ) Tj 1.186111 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 51.851852 Tz (degradation ) Tj 3.772222 0 Td 51.851852 Tz (process ) Tj 2.547222 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 58.333333 Tz (be ) Tj 51.428571 0 0 51.428571 0 2372.249001 Tm 25.2 0 Td 49.259259 Tz (controlled ) Tj 3.344444 0 Td 59.953704 Tz (by ) Tj 1.166667 0 Td 52.662037 Tz (manipulating ) Tj 4.219444 0 Td 48.611111 Tz (the ) Tj 1.283333 0 Td 50.231481 Tz (acid ) Tj 1.594444 0 Td 49.151235 Tz (buffer ) Tj 2.138889 0 Td 47.314815 Tz (type, ) Tj 1.827778 0 Td 44.444444 Tz (buffer, ) Tj 51.428571 0 0 51.428571 0 2329.426309 Tm 25.2 0 Td 49.305556 Tz (concentration, ) Tj 4.316667 0 Td 48.611111 Tz (buffer ) Tj 1.905556 0 Td 58.333333 Tz (pH, ) Tj 1.205556 0 Td 60.493827 Tz (and ) Tj 1.225 0 Td 49.691358 Tz (buffer ) Tj 1.925 0 Td 54.166667 Tz (soaking ) Tj 2.45 0 Td 53.472222 Tz (time ) Tj 1.458333 0 Td 50.555556 Tz (\(Step ) Tj 1.730556 0 Td 40.509259 Tz (6, ) Tj 0.680556 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 2285 Tm 25.180556 0 Td 55.092593 Tz (bold ) Tj 1.536111 0 Td 51.388889 Tz (above\). ) Tj 51.428571 0 0 51.428571 0 2245.961003 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 1.030556 0 Td 51.851852 Tz (degradation ) Tj 3.888889 0 Td 47.685185 Tz (studies ) Tj 2.45 0 Td 51.851852 Tz (\(FIG. ) Tj 2.041667 0 Td 42.12963 Tz (2\), ) Tj 1.263889 0 Td 48.316498 Tz (neutralized ) Tj 3.616667 0 Td 51.041667 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 2206.627451 Tm 25.219444 0 Td 55.092593 Tz (sponges ) Tj 2.508333 0 Td 46.180556 Tz (that ) Tj 1.302778 0 Td 59.41358 Tz (had ) Tj 1.283333 0 Td 49.691358 Tz (not ) Tj 1.088889 0 Td 56.532922 Tz (undergone ) Tj 3.227778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 49.331276 Tz (buffering ) Tj 2.858333 0 Td 47.800926 Tz (step ) Tj 1.380556 0 Td 56.30787 Tz (remained ) Tj 51.428571 0 0 51.428571 0 2166.496333 Tm 25.2 0 Td 46.759259 Tz (largely ) Tj 2.177778 0 Td 44.290123 Tz (intact ) Tj 1.730556 0 Td 52.572016 Tz (following ) Tj 2.975 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 53.472222 Tz (10 ) Tj 0.797222 0 Td 57.253086 Tz (day ) Tj 1.205556 0 Td 51.557239 Tz (degradation ) Tj 3.558333 0 Td 46.990741 Tz (study. ) Tj 1.886111 0 Td 48.611111 Tz (In ) Tj 0.738889 0 Td 41.481481 Tz (fact, ) Tj 51.428571 0 0 51.428571 0 2121.224909 Tm 25.2 0 Td 54.444444 Tz (about ) Tj 1.769444 0 Td 72.376543 Tz (90% ) Tj 1.477778 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 57.79321 Tz (sponge ) Tj 2.236111 0 Td 55.902778 Tz (remained ) Tj 2.819444 0 Td 46.018519 Tz (after ) Tj 1.555556 0 Td 49.826389 Tz (10-days. ) Tj 2.586111 0 Td 46.990741 Tz (In ) Tj 0.738889 0 Td 45.730453 Tz (contrast, ) Tj 51.428571 0 0 51.428571 0 2083.130435 Tm 25.219444 0 Td 55.092593 Tz (sponges ) Tj 2.488889 0 Td 48.611111 Tz (fabricated ) Tj 3.052778 0 Td 51.851852 Tz (using ) Tj 1.691667 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 48.971193 Tz (buffering ) Tj 2.819444 0 Td 48.611111 Tz (step ) Tj 1.322222 0 Td 55.092593 Tz (degraded ) Tj 2.761111 0 Td 48.611111 Tz (to ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 66.435185 Tz (much ) Tj 51.428571 0 0 51.428571 0 2041.694581 Tm 25.2 0 Td 48.611111 Tz (greater ) Tj 2.275 0 Td 50 Tz (degree. ) Tj 2.333333 0 Td 51.203704 Tz (After ) Tj 1.808333 0 Td 53.240741 Tz (10-days ) Tj 2.488889 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.96142 Tz (degradation, ) Tj 3.869444 0 Td 52.662037 Tz (only ) Tj 1.536111 0 Td 63.734568 Tz (40-55% ) Tj 51.428571 0 0 51.428571 0 1996.538922 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 57.253086 Tz (Sponge ) Tj 2.313889 0 Td 52.572016 Tz (remained. ) Tj 51.428571 0 0 51.428571 0 1957.748718 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 48.611111 Tz (surprising ) Tj 3.111111 0 Td 46.585648 Tz (efficacy ) Tj 2.45 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 49.691358 Tz (buffering ) Tj 2.916667 0 Td 48.611111 Tz (step ) Tj 1.361111 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 44.191919 Tz (illustrated ) Tj 51.428571 0 0 51.428571 0 1912.404826 Tm 25.2 0 Td 45.37037 Tz (at ) Tj 0.875 0 Td 53.472222 Tz (FIG. ) Tj 1.613889 0 Td 46.990741 Tz (3, ) Tj 0.894444 0 Td 58.333333 Tz (which ) Tj 2.080556 0 Td 60.277778 Tz (shows ) Tj 2.158333 0 Td 44.560185 Tz (that ) Tj 1.361111 0 Td 50.636574 Tz (chitosan ) Tj 2.780556 0 Td 60.648148 Tz (sponges ) Tj 2.877778 0 Td 46.180556 Tz (that ) Tj 1.419444 0 Td 58.333333 Tz (were ) Tj 51.428571 0 0 51.428571 0 1874.272859 Tm 25.180556 0 Td 51.041667 Tz (buffered ) Tj 2.683333 0 Td 58.333333 Tz (had ) Tj 1.302778 0 Td 45.868946 Tz (significantly ) Tj 3.830556 0 Td 50.771605 Tz (increased ) Tj 2.994444 0 Td 49.691358 Tz (degradation. ) Tj 51.428571 0 0 51.428571 0 1798.04 Tm 32.355556 0 Td 61.111111 Tz (Example ) Tj 2.780556 0 Td 58.333333 Tz (3 ) Tj 51.428571 0 0 51.428571 0 1713.123077 Tm 28.447222 0 Td 50.378788 Tz (Preparation ) Tj 3.558333 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 53.877315 Tz (Chitosan ) Tj 2.858333 0 Td 58.333333 Tz (Composite ) Tj 52.857143 0 0 52.857143 0 1628.935484 Tm 25.2 0 Td 88.288288 Tz (A ) Tj 0.662162 0 Td 53.953954 Tz (composite ) Tj 3.064865 0 Td 50.135135 Tz (containing ) Tj 3.121622 0 Td 48.873874 Tz (chitosan ) Tj 2.516216 0 Td 56.231231 Tz (Sponge ) Tj 2.156757 0 Td 45.720721 Tz (in ) Tj 0.718919 0 Td 51.023751 Tz (chitosangel ) Tj 3.556757 0 Td 42.567568 Tz (\(a ) Tj 51.428571 0 0 51.428571 0 1587.495737 Tm 25.2 0 Td 51.388889 Tz (sponge-in-gel ) Tj 4.822222 0 Td 53.472222 Tz (composite\) ) Tj 3.383333 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 64.814815 Tz (made ) Tj 1.711111 0 Td 58.333333 Tz (from ) Tj 1.575 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 52.146465 Tz (chitosangel ) Tj 51.428571 0 0 51.428571 0 1544.718499 Tm 25.2 0 Td 60.133745 Tz (component ) Tj 3.636111 0 Td 59.41358 Tz (and ) Tj 1.477778 0 Td 58.333333 Tz (a ) Tj 0.777778 0 Td 49.421296 Tz (chitosan ) Tj 2.838889 0 Td 57.253086 Tz (sponge ) Tj 2.469444 0 Td 60.133745 Tz (component ) Tj 3.675 0 Td 65.625 Tz (made ) Tj 1.983333 0 Td 48.611111 Tz (as ) Tj 51.428571 0 0 51.428571 0 1502.800995 Tm 25.2 0 Td 51.851852 Tz (described ) Tj 2.994444 0 Td 53.472222 Tz (above. ) Tj 2.158333 0 Td 84.259259 Tz (A ) Tj 0.680556 0 Td 49.691358 Tz (gel ) Tj 1.147222 0 Td 52.662037 Tz (matrix' ) Tj 2.780556 0 Td 60.133745 Tz (component ) Tj 3.480556 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 53.06713 Tz (prepared ) Tj 2.761111 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 1460.965895 Tm 25.2 0 Td 49.907407 Tz (dissolving ) Tj 3.227778 0 Td 49.826389 Tz (chitosan ) Tj 2.625 0 Td 40.509259 Tz (\(e.g., ) Tj 1.652778 0 Td 51.851852 Tz (as ) Tj 0.836111 0 Td 51.851852 Tz (described ) Tj 2.994444 0 Td 46.585648 Tz (herein\), ) Tj 2.45 0 Td 42.849794 Tz (filtering ) Tj 2.527778 0 Td 63.734568 Tz (par ) Tj 51.428571 0 0 51.428571 0 1419.048064 Tm 25.180556 0 Td 43.209877 Tz (ticulate, ) Tj 2.761111 0 Td 59.41358 Tz (and ) Tj 1.458333 0 Td 53.06713 Tz (allowing ) Tj 2.955556 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 48.206019 Tz (Solution ) Tj 2.702778 0 Td 48.611111 Tz (to ) Tj 1.011111 0 Td 52.391975 Tz (de-gas ) Tj 2.313889 0 Td 48.935185 Tz (overnight. ) Tj 40 0 0 40 0 1382 Tm 32.4 0 Td 68.75 Tz (Chitosan ) Tj 3.625 0 Td 62.5 Tz (Solution ) Tj 3.3 0 Td 50 Tz (is ) Tj 0.925 0 Td 61.363636 Tz (transferred ) Tj 4.375 0 Td 58.333333 Tz (into ) Tj 1.725 0 Td 70.833333 Tz (a ) Tj 0.725 0 Td 64.814815 Tz (container ) Tj 3.725 0 Td 76.388889 Tz (and ) Tj 1.675 0 Td 66.666667 Tz (frozen ) Tj 51.428571 0 0 51.428571 0 1332.915423 Tm 25.2 0 Td 49.691358 Tz (for ) Tj 1.030556 0 Td 43.75 Tz (at ) Tj 0.7 0 Td 44.722222 Tz (least ) Tj 1.575 0 Td 38.888889 Tz (1 ) Tj 0.466667 0 Td 58.333333 Tz (hour ) Tj 1.555556 0 Td 53.292181 Tz (\(-80C.\). ) Tj 3.052778 0 Td 64.814815 Tz (The ) Tj 1.341667 0 Td 49.691358 Tz (length ) Tj 1.963889 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (time ) Tj 1.497222 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1292.329949 Tm 25.219444 0 Td 47.800926 Tz (solution ) Tj 2.586111 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 50.771605 Tz (frozen ) Tj 2.061111 0 Td 57.253086 Tz (can ) Tj 1.244444 0 Td 59.953704 Tz (be ) Tj 0.933333 0 Td 44.560185 Tz (altered. ) Tj 2.372222 0 Td 51.851852 Tz (After ) Tj 1.769444 0 Td 47.170782 Tz (freezing, ) Tj 2.819444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 52.391975 Tz (frozen ) Tj 51.428571 0 0 51.428571 0 1252.034483 Tm 25.219444 0 Td 54.62963 Tz (samples ) Tj 2.644444 0 Td 50.771605 Tz (are ) Tj 1.263889 0 Td 49.494949 Tz (lyophilized ) Tj 3.616667 0 Td 48.611111 Tz (for ) Tj 1.205556 0 Td 60.493827 Tz (~48 ) Tj 1.458333 0 Td 53.148148 Tz (hours ) Tj 1.944444 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 44.398148 Tz (sterilized ) Tj 3.013889 0 Td 49.691358 Tz (via ) Tj 51.428571 0 0 51.428571 0 1210.709046 Tm 25.2 0 Td 71.296296 Tz (gamma ) Tj 2.352778 0 Td 44.290123 Tz (irradiation. ) Tj 3.402778 0 Td 54.282407 Tz (This ) Tj 1.516667 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 60.133745 Tz (component ) Tj 3.441667 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 50.771605 Tz (not ) Tj 1.166667 0 Td 52.777778 Tz (neutral ) Tj 51.428571 0 0 51.428571 0 1166.663139 Tm 25.2 0 Td 51.041667 Tz (ized ) Tj 1.458333 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 54.282407 Tz (used ) Tj 1.536111 0 Td 48.611111 Tz (as ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 53.877315 Tz (adhesive ) Tj 3.091667 0 Td 50.771605 Tz (gel ) Tj 1.516667 0 Td 48.148148 Tz (matrix. ) Tj 51.428571 0 0 51.428571 0 1131.017903 Tm 25.919444 0 Td 87.5 Tz (A ) Tj 0.719444 0 Td 55.902778 Tz ('sponge' ) Tj 2.916667 0 Td 60.133745 Tz (component ) Tj 3.480556 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 53.472222 Tz (prepared ) Tj 2.8 0 Td 52.5 Tz (using ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 49.494949 Tz (lyophilized ) Tj 51.428571 0 0 51.428571 0 1087.645783 Tm 25.219444 0 Td 55.092593 Tz (sponges ) Tj 2.508333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.633333 0 Td 51.851852 Tz (as ) Tj 0.816667 0 Td 51.49177 Tz (described ) Tj 2.955556 0 Td 46.180556 Tz (herein\). ) Tj 2.411111 0 Td 63.734568 Tz (The ) Tj 1.341667 0 Td 49.494949 Tz (lyophilized ) Tj 3.441667 0 Td 55.555556 Tz (sponges ) Tj 51.428571 0 0 51.428571 0 1044.506587 Tm 25.2 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 48.611111 Tz (neutralized ) Tj 3.344444 0 Td 61.574074 Tz (by ) Tj 0.952778 0 Td 56.712963 Tz (Submerging ) Tj 3.577778 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 58.873457 Tz (Sodium ) Tj 2.294444 0 Td 55.092593 Tz (hydroxide ) Tj 3.15 0 Td 49.016204 Tz (Solution ) Tj 51.428571 0 0 51.428571 0 1002.015038 Tm 25.219444 0 Td 49.016204 Tz (\(various ) Tj 2.625 0 Td 50.462963 Tz (concentrations ) Tj 4.530556 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 79.398148 Tz (NaOH ) Tj 2.197222 0 Td 68.055556 Tz (may ) Tj 1.516667 0 Td 56.712963 Tz (be ) Tj 0.972222 0 Td 47.530864 Tz (used\). ) Tj 2.061111 0 Td 55.902778 Tz (Hydrated ) Tj 51.428571 0 0 51.428571 0 959.305898 Tm 25.219444 0 Td 55.092593 Tz (sponges ) Tj 2.722222 0 Td 49.691358 Tz (are ) Tj 1.322222 0 Td 49.151235 Tz (rinsed ) Tj 2.158333 0 Td 54.282407 Tz (with ) Tj 1.730556 0 Td 53.796296 Tz (water ) Tj 2.002778 0 Td 48.611111 Tz (several ) Tj 2.45 0 Td 52.5 Tz (times ) Tj 1.963889 0 Td 52.391975 Tz (before ) Tj 2.313889 0 Td 64.814815 Tz (re ) Tj 51.428571 0 0 51.428571 0 919.197802 Tm 25.2 0 Td 49.826389 Tz (freezing ) Tj 2.644444 0 Td 49.691358 Tz (for ) Tj 1.108333 0 Td 45.37037 Tz (at ) Tj 0.816667 0 Td 44.722222 Tz (least ) Tj 1.672222 0 Td 35.648148 Tz (1 ) Tj 0.544444 0 Td 56.712963 Tz (hour ) Tj 1.633333 0 Td 54.444444 Tz (\(-80 ) Tj 1.905556 0 Td 44.560185 Tz (C.\). ) Tj 1.322222 0 Td 61.574074 Tz (At ) Tj 1.030556 0 Td 42.12963 Tz (this ) Tj 1.302778 0 Td 49.907407 Tz (point ) Tj 1.769444 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 879.945455 Tm 25.2 0 Td 49.016204 Tz (process, ) Tj 2.722222 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 57.253086 Tz (sponge ) Tj 2.430556 0 Td 66.975309 Tz (may ) Tj 1.575 0 Td 58.333333 Tz (be ) Tj 1.030556 0 Td 50.636574 Tz (buffered ) Tj 2.761111 0 Td 59.953704 Tz (by ) Tj 1.108333 0 Td 53.703704 Tz (soaking ) Tj 2.625 0 Td 32.407407 Tz (it ) Tj 0.719444 0 Td 46.990741 Tz (in ) Tj 0.933333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 834.282443 Tm 25.2 0 Td 63.518519 Tz (0.25M ) Tj 2.138889 0 Td 49.537037 Tz (acetate ) Tj 2.275 0 Td 49.151235 Tz (buffer ) Tj 2.002778 0 Td 48.206019 Tz (solution ) Tj 2.566667 0 Td 45.37037 Tz (at ) Tj 0.758333 0 Td 76.157407 Tz (pH ) Tj 1.166667 0 Td 50.771605 Tz (5.6 ) Tj 1.166667 0 Td 47.530864 Tz (for ) Tj 1.108333 0 Td 42.669753 Tz (thirty ) Tj 1.808333 0 Td 51.041667 Tz (minutes. ) Tj 51.428571 0 0 51.428571 0 794.764557 Tm 25.2 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 56.712963 Tz (sponge ) Tj 2.294444 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 51.041667 Tz (then ) Tj 1.458333 0 Td 51.311728 Tz (frozen ) Tj 2.061111 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 49.494949 Tz (lyophilized ) Tj 3.5 0 Td 46.450617 Tz (for ) Tj 1.030556 0 Td 56.388889 Tz (36-48 ) Tj 1.925 0 Td 49.691358 Tz (hours. ) Tj 51.428571 0 0 51.428571 0 755.207453 Tm 25.2 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 50.231481 Tz (duration ) Tj 2.683333 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 47.916667 Tz (lyophilization ) Tj 4.316667 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 55.452675 Tz (dependent ) Tj 3.266667 0 Td 59.953704 Tz (on ) Tj 1.011111 0 Td 48.021886 Tz (lyophilizer ) Tj 51.428571 0 0 51.428571 0 713 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.361111 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 46.990741 Tz (size ) Tj 1.419444 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 52.314815 Tz (sponge. ) Tj 2.508333 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 53.877315 Tz (double ) Tj 2.936111 0 Td 49.789562 Tz (lyophilized ) Tj 3.597222 0 Td 56.712963 Tz (sponge ) Tj 51.428571 0 0 51.428571 0 669.950081 Tm 25.219444 0 Td 55.092593 Tz (samples ) Tj 2.547222 0 Td 50.771605 Tz (are ) Tj 1.166667 0 Td 44.398148 Tz (sterilized ) Tj 2.936111 0 Td 47.530864 Tz (via ) Tj 1.088889 0 Td 71.296296 Tz (gamma ) Tj 2.372222 0 Td 44.290123 Tz (irradiation. ) Tj 51.428571 0 0 51.428571 0 631.522124 Tm 25.919444 0 Td 63.194444 Tz (To ) Tj 0.972222 0 Td 52.777778 Tz (prepare ) Tj 2.411111 0 Td 51.279956 Tz (the'sponge-in-gel ) Tj 5.775 0 Td 52.824074 Tz (composite, ) Tj 3.383333 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 55.387205 Tz (combination ) Tj 51.428571 0 0 51.428571 0 589.012658 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.894444 0 Td 49.421296 Tz ('gel ) Tj 1.497222 0 Td 51.851852 Tz (matrix ) Tj 2.45 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 55.902778 Tz (sponge' ) Tj 2.955556 0 Td 58.657407 Tz (components ) Tj 3.791667 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 53.240741 Tz (ground, ) Tj 2.508333 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 545.570164 Tm 25.2 0 Td 54.012346 Tz (degree ) Tj 2.119444 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 58.981481 Tz (which ) Tj 2.002778 0 Td 66.975309 Tz (may ) Tj 1.361111 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 54.166667 Tz (adapted ) Tj 2.469444 0 Td 56.712963 Tz (from ) Tj 1.575 0 Td 52.932099 Tz (course ) Tj 2.061111 0 Td 48.611111 Tz (to ) Tj 0.777778 0 Td 44.560185 Tz (fine ) Tj 1.263889 0 Td 39.969136 Tz (\(e.g., ) Tj 1.652778 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 504.222947 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 51.446759 Tz (standard ) Tj 2.8 0 Td 49.151235 Tz (coffee ) Tj 2.080556 0 Td 46.450617 Tz (grinder\). ) Tj 2.819444 0 Td 64.814815 Tz (The ) Tj 1.497222 0 Td 45.37037 Tz (finer ) Tj 1.652778 0 Td 58.333333 Tz (components ) Tj 3.85 0 Td 49.691358 Tz (are ) Tj 1.205556 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 466.04717 Tm 25.219444 0 Td 48.43107 Tz (single-lyophilized ) Tj 5.405556 0 Td 57.253086 Tz (sponge ) Tj 2.197222 0 Td 48.148148 Tz (pieces, ) Tj 2.197222 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 47.530864 Tz (larger ) Tj 1.847222 0 Td 58.333333 Tz (components ) Tj 51.428571 0 0 51.428571 0 421.87163 Tm 25.2 0 Td 49.691358 Tz (are ) Tj 1.166667 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 55.632716 Tz (double ) Tj 2.255556 0 Td 49.789562 Tz (lyophilized ) Tj 3.577778 0 Td 57.253086 Tz (sponge ) Tj 2.333333 0 Td 47.222222 Tz (pieces. ) Tj 2.313889 0 Td 46.990741 Tz (In ) Tj 0.894444 0 Td 57.253086 Tz (one ) Tj 1.302778 0 Td 67.515432 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 378.841584 Tm 25.2 0 Td 53.796296 Tz (ment, ) Tj 1.827778 0 Td 46.990741 Tz (at ) Tj 0.758333 0 Td 44.722222 Tz (least ) Tj 1.536111 0 Td 54.444444 Tz (about ) Tj 1.827778 0 Td 68.518519 Tz (25%-95% ) Tj 3.111111 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 55.452675 Tz (composite ) Tj 3.188889 0 Td 40.509259 Tz (is ) Tj 0.7 0 Td 53.877315 Tz (hydrogel ) Tj 51.428571 0 0 51.428571 0 336.687273 Tm 25.2 0 Td 56.388889 Tz (component. ) Tj 3.655556 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 52.777778 Tz (another ) Tj 2.372222 0 Td 58.038721 Tz (embodiment, ) Tj 4.044444 0 Td 45.37037 Tz (at ) Tj 0.758333 0 Td 44.722222 Tz (least ) Tj 1.497222 0 Td 54.444444 Tz (about ) Tj 1.847222 0 Td 70.216049 Tz (5%-75% ) Tj 51.428571 0 0 51.428571 0 297.313222 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.894444 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 55.452675 Tz (composite ) Tj 3.305556 0 Td 37.268519 Tz (is ) Tj 0.777778 0 Td 52.314815 Tz (sponge. ) Tj 2.488889 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 55.092593 Tz (composite ) Tj 3.266667 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 55.416667 Tz (customized ) Tj 51.428571 0 0 51.428571 0 252.274611 Tm 25.180556 0 Td 55.092593 Tz (based ) Tj 1.963889 0 Td 59.953704 Tz (on ) Tj 1.011111 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 52.662037 Tz (adhesiveness ) Tj 4.122222 0 Td 49.826389 Tz (required ) Tj 2.663889 0 Td 52.932099 Tz (and/or ) Tj 2.158333 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 46.990741 Tz (size ) Tj 1.4 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 40 0 0 40 0 218 Tm 32.375 0 Td 77.083333 Tz (wound. ) Tj 3.125 0 Td 93.75 Tz (An ) Tj 1.45 0 Td 65.277778 Tz (increased ) Tj 3.825 0 Td 79.166667 Tz (amount ) Tj 3.2 0 Td 72.916667 Tz (of ) Tj 1.075 0 Td 67.708333 Tz (adhesiveness ) Tj 5.25 0 Td 50 Tz (is ) Tj 0.95 0 Td 64.285714 Tz (desired ) Tj 3.025 0 Td 58.333333 Tz (if ) Tj 51.428571 0 0 51.428571 0 170.098039 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 65.462963 Tz (wound ) Tj 2.138889 0 Td 37.268519 Tz (is ) Tj 0.602778 0 Td 55.740741 Tz (prone ) Tj 1.808333 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 51.851852 Tz (drainage ) Tj 2.663889 0 Td 51.851852 Tz (or ) Tj 0.738889 0 Td 52.932099 Tz (has ) Tj 1.127778 0 Td 51.131687 Tz (increased ) Tj 2.897222 0 Td 50.462963 Tz (surface ) Tj 2.275 0 Td 45.37037 Tz (area. ) Tj ET Q endstream endobj 143 0 obj << /Length 1 >> stream q endstream endobj 144 0 obj << /Length 51101 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.113514 0 Td 77.252252 Tz (25 ) Tj 51.428571 0 0 51.428571 0 2914.110246 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.933333 0 Td 53.240741 Tz (another ) Tj 2.566667 0 Td 57.744108 Tz (embodiment, ) Tj 4.2 0 Td 55.092593 Tz (an ) Tj 1.069444 0 Td 50.411523 Tz (increased ) Tj 3.091667 0 Td 61.033951 Tz (amount ) Tj 2.547222 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 57.79321 Tz (Sponge ) Tj 51.428571 0 0 51.428571 0 2870.901961 Tm 6.261111 0 Td 49.421296 Tz (material ) Tj 2.566667 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 50 Tz (desired ) Tj 2.255556 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 49.691358 Tz (cavity ) Tj 1.944444 0 Td 59.41358 Tz (wound. ) Tj 2.313889 0 Td 53.472222 Tz (This ) Tj 1.477778 0 Td 54.62963 Tz (blended ) Tj 2.508333 0 Td 53.240741 Tz (mixture ) Tj 51.428571 0 0 51.428571 0 2831.992966 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.758333 0 Td 47.222222 Tz (single- ) Tj 2.119444 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 50.951646 Tz (double-lyophilized ) Tj 5.677778 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 56.712963 Tz (sponge ) Tj 2.197222 0 Td 53.652263 Tz (fragments ) Tj 51.428571 0 0 51.428571 0 2783.313433 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 52.662037 Tz (then ) Tj 1.497222 0 Td 53.472222 Tz (hydrated ) Tj 2.780556 0 Td 53.472222 Tz (with ) Tj 1.516667 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 48.611111 Tz (solution ) Tj 2.586111 0 Td 44.020062 Tz (\(antibiotic, ) Tj 3.402778 0 Td 44.907407 Tz (Saline, ) Tj 2.1 0 Td 55.092593 Tz (antifun ) Tj 51.428571 0 0 51.428571 0 2742.585845 Tm 6.261111 0 Td 44.560185 Tz (gal, ) Tj 1.283333 0 Td 46.180556 Tz (etc\) ) Tj 1.361111 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 57.523148 Tz (form ) Tj 1.633333 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 50.555556 Tz (paste ) Tj 1.788889 0 Td 49.421296 Tz (mixture. ) Tj 2.625 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 47.530864 Tz (resulting ) Tj 2.8 0 Td 49.907407 Tz (paste ) Tj 1.711111 0 Td 54.012346 Tz (has ) Tj 1.225 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2702.093458 Tm 6.241667 0 Td 53.703704 Tz (binding ) Tj 2.411111 0 Td 50.555556 Tz ('gel ) Tj 1.691667 0 Td 52.391975 Tz (matrix ) Tj 2.061111 0 Td 48.099415 Tz (\(single-lyophilized ) Tj 5.638889 0 Td 57.253086 Tz (sponge ) Tj 2.236111 0 Td 57.361111 Tz (component\) ) Tj 51.428571 0 0 51.428571 0 2657.87 Tm 6.241667 0 Td 54.282407 Tz (with ) Tj 1.652778 0 Td 43.055556 Tz (larger, ) Tj 2.138889 0 Td 50.771605 Tz (dispersed ) Tj 3.072222 0 Td 55.902778 Tz (sponge' ) Tj 2.994444 0 Td 53.652263 Tz (fragments ) Tj 3.208333 0 Td 53.796296 Tz (throughout ) Tj 3.538889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2615.436893 Tm 6.261111 0 Td 48.611111 Tz (gel ) Tj 1.186111 0 Td 50.146199 Tz (\(double-lyophilized ) Tj 6.008333 0 Td 57.253086 Tz (sponge ) Tj 2.333333 0 Td 54.79798 Tz (component\). ) Tj 3.908333 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 62.5 Tz (sponge ) Tj 51.428571 0 0 51.428571 0 2567.692308 Tm 6.261111 0 Td 46.990741 Tz (in-gel ) Tj 2.197222 0 Td 55.092593 Tz (composite ) Tj 3.15 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.855556 0 Td 53.472222 Tz (prepared ) Tj 2.741667 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 49.907407 Tz (short ) Tj 1.594444 0 Td 61.574074 Tz (amount ) Tj 2.391667 0 Td 55.092593 Tz (of ) Tj 0.719444 0 Td 49.259259 Tz (time. ) Tj 51.428571 0 0 51.428571 0 2520.77037 Tm 6.280556 0 Td 48.611111 Tz (In ) Tj 0.719444 0 Td 59.41358 Tz (one ) Tj 1.225 0 Td 57.449495 Tz (embodiment, ) Tj 3.966667 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 50.555556 Tz (paste ) Tj 1.691667 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 60.277778 Tz (mixed ) Tj 1.944444 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 49.691358 Tz (delivered ) Tj 2.838889 0 Td 43.75 Tz (at ) Tj 0.680556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2482.069519 Tm 6.261111 0 Td 46.990741 Tz (point-of-care. ) Tj 4.336111 0 Td 63.734568 Tz (The ) Tj 1.516667 0 Td 53.148148 Tz (agent ) Tj 1.963889 0 Td 38.888889 Tz (is ) Tj 0.875 0 Td 51.041667 Tz (incorporated ) Tj 4.025 0 Td 46.990741 Tz (at ) Tj 0.894444 0 Td 51.851852 Tz (the ) Tj 1.283333 0 Td 55.092593 Tz (time ) Tj 1.691667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2437.36452 Tm 6.261111 0 Td 55.452675 Tz (composite ) Tj 3.188889 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 50.411523 Tz (hydrated. ) Tj 2.955556 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 57.744108 Tz (embodiment, ) Tj 3.986111 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 55.812757 Tz (composite ) Tj 3.169444 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2390.451163 Tm 6.261111 0 Td 50.411523 Tz (delivered ) Tj 2.955556 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 42.12963 Tz (site ) Tj 1.263889 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 56.712963 Tz (trauma ) Tj 2.313889 0 Td 46.450617 Tz (via ) Tj 1.088889 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 42.592593 Tz (sterile ) Tj 2.041667 0 Td 47.395833 Tz (Syringe. ) Tj 51.428571 0 0 51.428571 0 2352.885161 Tm 7 0 Td 53.580247 Tz (Advantageously, ) Tj 5.113889 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 55.092593 Tz (composite ) Tj 3.247222 0 Td 51.851852 Tz (provides ) Tj 2.8 0 Td 47.530864 Tz (for ) Tj 1.088889 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 55.902778 Tz (complete ) Tj 51.428571 0 0 51.428571 0 2306.418491 Tm 6.261111 0 Td 54.282407 Tz (Void ) Tj 1.477778 0 Td 33.217593 Tz (fill ) Tj 0.991667 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 50.636574 Tz (prevents ) Tj 2.702778 0 Td 51.131687 Tz (migration ) Tj 2.975 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.605556 0 Td 55.092593 Tz (composition ) Tj 51.428571 0 0 51.428571 0 2259.230769 Tm 6.241667 0 Td 51.851852 Tz (within ) Tj 2.158333 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 59.41358 Tz (wound. ) Tj 2.411111 0 Td 53.472222 Tz (This ) Tj 1.594444 0 Td 42.424242 Tz (facilitates ) Tj 3.072222 0 Td 48.611111 Tz (localized ) Tj 2.897222 0 Td 49.421296 Tz (delivery ) Tj 2.644444 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 59.953704 Tz (an ) Tj 51.428571 0 0 51.428571 0 2217.832041 Tm 6.261111 0 Td 53.148148 Tz (agent ) Tj 1.808333 0 Td 48.611111 Tz (to ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 42.12963 Tz (site ) Tj 1.263889 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 52.314815 Tz (trauma. ) Tj 2.430556 0 Td 64.814815 Tz (The ) Tj 1.438889 0 Td 49.421296 Tz ('gel ) Tj 1.458333 0 Td 52.314815 Tz (matrix ) Tj 2.45 0 Td 47.170782 Tz (typically ) Tj 2.780556 0 Td 55.092593 Tz (has ) Tj 51.428571 0 0 51.428571 0 2175.62069 Tm 6.261111 0 Td 49.074074 Tz (greater ) Tj 2.236111 0 Td 54.73251 Tz (adherence ) Tj 3.169444 0 Td 48.611111 Tz (properties ) Tj 3.130556 0 Td 51.851852 Tz (than ) Tj 1.497222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 56.712963 Tz (sponge ) Tj 2.255556 0 Td 50 Tz (portion ) Tj 2.352778 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2129.549075 Tm 6.261111 0 Td 52.5 Tz (composite. ) Tj 3.616667 0 Td 55.092593 Tz (Thus, ) Tj 2.119444 0 Td 51.851852 Tz (the ) Tj 1.4 0 Td 60.493827 Tz (amount ) Tj 2.683333 0 Td 56.712963 Tz (of ) Tj 1.069444 0 Td 50.231481 Tz (gel ) Tj 1.730556 0 Td 51.851852 Tz (matrix' ) Tj 2.683333 0 Td 54.012346 Tz (can ) Tj 1.458333 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 2085.102757 Tm 6.261111 0 Td 51.49177 Tz (increased ) Tj 2.975 0 Td 51.851852 Tz (or ) Tj 0.816667 0 Td 52.572016 Tz (decreased ) Tj 3.052778 0 Td 55.092593 Tz (based ) Tj 1.866667 0 Td 58.333333 Tz (on ) Tj 0.894444 0 Td 51.851852 Tz (the ) Tj 1.147222 0 Td 53.796296 Tz (needs ) Tj 1.827778 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 44.560185 Tz (patient. ) Tj 2.411111 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 2041.210593 Tm 6.261111 0 Td 59.41358 Tz (one ) Tj 1.302778 0 Td 57.744108 Tz (embodiment, ) Tj 4.083333 0 Td 56.712963 Tz (an ) Tj 0.991667 0 Td 50.411523 Tz (increased ) Tj 2.955556 0 Td 61.574074 Tz (amount ) Tj 2.469444 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (gel ) Tj 1.166667 0 Td 52.391975 Tz (matrix ) Tj 2.138889 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 2000.095176 Tm 6.261111 0 Td 48.611111 Tz (greater ) Tj 2.275 0 Td 52.662037 Tz (than ) Tj 1.516667 0 Td 53.796296 Tz (about ) Tj 1.886111 0 Td 61.574074 Tz (50%, ) Tj 1.75 0 Td 62.384259 Tz (70%, ) Tj 1.75 0 Td 64.00463 Tz (80%, ) Tj 1.769444 0 Td 64.00463 Tz (90%, ) Tj 1.788889 0 Td 66.435185 Tz (95%\) ) Tj 1.827778 0 Td 40.509259 Tz (is ) Tj 0.758333 0 Td 54.282407 Tz (used ) Tj 1.575 0 Td 46.990741 Tz (to ) Tj 48.571429 0 0 48.571429 0 1959 Tm 6.629412 0 Td 52.757353 Tz (increase ) Tj 3.026471 0 Td 49.754902 Tz (tissue ) Tj 2.305882 0 Td 54.901961 Tz (adherence. ) Tj 3.891176 0 Td 49.754902 Tz (In ) Tj 1.132353 0 Td 55.882353 Tz (another ) Tj 2.841176 0 Td 61.14082 Tz (embodiment, ) Tj 4.55 0 Td 65.196078 Tz (an ) Tj 51.428571 0 0 51.428571 0 1919.504551 Tm 6.261111 0 Td 49.826389 Tz (increase ) Tj 2.761111 0 Td 60.493827 Tz (amount ) Tj 2.547222 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 57.253086 Tz (Sponge ) Tj 2.469444 0 Td 52.932099 Tz (fragments ) Tj 3.247222 0 Td 39.969136 Tz (\(e.g., ) Tj 1.827778 0 Td 49.074074 Tz (greater ) Tj 2.391667 0 Td 53.472222 Tz (than ) Tj 51.428571 0 0 51.428571 0 1875.141427 Tm 6.261111 0 Td 54.444444 Tz (about ) Tj 1.827778 0 Td 61.574074 Tz (50%, ) Tj 1.730556 0 Td 62.384259 Tz (70%, ) Tj 1.711111 0 Td 63.194444 Tz (80%, ) Tj 1.711111 0 Td 61.574074 Tz (90%. ) Tj 1.730556 0 Td 66.435185 Tz (95%\) ) Tj 1.808333 0 Td 42.12963 Tz (to ) Tj 0.738889 0 Td 52.777778 Tz (provide ) Tj 2.45 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 50.771605 Tz (sustained ) Tj 51.428571 0 0 51.428571 0 1836.189474 Tm 6.261111 0 Td 47.685185 Tz (elution ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.952778 0 Td 56.712963 Tz (an ) Tj 1.05 0 Td 52.5 Tz (agent ) Tj 1.925 0 Td 55.092593 Tz (over ) Tj 1.652778 0 Td 47.314815 Tz (time. ) Tj 1.808333 0 Td 47.727273 Tz (Preferably, ) Tj 3.5 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 55.812757 Tz (composite ) Tj 51.428571 0 0 51.428571 0 1794.57672 Tm 6.261111 0 Td 51.851852 Tz (provides ) Tj 2.780556 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 56.481481 Tz (bimodal ) Tj 2.683333 0 Td 49.016204 Tz (delivery ) Tj 2.625 0 Td 61.574074 Tz (of ) Tj 0.894444 0 Td 56.712963 Tz (an ) Tj 0.972222 0 Td 48.070988 Tz (agent. ) Tj 2.061111 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 48.611111 Tz (the ) Tj 1.186111 0 Td 37.592593 Tz (first ) Tj 51.428571 0 0 51.428571 0 1752.319255 Tm 6.261111 0 Td 50.771605 Tz (phase, ) Tj 2.002778 0 Td 56.712963 Tz (an ) Tj 0.855556 0 Td 53.796296 Tz (agent ) Tj 1.769444 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 51.851852 Tz (quickly ) Tj 2.352778 0 Td 49.421296 Tz (released ) Tj 2.547222 0 Td 58.333333 Tz (from ) Tj 1.575 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 48.611111 Tz (gel ) Tj 1.088889 0 Td 48.148148 Tz (matrix. ) Tj 2.197222 0 Td 54.282407 Tz (This ) Tj 51.428571 0 0 51.428571 0 1710.26178 Tm 6.261111 0 Td 38.240741 Tz (first ) Tj 1.458333 0 Td 55.740741 Tz (phase ) Tj 1.963889 0 Td 61.574074 Tz (of ) Tj 0.952778 0 Td 47.685185 Tz (elution ) Tj 2.352778 0 Td 46.8107 Tz (typically ) Tj 2.858333 0 Td 52.391975 Tz (occurs ) Tj 2.216667 0 Td 55.092593 Tz (over ) Tj 1.613889 0 Td 51.851852 Tz (the ) Tj 1.225 0 Td 53.472222 Tz (course ) Tj 2.216667 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 1668.467719 Tm 6.241667 0 Td 54.444444 Tz (hours ) Tj 1.905556 0 Td 39.969136 Tz (\(e.g., ) Tj 1.75 0 Td 38.888889 Tz (1, ) Tj 0.719444 0 Td 45.37037 Tz (2, ) Tj 0.758333 0 Td 46.990741 Tz (3, ) Tj 0.816667 0 Td 43.75 Tz (4, ) Tj 0.777778 0 Td 45.37037 Tz (5, ) Tj 0.797222 0 Td 55.092593 Tz (6 ) Tj 0.583333 0 Td 53.472222 Tz (or ) Tj 0.933333 0 Td 51.851852 Tz (12 ) Tj 0.855556 0 Td 52.391975 Tz (hours\) ) Tj 2.119444 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 54.282407 Tz (days ) Tj 1.575 0 Td 39.969136 Tz (\(e.g., ) Tj 1.75 0 Td 37.268519 Tz (1, ) Tj 0.719444 0 Td 43.75 Tz (2, ) Tj 52.857143 0 0 52.857143 0 1624.726264 Tm 6.091892 0 Td 53.603604 Tz (3 ) Tj 0.548649 0 Td 46.771772 Tz (days\). ) Tj 1.872973 0 Td 63.063063 Tz (The ) Tj 1.343243 0 Td 54.129129 Tz (second ) Tj 2.137838 0 Td 54.234234 Tz (phase ) Tj 1.816216 0 Td 55.18018 Tz (of ) Tj 0.737838 0 Td 50.45045 Tz (the ) Tj 1.078378 0 Td 55.968468 Tz (biomodal ) Tj 2.875676 0 Td 46.846847 Tz (elution ) Tj 2.175676 0 Td 50.056306 Tz (involves ) Tj 51.428571 0 0 51.428571 0 1584.932349 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 50.05144 Tz (Sustained ) Tj 2.897222 0 Td 47.685185 Tz (release ) Tj 2.177778 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (an ) Tj 0.875 0 Td 53.796296 Tz (agent ) Tj 1.788889 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 57.79321 Tz (sponge ) Tj 2.236111 0 Td 50 Tz (portion ) Tj 2.333333 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1543.620648 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 52.175926 Tz (composite. ) Tj 3.286111 0 Td 53.472222 Tz (This ) Tj 1.458333 0 Td 55.092593 Tz (phase ) Tj 1.788889 0 Td 47.170782 Tz (typically ) Tj 2.722222 0 Td 51.851852 Tz (occurs ) Tj 2.041667 0 Td 54.282407 Tz (over ) Tj 1.419444 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 52.932099 Tz (course ) Tj 2.061111 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1504.148615 Tm 6.261111 0 Td 50.555556 Tz (days, ) Tj 1.769444 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 54.012346 Tz (weeks. ) Tj 2.236111 0 Td 48.935185 Tz (Desirably, ) Tj 3.169444 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 55.452675 Tz (composite ) Tj 3.208333 0 Td 51.851852 Tz (provides ) Tj 2.761111 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 63.734568 Tz (Sus ) Tj 51.428571 0 0 51.428571 0 1460.070807 Tm 6.241667 0 Td 50.231481 Tz (tained ) Tj 1.983333 0 Td 48.611111 Tz (elution ) Tj 2.275 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 56.712963 Tz (an ) Tj 0.875 0 Td 53.796296 Tz (agent ) Tj 1.808333 0 Td 52.932099 Tz (during ) Tj 2.1 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 52.932099 Tz (course ) Tj 2.119444 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 69.135802 Tz (compos ) Tj 51.428571 0 0 51.428571 0 1418.360595 Tm 6.261111 0 Td 41.481481 Tz (ite's ) Tj 1.497222 0 Td 49.96142 Tz (degradation. ) Tj 3.888889 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 59.41358 Tz (one ) Tj 1.283333 0 Td 58.038721 Tz (embodiment, ) Tj 4.083333 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 55.452675 Tz (composite ) Tj 3.227778 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 1376.389486 Tm 6.261111 0 Td 47.530864 Tz (prises ) Tj 1.847222 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 50.339506 Tz (non-neutralized ) Tj 4.666667 0 Td 49.691358 Tz (gel ) Tj 1.05 0 Td 46.990741 Tz (portion. ) Tj 2.488889 0 Td 48.611111 Tz (In ) Tj 0.738889 0 Td 51.851852 Tz (another ) Tj 2.333333 0 Td 57.449495 Tz (embodiment, ) Tj 51.428571 0 0 51.428571 0 1337.57672 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 55.092593 Tz (composite ) Tj 3.227778 0 Td 54.372428 Tz (comprises ) Tj 3.169444 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 48.316498 Tz (neutralized ) Tj 3.441667 0 Td 57.253086 Tz (sponge ) Tj 2.275 0 Td 47.395833 Tz (portion. ) Tj 51.428571 0 0 51.428571 0 1292.970149 Tm 7 0 Td 62.654321 Tz (The ) Tj 1.283333 0 Td 46.234568 Tz (characteristics ) Tj 4.355556 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 49.826389 Tz (chitosan ) Tj 2.605556 0 Td 53.472222 Tz (compositions ) Tj 4.044444 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 61.574074 Tz (inven ) Tj 51.428571 0 0 51.428571 0 1251.285714 Tm 6.241667 0 Td 47.800926 Tz (tion ) Tj 1.419444 0 Td 54.012346 Tz (can ) Tj 1.225 0 Td 58.333333 Tz (be ) Tj 0.913889 0 Td 54.62963 Tz (assayed ) Tj 2.527778 0 Td 48.611111 Tz (as ) Tj 0.855556 0 Td 48.611111 Tz (follows. ) Tj 51.428571 0 0 51.428571 0 1211.047619 Tm 6.280556 0 Td 60.493827 Tz (Sponge ) Tj 2.45 0 Td 49.074074 Tz (Elution ) Tj 2.333333 0 Td 49.259259 Tz (Tests ) Tj 51.428571 0 0 51.428571 0 1171.322449 Tm 7.019444 0 Td 57.87037 Tz (Sponges ) Tj 2.761111 0 Td 50.771605 Tz (are ) Tj 1.283333 0 Td 50.411523 Tz (Subjected ) Tj 3.072222 0 Td 45.37037 Tz (to ) Tj 0.913889 0 Td 47.685185 Tz (elution ) Tj 2.352778 0 Td 44.074074 Tz (tests ) Tj 1.633333 0 Td 61.574074 Tz (by ) Tj 1.088889 0 Td 50.231481 Tz (re-hydrating ) Tj 51.428571 0 0 51.428571 0 1126.598383 Tm 6.280556 0 Td 55.092593 Tz (sponges ) Tj 2.741667 0 Td 64.00463 Tz (made ) Tj 1.886111 0 Td 50.231481 Tz (as ) Tj 1.011111 0 Td 51.49177 Tz (described ) Tj 3.130556 0 Td 50.231481 Tz (herein ) Tj 2.177778 0 Td 58.981481 Tz (above ) Tj 2.119444 0 Td 46.990741 Tz (in ) Tj 0.933333 0 Td 56.712963 Tz (an ) Tj 1.069444 0 Td 56.481481 Tz (aqueous ) Tj 51.428571 0 0 51.428571 0 1087.552846 Tm 6.241667 0 Td 49.200337 Tz (therapeutic ) Tj 3.577778 0 Td 53.796296 Tz (agent ) Tj 1.963889 0 Td 39.969136 Tz (\(e.g., ) Tj 1.866667 0 Td 55.092593 Tz (10 ) Tj 1.030556 0 Td 61.574074 Tz (ml ) Tj 1.108333 0 Td 55.092593 Tz (of ) Tj 0.933333 0 Td 58.333333 Tz (5 ) Tj 0.719444 0 Td 62.222222 Tz (mg/ml ) Tj 2.216667 0 Td 55.497685 Tz (amikacin ) Tj 2.994444 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 1044.107097 Tm 6.261111 0 Td 57.744108 Tz (Vancomycin\) ) Tj 4.044444 0 Td 48.611111 Tz (solution ) Tj 2.625 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 53.148148 Tz (load ) Tj 2.158333 0 Td 48.611111 Tz (the ) Tj 1.166667 0 Td 56.712963 Tz (sponge ) Tj 2.294444 0 Td 53.472222 Tz (with ) Tj 1.536111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 56.388889 Tz (thera ) Tj 51.428571 0 0 51.428571 0 1004.52129 Tm 6.261111 0 Td 49.151235 Tz (peutic ) Tj 2.061111 0 Td 48.611111 Tz (agent. ) Tj 2.061111 0 Td 64.814815 Tz (Once ) Tj 1.847222 0 Td 54.012346 Tz (loaded ) Tj 2.255556 0 Td 52.662037 Tz (with ) Tj 1.575 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 49.200337 Tz (therapeutic ) Tj 3.558333 0 Td 48.611111 Tz (agent, ) Tj 2.061111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 962.747613 Tm 6.280556 0 Td 55.092593 Tz (sponges ) Tj 2.702778 0 Td 64.814815 Tz (made ) Tj 1.886111 0 Td 49.691358 Tz (are ) Tj 1.244444 0 Td 58.693416 Tz (Submerged ) Tj 3.5 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 61.574074 Tz (20 ) Tj 1.108333 0 Td 59.953704 Tz (ml ) Tj 1.088889 0 Td 56.712963 Tz (of ) Tj 1.011111 0 Td 55.092593 Tz (1x ) Tj 1.05 0 Td 55.092593 Tz (Phosphate ) Tj 51.428571 0 0 51.428571 0 917.652658 Tm 6.261111 0 Td 53.06713 Tz (Buffered ) Tj 2.702778 0 Td 50.771605 Tz (Saline ) Tj 2.002778 0 Td 53.472222 Tz (\(PBS\), ) Tj 2.1 0 Td 58.333333 Tz (and ) Tj 1.186111 0 Td 53.472222 Tz (kept ) Tj 1.438889 0 Td 48.611111 Tz (in ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 55.092593 Tz (37 ) Tj 1.166667 0 Td 55.092593 Tz (C. ) Tj 0.836111 0 Td 51.49177 Tz (incubator ) Tj 2.916667 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 877.063211 Tm 6.261111 0 Td 50.231481 Tz (duration ) Tj 2.586111 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 46.450617 Tz (study. ) Tj 1.847222 0 Td 68.055556 Tz (One ) Tj 1.419444 0 Td 59.953704 Tz (ml ) Tj 0.875 0 Td 47.800926 Tz (aliquots ) Tj 2.45 0 Td 50.771605 Tz (are ) Tj 1.030556 0 Td 53.148148 Tz (taken ) Tj 1.75 0 Td 46.990741 Tz (at ) Tj 0.758333 0 Td 38.888889 Tz (1, ) Tj 0.602778 0 Td 46.990741 Tz (3, ) Tj 0.758333 0 Td 42.12963 Tz (6, ) Tj 0.680556 0 Td 48.611111 Tz (24. ) Tj 51.428571 0 0 51.428571 0 834.289673 Tm 6.261111 0 Td 50.771605 Tz (48, ) Tj 1.127778 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 58.333333 Tz (72 ) Tj 0.933333 0 Td 49.151235 Tz (hours. ) Tj 1.983333 0 Td 51.851852 Tz (Aliquots ) Tj 2.741667 0 Td 49.691358 Tz (are ) Tj 1.127778 0 Td 46.450617 Tz (tested ) Tj 1.925 0 Td 47.530864 Tz (for ) Tj 1.030556 0 Td 46.018519 Tz (antibiotic ) Tj 2.975 0 Td 64.274691 Tz (concen ) Tj 51.428571 0 0 51.428571 0 796.404281 Tm 6.241667 0 Td 45.37037 Tz (tration ) Tj 2.119444 0 Td 52.5 Tz (using ) Tj 1.730556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 50.771605 Tz (fluorescence ) Tj 3.811111 0 Td 48.070988 Tz (polarization ) Tj 3.675 0 Td 60.10101 Tz (immunoassay ) Tj 4.180556 0 Td 59.953704 Tz (tech ) Tj 51.428571 0 0 51.428571 0 752.799514 Tm 6.261111 0 Td 54.444444 Tz (nique ) Tj 1.808333 0 Td 57.037037 Tz (\(TDx, ) Tj 1.886111 0 Td 56.17284 Tz (Abbott ) Tj 2.216667 0 Td 51.851852 Tz (Labs, ) Tj 1.711111 0 Td 56.17284 Tz (Abbott ) Tj 2.216667 0 Td 47.962963 Tz (Park, ) Tj 1.672222 0 Td 34.351852 Tz (Ill.\) ) Tj 1.225 0 Td 51.851852 Tz (or ) Tj 0.777778 0 Td 50.854701 Tz (high-pressure ) Tj 51.428571 0 0 51.428571 0 714.786492 Tm 6.261111 0 Td 47.530864 Tz (liquid ) Tj 1.944444 0 Td 56.481481 Tz (chromatography ) Tj 5.036111 0 Td 58.796296 Tz (\(HPLC\). ) Tj 51.428571 0 0 51.428571 0 670.575092 Tm 6.261111 0 Td 48.935185 Tz (Antibiotic ) Tj 3.169444 0 Td 49.421296 Tz (Activity ) Tj 51.428571 0 0 51.428571 0 631.692308 Tm 7.019444 0 Td 61.574074 Tz (Drug ) Tj 1.75 0 Td 45.37037 Tz (activity ) Tj 2.508333 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 47.800926 Tz (aliquots ) Tj 2.605556 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 46.450617 Tz (tested ) Tj 1.983333 0 Td 53.148148 Tz (using ) Tj 1.866667 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 46.8107 Tz (turbidity ) Tj 51.428571 0 0 51.428571 0 585.532567 Tm 6.261111 0 Td 46.990741 Tz (assay. ) Tj 1.925 0 Td 71.296296 Tz (Two ) Tj 1.516667 0 Td 45.730453 Tz (different ) Tj 2.702778 0 Td 44.907407 Tz (strains ) Tj 2.119444 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 47.395833 Tz (bacteria ) Tj 2.547222 0 Td 68.055556 Tz (may ) Tj 1.438889 0 Td 59.953704 Tz (be ) Tj 0.952778 0 Td 55.902778 Tz (used ) Tj 1.555556 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 43.75 Tz (this ) Tj 51.428571 0 0 51.428571 0 545.851117 Tm 6.280556 0 Td 46.450617 Tz (study. ) Tj 1.963889 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 58.333333 Tz (one ) Tj 1.283333 0 Td 58.038721 Tz (embodiment, ) Tj 4.102778 0 Td 58.981481 Tz (Vancomycin ) Tj 3.791667 0 Td 55.555556 Tz (samples ) Tj 2.586111 0 Td 50.771605 Tz (are ) Tj 1.147222 0 Td 48.611111 Tz (tested ) Tj 51.428571 0 0 51.428571 0 505.61461 Tm 6.261111 0 Td 49.537037 Tz (against ) Tj 2.391667 0 Td 53.472222 Tz (Staphylococcus ) Tj 4.861111 0 Td 53.472222 Tz (aureus ) Tj 2.275 0 Td 58.333333 Tz (and ) Tj 1.361111 0 Td 55.497685 Tz (amikacin ) Tj 3.013889 0 Td 55.555556 Tz (samples ) Tj 2.683333 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 462.339901 Tm 6.241667 0 Td 48.070988 Tz (tested ) Tj 1.963889 0 Td 50 Tz (against ) Tj 2.352778 0 Td 53.472222 Tz (both ) Tj 1.555556 0 Td 53.472222 Tz (Staphylococcus ) Tj 4.802778 0 Td 53.472222 Tz (aureus ) Tj 2.216667 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 66.840278 Tz (Pseudomo ) Tj 51.428571 0 0 51.428571 0 420.920469 Tm 6.261111 0 Td 55.092593 Tz (nas ) Tj 1.244444 0 Td 51.262626 Tz (aeruginosa. ) Tj 3.675 0 Td 61.574074 Tz (200 ) Tj 1.361111 0 Td 43.75 Tz (ul ) Tj 0.758333 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 55.902778 Tz (each ) Tj 1.555556 0 Td 49.074074 Tz (aliquot ) Tj 2.275 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 58.981481 Tz (added ) Tj 1.983333 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 46.450617 Tz (1.8 ) Tj 1.108333 0 Td 61.574074 Tz (ml ) Tj 51.428571 0 0 51.428571 0 376 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 54.166667 Tz (Mueller-Hinton ) Tj 4.744444 0 Td 38.888889 Tz (II ) Tj 0.622222 0 Td 51.851852 Tz (broth ) Tj 1.711111 0 Td 60.358796 Tz (combined ) Tj 3.052778 0 Td 53.472222 Tz (with ) Tj 1.497222 0 Td 59.953704 Tz (20 ) Tj 0.933333 0 Td 40.509259 Tz (ul ) Tj 0.680556 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 42.12963 Tz (S. ) Tj 0.738889 0 Td 54.012346 Tz (aureus ) Tj 51.428571 0 0 51.428571 0 336.185185 Tm 6.261111 0 Td 53.652263 Tz (inoculum. ) Tj 3.091667 0 Td 59.143519 Tz (Amikacin ) Tj 3.013889 0 Td 55.555556 Tz (samples ) Tj 2.547222 0 Td 55.902778 Tz (\(200 ) Tj 1.555556 0 Td 42.12963 Tz (ul\) ) Tj 0.913889 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 49.421296 Tz (also ) Tj 1.361111 0 Td 58.981481 Tz (added ) Tj 1.925 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 49.421296 Tz (1.75 ) Tj 51.428571 0 0 51.428571 0 296.676768 Tm 6.261111 0 Td 63.194444 Tz (ml ) Tj 0.972222 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 46.990741 Tz (trypticase ) Tj 3.013889 0 Td 55.092593 Tz (soy ) Tj 1.166667 0 Td 51.851852 Tz (broth ) Tj 1.75 0 Td 60.925926 Tz (\(TSB\) ) Tj 2.002778 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 61.574074 Tz (50 ) Tj 0.933333 0 Td 43.75 Tz (ul ) Tj 0.719444 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 37.268519 Tz (P. ) Tj 0.680556 0 Td 54.444444 Tz (aeruginosa ) Tj 51.428571 0 0 51.428571 0 252.389877 Tm 6.261111 0 Td 53.652263 Tz (inoculum. ) Tj 3.286111 0 Td 58.796296 Tz (Samples ) Tj 2.819444 0 Td 50.771605 Tz (are ) Tj 1.263889 0 Td 52.572016 Tz (incubated ) Tj 3.188889 0 Td 48.611111 Tz (for ) Tj 1.225 0 Td 58.333333 Tz (24 ) Tj 1.069444 0 Td 53.148148 Tz (hours ) Tj 1.963889 0 Td 45.37037 Tz (at ) Tj 0.894444 0 Td 61.574074 Tz (37 ) Tj 1.088889 0 Td 53.472222 Tz (C. ) Tj 40 0 0 40 0 218 Tm 8.05 0 Td 74.583333 Tz (Absorbance ) Tj 4.725 0 Td 73.611111 Tz (measurements ) Tj 5.525 0 Td 63.888889 Tz (are ) Tj 1.375 0 Td 67.708333 Tz (recorded ) Tj 3.425 0 Td 59.166667 Tz (after ) Tj 1.975 0 Td 65 Tz (incubation ) Tj 4.1 0 Td 60.416667 Tz (at ) Tj 0.925 0 Td 70.833333 Tz (a ) Tj 51.428571 0 0 51.428571 0 171.233645 Tm 6.241667 0 Td 56.064815 Tz (wavelength ) Tj 3.597222 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 58.333333 Tz (530 ) Tj 1.302778 0 Td 76.157407 Tz (nm ) Tj 1.166667 0 Td 54.166667 Tz (\(A530\). ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.540541 0 Td 77.252252 Tz (26 ) Tj 51.428571 0 0 51.428571 0 2915.462411 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 1.011111 0 Td 51.203704 Tz (other ) Tj 1.944444 0 Td 45.37037 Tz (studies, ) Tj 2.605556 0 Td 45.37037 Tz (antibiotic ) Tj 3.169444 0 Td 44.560185 Tz (activity ) Tj 2.586111 0 Td 49.537037 Tz (against ) Tj 2.469444 0 Td 43.75 Tz (S. ) Tj 1.011111 0 Td 54.012346 Tz (aureus ) Tj 51.428571 0 0 51.428571 0 2873.228978 Tm 25.219444 0 Td 63.194444 Tz (\(Cowan ) Tj 2.586111 0 Td 35.648148 Tz (I ) Tj 0.525 0 Td 43.981481 Tz (strain\) ) Tj 2.158333 0 Td 37.268519 Tz (is ) Tj 0.758333 0 Td 54.444444 Tz (determined ) Tj 3.558333 0 Td 59.953704 Tz (by ) Tj 1.030556 0 Td 44.650206 Tz (utilizing ) Tj 2.683333 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 54.372428 Tz (remaining ) Tj 51.428571 0 0 51.428571 0 2830.841584 Tm 25.2 0 Td 45.694444 Tz (antibiotic ) Tj 2.955556 0 Td 48.148148 Tz (elution ) Tj 2.236111 0 Td 52.662037 Tz (samples, ) Tj 2.780556 0 Td 43.75 Tz (in ) Tj 0.758333 0 Td 41.835017 Tz (triplicate, ) Tj 2.975 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 46.450617 Tz (turbidity ) Tj 2.722222 0 Td 47.530864 Tz (assay. ) Tj 51.428571 0 0 51.428571 0 2785.157088 Tm 25.219444 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 42.939815 Tz (this ) Tj 1.322222 0 Td 45.730453 Tz (turbidity ) Tj 2.780556 0 Td 46.990741 Tz (study, ) Tj 1.963889 0 Td 48.206019 Tz (solution ) Tj 2.625 0 Td 43.981481 Tz (clarity ) Tj 2.1 0 Td 46.018519 Tz (after ) Tj 1.613889 0 Td 44.722222 Tz (sufficient ) Tj 2.936111 0 Td 69.135802 Tz (bac ) Tj 40 0 0 40 0 2747 Tm 32.375 0 Td 52.777778 Tz (terial ) Tj 2.325 0 Td 65.416667 Tz (incubation ) Tj 4.35 0 Td 66.666667 Tz (with ) Tj 1.975 0 Td 59.166667 Tz (antibiotic ) Tj 3.925 0 Td 61.904762 Tz (eluates ) Tj 3 0 Td 61.111111 Tz (indicates ) Tj 3.675 0 Td 59.722222 Tz (bacterial ) Tj 51.428571 0 0 51.428571 0 2696.95082 Tm 25.2 0 Td 46.990741 Tz (inhibition ) Tj 3.091667 0 Td 57.253086 Tz (due ) Tj 1.263889 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 46.018519 Tz (antibiotic ) Tj 2.994444 0 Td 42.849794 Tz (activity. ) Tj 51.428571 0 0 51.428571 0 2656.252632 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 41.835017 Tz (triplicate, ) Tj 3.013889 0 Td 60.493827 Tz (200 ) Tj 1.361111 0 Td 43.75 Tz (ul ) Tj 0.777778 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 58.333333 Tz (Vancomycin ) Tj 3.772222 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 57.361111 Tz (daptomycin ) Tj 3.675 0 Td 62.654321 Tz (elu ) Tj 51.428571 0 0 51.428571 0 2611.349068 Tm 25.2 0 Td 46.990741 Tz (ates ) Tj 1.341667 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 48.341049 Tz (individually ) Tj 3.675 0 Td 58.981481 Tz (added ) Tj 1.983333 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 56.712963 Tz (inoculum ) Tj 2.955556 0 Td 51.203704 Tz (containing ) Tj 3.344444 0 Td 48.611111 Tz (1.75 ) Tj 51.428571 0 0 51.428571 0 2565.557895 Tm 25.2 0 Td 63.194444 Tz (ml ) Tj 0.952778 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 44.907407 Tz (tryptic ) Tj 2.1 0 Td 55.092593 Tz (soy ) Tj 1.186111 0 Td 51.203704 Tz (broth ) Tj 1.730556 0 Td 60.925926 Tz (\(TSB\) ) Tj 2.002778 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 58.333333 Tz (25 ) Tj 0.952778 0 Td 43.75 Tz (ul ) Tj 0.7 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 40.509259 Tz (S. ) Tj 0.738889 0 Td 54.012346 Tz (aureus ) Tj 2.158333 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 55.092593 Tz (5 ) Tj 0.563889 0 Td 61.574074 Tz (ml ) Tj 51.428571 0 0 51.428571 0 2523.305211 Tm 25.2 0 Td 51.557239 Tz (polystyrene ) Tj 3.616667 0 Td 43.75 Tz (test ) Tj 1.263889 0 Td 47.530864 Tz (tubes. ) Tj 2.022222 0 Td 54.552469 Tz (Blanks ) Tj 2.236111 0 Td 51.203704 Tz (containing ) Tj 3.325 0 Td 48.611111 Tz (neither ) Tj 2.255556 0 Td 40.509259 Tz (S. ) Tj 0.816667 0 Td 54.012346 Tz (aureus ) Tj 51.428571 0 0 51.428571 0 2481.096081 Tm 25.2 0 Td 55.092593 Tz (nor ) Tj 1.244444 0 Td 48.611111 Tz (eluate ) Tj 2.041667 0 Td 52.256944 Tz (samples, ) Tj 2.8 0 Td 48.206019 Tz (positive ) Tj 2.625 0 Td 48.206019 Tz (controls ) Tj 2.625 0 Td 50.87963 Tz (containing ) Tj 3.325 0 Td 42.12963 Tz (S. ) Tj 0.875 0 Td 54.012346 Tz (aureus ) Tj 51.428571 0 0 51.428571 0 2435.740651 Tm 25.180556 0 Td 53.703704 Tz (without ) Tj 2.469444 0 Td 45.694444 Tz (antibiotic ) Tj 2.955556 0 Td 46.180556 Tz (eluates, ) Tj 2.430556 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 51.041667 Tz (negative ) Tj 2.683333 0 Td 48.206019 Tz (controls ) Tj 2.547222 0 Td 51.203704 Tz (containing ) Tj 51.428571 0 0 51.428571 0 2389.672522 Tm 25.180556 0 Td 54.282407 Tz (both ) Tj 1.555556 0 Td 42.12963 Tz (S. ) Tj 0.855556 0 Td 52.932099 Tz (aureus ) Tj 2.177778 0 Td 60.493827 Tz (and ) Tj 1.322222 0 Td 54.282407 Tz (high ) Tj 1.575 0 Td 50.356125 Tz (concentration ) Tj 4.219444 0 Td 45.694444 Tz (antibiotic ) Tj 3.052778 0 Td 50.411523 Tz (standards ) Tj 51.428571 0 0 51.428571 0 2346.906883 Tm 25.2 0 Td 49.691358 Tz (are ) Tj 1.225 0 Td 60.277778 Tz (mixed ) Tj 2.080556 0 Td 60.493827 Tz (and ) Tj 1.4 0 Td 52.572016 Tz (incubated ) Tj 3.130556 0 Td 45.37037 Tz (at ) Tj 0.816667 0 Td 57.253086 Tz (37 ) Tj 1.361111 0 Td 53.472222 Tz (C. ) Tj 0.972222 0 Td 54.444444 Tz (along ) Tj 1.925 0 Td 53.472222 Tz (with ) Tj 1.613889 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 48.611111 Tz (eluate ) Tj 51.428571 0 0 51.428571 0 2303.235223 Tm 25.219444 0 Td 51.851852 Tz (samples. ) Tj 2.625 0 Td 51.851852 Tz (After ) Tj 1.711111 0 Td 56.712963 Tz (24 ) Tj 0.836111 0 Td 53.796296 Tz (hours ) Tj 1.769444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.200337 Tz (incubation, ) Tj 3.422222 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 50.555556 Tz (tubes ) Tj 1.672222 0 Td 50.771605 Tz (are ) Tj 1.088889 0 Td 52.662037 Tz (vortexed ) Tj 40 0 0 40 0 2266 Tm 32.4 0 Td 75 Tz (and ) Tj 1.65 0 Td 62.5 Tz (the ) Tj 1.4 0 Td 70.416667 Tz (absorbance ) Tj 4.475 0 Td 58.333333 Tz (at ) Tj 0.975 0 Td 79.166667 Tz (530 ) Tj 1.725 0 Td 93.75 Tz (nm ) Tj 1.45 0 Td 72.916667 Tz (of ) Tj 1.025 0 Td 71.875 Tz (each ) Tj 2.025 0 Td 72.916667 Tz (inoculum ) Tj 3.8 0 Td 62.5 Tz (solution ) Tj 3.325 0 Td 50 Tz (is ) Tj 51.428571 0 0 51.428571 0 2220.685437 Tm 25.2 0 Td 53.06713 Tz (recorded ) Tj 2.780556 0 Td 53.148148 Tz (using ) Tj 1.808333 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 51.131687 Tz (spectrophotometer. ) Tj 51.428571 0 0 51.428571 0 2171 Tm 25.2 0 Td 48.935185 Tz (Antibiotic ) Tj 3.208333 0 Td 50.771605 Tz (Quantitation ) Tj 51.428571 0 0 51.428571 0 2132.547074 Tm 25.938889 0 Td 52.849003 Tz (High-pressure ) Tj 4.355556 0 Td 46.990741 Tz (liquid ) Tj 1.905556 0 Td 56.944444 Tz (chromatography ) Tj 5.036111 0 Td 65.354938 Tz (\(HPLC\) ) Tj 2.566667 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 55.092593 Tz (used ) Tj 1.575 0 Td 43.75 Tz (to ) Tj 51.428571 0 0 51.428571 0 2087.660517 Tm 25.2 0 Td 50.231481 Tz (quantify ) Tj 2.644444 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 53.472222 Tz (uptake ) Tj 2.138889 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 47.685185 Tz (elution ) Tj 2.236111 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 45.664983 Tz (antibiotics ) Tj 3.247222 0 Td 68.981481 Tz (Vancomy ) Tj 51.428571 0 0 51.428571 0 2041.793451 Tm 25.2 0 Td 49.691358 Tz (cin ) Tj 1.186111 0 Td 57.523148 Tz (from ) Tj 1.691667 0 Td 89.12037 Tz (MP ) Tj 1.341667 0 Td 54.208754 Tz (Biomedicals ) Tj 3.888889 0 Td 44.560185 Tz (\(Irvine, ) Tj 2.430556 0 Td 44.444444 Tz (Calif.\) ) Tj 2.158333 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 57.685185 Tz (daptomycin ) Tj 51.428571 0 0 51.428571 0 2000.709402 Tm 25.2 0 Td 58.333333 Tz (from ) Tj 1.652778 0 Td 52.932099 Tz (Cubist ) Tj 2.197222 0 Td 52.5 Tz (Pharmaceuticals ) Tj 4.977778 0 Td 51.557239 Tz (\(Lexington, ) Tj 3.655556 0 Td 50.462963 Tz (Mass.\). ) Tj 2.352778 0 Td 64.814815 Tz (The ) Tj 1.419444 0 Td 66.975309 Tz (Var ) Tj 51.428571 0 0 51.428571 0 1959.65641 Tm 25.2 0 Td 49.691358 Tz (ian ) Tj 1.205556 0 Td 49.907407 Tz (\(Palo ) Tj 1.75 0 Td 49.259259 Tz (Alto, ) Tj 1.75 0 Td 45.37037 Tz (Calif.\) ) Tj 2.197222 0 Td 76.967593 Tz (HPLC ) Tj 2.158333 0 Td 55.092593 Tz (system ) Tj 2.275 0 Td 56.532922 Tz (comprised ) Tj 3.305556 0 Td 51.851852 Tz (a ) Tj 0.661111 0 Td 52.314815 Tz (ProStar ) Tj 51.428571 0 0 51.428571 0 1918.194313 Tm 25.2 0 Td 60.493827 Tz (240 ) Tj 1.244444 0 Td 53.240741 Tz (Solvent ) Tj 2.411111 0 Td 48.971193 Tz (Delivery, ) Tj 2.819444 0 Td 52.314815 Tz (ProStar ) Tj 2.333333 0 Td 60.493827 Tz (410 ) Tj 1.205556 0 Td 54.282407 Tz (Autosampler, ) Tj 4.044444 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 52.314815 Tz (ProStar ) Tj 40 0 0 40 0 1882 Tm 32.4 0 Td 76.388889 Tz (325 ) Tj 1.875 0 Td 77.083333 Tz (UV-Vis ) Tj 3.3 0 Td 66.666667 Tz (Detector ) Tj 3.625 0 Td 69.791667 Tz (modules. ) Tj 3.85 0 Td 80.555556 Tz (Module ) Tj 3.325 0 Td 63.095238 Tz (control ) Tj 3.1 0 Td 76.388889 Tz (and ) Tj 1.85 0 Td 64.583333 Tz (data ) Tj 51.428571 0 0 51.428571 0 1835.777515 Tm 25.2 0 Td 51.851852 Tz (processing ) Tj 3.286111 0 Td 59.143519 Tz (were ) Tj 1.575 0 Td 56.532922 Tz (performed ) Tj 3.227778 0 Td 53.148148 Tz (using ) Tj 1.769444 0 Td 49.826389 Tz (Varian's ) Tj 2.586111 0 Td 53.703704 Tz (Galaxie ) Tj 2.411111 0 Td 72.376543 Tz (Chroma ) Tj 51.428571 0 0 51.428571 0 1794.858709 Tm 25.180556 0 Td 53.877315 Tz (tography ) Tj 2.838889 0 Td 55.902778 Tz (Data ) Tj 1.613889 0 Td 58.333333 Tz (System ) Tj 2.333333 0 Td 47.863248 Tz (\(v1.8.508.1\). ) Tj 4.044444 0 Td 55.902778 Tz (Both ) Tj 1.594444 0 Td 76.967593 Tz (HPLC ) Tj 2.061111 0 Td 50.231481 Tz (separation ) Tj 51.428571 0 0 51.428571 0 1750.62776 Tm 25.2 0 Td 57.87037 Tz (methods ) Tj 2.702778 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 53.877315 Tz (modified ) Tj 2.838889 0 Td 56.712963 Tz (from ) Tj 1.613889 0 Td 52.256944 Tz (previous ) Tj 2.8 0 Td 47.170782 Tz (research. ) Tj 51.428571 0 0 51.428571 0 1712.747141 Tm 25.938889 0 Td 57.253086 Tz (For ) Tj 1.244444 0 Td 56.712963 Tz (daptomycin ) Tj 3.655556 0 Td 47.453704 Tz (quantification ) Tj 4.219444 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 55.632716 Tz (mobile ) Tj 2.197222 0 Td 56.388889 Tz (phase ) Tj 1.944444 0 Td 47.395833 Tz (consists ) Tj 51.428571 0 0 51.428571 0 1666.856423 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 55.092593 Tz (an ) Tj 0.952778 0 Td 76.157407 Tz (HPLC ) Tj 2.041667 0 Td 55.092593 Tz (grade ) Tj 1.827778 0 Td 45.640432 Tz (acetonitrile ) Tj 3.5 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 53.796296 Tz (water ) Tj 1.827778 0 Td 49.074074 Tz (\(62:38, ) Tj 2.333333 0 Td 47.800926 Tz (V/v\) ) Tj 1.380556 0 Td 59.953704 Tz (solu ) Tj 52.857143 0 0 52.857143 0 1627.818653 Tm 24.5 0 Td 45.720721 Tz (tion ) Tj 1.513514 0 Td 49.74975 Tz (including ) Tj 3.064865 0 Td 59.90991 Tz (4 ) Tj 0.775676 0 Td 96.171171 Tz (mM ) Tj 1.532432 0 Td 66.61036 Tz (ammonium ) Tj 3.651351 0 Td 53.288288 Tz (dihydrogen ) Tj 3.575676 0 Td 53.953954 Tz (phosphate ) Tj 51.428571 0 0 51.428571 0 1587.6267 Tm 25.180556 0 Td 54.62963 Tz (brought ) Tj 2.45 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 72.916667 Tz (pH ) Tj 1.088889 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 52.662037 Tz (3.25 ) Tj 1.438889 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 53.472222 Tz (phosphoric ) Tj 3.422222 0 Td 45.37037 Tz (acid. ) Tj 1.575 0 Td 51.527778 Tz (Separation ) Tj 3.266667 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1542.885246 Tm 25.2 0 Td 55.632716 Tz (accomplished ) Tj 4.355556 0 Td 51.851852 Tz (using ) Tj 1.905556 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 52.932099 Tz (Varian ) Tj 2.236111 0 Td 61.574074 Tz (Microsorb-MV ) Tj 4.744444 0 Td 71.296296 Tz (C8 ) Tj 1.225 0 Td 55.555556 Tz (column, ) Tj 51.428571 0 0 51.428571 0 1499.964613 Tm 25.277778 0 Td 57.253086 Tz (150 ) Tj 1.263889 0 Td 89.12037 Tz (mm ) Tj 1.322222 0 Td 49.691358 Tz (length ) Tj 2.002778 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 48.611111 Tz (4.6 ) Tj 1.127778 0 Td 89.12037 Tz (mm ) Tj 1.302778 0 Td 50.555556 Tz (inner ) Tj 1.730556 0 Td 52.662037 Tz (diameter ) Tj 2.722222 0 Td 53.472222 Tz (with ) Tj 1.516667 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 51.851852 Tz (flow ) Tj 1.536111 0 Td 44.560185 Tz (rate ) Tj 51.428571 0 0 51.428571 0 1459.105866 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 1.030556 0 Td 38.888889 Tz (1 ) Tj 0.7 0 Td 57.79321 Tz (ml/min ) Tj 2.469444 0 Td 59.62963 Tz (Daptomycin ) Tj 3.966667 0 Td 40.509259 Tz (is ) Tj 0.875 0 Td 50.231481 Tz (detected ) Tj 2.761111 0 Td 45.37037 Tz (at ) Tj 0.933333 0 Td 58.333333 Tz (232 ) Tj 1.458333 0 Td 74.537037 Tz (nm ) Tj 1.283333 0 Td 53.472222 Tz (with ) Tj 1.672222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1418.070807 Tm 25.2 0 Td 47.530864 Tz (retention ) Tj 2.819444 0 Td 55.092593 Tz (time ) Tj 1.555556 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (13.8 ) Tj 1.458333 0 Td 54.62963 Tz (minutes ) Tj 2.547222 0 Td 53.148148 Tz (\(min\) ) Tj 1.866667 0 Td 59.305556 Tz (Daptomycin ) Tj 3.830556 0 Td 51.041667 Tz (quantifi ) Tj 51.428571 0 0 51.428571 0 1378.088452 Tm 25.2 0 Td 49.151235 Tz (cation ) Tj 1.963889 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 56.17284 Tz (performed ) Tj 3.227778 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 52.441077 Tz (temperature ) Tj 3.655556 0 Td 53.148148 Tz (range ) Tj 1.75 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 53.292181 Tz (23.3+1.1 ) Tj 3.072222 0 Td 53.472222 Tz (C. ) Tj 51.428571 0 0 51.428571 0 1336.811955 Tm 25.938889 0 Td 57.253086 Tz (For ) Tj 1.186111 0 Td 58.981481 Tz (Vancomycin ) Tj 3.733333 0 Td 46.450617 Tz (quantification, ) Tj 4.375 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 56.17284 Tz (mobile ) Tj 2.177778 0 Td 55.740741 Tz (phase ) Tj 1.886111 0 Td 47.395833 Tz (consists ) Tj 51.428571 0 0 51.428571 0 1291.82793 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 76.967593 Tz (HPLC ) Tj 2.061111 0 Td 53.796296 Tz (grade ) Tj 1.827778 0 Td 45.37037 Tz (acetonitrile ) Tj 3.480556 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 53.796296 Tz (water ) Tj 1.808333 0 Td 46.990741 Tz (\(92:8, ) Tj 1.963889 0 Td 46.990741 Tz (V/v\) ) Tj 1.341667 0 Td 49.421296 Tz (solution ) Tj 51.428571 0 0 51.428571 0 1254.432905 Tm 25.2 0 Td 51.49177 Tz (including ) Tj 2.916667 0 Td 59.953704 Tz (50 ) Tj 0.894444 0 Td 77.12963 Tz (mMammonium ) Tj 4.822222 0 Td 54.768519 Tz (dihydrogen ) Tj 3.461111 0 Td 54.73251 Tz (phosphate ) Tj 3.091667 0 Td 54.62963 Tz (brought ) Tj 51.428571 0 0 51.428571 0 1212.802111 Tm 25.180556 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 76.157407 Tz (pH ) Tj 1.205556 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 61.574074 Tz (4 ) Tj 0.641667 0 Td 52.5 Tz (using ) Tj 1.827778 0 Td 54.12037 Tz (phosphoric ) Tj 3.538889 0 Td 45.37037 Tz (acid. ) Tj 1.652778 0 Td 51.851852 Tz (Separation ) Tj 3.402778 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 71.296296 Tz (accom ) Tj 51.428571 0 0 51.428571 0 1167.831912 Tm 25.2 0 Td 50 Tz (plished ) Tj 2.294444 0 Td 51.851852 Tz (using ) Tj 1.730556 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 52.391975 Tz (Varian ) Tj 2.1 0 Td 66.435185 Tz (Microsorb-MVCs ) Tj 5.852778 0 Td 56.018519 Tz (column, ) Tj 2.605556 0 Td 58.333333 Tz (150 ) Tj 1.263889 0 Td 92.361111 Tz (mm ) Tj 51.428571 0 0 51.428571 0 1125.056818 Tm 25.2 0 Td 50.231481 Tz (length ) Tj 2.138889 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 48.611111 Tz (4.6 ) Tj 1.244444 0 Td 89.12037 Tz (mm ) Tj 1.438889 0 Td 49.907407 Tz (inner ) Tj 1.788889 0 Td 53.877315 Tz (diameter ) Tj 2.877778 0 Td 53.472222 Tz (with ) Tj 1.594444 0 Td 55.092593 Tz (a ) Tj 0.680556 0 Td 51.041667 Tz (flow ) Tj 1.633333 0 Td 44.560185 Tz (rate ) Tj 1.380556 0 Td 56.712963 Tz (of ) Tj 0.991667 0 Td 35.648148 Tz (1 ) Tj 51.428571 0 0 51.428571 0 1084.818182 Tm 25.2 0 Td 57.79321 Tz (ml/min ) Tj 2.275 0 Td 59.953704 Tz (Vancomycin ) Tj 3.791667 0 Td 60.493827 Tz (was ) Tj 1.283333 0 Td 50.231481 Tz (detected ) Tj 2.547222 0 Td 46.990741 Tz (at ) Tj 0.719444 0 Td 59.41358 Tz (208 ) Tj 1.283333 0 Td 71.296296 Tz (nm ) Tj 1.05 0 Td 52.662037 Tz (with ) Tj 1.419444 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 47.530864 Tz (retention ) Tj 51.428571 0 0 51.428571 0 1046.294545 Tm 25.180556 0 Td 55.092593 Tz (time ) Tj 1.497222 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 52.662037 Tz (24.4 ) Tj 1.497222 0 Td 61.574074 Tz (min ) Tj 1.302778 0 Td 59.62963 Tz (Vancomycin ) Tj 3.772222 0 Td 47.685185 Tz (quantification ) Tj 4.2 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 56.17284 Tz (performed ) Tj 3.227778 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 1004.242915 Tm 25.2 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 53.030303 Tz (temperature ) Tj 3.752778 0 Td 53.148148 Tz (range ) Tj 1.808333 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 52.572016 Tz (23.3+1.1 ) Tj 3.091667 0 Td 53.472222 Tz (C. ) Tj 40 0 0 40 0 966 Tm 32.4 0 Td 72.916667 Tz (Film ) Tj 2.125 0 Td 64.285714 Tz (Elution ) Tj 3 0 Td 63.333333 Tz (Tests ) Tj 51.428571 0 0 51.428571 0 921.995633 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.991667 0 Td 58.333333 Tz (one ) Tj 1.458333 0 Td 52.572016 Tz (approach, ) Tj 3.247222 0 Td 55.555556 Tz (Samples ) Tj 2.741667 0 Td 49.691358 Tz (are ) Tj 1.302778 0 Td 58.693416 Tz (Submerged ) Tj 3.558333 0 Td 46.180556 Tz (into ) Tj 1.594444 0 Td 53.472222 Tz (15 ) Tj 1.088889 0 Td 61.574074 Tz (ml ) Tj 51.428571 0 0 51.428571 0 877.313878 Tm 25.2 0 Td 55.092593 Tz (amikacin ) Tj 2.936111 0 Td 48.611111 Tz (solution ) Tj 2.625 0 Td 46.990741 Tz (\(5 ) Tj 0.875 0 Td 59.41358 Tz (mg/ml\) ) Tj 2.372222 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 55.092593 Tz (allowed ) Tj 2.605556 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 52.314815 Tz (hydrate ) Tj 2.469444 0 Td 47.530864 Tz (for ) Tj 1.108333 0 Td 55.092593 Tz (2 ) Tj 51.428571 0 0 51.428571 0 836.317872 Tm 25.2 0 Td 50.636574 Tz (minutes. ) Tj 2.877778 0 Td 57.87037 Tz (Samples ) Tj 2.819444 0 Td 49.691358 Tz (are ) Tj 1.283333 0 Td 51.041667 Tz (then ) Tj 1.633333 0 Td 50.771605 Tz (subjected ) Tj 3.130556 0 Td 42.12963 Tz (to ) Tj 0.913889 0 Td 48.148148 Tz (elution ) Tj 2.430556 0 Td 42.12963 Tz (tests ) Tj 1.633333 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 795.489362 Tm 25.219444 0 Td 56.712963 Tz (submerging ) Tj 3.713889 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 47.314815 Tz (films ) Tj 1.75 0 Td 43.75 Tz (in ) Tj 0.875 0 Td 61.574074 Tz (50 ) Tj 1.05 0 Td 59.953704 Tz (ml ) Tj 1.011111 0 Td 61.574074 Tz (of ) Tj 0.991667 0 Td 58.333333 Tz (1x ) Tj 1.030556 0 Td 55.092593 Tz (Phosphate ) Tj 3.325 0 Td 52.256944 Tz (Buffered ) Tj 51.428571 0 0 51.428571 0 751.356125 Tm 25.219444 0 Td 50.231481 Tz (Saline ) Tj 2.197222 0 Td 59.62963 Tz (\(PBS\) ) Tj 2.158333 0 Td 59.41358 Tz (and ) Tj 1.438889 0 Td 48.206019 Tz (agitated ) Tj 2.702778 0 Td 46.990741 Tz (in ) Tj 0.952778 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 61.574074 Tz (37 ) Tj 1.127778 0 Td 81.018519 Tz (C ) Tj 0.875 0 Td 51.49177 Tz (incubator ) Tj 3.15 0 Td 48.611111 Tz (for ) Tj 1.225 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 711.120104 Tm 25.2 0 Td 50.231481 Tz (duration ) Tj 2.625 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 45.910494 Tz (study. ) Tj 1.905556 0 Td 68.055556 Tz (One ) Tj 1.458333 0 Td 61.574074 Tz (ml ) Tj 0.972222 0 Td 47.800926 Tz (aliquots ) Tj 2.527778 0 Td 50.771605 Tz (are ) Tj 1.147222 0 Td 60.185185 Tz (removed ) Tj 2.761111 0 Td 42.12963 Tz (at ) Tj 0.816667 0 Td 38.888889 Tz (1, ) Tj 0.680556 0 Td 45.37037 Tz (3, ) Tj 51.428571 0 0 51.428571 0 668.360107 Tm 25.219444 0 Td 43.75 Tz (6, ) Tj 0.836111 0 Td 48.611111 Tz (24, ) Tj 1.166667 0 Td 50.771605 Tz (48, ) Tj 1.205556 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 58.333333 Tz (72 ) Tj 1.011111 0 Td 49.151235 Tz (hours. ) Tj 2.061111 0 Td 51.446759 Tz (Aliquots ) Tj 2.761111 0 Td 50.771605 Tz (are ) Tj 1.205556 0 Td 46.990741 Tz (tested ) Tj 1.963889 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 45.694444 Tz (antibiotic ) Tj 51.428571 0 0 51.428571 0 628.494005 Tm 25.2 0 Td 50.605413 Tz (concentration ) Tj 4.219444 0 Td 52.5 Tz (using ) Tj 1.788889 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (fluorescence ) Tj 3.85 0 Td 48.341049 Tz (polarization ) Tj 3.752778 0 Td 67.650463 Tz (immunoas ) Tj 51.428571 0 0 51.428571 0 586.01297 Tm 25.219444 0 Td 51.851852 Tz (say ) Tj 1.186111 0 Td 52.572016 Tz (technique ) Tj 3.072222 0 Td 61.168981 Tz (\(TDXFLX. ) Tj 3.169444 0 Td 56.712963 Tz (Abbott ) Tj 2.313889 0 Td 51.851852 Tz (Labs, ) Tj 1.75 0 Td 56.712963 Tz (Abbott ) Tj 2.313889 0 Td 48.611111 Tz (Park, ) Tj 1.75 0 Td 32.947531 Tz (Ill.\). ) Tj 51.428571 0 0 51.428571 0 543.507097 Tm 25.938889 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 52.777778 Tz (another ) Tj 2.391667 0 Td 52.572016 Tz (approach, ) Tj 3.052778 0 Td 43.75 Tz (lactic ) Tj 1.769444 0 Td 51.041667 Tz (acid ) Tj 1.438889 0 Td 47.962963 Tz (films ) Tj 1.672222 0 Td 52.662037 Tz (with ) Tj 1.477778 0 Td 49.259259 Tz (three ) Tj 1.691667 0 Td 45.37037 Tz (different ) Tj 51.428571 0 0 51.428571 0 505.801968 Tm 25.2 0 Td 52.777778 Tz (degrees ) Tj 2.469444 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 49.608262 Tz (deacetylation ) Tj 4.122222 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 57.523148 Tz (measured ) Tj 3.013889 0 Td 47.530864 Tz (for ) Tj 1.088889 0 Td 56.712963 Tz (daptomycin ) Tj 3.655556 0 Td 62.654321 Tz (elu ) Tj 51.428571 0 0 51.428571 0 461.371464 Tm 25.180556 0 Td 44.074074 Tz (tion, ) Tj 1.497222 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 46.990741 Tz (acetic ) Tj 1.886111 0 Td 50.231481 Tz (acid ) Tj 1.419444 0 Td 47.314815 Tz (films ) Tj 1.613889 0 Td 52.662037 Tz (with ) Tj 1.516667 0 Td 45.010288 Tz (different ) Tj 2.625 0 Td 52.777778 Tz (degrees ) Tj 2.391667 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 58.796296 Tz (deacety ) Tj 51.428571 0 0 51.428571 0 419.881137 Tm 25.2 0 Td 45.37037 Tz (lation ) Tj 1.983333 0 Td 50.771605 Tz (are ) Tj 1.283333 0 Td 57.523148 Tz (measured ) Tj 3.111111 0 Td 46.450617 Tz (for ) Tj 1.166667 0 Td 58.981481 Tz (Vancomycin ) Tj 3.888889 0 Td 45.37037 Tz (elution. ) Tj 2.527778 0 Td 62.654321 Tz (The ) Tj 1.458333 0 Td 49.074074 Tz (elution ) Tj 51.428571 0 0 51.428571 0 382.500605 Tm 25.2 0 Td 55.092593 Tz (experiment ) Tj 3.461111 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 56.532922 Tz (performed ) Tj 3.208333 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 43.425926 Tz (triplicate ) Tj 2.780556 0 Td 58.333333 Tz (by ) Tj 0.894444 0 Td 56.712963 Tz (Submerging ) Tj 3.597222 0 Td 47.962963 Tz (films ) Tj 1.633333 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 338.616438 Tm 25.219444 0 Td 61.574074 Tz (50 ) Tj 1.147222 0 Td 59.953704 Tz (ml ) Tj 1.127778 0 Td 59.953704 Tz (of ) Tj 1.030556 0 Td 70.216049 Tz (PBS ) Tj 1.691667 0 Td 54.79798 Tz (immediately ) Tj 4.063889 0 Td 51.851852 Tz (following ) Tj 3.208333 0 Td 45.37037 Tz (in ) Tj 0.972222 0 Td 42.939815 Tz (situ ) Tj 1.438889 0 Td 46.018519 Tz (antibiotic ) Tj 51.428571 0 0 51.428571 0 296.783355 Tm 25.2 0 Td 51.851852 Tz (loading ) Tj 2.547222 0 Td 46.990741 Tz (at ) Tj 0.875 0 Td 58.333333 Tz (3 ) Tj 0.777778 0 Td 61.574074 Tz (mg/ml ) Tj 2.216667 0 Td 59.953704 Tz (of ) Tj 0.952778 0 Td 44.486532 Tz (antibiotic. ) Tj 3.305556 0 Td 63.734568 Tz (The ) Tj 1.477778 0 Td 48.611111 Tz (elution ) Tj 2.391667 0 Td 54.372428 Tz (procedure ) Tj 51.428571 0 0 51.428571 0 251.841051 Tm 25.2 0 Td 52.662037 Tz (excludes ) Tj 2.8 0 Td 70.216049 Tz (PBS ) Tj 1.516667 0 Td 48.206019 Tz (solution ) Tj 2.586111 0 Td 52.441077 Tz (refreshment ) Tj 3.655556 0 Td 46.990741 Tz (at ) Tj 0.777778 0 Td 55.092593 Tz (each ) Tj 1.575 0 Td 54.282407 Tz (time ) Tj 1.516667 0 Td 45.37037 Tz (point. ) Tj 1.905556 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 211.273954 Tm 25.2 0 Td 47.962963 Tz (films ) Tj 1.691667 0 Td 50.771605 Tz (are ) Tj 1.205556 0 Td 50.231481 Tz (then ) Tj 1.497222 0 Td 51.851852 Tz (incubated ) Tj 3.091667 0 Td 42.12963 Tz (at ) Tj 0.777778 0 Td 55.092593 Tz (37 ) Tj 1.283333 0 Td 53.472222 Tz (C. ) Tj 0.933333 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 49.691358 Tz (0.5 ) Tj 1.205556 0 Td 59.953704 Tz (ml ) Tj 0.991667 0 Td 47.800926 Tz (aliquots ) Tj 2.547222 0 Td 51.851852 Tz (are ) Tj 48.571429 0 0 48.571429 0 170 Tm 26.682353 0 Td 64.215686 Tz (removed ) Tj 2.902941 0 Td 49.754902 Tz (at ) Tj 0.864706 0 Td 42.892157 Tz (1, ) Tj 0.741176 0 Td 48.039216 Tz (3, ) Tj 0.823529 0 Td 46.323529 Tz (6, ) Tj 0.844118 0 Td 50.326797 Tz (12, ) Tj 1.111765 0 Td 54.901961 Tz (24, ) Tj 1.214706 0 Td 53.75817 Tz (48, ) Tj 1.194118 0 Td 61.764706 Tz (and ) Tj 1.338235 0 Td 63.480392 Tz (72 ) Tj 1.008824 0 Td 52.042484 Tz (hours. ) Tj 2.1 0 Td 67.48366 Tz (The ) Tj 1.420588 0 Td 48.382353 Tz (antibiotic ) Tj ET Q endstream endobj 145 0 obj << /Length 1 >> stream q endstream endobj 146 0 obj << /Length 50494 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.113514 0 Td 78.828829 Tz (27 ) Tj 51.428571 0 0 51.428571 0 2915.117955 Tm 6.261111 0 Td 50.462963 Tz (concentrations ) Tj 4.705556 0 Td 58.333333 Tz (of ) Tj 1.05 0 Td 50.231481 Tz (eluant ) Tj 2.255556 0 Td 55.555556 Tz (samples ) Tj 2.8 0 Td 49.691358 Tz (are ) Tj 1.361111 0 Td 54.444444 Tz (determined ) Tj 3.713889 0 Td 53.148148 Tz (using ) Tj 51.428571 0 0 51.428571 0 2873.017995 Tm 6.280556 0 Td 76.967593 Tz (HPLC ) Tj 2.138889 0 Td 45.37037 Tz (to ) Tj 0.836111 0 Td 50.231481 Tz (obtain ) Tj 2.119444 0 Td 55.092593 Tz (an ) Tj 0.972222 0 Td 47.685185 Tz (elution ) Tj 2.294444 0 Td 45.833333 Tz (profile ) Tj 2.197222 0 Td 49.691358 Tz (for ) Tj 1.127778 0 Td 55.902778 Tz (each ) Tj 1.652778 0 Td 45.58642 Tz (film/antibiotic ) Tj 40 0 0 40 0 2838 Tm 8.05 0 Td 67.708333 Tz (combination. ) Tj 51.428571 0 0 51.428571 0 2793.769821 Tm 7 0 Td 53.580247 Tz (Advantageously, ) Tj 5.094444 0 Td 49.151235 Tz (lyophilizing ) Tj 3.752778 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 50.231481 Tz (buffered ) Tj 2.683333 0 Td 46.990741 Tz (film ) Tj 1.380556 0 Td 54.282407 Tz (produces ) Tj 2.877778 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2751.853755 Tm 6.241667 0 Td 51.851852 Tz (highly ) Tj 2.119444 0 Td 54.012346 Tz (porous ) Tj 2.216667 0 Td 51.388889 Tz (coating ) Tj 2.391667 0 Td 59.953704 Tz (on ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.990741 Tz (Surface. ) Tj 51.428571 0 0 51.428571 0 2709.929293 Tm 6.261111 0 Td 49.421296 Tz (Activity ) Tj 2.605556 0 Td 49.259259 Tz (Tests ) Tj 51.428571 0 0 51.428571 0 2669.692308 Tm 7.019444 0 Td 61.574074 Tz (Drug ) Tj 1.75 0 Td 45.37037 Tz (activity ) Tj 2.508333 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 47.800926 Tz (aliquots ) Tj 2.605556 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 46.450617 Tz (tested ) Tj 1.983333 0 Td 53.148148 Tz (using ) Tj 1.866667 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 46.8107 Tz (turbidity ) Tj 51.428571 0 0 51.428571 0 2626.748201 Tm 6.261111 0 Td 46.990741 Tz (assay. ) Tj 1.925 0 Td 57.87037 Tz (Samples ) Tj 2.625 0 Td 50.771605 Tz (are ) Tj 1.088889 0 Td 47.530864 Tz (tested ) Tj 1.866667 0 Td 50 Tz (against ) Tj 2.333333 0 Td 60.10101 Tz (Pseudomonas ) Tj 4.2 0 Td 51.557239 Tz (aeruginosa. ) Tj 51.428571 0 0 51.428571 0 2584.64219 Tm 6.280556 0 Td 57.87037 Tz (Samples ) Tj 2.761111 0 Td 55.092593 Tz (\(200 ) Tj 1.633333 0 Td 43.209877 Tz (ul\) ) Tj 1.05 0 Td 49.691358 Tz (are ) Tj 1.147222 0 Td 58.981481 Tz (added ) Tj 2.041667 0 Td 46.990741 Tz (to ) Tj 0.933333 0 Td 49.421296 Tz (1.75 ) Tj 1.497222 0 Td 59.953704 Tz (ml ) Tj 1.05 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 51.203704 Tz (Trypticase ) Tj 3.363889 0 Td 62.654321 Tz (Soy ) Tj 51.428571 0 0 51.428571 0 2541.94 Tm 6.280556 0 Td 54.444444 Tz (Broth ) Tj 1.847222 0 Td 60.925926 Tz (\(TSB\) ) Tj 2.002778 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 61.574074 Tz (50 ) Tj 0.952778 0 Td 43.75 Tz (ul ) Tj 0.738889 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 68.055556 Tz (P ) Tj 0.680556 0 Td 54.12037 Tz (aeruginosa ) Tj 3.480556 0 Td 54.012346 Tz (inoculum. ) Tj 3.130556 0 Td 58.796296 Tz (Samples ) Tj 40 0 0 40 0 2505 Tm 8.05 0 Td 63.888889 Tz (are ) Tj 1.525 0 Td 67.12963 Tz (incubated ) Tj 4 0 Td 61.111111 Tz (for ) Tj 1.425 0 Td 79.166667 Tz (24 ) Tj 1.3 0 Td 69.166667 Tz (hours ) Tj 2.45 0 Td 56.25 Tz (at ) Tj 1.025 0 Td 77.083333 Tz (37 ) Tj 1.3 0 Td 68.75 Tz (C. ) Tj 1.2 0 Td 74.166667 Tz (Absorbance ) Tj 4.825 0 Td 80.952381 Tz (measure ) Tj 51.428571 0 0 51.428571 0 2459.216138 Tm 6.261111 0 Td 57.685185 Tz (ments ) Tj 1.963889 0 Td 46.990741 Tz (at ) Tj 0.797222 0 Td 60.493827 Tz (530 ) Tj 1.361111 0 Td 72.916667 Tz (nm ) Tj 1.127778 0 Td 59.953704 Tz (on ) Tj 0.972222 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 53.186275 Tz (spectrophotometer ) Tj 5.638889 0 Td 51.49177 Tz (\(BioTek\). ) Tj 51.428571 0 0 51.428571 0 2419.733333 Tm 6.280556 0 Td 55.092593 Tz (Film ) Tj 1.633333 0 Td 50.673401 Tz (Preparation ) Tj 51.428571 0 0 51.428571 0 2377.278075 Tm 7.019444 0 Td 57.037037 Tz (Using ) Tj 2.022222 0 Td 49.259259 Tz (three ) Tj 1.788889 0 Td 50.231481 Tz (chitosan ) Tj 2.761111 0 Td 54.012346 Tz (degree ) Tj 2.255556 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 49.074074 Tz (deacetylations ) Tj 4.452778 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 61.574074 Tz (two ) Tj 48.571429 0 0 48.571429 0 2333 Tm 6.629412 0 Td 54.044118 Tz (acid ) Tj 1.688235 0 Td 49.945534 Tz (solvents, ) Tj 3.108824 0 Td 49.183007 Tz (six ) Tj 1.276471 0 Td 53.186275 Tz (chitosan ) Tj 2.964706 0 Td 50.098039 Tz (variations ) Tj 3.397059 0 Td 53.75817 Tz (are ) Tj 1.338235 0 Td 52.156863 Tz (evaluated. ) Tj 3.520588 0 Td 67.48366 Tz (The ) Tj 51.428571 0 0 51.428571 0 2291.016688 Tm 6.261111 0 Td 59.259259 Tz (numbers ) Tj 2.741667 0 Td 47.530864 Tz (61, ) Tj 1.069444 0 Td 48.611111 Tz (71, ) Tj 1.05 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 61.574074 Tz (80 ) Tj 0.913889 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 55.092593 Tz (used ) Tj 1.497222 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 48.206019 Tz (indicate ) Tj 2.508333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 87.5 Tz (% ) Tj 0.758333 0 Td 53.472222 Tz (degree ) Tj 2.1 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 2250.122667 Tm 6.261111 0 Td 49.608262 Tz (deacetylation ) Tj 4.297222 0 Td 61.574074 Tz (\(DDA\); ) Tj 2.644444 0 Td 49.691358 Tz (the ) Tj 1.302778 0 Td 50.231481 Tz (acid ) Tj 1.633333 0 Td 46.8107 Tz (solvents, ) Tj 2.975 0 Td 42.669753 Tz (lactic ) Tj 1.944444 0 Td 51.041667 Tz (acid ) Tj 1.594444 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 2207.986649 Tm 6.261111 0 Td 46.990741 Tz (acetic ) Tj 1.944444 0 Td 46.018519 Tz (acid, ) Tj 1.613889 0 Td 50.771605 Tz (are ) Tj 1.127778 0 Td 51.851852 Tz (abbreviated ) Tj 3.675 0 Td 79.398148 Tz (LA ) Tj 1.127778 0 Td 60.493827 Tz (and ) Tj 1.361111 0 Td 62.384259 Tz (HAc, ) Tj 1.769444 0 Td 46.367521 Tz (respectively. ) Tj 51.428571 0 0 51.428571 0 2166.196359 Tm 7.019444 0 Td 57.79321 Tz (Primex ) Tj 2.313889 0 Td 54.12037 Tz (ChitoClear ) Tj 3.480556 0 Td 48.971193 Tz (\(Iceland\) ) Tj 2.877778 0 Td 50.636574 Tz (chitosan ) Tj 2.683333 0 Td 62.114198 Tz (powder ) Tj 2.469444 0 Td 45.37037 Tz (at ) Tj 0.816667 0 Td 48.611111 Tz (61, ) Tj 1.147222 0 Td 49.691358 Tz (71, ) Tj 51.428571 0 0 51.428571 0 2126.073739 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 74.537037 Tz (80% ) Tj 1.613889 0 Td 52.932099 Tz (degree ) Tj 2.177778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.608262 Tz (deacetylation ) Tj 4.141667 0 Td 53.472222 Tz (with ) Tj 1.613889 0 Td 49.421296 Tz (124, ) Tj 1.516667 0 Td 51.851852 Tz (1480, ) Tj 1.847222 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 59.41358 Tz (332 ) Tj 51.428571 0 0 51.428571 0 2083.81774 Tm 6.261111 0 Td 65.625 Tz (mPas ) Tj 1.75 0 Td 44.560185 Tz (Viscosities, ) Tj 3.363889 0 Td 46.616809 Tz (respectively, ) Tj 3.830556 0 Td 48.611111 Tz (are ) Tj 1.069444 0 Td 55.092593 Tz (used ) Tj 1.458333 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 48.070988 Tz (create ) Tj 1.866667 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 44.830247 Tz (films. ) Tj 1.75 0 Td 90.740741 Tz (A ) Tj 51.428571 0 0 51.428571 0 2043.286979 Tm 6.338889 0 Td 59.143519 Tz (1.5% ) Tj 1.691667 0 Td 52.5 Tz (\(w/v\) ) Tj 1.808333 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 48.206019 Tz (solution ) Tj 2.566667 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 53.877315 Tz (prepared ) Tj 2.8 0 Td 61.574074 Tz (by ) Tj 0.991667 0 Td 49.907407 Tz (dissolving ) Tj 3.266667 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 1999 Tm 6.261111 0 Td 50 Tz (desired ) Tj 2.469444 0 Td 47.170782 Tz (variation ) Tj 2.897222 0 Td 46.990741 Tz (in ) Tj 0.913889 0 Td 46.990741 Tz (either ) Tj 2.061111 0 Td 74.537037 Tz (1% ) Tj 1.263889 0 Td 47.314815 Tz (\(v/v\) ) Tj 1.730556 0 Td 46.990741 Tz (acetic ) Tj 2.061111 0 Td 53.472222 Tz (or ) Tj 0.933333 0 Td 43.75 Tz (lactic ) Tj 1.905556 0 Td 52.662037 Tz (acid ) Tj 51.428571 0 0 51.428571 0 1958.058252 Tm 6.280556 0 Td 46.090535 Tz (Solution, ) Tj 2.683333 0 Td 55.740741 Tz (under ) Tj 1.808333 0 Td 50.231481 Tz (constant ) Tj 2.547222 0 Td 44.155093 Tz (stirring ) Tj 2.275 0 Td 47.530864 Tz (for ) Tj 1.011111 0 Td 58.333333 Tz (24 ) Tj 0.836111 0 Td 53.796296 Tz (hours ) Tj 1.808333 0 Td 40.833333 Tz (\(hr\). ) Tj 1.361111 0 Td 63.194444 Tz (To ) Tj 0.952778 0 Td 60.493827 Tz (remove ) Tj 51.428571 0 0 51.428571 0 1916.126354 Tm 6.261111 0 Td 44.675926 Tz (insolubilities ) Tj 3.908333 0 Td 59.143519 Tz (from ) Tj 1.575 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 50.231481 Tz (chitosan ) Tj 2.566667 0 Td 46.450617 Tz (solution, ) Tj 2.702778 0 Td 34.027778 Tz (it ) Tj 0.563889 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 42.534722 Tz (filtered ) Tj 2.216667 0 Td 54.166667 Tz (through ) Tj 51.428571 0 0 51.428571 0 1876.830441 Tm 6.319444 0 Td 58.333333 Tz (180 ) Tj 1.341667 0 Td 71.296296 Tz (um ) Tj 1.147222 0 Td 50.231481 Tz (nylon, ) Tj 2.080556 0 Td 52.391975 Tz (placed ) Tj 2.138889 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 48.611111 Tz (glass ) Tj 1.75 0 Td 61.574074 Tz (mold ) Tj 1.730556 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 48.021886 Tz (transferred ) Tj 3.402778 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1834.17734 Tm 6.261111 0 Td 53.148148 Tz (convection ) Tj 3.344444 0 Td 58.333333 Tz (oven ) Tj 1.575 0 Td 46.990741 Tz (at ) Tj 0.7 0 Td 54.012346 Tz (60 ) Tj 1.127778 0 Td 55.092593 Tz (C. ) Tj 0.875 0 Td 43.425926 Tz (until ) Tj 1.477778 0 Td 44.560185 Tz (dry. ) Tj 1.225 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 53.796296 Tz (dehydrated ) Tj 3.383333 0 Td 47.800926 Tz (film ) Tj 1.341667 0 Td 61.574074 Tz (was ) Tj 51.428571 0 0 51.428571 0 1792.454545 Tm 6.261111 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 48.316498 Tz (neutralized ) Tj 3.363889 0 Td 58.333333 Tz (by ) Tj 0.875 0 Td 50.925926 Tz (placing ) Tj 2.333333 0 Td 34.027778 Tz (it ) Tj 0.583333 0 Td 45.37037 Tz (in ) Tj 0.7 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 77.777778 Tz (NaOH ) Tj 2.061111 0 Td 48.206019 Tz (solution ) Tj 2.508333 0 Td 54.282407 Tz (followed ) Tj 51.428571 0 0 51.428571 0 1751.928177 Tm 6.241667 0 Td 61.574074 Tz (by ) Tj 1.069444 0 Td 47.685185 Tz (rinsing ) Tj 2.313889 0 Td 45.37037 Tz (in ) Tj 0.855556 0 Td 48.070988 Tz (water. ) Tj 2.022222 0 Td 59.953704 Tz (At ) Tj 1.011111 0 Td 42.939815 Tz (this ) Tj 1.361111 0 Td 45.910494 Tz (point, ) Tj 1.963889 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 46.990741 Tz (film ) Tj 1.458333 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 50.636574 Tz (buffered ) Tj 2.702778 0 Td 63.194444 Tz (by ) Tj 51.428571 0 0 51.428571 0 1709.699208 Tm 6.280556 0 Td 53.703704 Tz (soaking ) Tj 2.488889 0 Td 35.648148 Tz (it ) Tj 0.661111 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 63.518519 Tz (0.25M ) Tj 2.158333 0 Td 48.611111 Tz (acetate ) Tj 2.275 0 Td 48.611111 Tz (buffer ) Tj 2.002778 0 Td 48.206019 Tz (solution ) Tj 2.566667 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 72.916667 Tz (pH ) Tj 1.147222 0 Td 48.611111 Tz (5.6 ) Tj 1.147222 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1667.324905 Tm 6.241667 0 Td 43.75 Tz (thirty ) Tj 1.827778 0 Td 50.636574 Tz (minutes. ) Tj 2.644444 0 Td 62.654321 Tz (The ) Tj 1.322222 0 Td 50.231481 Tz (buffered ) Tj 2.625 0 Td 46.990741 Tz (film ) Tj 1.361111 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 54.166667 Tz (allowed ) Tj 2.488889 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 54.012346 Tz (dry ) Tj 1.147222 0 Td 46.990741 Tz (at ) Tj 0.738889 0 Td 62.222222 Tz (25C. ) Tj 52.857143 0 0 52.857143 0 1624.591281 Tm 6.82973 0 Td 45.720721 Tz (In ) Tj 0.851351 0 Td 51.351351 Tz (another ) Tj 2.440541 0 Td 51.151151 Tz (approach, ) Tj 3.064865 0 Td 50.45045 Tz (a ) Tj 0.624324 0 Td 48.873874 Tz (chitosan ) Tj 2.667568 0 Td 47.297297 Tz (solution ) Tj 2.554054 0 Td 45.720721 Tz (that ) Tj 1.4 0 Td 56.756757 Tz (had ) Tj 1.305405 0 Td 57.545045 Tz (been ) Tj 51.428571 0 0 51.428571 0 1584.160982 Tm 6.261111 0 Td 42.939815 Tz (filtered ) Tj 2.411111 0 Td 52.777778 Tz (through ) Tj 2.566667 0 Td 53.472222 Tz (an ) Tj 1.088889 0 Td 57.253086 Tz (180 ) Tj 1.4 0 Td 69.675926 Tz (um ) Tj 1.205556 0 Td 54.444444 Tz (nylon ) Tj 1.983333 0 Td 50.771605 Tz (screen ) Tj 2.158333 0 Td 62.654321 Tz (was ) Tj 1.458333 0 Td 55.092593 Tz (allowed ) Tj 2.625 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1541.959839 Tm 6.261111 0 Td 55.092593 Tz (degas ) Tj 1.944444 0 Td 45.37037 Tz (at ) Tj 0.836111 0 Td 55.092593 Tz (20 ) Tj 1.283333 0 Td 55.092593 Tz (C. ) Tj 0.952778 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 49.016204 Tz (solution ) Tj 2.644444 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 52.932099 Tz (placed ) Tj 2.216667 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 55.092593 Tz (a ) Tj 0.641667 0 Td 50.605413 Tz (flat-bottomed ) Tj 57.142857 0 0 57.142857 0 1501.945223 Tm 5.635 0 Td 43.75 Tz (glass ) Tj 1.4875 0 Td 44.479167 Tz (dish ) Tj 1.2775 0 Td 40.833333 Tz (at ) Tj 0.665 0 Td 48.012821 Tz (approximately ) Tj 3.9725 0 Td 43.75 Tz (0.8 ) Tj 1.015 0 Td 54.833333 Tz (ml/cm ) Tj 2.0825 0 Td 53.472222 Tz (and ) Tj 1.1375 0 Td 44.722222 Tz (the ) Tj 0.98 0 Td 45.416667 Tz (solvent ) Tj 2.0825 0 Td 56.388889 Tz (was ) Tj 51.428571 0 0 51.428571 0 1458.505762 Tm 6.261111 0 Td 54.62963 Tz (allowed ) Tj 2.547222 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 52.932099 Tz (evaporate ) Tj 3.091667 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 53.148148 Tz (convection ) Tj 3.441667 0 Td 58.333333 Tz (oven ) Tj 1.613889 0 Td 46.990741 Tz (at ) Tj 0.777778 0 Td 62.87037 Tz (38C. ) Tj 2.158333 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 59.953704 Tz (24 ) Tj 51.428571 0 0 51.428571 0 1416.948016 Tm 6.241667 0 Td 44.560185 Tz (hrs. ) Tj 1.438889 0 Td 53.472222 Tz (This ) Tj 1.633333 0 Td 56.30787 Tz (produced ) Tj 3.052778 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 48.611111 Tz (dried ) Tj 1.827778 0 Td 47.800926 Tz (film ) Tj 1.536111 0 Td 58.981481 Tz (which ) Tj 2.119444 0 Td 40.509259 Tz (is ) Tj 0.875 0 Td 48.611111 Tz (neutralized ) Tj 3.538889 0 Td 63.194444 Tz (by ) Tj 51.428571 0 0 51.428571 0 1378.747253 Tm 6.261111 0 Td 53.240741 Tz (dipping ) Tj 2.411111 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 47.800926 Tz (film ) Tj 1.341667 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 58.333333 Tz (2 ) Tj 0.544444 0 Td 103.703704 Tz (M ) Tj 0.816667 0 Td 57.79321 Tz (sodium ) Tj 2.255556 0 Td 55.092593 Tz (hydroxide ) Tj 3.15 0 Td 47.530864 Tz (for ) Tj 0.972222 0 Td 54.344729 Tz (approximately ) Tj 51.428571 0 0 51.428571 0 1333.56962 Tm 6.338889 0 Td 32.407407 Tz (1 ) Tj 0.525 0 Td 45.37037 Tz (sec, ) Tj 1.322222 0 Td 53.877315 Tz (followed ) Tj 2.819444 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 54.62963 Tz (pouring ) Tj 2.527778 0 Td 58.333333 Tz (2 ) Tj 0.602778 0 Td 68.055556 Tz (L ) Tj 0.602778 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 47.076023 Tz (distilled/deionized ) Tj 5.580556 0 Td 55.092593 Tz (water ) Tj 51.428571 0 0 51.428571 0 1293.380832 Tm 6.261111 0 Td 55.092593 Tz (over ) Tj 1.477778 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 47.800926 Tz (film ) Tj 1.361111 0 Td 47.530864 Tz (for ) Tj 1.011111 0 Td 44.965278 Tz (rinsing. ) Tj 2.313889 0 Td 59.953704 Tz (At ) Tj 0.894444 0 Td 42.12963 Tz (this ) Tj 1.186111 0 Td 46.450617 Tz (point, ) Tj 1.866667 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 47.800926 Tz (film ) Tj 1.361111 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 50.636574 Tz (buffered ) Tj 2.566667 0 Td 63.194444 Tz (by ) Tj 51.428571 0 0 51.428571 0 1250.699208 Tm 6.280556 0 Td 53.703704 Tz (soaking ) Tj 2.488889 0 Td 35.648148 Tz (it ) Tj 0.661111 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 63.518519 Tz (0.25M ) Tj 2.158333 0 Td 48.611111 Tz (acetate ) Tj 2.275 0 Td 48.611111 Tz (buffer ) Tj 2.002778 0 Td 48.206019 Tz (solution ) Tj 2.566667 0 Td 45.37037 Tz (at ) Tj 0.777778 0 Td 72.916667 Tz (pH ) Tj 1.147222 0 Td 48.611111 Tz (5.6 ) Tj 1.147222 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1209.324905 Tm 6.241667 0 Td 43.75 Tz (thirty ) Tj 1.827778 0 Td 50.636574 Tz (minutes. ) Tj 2.644444 0 Td 62.654321 Tz (The ) Tj 1.322222 0 Td 50.231481 Tz (buffered ) Tj 2.625 0 Td 46.990741 Tz (film ) Tj 1.361111 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 54.166667 Tz (allowed ) Tj 2.488889 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 54.012346 Tz (dry ) Tj 1.147222 0 Td 46.990741 Tz (at ) Tj 0.738889 0 Td 62.222222 Tz (25C. ) Tj 51.428571 0 0 51.428571 0 1168.413181 Tm 6.261111 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 48.316498 Tz (neutralized ) Tj 3.441667 0 Td 47.962963 Tz (films ) Tj 1.652778 0 Td 50.771605 Tz (are ) Tj 1.166667 0 Td 49.259259 Tz (dried ) Tj 1.711111 0 Td 58.333333 Tz (on ) Tj 0.952778 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 49.583333 Tz (large-pore ) Tj 3.188889 0 Td 50.555556 Tz (sized ) Tj 1.769444 0 Td 55.092593 Tz (nylon ) Tj 40 0 0 40 0 1132 Tm 8.075 0 Td 65.277778 Tz (screen ) Tj 2.7 0 Td 58.333333 Tz (in ) Tj 1 0 Td 75 Tz (a ) Tj 0.75 0 Td 67.916667 Tz (convection ) Tj 4.4 0 Td 75 Tz (oven ) Tj 2.125 0 Td 58.333333 Tz (at ) Tj 1 0 Td 70.833333 Tz (38 ) Tj 1.6 0 Td 70.833333 Tz (C. ) Tj 1.2 0 Td 62.5 Tz (for ) Tj 1.475 0 Td 68.75 Tz (12 ) Tj 1.15 0 Td 56.25 Tz (hrs. ) Tj 51.428571 0 0 51.428571 0 1085.535286 Tm 7.019444 0 Td 46.990741 Tz (In ) Tj 0.836111 0 Td 52.777778 Tz (another ) Tj 2.45 0 Td 52.572016 Tz (approach, ) Tj 3.130556 0 Td 49.691358 Tz (2.5 ) Tj 1.147222 0 Td 59.62963 Tz (grams ) Tj 2.080556 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 49.826389 Tz (chitosan ) Tj 2.683333 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 51.131687 Tz (dissolved ) Tj 51.428571 0 0 51.428571 0 1042.645244 Tm 6.261111 0 Td 46.990741 Tz (into ) Tj 1.361111 0 Td 53.796296 Tz (247.5 ) Tj 1.886111 0 Td 61.574074 Tz (ml ) Tj 0.972222 0 Td 58.333333 Tz (of ) Tj 0.894444 0 Td 35.648148 Tz (1 ) Tj 0.525 0 Td 46.666667 Tz (\(v/v\) ) Tj 1.613889 0 Td 51.851852 Tz ('% ) Tj 0.855556 0 Td 54.62963 Tz (blended ) Tj 2.527778 0 Td 50.231481 Tz (acid ) Tj 1.458333 0 Td 50 Tz (solvent ) Tj 2.275 0 Td 51.851852 Tz (containing ) Tj 40 0 0 40 0 1008 Tm 8.05 0 Td 86.904762 Tz (75%/25% ) Tj 3.95 0 Td 54.861111 Tz (lactic ) Tj 2.225 0 Td 60.416667 Tz (to ) Tj 0.95 0 Td 61.111111 Tz (acetic ) Tj 2.425 0 Td 59.166667 Tz (acid. ) Tj 2.025 0 Td 81.944444 Tz (The ) Tj 1.725 0 Td 68.452381 Tz (mixture ) Tj 3.1 0 Td 52.083333 Tz (is ) Tj 0.875 0 Td 56.547619 Tz (stirred ) Tj 2.625 0 Td 62.5 Tz (for ) Tj 1.3 0 Td 69.444444 Tz (4-6 ) Tj 51.428571 0 0 51.428571 0 959.712062 Tm 6.241667 0 Td 54.444444 Tz (hours ) Tj 1.886111 0 Td 45.37037 Tz (at ) Tj 0.816667 0 Td 66.975309 Tz (max ) Tj 1.438889 0 Td 52.932099 Tz (allowable ) Tj 3.091667 0 Td 55.092593 Tz (speed ) Tj 1.905556 0 Td 58.333333 Tz (on ) Tj 0.972222 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 39.699074 Tz (stir ) Tj 1.186111 0 Td 43.209877 Tz (plate. ) Tj 1.827778 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 50.636574 Tz (chitosan ) Tj 48.571429 0 0 48.571429 0 919 Tm 6.65 0 Td 51.041667 Tz (solution ) Tj 2.697059 0 Td 42.892157 Tz (is ) Tj 0.782353 0 Td 45.036765 Tz (filtered ) Tj 2.388235 0 Td 49.754902 Tz (to ) Tj 0.864706 0 Td 64.052288 Tz (remove ) Tj 2.532353 0 Td 55.83779 Tz (undissolved ) Tj 3.891176 0 Td 51.470588 Tz (chitosan, ) Tj 3.026471 0 Td 61.764706 Tz (and ) Tj 1.358824 0 Td 52.614379 Tz (the ) Tj 51.428571 0 0 51.428571 0 876.933086 Tm 6.261111 0 Td 39.699074 Tz (filtrate ) Tj 2.080556 0 Td 61.574074 Tz (was ) Tj 1.263889 0 Td 49.016204 Tz (pipetted ) Tj 2.527778 0 Td 46.180556 Tz (into ) Tj 1.283333 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 47.962963 Tz (glass ) Tj 1.633333 0 Td 44.722222 Tz (Petri ) Tj 1.536111 0 Td 45.37037 Tz (dish, ) Tj 1.555556 0 Td 57.685185 Tz (which ) Tj 1.925 0 Td 61.574074 Tz (was ) Tj 1.283333 0 Td 53.472222 Tz (heated ) Tj 40 0 0 40 0 841 Tm 8.05 0 Td 58.333333 Tz (at ) Tj 0.925 0 Td 73.611111 Tz (37 ) Tj 1.6 0 Td 68.75 Tz (C. ) Tj 1.15 0 Td 62.5 Tz (for ) Tj 1.45 0 Td 70.833333 Tz (18-20 ) Tj 2.35 0 Td 63.888889 Tz (hours. ) Tj 2.575 0 Td 81.944444 Tz (The ) Tj 1.775 0 Td 63.333333 Tz (dried ) Tj 2.175 0 Td 61.666667 Tz (films ) Tj 2.125 0 Td 65.277778 Tz (are ) Tj 1.425 0 Td 77.97619 Tz (removed ) Tj 3.525 0 Td 79.166667 Tz (and ) Tj 40 0 0 40 0 800 Tm 8.1 0 Td 62.5 Tz (neutralized ) Tj 4.45 0 Td 58.333333 Tz (in ) Tj 1.075 0 Td 66.666667 Tz (2.0 ) Tj 1.5 0 Td 137.5 Tz (M ) Tj 1.175 0 Td 101.041667 Tz (NaOH ) Tj 3.175 0 Td 62.5 Tz (solution ) Tj 3.375 0 Td 61.111111 Tz (for ) Tj 1.45 0 Td 75 Tz (-30-40 ) Tj 3.025 0 Td 65.625 Tz (seconds. ) Tj 51.428571 0 0 51.428571 0 751.673267 Tm 6.261111 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 47.962963 Tz (films ) Tj 1.613889 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 48.070988 Tz (rinsed ) Tj 1.925 0 Td 53.472222 Tz (with ) Tj 1.497222 0 Td 43.209877 Tz (distilled ) Tj 2.527778 0 Td 53.796296 Tz (water ) Tj 1.769444 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 76.157407 Tz (pH ) Tj 1.069444 0 Td 56.481481 Tz (changes ) Tj 2.527778 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 710.659574 Tm 6.261111 0 Td 55.452675 Tz (monitored ) Tj 3.266667 0 Td 44.074074 Tz (until ) Tj 1.633333 0 Td 47.530864 Tz (the ) Tj 1.166667 0 Td 47.685185 Tz (rinsing ) Tj 2.255556 0 Td 55.092593 Tz (water ) Tj 1.905556 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 47.222222 Tz (neutral ) Tj 2.294444 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 57.253086 Tz (pH. ) Tj 1.302778 0 Td 61.574074 Tz (At ) Tj 0.991667 0 Td 43.75 Tz (this ) Tj 51.428571 0 0 51.428571 0 669.513089 Tm 6.261111 0 Td 46.450617 Tz (point, ) Tj 1.944444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 47.800926 Tz (film ) Tj 1.419444 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 51.041667 Tz (buffered ) Tj 2.663889 0 Td 59.953704 Tz (by ) Tj 0.972222 0 Td 54.166667 Tz (soaking ) Tj 2.508333 0 Td 34.027778 Tz (it ) Tj 0.641667 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 63.518519 Tz (0.25M ) Tj 2.119444 0 Td 49.074074 Tz (acetate ) Tj 51.428571 0 0 51.428571 0 627.308901 Tm 6.241667 0 Td 49.691358 Tz (buffer ) Tj 2.041667 0 Td 48.611111 Tz (solution ) Tj 2.625 0 Td 45.37037 Tz (at ) Tj 0.816667 0 Td 74.537037 Tz (pH ) Tj 1.205556 0 Td 48.611111 Tz (5.6 ) Tj 1.186111 0 Td 48.611111 Tz (for ) Tj 1.166667 0 Td 42.669753 Tz (thirty ) Tj 1.866667 0 Td 50.636574 Tz (minutes. ) Tj 2.741667 0 Td 62.654321 Tz (The ) Tj 1.419444 0 Td 51.041667 Tz (buffered ) Tj 51.428571 0 0 51.428571 0 586.32053 Tm 6.261111 0 Td 47.800926 Tz (film ) Tj 1.458333 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 55.555556 Tz (allowed ) Tj 2.605556 0 Td 45.37037 Tz (to ) Tj 0.836111 0 Td 51.851852 Tz (dry ) Tj 1.225 0 Td 45.37037 Tz (at ) Tj 0.797222 0 Td 63.518519 Tz (25C. ) Tj 2.197222 0 Td 62.654321 Tz (The ) Tj 1.438889 0 Td 50.378788 Tz (re-hydrated ) Tj 3.577778 0 Td 47.962963 Tz (films ) Tj 1.711111 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 543.654501 Tm 6.241667 0 Td 52.662037 Tz (then ) Tj 1.438889 0 Td 50.771605 Tz (frozen ) Tj 1.983333 0 Td 45.37037 Tz (at ) Tj 0.680556 0 Td 61.033951 Tz (-80C. ) Tj 2.372222 0 Td 48.611111 Tz (freezer ) Tj 2.158333 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 35.648148 Tz (1 ) Tj 0.408333 0 Td 58.333333 Tz (hour ) Tj 1.497222 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 51.851852 Tz (then ) Tj 1.4 0 Td 50.084175 Tz (lyophilized ) Tj 51.428571 0 0 51.428571 0 501.841558 Tm 6.261111 0 Td 49.691358 Tz (for ) Tj 1.147222 0 Td 58.333333 Tz (24 ) Tj 0.972222 0 Td 48.611111 Tz (hours. ) Tj 2.061111 0 Td 63.734568 Tz (The ) Tj 1.419444 0 Td 47.962963 Tz (films ) Tj 1.711111 0 Td 49.691358 Tz (are ) Tj 1.166667 0 Td 51.851852 Tz (then ) Tj 1.555556 0 Td 44.074074 Tz (sterilized ) Tj 2.916667 0 Td 52.5 Tz (using ) Tj 1.847222 0 Td 55.902778 Tz (low-dose ) Tj 51.428571 0 0 51.428571 0 462.502222 Tm 6.261111 0 Td 71.944444 Tz (gamma ) Tj 2.411111 0 Td 45.37037 Tz (irradiation ) Tj 3.247222 0 Td 53.472222 Tz (\(25-32 ) Tj 2.158333 0 Td 55.740741 Tz (kGy\). ) Tj 51.428571 0 0 51.428571 0 422.036697 Tm 6.261111 0 Td 59.41358 Tz (Uptake ) Tj 2.372222 0 Td 50 Tz (Studies ) Tj 51.428571 0 0 51.428571 0 380.639594 Tm 7 0 Td 72.916667 Tz (An ) Tj 1.069444 0 Td 53.472222 Tz (uptake ) Tj 2.1 0 Td 51.203704 Tz (study ) Tj 1.711111 0 Td 42.12963 Tz (is ) Tj 0.641667 0 Td 56.532922 Tz (performed ) Tj 3.208333 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 53.652263 Tz (determine ) Tj 3.033333 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 49.421296 Tz (quantity ) Tj 2.547222 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 336.892031 Tm 6.261111 0 Td 45.694444 Tz (antibiotic ) Tj 3.130556 0 Td 48.611111 Tz (solution ) Tj 2.741667 0 Td 46.180556 Tz (that ) Tj 1.458333 0 Td 55.092593 Tz (each ) Tj 1.730556 0 Td 50.231481 Tz (chitosan ) Tj 2.819444 0 Td 54.208754 Tz (composition ) Tj 3.986111 0 Td 54.444444 Tz (could ) Tj 51.428571 0 0 51.428571 0 294.859356 Tm 6.261111 0 Td 50 Tz (absorb. ) Tj 2.255556 0 Td 48.611111 Tz (Antibiotic ) Tj 3.072222 0 Td 54.012346 Tz (uptake ) Tj 2.1 0 Td 52.824074 Tz (determines ) Tj 3.363889 0 Td 48.611111 Tz (the ) Tj 1.011111 0 Td 43.981481 Tz (ability ) Tj 2.002778 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 253.531889 Tm 6.261111 0 Td 53.914141 Tz (composition ) Tj 3.772222 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 53.472222 Tz (absorb ) Tj 2.1 0 Td 44.560185 Tz (antibiotics. ) Tj 3.383333 0 Td 53.472222 Tz (This ) Tj 1.477778 0 Td 51.851852 Tz (study ) Tj 1.75 0 Td 53.148148 Tz (determines ) Tj 3.363889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 211.89392 Tm 6.261111 0 Td 50.605413 Tz (concentration ) Tj 4.375 0 Td 58.333333 Tz (of ) Tj 1.011111 0 Td 46.018519 Tz (antibiotic ) Tj 3.169444 0 Td 46.990741 Tz (that ) Tj 1.536111 0 Td 54.282407 Tz (each ) Tj 1.769444 0 Td 53.914141 Tz (composition ) Tj 4.005556 0 Td 54.444444 Tz (could ) Tj 51.428571 0 0 51.428571 0 170.763092 Tm 6.261111 0 Td 53.472222 Tz (absorb ) Tj 2.158333 0 Td 52.391975 Tz (during ) Tj 2.158333 0 Td 32.407407 Tz (1 ) Tj 0.544444 0 Td 55.092593 Tz (minute ) Tj 2.177778 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 48.611111 Tz (rehydration. ) Tj 3.772222 0 Td 45.37037 Tz (In ) Tj 0.777778 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 57.744108 Tz (embodiment, ) Tj 30 0 0 30 0 2755 Tm 41.666667 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.5 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.5 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.433333 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.433333 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.433333 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.4 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.4 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.433333 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.433333 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.466667 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.466667 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.540541 0 Td 77.252252 Tz (28 ) Tj 51.428571 0 0 51.428571 0 2920.392279 Tm 25.2 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 35.648148 Tz (1 ) Tj 0.602778 0 Td 62.222222 Tz (mg/ml ) Tj 2.177778 0 Td 58.981481 Tz (Vancomycin ) Tj 3.811111 0 Td 53.472222 Tz (or ) Tj 0.913889 0 Td 56.712963 Tz (daptomycin ) Tj 3.694444 0 Td 52.031893 Tz (phosphate-buffered ) Tj 51.428571 0 0 51.428571 0 2872.637576 Tm 25.219444 0 Td 46.990741 Tz (saline ) Tj 1.847222 0 Td 58.981481 Tz (\(PBS\) ) Tj 1.925 0 Td 48.206019 Tz (solution ) Tj 2.508333 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 47.395833 Tz (created. ) Tj 2.469444 0 Td 57.685185 Tz (Using ) Tj 1.905556 0 Td 45.37037 Tz (six ) Tj 0.991667 0 Td 45.619658 Tz (replications, ) Tj 3.733333 0 Td 47.962963 Tz (films ) Tj 51.428571 0 0 51.428571 0 2828.821745 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 64.814815 Tz (known ) Tj 2.197222 0 Td 53.240741 Tz (weights ) Tj 2.45 0 Td 51.851852 Tz (are ) Tj 1.127778 0 Td 59.053498 Tz (submerged ) Tj 3.422222 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 61.574074 Tz (50 ) Tj 0.952778 0 Td 61.574074 Tz (ml ) Tj 0.952778 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 47.530864 Tz (the ) Tj 1.069444 0 Td 46.018519 Tz (antibiotic ) Tj 51.428571 0 0 51.428571 0 2784.097378 Tm 25.219444 0 Td 47.800926 Tz (solution ) Tj 2.488889 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 38.888889 Tz (1 ) Tj 0.486111 0 Td 54.282407 Tz (min, ) Tj 1.458333 0 Td 59.62963 Tz (where ) Tj 2.022222 0 Td 35.648148 Tz (1 ) Tj 0.486111 0 Td 60.493827 Tz (min ) Tj 1.263889 0 Td 40.509259 Tz (is ) Tj 0.680556 0 Td 48.611111 Tz (representative ) Tj 4.219444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 46.450617 Tz (effective ) Tj 51.428571 0 0 51.428571 0 2744.776675 Tm 25.2 0 Td 51.49177 Tz (operating ) Tj 3.013889 0 Td 62.384259 Tz (room ) Tj 1.769444 0 Td 50.231481 Tz (usage. ) Tj 2.061111 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 53.914141 Tz (composition ) Tj 3.811111 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 51.851852 Tz (then ) Tj 1.536111 0 Td 58.693416 Tz (Submerged ) Tj 51.428571 0 0 51.428571 0 2695.821847 Tm 25.2 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 46.018519 Tz (antibiotic ) Tj 3.091667 0 Td 48.206019 Tz (solution ) Tj 2.644444 0 Td 48.611111 Tz (for ) Tj 1.147222 0 Td 42.669753 Tz (thirty ) Tj 1.866667 0 Td 54.62963 Tz (seconds ) Tj 2.586111 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 55.497685 Tz (removed. ) Tj 51.428571 0 0 51.428571 0 2655.991453 Tm 25.2 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 54.73251 Tz (remaining ) Tj 3.111111 0 Td 48.611111 Tz (solution ) Tj 2.547222 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 47.530864 Tz (tested ) Tj 1.905556 0 Td 51.851852 Tz (using ) Tj 1.711111 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 54.282407 Tz (high ) Tj 1.477778 0 Td 50.636574 Tz (pressure ) Tj 2.625 0 Td 46.990741 Tz (liquid ) Tj 51.428571 0 0 51.428571 0 2610.449184 Tm 25.2 0 Td 56.481481 Tz (chromatography ) Tj 5.113889 0 Td 47.800926 Tz (\(Varian, ) Tj 2.605556 0 Td 45.37037 Tz (Calif.\) ) Tj 2.236111 0 Td 60.493827 Tz (method ) Tj 2.488889 0 Td 46.990741 Tz (to ) Tj 0.913889 0 Td 53.652263 Tz (determine ) Tj 3.208333 0 Td 50.771605 Tz (the ) Tj 40 0 0 40 0 2572 Tm 32.4 0 Td 58.75 Tz (antibiotic ) Tj 3.875 0 Td 62.5 Tz (concentration. ) Tj 51.428571 0 0 51.428571 0 2521.173052 Tm 25.919444 0 Td 53.472222 Tz (This ) Tj 1.536111 0 Td 60.493827 Tz (method ) Tj 2.372222 0 Td 61.574074 Tz (of ) Tj 0.855556 0 Td 46.118234 Tz (antibacterial ) Tj 3.85 0 Td 51.388889 Tz (loading ) Tj 2.391667 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 50.925926 Tz (defined ) Tj 2.352778 0 Td 48.611111 Tz (as ) Tj 0.855556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 42.939815 Tz (situ ) Tj 51.428571 0 0 51.428571 0 2481.130277 Tm 25.2 0 Td 49.016204 Tz (loading, ) Tj 2.527778 0 Td 51.851852 Tz (as ) Tj 0.816667 0 Td 57.87037 Tz (opposed ) Tj 2.605556 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 49.151235 Tz (pre-loading, ) Tj 3.752778 0 Td 58.981481 Tz (where ) Tj 1.963889 0 Td 45.664983 Tz (antibiotics ) Tj 3.227778 0 Td 60.925926 Tz (would ) Tj 51.428571 0 0 51.428571 0 2435.756627 Tm 25.180556 0 Td 59.953704 Tz (be ) Tj 0.875 0 Td 51.041667 Tz (incorporated ) Tj 3.830556 0 Td 45.37037 Tz (in ) Tj 0.7 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 48.611111 Tz (Solution ) Tj 2.527778 0 Td 52.391975 Tz (during ) Tj 2.041667 0 Td 47.800926 Tz (film ) Tj 1.322222 0 Td 46.450617 Tz (creation. ) Tj 51.428571 0 0 51.428571 0 2390.087179 Tm 25.2 0 Td 51.851852 Tz (After ) Tj 1.808333 0 Td 35.648148 Tz (1 ) Tj 0.505556 0 Td 55.632716 Tz (minute ) Tj 2.197222 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 47.800926 Tz (film ) Tj 1.380556 0 Td 37.268519 Tz (is ) Tj 0.680556 0 Td 60.185185 Tz (removed ) Tj 2.702778 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 57.253086 Tz (sample ) Tj 2.255556 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 61.574074 Tz (remain ) Tj 51.428571 0 0 51.428571 0 2346.522449 Tm 25.2 0 Td 51.851852 Tz (ing ) Tj 1.244444 0 Td 46.018519 Tz (antibiotic ) Tj 3.111111 0 Td 48.611111 Tz (solution ) Tj 2.683333 0 Td 38.888889 Tz (is ) Tj 0.816667 0 Td 55.902778 Tz (used ) Tj 1.691667 0 Td 42.12963 Tz (in ) Tj 0.913889 0 Td 75.347222 Tz (HPLC ) Tj 2.158333 0 Td 46.990741 Tz (to ) Tj 0.913889 0 Td 54.012346 Tz (determine ) Tj 3.266667 0 Td 36.728395 Tz (its ) Tj 51.428571 0 0 51.428571 0 2303.454545 Tm 25.2 0 Td 49.074074 Tz (concentration. ) Tj 4.588889 0 Td 48.611111 Tz (Antibiotic ) Tj 3.422222 0 Td 53.472222 Tz (uptake ) Tj 2.391667 0 Td 38.888889 Tz (is ) Tj 0.991667 0 Td 53.796296 Tz (normalized ) Tj 3.694444 0 Td 59.953704 Tz (by ) Tj 1.225 0 Td 48.611111 Tz (film ) Tj 51.428571 0 0 51.428571 0 2261.22549 Tm 25.180556 0 Td 55.632716 Tz (weight ) Tj 2.236111 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 54.444444 Tz (determined ) Tj 3.5 0 Td 52.5 Tz (using ) Tj 1.788889 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 52.211934 Tz (following ) Tj 3.052778 0 Td 44.722222 Tz (relations: ) Tj 2.897222 0 Td 64.00463 Tz (Anti ) Tj 51.428571 0 0 51.428571 0 2217.210153 Tm 25.180556 0 Td 45.910494 Tz (biotic ) Tj 1.925 0 Td 50.555556 Tz (uptake=\(Initial ) Tj 4.783333 0 Td 45.694444 Tz (antibiotic ) Tj 3.013889 0 Td 48.206019 Tz (solution ) Tj 2.547222 0 Td 54.282407 Tz (concentration-Fi ) Tj 51.428571 0 0 51.428571 0 2171 Tm 25.2 0 Td 48.611111 Tz (nal ) Tj 1.263889 0 Td 46.018519 Tz (antibiotic ) Tj 3.169444 0 Td 48.611111 Tz (Solution ) Tj 2.761111 0 Td 50.166667 Tz (concentration\)xAntibiotic ) Tj 7.933333 0 Td 49.016204 Tz (Solution ) Tj 51.428571 0 0 51.428571 0 2132.675676 Tm 25.2 0 Td 62.114198 Tz (Volume ) Tj 2.469444 0 Td 52.314815 Tz (\(mg\)/\(Chitosan ) Tj 4.666667 0 Td 46.180556 Tz (film ) Tj 1.4 0 Td 52.314815 Tz (weight\) ) Tj 2.45 0 Td 52.5 Tz (\(mg\). ) Tj 51.428571 0 0 51.428571 0 2088.8 Tm 25.219444 0 Td 53.472222 Tz (Swelling ) Tj 2.838889 0 Td 47.530864 Tz (Ratio. ) Tj 51.428571 0 0 51.428571 0 2043.299735 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.419444 0 Td 51.041667 Tz (Swelling ) Tj 2.722222 0 Td 44.074074 Tz (ratio ) Tj 1.594444 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 54.503367 Tz (composition ) Tj 3.869444 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 55.092593 Tz (deter ) Tj 51.428571 0 0 51.428571 0 2002.247232 Tm 25.2 0 Td 60.925926 Tz (mined ) Tj 1.983333 0 Td 46.018519 Tz (after ) Tj 1.594444 0 Td 38.888889 Tz (1 ) Tj 0.505556 0 Td 60.493827 Tz (min ) Tj 1.283333 0 Td 58.333333 Tz (Submergence ) Tj 4.025 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 53.472222 Tz (presence ) Tj 2.741667 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 55.555556 Tz (absence ) Tj 51.428571 0 0 51.428571 0 1961.344828 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 56.712963 Tz (daptomycin ) Tj 3.597222 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 58.981481 Tz (Vancomycin ) Tj 3.772222 0 Td 46.018519 Tz (solutions. ) Tj 3.013889 0 Td 46.990741 Tz (In ) Tj 0.797222 0 Td 51.851852 Tz (order ) Tj 1.730556 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 68.055556 Tz (quan ) Tj 51.428571 0 0 51.428571 0 1916.896689 Tm 25.180556 0 Td 42.12963 Tz (tify ) Tj 1.341667 0 Td 51.446759 Tz (swelling ) Tj 2.8 0 Td 40.509259 Tz (ratio, ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 39.814815 Tz (initial ) Tj 2.002778 0 Td 59.953704 Tz (volume ) Tj 2.469444 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 50.636574 Tz (chitosan ) Tj 2.780556 0 Td 47.314815 Tz (films ) Tj 1.75 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 1876.900878 Tm 25.2 0 Td 55.092593 Tz (determined ) Tj 3.597222 0 Td 52.5 Tz (using ) Tj 1.866667 0 Td 47.962963 Tz (electronic ) Tj 3.247222 0 Td 43.518519 Tz (digital ) Tj 2.177778 0 Td 46.180556 Tz (calipers ) Tj 2.566667 0 Td 51.041667 Tz (accurate ) Tj 2.741667 0 Td 51.851852 Tz (0.03 ) Tj 51.428571 0 0 51.428571 0 1832.921348 Tm 25.2 0 Td 92.361111 Tz (mm ) Tj 1.438889 0 Td 50.771605 Tz (within ) Tj 2.119444 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 53.148148 Tz (range ) Tj 1.866667 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 61.574074 Tz (0 ) Tj 0.641667 0 Td 45.37037 Tz (to ) Tj 0.933333 0 Td 57.253086 Tz (150 ) Tj 1.322222 0 Td 70.216049 Tz (mm. ) Tj 1.555556 0 Td 64.814815 Tz (The ) Tj 1.438889 0 Td 42.777778 Tz (final ) Tj 1.613889 0 Td 59.953704 Tz (volume ) Tj 2.469444 0 Td 37.268519 Tz (is ) Tj 51.428571 0 0 51.428571 0 1794.777503 Tm 25.2 0 Td 54.768519 Tz (determined ) Tj 3.577778 0 Td 54.79798 Tz (immediately ) Tj 3.927778 0 Td 45.37037 Tz (after ) Tj 1.633333 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 46.018519 Tz (antibiotic ) Tj 3.052778 0 Td 54.012346 Tz (uptake ) Tj 2.216667 0 Td 62.222222 Tz (proce ) Tj 51.428571 0 0 51.428571 0 1751.87053 Tm 25.2 0 Td 54.282407 Tz (dure ) Tj 1.497222 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 53.148148 Tz (performed. ) Tj 3.363889 0 Td 54.282407 Tz (This ) Tj 1.516667 0 Td 49.421296 Tz (data ) Tj 1.361111 0 Td 55.555556 Tz (allowed ) Tj 2.508333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 51.446759 Tz (swelling ) Tj 2.683333 0 Td 42.12963 Tz (ratio ) Tj 1.477778 0 Td 46.018519 Tz (after ) Tj 51.428571 0 0 51.428571 0 1712.08933 Tm 25.258333 0 Td 35.648148 Tz (1 ) Tj 0.544444 0 Td 55.092593 Tz (minute ) Tj 2.177778 0 Td 48.611111 Tz (to ) Tj 0.777778 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 54.444444 Tz (determined ) Tj 3.461111 0 Td 53.148148 Tz (using ) Tj 1.769444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 52.572016 Tz (following ) Tj 3.052778 0 Td 45.868946 Tz (relationship: ) Tj 51.428571 0 0 51.428571 0 1667.260143 Tm 25.219444 0 Td 53.472222 Tz (Swelling ) Tj 2.761111 0 Td 43.425926 Tz (ratio ) Tj 1.477778 0 Td 53.796296 Tz (\(%\)=\(Final ) Tj 3.422222 0 Td 47.800926 Tz (film ) Tj 1.341667 0 Td 51.157407 Tz (volume-Initial ) Tj 4.491667 0 Td 46.990741 Tz (film ) Tj 1.341667 0 Td 54.6875 Tz (volume\)/ ) Tj 52.857143 0 0 52.857143 0 1623 Tm 24.537838 0 Td 39.02027 Tz (\(Initial ) Tj 2.137838 0 Td 45.720721 Tz (film ) Tj 1.362162 0 Td 58.190008 Tz (volume\)x100 ) Tj 51.428571 0 0 51.428571 0 1584.111834 Tm 25.919444 0 Td 59.143519 Tz (Absorbed ) Tj 3.111111 0 Td 46.018519 Tz (antibiotic ) Tj 3.052778 0 Td 49.421296 Tz (quantity ) Tj 2.683333 0 Td 61.574074 Tz (was ) Tj 1.438889 0 Td 54.12037 Tz (determined ) Tj 3.538889 0 Td 52.5 Tz (using ) Tj 1.866667 0 Td 58.333333 Tz (dif ) Tj 51.428571 0 0 51.428571 0 1541.055409 Tm 25.2 0 Td 50.231481 Tz (ferences ) Tj 2.858333 0 Td 46.990741 Tz (in ) Tj 1.011111 0 Td 48.82716 Tz (concentrations. ) Tj 4.880556 0 Td 54.444444 Tz (Concurrent ) Tj 3.713889 0 Td 52.662037 Tz (with ) Tj 1.730556 0 Td 49.691358 Tz (the ) Tj 1.341667 0 Td 54.012346 Tz (uptake ) Tj 51.428571 0 0 51.428571 0 1502.674362 Tm 25.219444 0 Td 46.990741 Tz (study, ) Tj 1.866667 0 Td 47.800926 Tz (film ) Tj 1.341667 0 Td 54.768519 Tz (dimensions ) Tj 3.461111 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 57.523148 Tz (measured ) Tj 2.916667 0 Td 53.148148 Tz (using ) Tj 1.769444 0 Td 43.518519 Tz (digital ) Tj 2.022222 0 Td 46.585648 Tz (calipers ) Tj 2.430556 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 1458.308511 Tm 25.2 0 Td 51.851852 Tz (order ) Tj 1.944444 0 Td 45.37037 Tz (to ) Tj 0.952778 0 Td 47.890947 Tz (calculate ) Tj 2.994444 0 Td 47.800926 Tz (film ) Tj 1.594444 0 Td 59.953704 Tz (volume ) Tj 2.566667 0 Td 46.180556 Tz (differences, ) Tj 3.733333 0 Td 49.826389 Tz (yielding ) Tj 2.780556 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1419.102041 Tm 25.219444 0 Td 51.041667 Tz (Swelling ) Tj 2.761111 0 Td 41.049383 Tz (ratio. ) Tj 1.808333 0 Td 53.472222 Tz (Chitosan ) Tj 2.916667 0 Td 46.990741 Tz (film ) Tj 1.477778 0 Td 51.041667 Tz (Swelling ) Tj 2.741667 0 Td 44.074074 Tz (ratio ) Tj 1.633333 0 Td 48.611111 Tz (quantified ) Tj 3.188889 0 Td 51.851852 Tz (the ) Tj 51.428571 0 0 51.428571 0 1376.364602 Tm 25.2 0 Td 49.826389 Tz (increase ) Tj 2.625 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 59.953704 Tz (volume ) Tj 2.372222 0 Td 51.851852 Tz (as ) Tj 0.894444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 47.800926 Tz (film ) Tj 1.438889 0 Td 49.200337 Tz (rehydrated. ) Tj 51.428571 0 0 51.428571 0 1335.27619 Tm 25.2 0 Td 53.06713 Tz (Ultimate ) Tj 2.761111 0 Td 50.462963 Tz (Tensile ) Tj 2.372222 0 Td 48.251029 Tz (Strength, ) Tj 2.838889 0 Td 57.407407 Tz (Young's ) Tj 2.683333 0 Td 61.111111 Tz (Modulus ) Tj 51.428571 0 0 51.428571 0 1294.343137 Tm 25.919444 0 Td 51.557239 Tz (Neutralized ) Tj 3.558333 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 53.742284 Tz (compositions ) Tj 4.005556 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 51.131687 Tz (subjected ) Tj 2.877778 0 Td 48.611111 Tz (to ) Tj 0.738889 0 Td 45.833333 Tz (tensile ) Tj 51.428571 0 0 51.428571 0 1251.991037 Tm 25.180556 0 Td 46.759259 Tz (testing ) Tj 2.294444 0 Td 52.5 Tz (using ) Tj 1.886111 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 51.851852 Tz (Universal ) Tj 3.15 0 Td 50.411523 Tz (Materials ) Tj 3.052778 0 Td 50.925926 Tz (Testing ) Tj 2.45 0 Td 61.111111 Tz (Machine ) Tj 2.897222 0 Td 59.41358 Tz (\(In ) Tj 51.428571 0 0 51.428571 0 1209.258427 Tm 25.219444 0 Td 44.830247 Tz (stron, ) Tj 1.944444 0 Td 59.953704 Tz (Norwood, ) Tj 3.208333 0 Td 50.462963 Tz (Mass.\). ) Tj 2.430556 0 Td 53.472222 Tz (Ultimate ) Tj 2.819444 0 Td 50.462963 Tz (Tensile ) Tj 2.411111 0 Td 51.041667 Tz (Strength ) Tj 2.8 0 Td 60.925926 Tz (\(UTS\) ) Tj 51.428571 0 0 51.428571 0 1169.662651 Tm 25.2 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 57.87037 Tz (Young's ) Tj 2.644444 0 Td 61.574074 Tz (Modulus ) Tj 2.761111 0 Td 52.824074 Tz (determines ) Tj 3.402778 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 48.206019 Tz (strength ) Tj 2.508333 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 44.074074 Tz (elasticity ) Tj 51.428571 0 0 51.428571 0 1128.939787 Tm 25.2 0 Td 56.712963 Tz (of ) Tj 0.738889 0 Td 52.777778 Tz (dry/dehydrated ) Tj 4.608333 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 49.826389 Tz (chitosan ) Tj 2.586111 0 Td 51.353276 Tz (compositions. ) Tj 4.219444 0 Td 57.685185 Tz (Using ) Tj 1.886111 0 Td 46.450617 Tz (six ) Tj 51.428571 0 0 51.428571 0 1088.214286 Tm 25.2 0 Td 45.868946 Tz (replications, ) Tj 3.947222 0 Td 49.826389 Tz (chitosan ) Tj 2.780556 0 Td 53.742284 Tz (compositions ) Tj 4.219444 0 Td 50.771605 Tz (are ) Tj 1.244444 0 Td 59.259259 Tz (punched ) Tj 2.877778 0 Td 50.771605 Tz (out ) Tj 1.283333 0 Td 45.37037 Tz (into ) Tj 51.428571 0 0 51.428571 0 1043.837274 Tm 25.2 0 Td 84.259259 Tz (ASTM ) Tj 2.469444 0 Td 64.814815 Tz (E8 ) Tj 1.225 0 Td 44.907407 Tz (tensile ) Tj 2.313889 0 Td 45.833333 Tz (testing ) Tj 2.333333 0 Td 56.17284 Tz (specimens ) Tj 3.461111 0 Td 53.472222 Tz (with ) Tj 1.711111 0 Td 56.712963 Tz (an ) Tj 1.108333 0 Td 40.277778 Tz (initial ) Tj 2.119444 0 Td 56.712963 Tz (25 ) Tj 57.142857 0 0 57.142857 0 1003.828349 Tm 22.68 0 Td 58.75 Tz (mm-gage ) Tj 2.695 0 Td 44.722222 Tz (length ) Tj 1.82 0 Td 54.444444 Tz (and ) Tj 1.225 0 Td 52.5 Tz (175 ) Tj 1.155 0 Td 86.041667 Tz (mm ) Tj 1.4875 0 Td 40.833333 Tz (area. ) Tj 1.505 0 Td 42.291667 Tz (In ) Tj 0.735 0 Td 58.333333 Tz (some ) Tj 1.5925 0 Td 43.75 Tz (analyses, ) Tj 2.59 0 Td 38.645833 Tz (test ) Tj 51.428571 0 0 51.428571 0 962.936803 Tm 25.219444 0 Td 55.452675 Tz (specimens ) Tj 3.208333 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 49.691358 Tz (cut ) Tj 1.088889 0 Td 52.932099 Tz (uniformly ) Tj 3.130556 0 Td 51.851852 Tz (with ) Tj 1.477778 0 Td 57.685185 Tz (gauge ) Tj 1.925 0 Td 50 Tz (lengths ) Tj 2.313889 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 53.472222 Tz (widths ) Tj 51.428571 0 0 51.428571 0 919.773869 Tm 25.2 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 49.421296 Tz (12.7 ) Tj 1.4 0 Td 90.740741 Tz (mm ) Tj 1.283333 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 50.771605 Tz (3.5 ) Tj 1.147222 0 Td 89.12037 Tz (mm ) Tj 1.283333 0 Td 46.367521 Tz (respectively. ) Tj 3.811111 0 Td 58.333333 Tz (Using ) Tj 1.905556 0 Td 58.333333 Tz (an ) Tj 0.913889 0 Td 48.148148 Tz (Instron ) Tj 2.216667 0 Td 57.523148 Tz (33R, ) Tj 51.428571 0 0 51.428571 0 876.082411 Tm 25.2 0 Td 59.62963 Tz (model ) Tj 2.1 0 Td 59.143519 Tz (4465 ) Tj 1.711111 0 Td 58.333333 Tz (\(Norwood, ) Tj 3.422222 0 Td 54.552469 Tz (Mass.\) ) Tj 2.216667 0 Td 51.851852 Tz (Universal ) Tj 3.072222 0 Td 50.925926 Tz (Testing ) Tj 2.411111 0 Td 60.648148 Tz (Machine ) Tj 51.428571 0 0 51.428571 0 833.409405 Tm 25.180556 0 Td 54.282407 Tz (with ) Tj 1.633333 0 Td 51.851852 Tz (a ) Tj 0.661111 0 Td 61.574074 Tz (50 ) Tj 1.05 0 Td 84.259259 Tz (N ) Tj 0.855556 0 Td 51.851852 Tz (load ) Tj 1.555556 0 Td 43.75 Tz (cell ) Tj 1.380556 0 Td 56.17284 Tz (automated ) Tj 3.344444 0 Td 59.953704 Tz (by ) Tj 1.108333 0 Td 46.8107 Tz (Instron's ) Tj 2.897222 0 Td 47.800926 Tz (Bluehill ) Tj 2.644444 0 Td 55.092593 Tz (2 ) Tj 51.428571 0 0 51.428571 0 793.220513 Tm 25.219444 0 Td 50.462963 Tz (\(v2.13\) ) Tj 2.430556 0 Td 49.331276 Tz (software, ) Tj 3.013889 0 Td 48.611111 Tz (the ) Tj 1.186111 0 Td 49.826389 Tz (ultimate ) Tj 2.722222 0 Td 44.907407 Tz (tensile ) Tj 2.216667 0 Td 48.206019 Tz (strength ) Tj 2.644444 0 Td 61.574074 Tz (\(UTS\) ) Tj 2.177778 0 Td 59.41358 Tz (and ) Tj 51.428571 0 0 51.428571 0 752.787589 Tm 25.2 0 Td 57.87037 Tz (Young's ) Tj 2.625 0 Td 58.796296 Tz (modulus ) Tj 2.644444 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 54.12037 Tz (dehydrated ) Tj 3.402778 0 Td 47.962963 Tz (films ) Tj 1.613889 0 Td 59.953704 Tz (were ) Tj 1.613889 0 Td 51.262626 Tz (determined. ) Tj 3.616667 0 Td 66.975309 Tz (Due ) Tj 51.428571 0 0 51.428571 0 714.867347 Tm 25.180556 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 48.971193 Tz (necessity ) Tj 2.975 0 Td 55.092593 Tz (of ) Tj 0.875 0 Td 48.316498 Tz (controlling ) Tj 3.461111 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 42.939815 Tz (test ) Tj 1.322222 0 Td 54.12037 Tz (specimens ) Tj 3.519444 0 Td 50 Tz (precise ) Tj 51.428571 0 0 51.428571 0 671.335025 Tm 25.2 0 Td 52.73569 Tz (dimensions, ) Tj 3.733333 0 Td 34.027778 Tz (it ) Tj 0.622222 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 51.131687 Tz (necessary ) Tj 2.994444 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 55.555556 Tz (perform ) Tj 2.566667 0 Td 43.75 Tz (this ) Tj 1.283333 0 Td 43.75 Tz (test ) Tj 1.263889 0 Td 52.5 Tz (using ) Tj 1.808333 0 Td 68.055556 Tz (dehy ) Tj 51.428571 0 0 51.428571 0 629.885998 Tm 25.2 0 Td 50.771605 Tz (drated ) Tj 2.041667 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 47.800926 Tz (film ) Tj 1.4 0 Td 51.851852 Tz (samples. ) Tj 2.702778 0 Td 63.734568 Tz (The ) Tj 1.341667 0 Td 43.75 Tz (test ) Tj 1.263889 0 Td 56.712963 Tz (specimen ) Tj 2.936111 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 50.231481 Tz (securely ) Tj 51.428571 0 0 51.428571 0 587.275098 Tm 25.2 0 Td 52.932099 Tz (placed ) Tj 2.158333 0 Td 43.75 Tz (in ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 50.771605 Tz (hydraulic ) Tj 2.975 0 Td 48.611111 Tz (grips ) Tj 1.691667 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 47.530864 Tz (tested ) Tj 1.944444 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 50.462963 Tz (tension ) Tj 2.352778 0 Td 43.75 Tz (at ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 45.37037 Tz (rate ) Tj 40 0 0 40 0 550 Tm 32.4 0 Td 75 Tz (of ) Tj 1.2 0 Td 50 Tz (1 ) Tj 0.775 0 Td 86.805556 Tz (mm/min ) Tj 3.5 0 Td 67.708333 Tz (with ) Tj 2 0 Td 65.625 Tz (data ) Tj 1.925 0 Td 67.708333 Tz (recorded ) Tj 3.6 0 Td 58.333333 Tz (at ) Tj 1 0 Td 80.555556 Tz (200 ) Tj 1.825 0 Td 85.416667 Tz (ms ) Tj 1.375 0 Td 57.083333 Tz (intervals. ) Tj 3.8 0 Td 80.555556 Tz (The ) Tj 51.428571 0 0 51.428571 0 505 Tm 25.180556 0 Td 46.759259 Tz (testing ) Tj 2.469444 0 Td 52.932099 Tz (device ) Tj 2.391667 0 Td 52.662037 Tz (software ) Tj 3.013889 0 Td 40.509259 Tz (is ) Tj 0.972222 0 Td 52.5 Tz (configured ) Tj 3.636111 0 Td 46.990741 Tz (to ) Tj 1.069444 0 Td 52.932099 Tz (output ) Tj 2.372222 0 Td 64.00463 Tz (UTS, ) Tj 51.428571 0 0 51.428571 0 464.057935 Tm 25.180556 0 Td 58.333333 Tz (Young's ) Tj 2.741667 0 Td 58.333333 Tz (modulus ) Tj 2.683333 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 53.472222 Tz (breaking ) Tj 2.780556 0 Td 50.555556 Tz (point ) Tj 1.769444 0 Td 93.981481 Tz (% ) Tj 0.855556 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 48.905724 Tz (elongation. ) Tj 51.428571 0 0 51.428571 0 421.775281 Tm 25.2 0 Td 57.118056 Tz (Adhesive ) Tj 3.013889 0 Td 51.041667 Tz (Strength ) Tj 51.428571 0 0 51.428571 0 378.899263 Tm 25.919444 0 Td 57.523148 Tz (Adhesive ) Tj 2.955556 0 Td 48.206019 Tz (strength ) Tj 2.527778 0 Td 58.627946 Tz (measurement ) Tj 4.044444 0 Td 47.530864 Tz (investigates ) Tj 3.597222 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 53.472222 Tz (adhesive ) Tj 51.428571 0 0 51.428571 0 341.360825 Tm 25.219444 0 Td 48.206019 Tz (strength ) Tj 2.8 0 Td 58.333333 Tz (of ) Tj 1.069444 0 Td 52.083333 Tz (wet/rehydrated ) Tj 4.861111 0 Td 49.826389 Tz (chitosan ) Tj 2.897222 0 Td 53.472222 Tz (compositions ) Tj 4.336111 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 295.719801 Tm 25.2 0 Td 47.530864 Tz (films\) ) Tj 1.963889 0 Td 43.75 Tz (to ) Tj 0.797222 0 Td 52.777778 Tz (implant ) Tj 2.430556 0 Td 54.444444 Tz (grade ) Tj 1.847222 0 Td 48.611111 Tz (alloy ) Tj 1.730556 0 Td 43.209877 Tz (fixtures, ) Tj 2.566667 0 Td 47.530864 Tz (either ) Tj 1.905556 0 Td 51.851852 Tz (31.6L ) Tj 1.75 0 Td 45.730453 Tz (stainless ) Tj 51.428571 0 0 51.428571 0 251.82338 Tm 25.219444 0 Td 43.425926 Tz (steel ) Tj 1.555556 0 Td 74.537037 Tz (\(ASTM ) Tj 2.488889 0 Td 57.037037 Tz (F138\) ) Tj 1.944444 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 52.932099 Tz (6-4 ) Tj 1.186111 0 Td 49.826389 Tz (titanium ) Tj 2.644444 0 Td 75.185185 Tz (\(ASTM ) Tj 2.527778 0 Td 52.391975 Tz (F136\), ) Tj 2.138889 0 Td 52.5 Tz (using ) Tj 1.75 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 210 Tm 25.2 0 Td 53.877315 Tz (modified ) Tj 2.877778 0 Td 84.259259 Tz (ASTM ) Tj 2.391667 0 Td 51.041667 Tz (standard ) Tj 2.8 0 Td 54.208754 Tz (\(D5179-02\). ) Tj 3.888889 0 Td 58.981481 Tz (These ) Tj 2.1 0 Td 45.37037 Tz (fixtures ) Tj 2.508333 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 170.511743 Tm 25.2 0 Td 53.703704 Tz (gripped ) Tj 2.430556 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 49.331276 Tz (universal ) Tj 2.858333 0 Td 46.759259 Tz (testing ) Tj 2.216667 0 Td 58.333333 Tz (machine ) Tj 2.663889 0 Td 58.333333 Tz (which ) Tj 2.022222 0 Td 55.497685 Tz (measures ) Tj 2.877778 0 Td 50.771605 Tz (the ) Tj ET Q endstream endobj 147 0 obj << /Length 1 >> stream q endstream endobj 148 0 obj << /Length 47623 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.113514 0 Td 77.252252 Tz (29 ) Tj 51.428571 0 0 51.428571 0 2919.819188 Tm 6.280556 0 Td 48.206019 Tz (strength ) Tj 2.508333 0 Td 50.636574 Tz (required ) Tj 2.586111 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 46.180556 Tz (pull ) Tj 1.302778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 52.777778 Tz (implant ) Tj 2.372222 0 Td 48.070988 Tz (alloys ) Tj 1.905556 0 Td 44.830247 Tz (apart. ) Tj 1.808333 0 Td 49.691358 Tz (All ) Tj 1.069444 0 Td 57.253086 Tz (experi ) Tj 51.428571 0 0 51.428571 0 2876.969267 Tm 6.261111 0 Td 57.685185 Tz (ments ) Tj 1.963889 0 Td 50.771605 Tz (are ) Tj 1.127778 0 Td 56.532922 Tz (performed ) Tj 3.305556 0 Td 53.472222 Tz (with ) Tj 1.555556 0 Td 51.851852 Tz (na5. ) Tj 51.428571 0 0 51.428571 0 2838.391574 Tm 7 0 Td 61.574074 Tz (To ) Tj 0.913889 0 Td 54.012346 Tz (determine ) Tj 3.072222 0 Td 53.472222 Tz (adhesive ) Tj 2.722222 0 Td 46.450617 Tz (strength, ) Tj 2.683333 0 Td 47.530864 Tz (six ) Tj 1.030556 0 Td 56.712963 Tz (specimen ) Tj 2.916667 0 Td 46.990741 Tz (replications ) Tj 40 0 0 40 0 2803 Tm 8.05 0 Td 75 Tz (from ) Tj 2.025 0 Td 52.777778 Tz (all ) Tj 1.175 0 Td 65.104167 Tz (chitosan ) Tj 3.425 0 Td 60.416667 Tz (film ) Tj 1.7 0 Td 61.25 Tz (variations ) Tj 3.9 0 Td 66.666667 Tz (are ) Tj 1.4 0 Td 65.277778 Tz (cut ) Tj 1.4 0 Td 59.375 Tz (into ) Tj 1.75 0 Td 72.619048 Tz (minimal ) Tj 3.275 0 Td 80 Tz (38x38 ) Tj 51.428571 0 0 51.428571 0 2757.955345 Tm 6.261111 0 Td 92.361111 Tz (mm ) Tj 1.477778 0 Td 50.925926 Tz (squares ) Tj 2.527778 0 Td 53.148148 Tz (Films ) Tj 1.905556 0 Td 50.771605 Tz (are ) Tj 1.244444 0 Td 51.041667 Tz (then ) Tj 1.575 0 Td 58.693416 Tz (submerged ) Tj 3.5 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 63.194444 Tz (50 ) Tj 1.069444 0 Td 61.574074 Tz (ml ) Tj 1.069444 0 Td 59.953704 Tz (of ) Tj 0.972222 0 Td 68.055556 Tz (PBS ) Tj 1.847222 0 Td 38.888889 Tz (s ) Tj 51.428571 0 0 51.428571 0 2717.209177 Tm 6.280556 0 Td 48.206019 Tz (Solution ) Tj 2.586111 0 Td 48.611111 Tz (for ) Tj 1.166667 0 Td 32.407407 Tz (1 ) Tj 0.583333 0 Td 52.662037 Tz (min, ) Tj 1.536111 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 51.851852 Tz (order ) Tj 1.769444 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 51.446759 Tz (simulate ) Tj 2.683333 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 42.12963 Tz (situ ) Tj 1.302778 0 Td 51.851852 Tz (loading ) Tj 51.428571 0 0 51.428571 0 2680.635697 Tm 6.261111 0 Td 51.527778 Tz (procedure, ) Tj 3.305556 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 52.662037 Tz (then ) Tj 1.497222 0 Td 50.87963 Tz (positioned ) Tj 3.247222 0 Td 57.87037 Tz (between ) Tj 2.702778 0 Td 46.548822 Tz (cylindrical ) Tj 3.305556 0 Td 56.17284 Tz (fix ) Tj 40 0 0 40 0 2645 Tm 8.025 0 Td 60.833333 Tz (tures ) Tj 2.15 0 Td 67.708333 Tz (with ) Tj 1.95 0 Td 70.833333 Tz (a ) Tj 0.7 0 Td 69.270833 Tz (diameter ) Tj 3.575 0 Td 75 Tz (of ) Tj 1.075 0 Td 64.583333 Tz (35.1 ) Tj 1.95 0 Td 116.666667 Tz (mm ) Tj 1.75 0 Td 58.333333 Tz (to ) Tj 1.025 0 Td 54.166667 Tz (facilitate ) Tj 3.55 0 Td 63.888889 Tz (the ) Tj 1.425 0 Td 70.3125 Tz (adhesion ) Tj 51.428571 0 0 51.428571 0 2597.960384 Tm 6.241667 0 Td 40.185185 Tz (test. ) Tj 1.341667 0 Td 64.814815 Tz (The ) Tj 1.302778 0 Td 54.282407 Tz (adhesion ) Tj 2.780556 0 Td 46.296296 Tz (testing ) Tj 2.1 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 59.722222 Tz (modeled ) Tj 2.663889 0 Td 57.523148 Tz (from ) Tj 1.536111 0 Td 84.259259 Tz (ASTM ) Tj 2.216667 0 Td 60.763889 Tz (D5179-02 ) Tj 51.428571 0 0 51.428571 0 2559.604087 Tm 6.261111 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 51.851852 Tz (order ) Tj 1.788889 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 56.532922 Tz (performed ) Tj 3.325 0 Td 48.971193 Tz (in-house. ) Tj 2.994444 0 Td 55.902778 Tz (Both ) Tj 1.633333 0 Td 48.611111 Tz (Instron ) Tj 2.333333 0 Td 51.851852 Tz (Universal ) Tj 51.428571 0 0 51.428571 0 2521.304786 Tm 6.261111 0 Td 51.388889 Tz (Testing ) Tj 2.411111 0 Td 60.185185 Tz (Machine ) Tj 2.761111 0 Td 51.131687 Tz (hydraulic ) Tj 3.013889 0 Td 48.611111 Tz (grips ) Tj 1.730556 0 Td 58.333333 Tz (were ) Tj 1.711111 0 Td 64.814815 Tz (made ) Tj 1.808333 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 55.092593 Tz (hold ) Tj 1.555556 0 Td 47.530864 Tz (either ) Tj 51.428571 0 0 51.428571 0 2479.763321 Tm 6.261111 0 Td 64.00463 Tz (316L ) Tj 1.730556 0 Td 63.194444 Tz (SS ) Tj 0.972222 0 Td 75.833333 Tz (\(ASTM ) Tj 2.508333 0 Td 56.388889 Tz (F138\) ) Tj 1.905556 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 51.851852 Tz (Ti ) Tj 0.836111 0 Td 51.262626 Tz (\(Ti-6Al-4V, ) Tj 3.577778 0 Td 84.259259 Tz (ASTM ) Tj 2.255556 0 Td 53.472222 Tz (136\) ) Tj 1.438889 0 Td 49.907407 Tz (alloy ) Tj 40 0 0 40 0 2447 Tm 8.05 0 Td 55.555556 Tz (fixtures. ) Tj 3.325 0 Td 81.944444 Tz (The ) Tj 1.825 0 Td 70 Tz (mechanical ) Tj 4.525 0 Td 57.738095 Tz (fixture ) Tj 2.75 0 Td 63.541667 Tz (surfaces ) Tj 3.4 0 Td 75 Tz (which ) Tj 2.6 0 Td 67.5 Tz (faced ) Tj 2.325 0 Td 71.875 Tz (each ) Tj 52.857143 0 0 52.857143 0 2403.120301 Tm 6.091892 0 Td 49.81982 Tz (other ) Tj 1.683784 0 Td 57.545045 Tz (were ) Tj 1.627027 0 Td 57.150901 Tz (smoothed ) Tj 2.951351 0 Td 59.90991 Tz (by ) Tj 0.964865 0 Td 47.972973 Tz (Superfinishing ) Tj 4.237838 0 Td 44.144144 Tz (to ) Tj 0.775676 0 Td 50.45045 Tz (a ) Tj 0.567568 0 Td 50.45045 Tz (roughness, ) Tj 3.291892 0 Td 72.522523 Tz (R. ) Tj 51.428571 0 0 51.428571 0 2364.015094 Tm 6.261111 0 Td 53.148148 Tz (value ) Tj 1.808333 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 53.796296 Tz (0.025 ) Tj 1.886111 0 Td 58.333333 Tz (um. ) Tj 1.283333 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 49.074074 Tz (superfinishing ) Tj 4.336111 0 Td 61.574074 Tz (on ) Tj 0.991667 0 Td 47.530864 Tz (the ) Tj 1.127778 0 Td 45.833333 Tz (testing ) Tj 2.119444 0 Td 57.037037 Tz (cylin ) Tj 55.714286 0 0 55.714286 0 2326.196078 Tm 5.779487 0 Td 46.367521 Tz (ders ) Tj 1.346154 0 Td 35.897436 Tz (is ) Tj 0.682051 0 Td 50.854701 Tz (used ) Tj 1.417949 0 Td 41.880342 Tz (to ) Tj 0.753846 0 Td 48.717949 Tz (provide ) Tj 2.261538 0 Td 52.350427 Tz (comparison ) Tj 3.338462 0 Td 41.132479 Tz (testing, ) Tj 2.189744 0 Td 48.860399 Tz (not ) Tj 1.076923 0 Td 43.376068 Tz (to ) Tj 0.735897 0 Td 43.54226 Tz (replicate ) Tj 2.764103 0 Td 38.888889 Tz (15 ) Tj 51.428571 0 0 51.428571 0 2284.714988 Tm 6.241667 0 Td 47.685185 Tz (typical ) Tj 2.236111 0 Td 53.240741 Tz (implant ) Tj 2.469444 0 Td 47.170782 Tz (Surfaces. ) Tj 2.780556 0 Td 64.814815 Tz (The ) Tj 1.4 0 Td 51.851852 Tz (rehydrated ) Tj 3.344444 0 Td 50.231481 Tz (chitosan ) Tj 2.663889 0 Td 48.611111 Tz (films ) Tj 1.711111 0 Td 49.691358 Tz (are ) Tj 40 0 0 40 0 2250 Tm 8.075 0 Td 73.333333 Tz (sandwiched ) Tj 4.775 0 Td 73.809524 Tz (between ) Tj 3.525 0 Td 63.888889 Tz (the ) Tj 1.55 0 Td 76.388889 Tz (two ) Tj 1.825 0 Td 70 Tz (mechanical ) Tj 4.625 0 Td 57.8125 Tz (fixtures ) Tj 3.225 0 Td 66.666667 Tz (with ) Tj 2 0 Td 79.166667 Tz (an ) Tj 51.428571 0 0 51.428571 0 2206.864078 Tm 6.261111 0 Td 52.932099 Tz (automatic ) Tj 3.072222 0 Td 55.387205 Tz (compression ) Tj 3.869444 0 Td 51.041667 Tz (pre-load ) Tj 2.644444 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 53.472222 Tz (15 ) Tj 0.855556 0 Td 56.712963 Tz (N. ) Tj 0.933333 0 Td 55.092593 Tz (Immediately ) Tj 3.85 0 Td 46.018519 Tz (after ) Tj 51.428571 0 0 51.428571 0 2165.652796 Tm 6.261111 0 Td 52.256944 Tz (reaching ) Tj 2.858333 0 Td 50.771605 Tz (the ) Tj 1.244444 0 Td 51.041667 Tz (pre-load ) Tj 2.819444 0 Td 45.910494 Tz (force, ) Tj 2.022222 0 Td 48.611111 Tz (the ) Tj 1.263889 0 Td 60.185185 Tz (movable ) Tj 2.858333 0 Td 52.175926 Tz (crossheads ) Tj 3.519444 0 Td 49.691358 Tz (are ) Tj 40 0 0 40 0 2131 Tm 8.05 0 Td 65.625 Tz (reversed ) Tj 3.375 0 Td 58.333333 Tz (at ) Tj 0.95 0 Td 79.166667 Tz (50 ) Tj 1.175 0 Td 86.805556 Tz (mm/min ) Tj 3.35 0 Td 68.75 Tz (with ) Tj 1.925 0 Td 64.583333 Tz (data ) Tj 1.75 0 Td 68.229167 Tz (recorded ) Tj 3.475 0 Td 60.416667 Tz (at ) Tj 0.925 0 Td 81.25 Tz (30 ) Tj 1.225 0 Td 65.530303 Tz (millisecond ) Tj 4.875 0 Td 60.416667 Tz (20 ) Tj 40 0 0 40 0 2092 Tm 8.05 0 Td 57.083333 Tz (intervals. ) Tj 3.925 0 Td 69.791667 Tz (Film ) Tj 2.125 0 Td 64.351852 Tz (thickness ) Tj 3.9 0 Td 64.583333 Tz (varied ) Tj 2.725 0 Td 58.333333 Tz (at ) Tj 1.1 0 Td 82.738095 Tz (0.18+08 ) Tj 3.925 0 Td 118.75 Tz (mm ) Tj 1.85 0 Td 75 Tz (and ) Tj 1.775 0 Td 63.888889 Tz (the ) Tj 51.428571 0 0 51.428571 0 2045.767196 Tm 6.280556 0 Td 51.851852 Tz (Software ) Tj 2.780556 0 Td 57.523148 Tz (gave ) Tj 1.672222 0 Td 49.421296 Tz (data ) Tj 1.497222 0 Td 51.851852 Tz (output ) Tj 2.158333 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 59.722222 Tz (maximal ) Tj 2.8 0 Td 49.907407 Tz (force ) Tj 1.788889 0 Td 54.012346 Tz (\(N\) ) Tj 1.302778 0 Td 58.981481 Tz (which ) Tj 2.061111 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2007.432161 Tm 6.261111 0 Td 53.292181 Tz (converted ) Tj 3.15 0 Td 46.990741 Tz (into ) Tj 1.4 0 Td 53.472222 Tz (adhesive ) Tj 2.838889 0 Td 48.611111 Tz (strength ) Tj 2.644444 0 Td 47.530864 Tz (\(kPa\). ) Tj 1.983333 0 Td 56.481481 Tz (Tukey's ) Tj 2.683333 0 Td 79.938272 Tz (HSD ) Tj 1.711111 0 Td 58.333333 Tz (sta ) Tj 51.428571 0 0 51.428571 0 1967.950732 Tm 6.241667 0 Td 40.509259 Tz (tistical ) Tj 2.333333 0 Td 48.611111 Tz (analysis ) Tj 2.780556 0 Td 37.268519 Tz (is ) Tj 0.836111 0 Td 56.532922 Tz (performed ) Tj 3.461111 0 Td 52.662037 Tz (with ) Tj 1.691667 0 Td 50 Tz (CL=0.05 ) Tj 2.527778 0 Td 46.990741 Tz (to ) Tj 0.972222 0 Td 53.652263 Tz (determine ) Tj 38.333333 0 0 38.333333 0 1933.538922 Tm 8.426087 0 Td 55.335968 Tz (statistical ) Tj 4.017391 0 Td 64.031621 Tz (differences ) Tj 4.565217 0 Td 77.018634 Tz (between ) Tj 3.6 0 Td 63.043478 Tz (film ) Tj 1.878261 0 Td 61.660079 Tz (variations. ) Tj 9.93913 0 Td 60.869565 Tz (25 ) Tj 51.428571 0 0 51.428571 0 1890.740741 Tm 6.261111 0 Td 53.472222 Tz (Chitosan ) Tj 2.858333 0 Td 51.851852 Tz (Degradation. ) Tj 51.428571 0 0 51.428571 0 1848.544757 Tm 7 0 Td 87.5 Tz (A ) Tj 0.7 0 Td 53.06713 Tz (modified ) Tj 2.702778 0 Td 54.372428 Tz (procedure ) Tj 3.111111 0 Td 54.73251 Tz (\(Tomihata ) Tj 3.15 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 48.611111 Tz (Ikada, ) Tj 1.983333 0 Td 55.092593 Tz (1997\) ) Tj 1.847222 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 55.902778 Tz (used ) Tj 51.428571 0 0 51.428571 0 1810.08 Tm 6.241667 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 49.826389 Tz (quantify ) Tj 2.644444 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 45.694444 Tz (antibiotic ) Tj 2.975 0 Td 45.37037 Tz (effect ) Tj 1.847222 0 Td 59.953704 Tz (on ) Tj 0.972222 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 49.96142 Tz (degradation. ) Tj 3.888889 0 Td 50.231481 Tz (In ) Tj 51.428571 0 0 51.428571 0 1769.77458 Tm 6.280556 0 Td 42.12963 Tz (situ ) Tj 1.205556 0 Td 54.012346 Tz (loaded ) Tj 2.080556 0 Td 60.493827 Tz (and ) Tj 1.283333 0 Td 54.12037 Tz (non-loaded ) Tj 3.422222 0 Td 49.421296 Tz (chitosan ) Tj 2.586111 0 Td 47.962963 Tz (films ) Tj 1.613889 0 Td 59.953704 Tz (groupsthe ) Tj 3.752778 0 Td 63.194444 Tz (same ) Tj 51.428571 0 0 51.428571 0 1731.342037 Tm 6.261111 0 Td 54.552469 Tz (groups ) Tj 2.313889 0 Td 55.902778 Tz (used ) Tj 1.672222 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 45.694444 Tz (antibiotic ) Tj 3.052778 0 Td 48.611111 Tz (elution ) Tj 2.352778 0 Td 60.493827 Tz (and ) Tj 1.4 0 Td 45.37037 Tz (activity ) Tj 2.488889 0 Td 57.79321 Tz (experi ) Tj 51.428571 0 0 51.428571 0 1691.119403 Tm 6.261111 0 Td 57.685185 Tz (ments ) Tj 1.983333 0 Td 54.282407 Tz (with ) Tj 1.536111 0 Td 47.962963 Tz (additional ) Tj 3.15 0 Td 54.444444 Tz (non-loaded ) Tj 3.480556 0 Td 55.092593 Tz (groups ) Tj 2.236111 0 Td 51.388889 Tz (yielded ) Tj 2.391667 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 43.425926 Tz (total ) Tj 1.555556 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1653.728745 Tm 6.338889 0 Td 53.472222 Tz (12 ) Tj 1.011111 0 Td 52.391975 Tz (experimental ) Tj 4.141667 0 Td 55.092593 Tz (groups ) Tj 2.352778 0 Td 45.37037 Tz (to ) Tj 0.913889 0 Td 55.092593 Tz (be ) Tj 1.030556 0 Td 46.990741 Tz (tested ) Tj 2.061111 0 Td 53.472222 Tz (with ) Tj 1.672222 0 Td 44.560185 Tz (five ) Tj 1.438889 0 Td 46.018519 Tz (replicates ) Tj 51.428571 0 0 51.428571 0 1614.26 Tm 6.261111 0 Td 61.574074 Tz (eachare ) Tj 3.247222 0 Td 50.771605 Tz (subjected ) Tj 2.994444 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 51.557239 Tz (degradation ) Tj 3.694444 0 Td 43.75 Tz (testing. ) Tj 2.391667 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 55.092593 Tz (weight ) Tj 2.275 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1570.621622 Tm 6.261111 0 Td 49.907407 Tz (clean ) Tj 1.711111 0 Td 64.814815 Tz (90 ) Tj 0.991667 0 Td 89.12037 Tz (mm ) Tj 1.322222 0 Td 53.472222 Tz (diameter ) Tj 2.741667 0 Td 45.37037 Tz (Petri ) Tj 1.555556 0 Td 50.231481 Tz (dishes ) Tj 2.022222 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 53.472222 Tz (dehydrated ) Tj 3.402778 0 Td 51.446759 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 1531.182423 Tm 6.261111 0 Td 47.962963 Tz (films ) Tj 1.788889 0 Td 37.268519 Tz (is ) Tj 0.758333 0 Td 46.990741 Tz (established. ) Tj 3.733333 0 Td 54.444444 Tz (Films ) Tj 1.983333 0 Td 59.953704 Tz (marked ) Tj 2.45 0 Td 48.611111 Tz (for ) Tj 1.147222 0 Td 46.990741 Tz (in ) Tj 0.875 0 Td 42.939815 Tz (situ ) Tj 1.380556 0 Td 51.388889 Tz (loading ) Tj 2.45 0 Td 50.771605 Tz (are ) Tj 54.285714 0 0 54.285714 0 1491.654822 Tm 5.95 0 Td 55.604288 Tz (submerged ) Tj 3.278947 0 Td 42.982456 Tz (in ) Tj 0.828947 0 Td 58.333333 Tz (50 ) Tj 0.976316 0 Td 56.798246 Tz (ml ) Tj 0.994737 0 Td 56.798246 Tz (of ) Tj 0.865789 0 Td 49.122807 Tz (a ) Tj 0.589474 0 Td 48.739035 Tz (standard ) Tj 2.597368 0 Td 43.289474 Tz (antibiotic ) Tj 2.892105 0 Td 45.66886 Tz (solution ) Tj 2.505263 0 Td 56.28655 Tz (and ) Tj 1.436842 0 Td 41.447368 Tz (35 ) Tj 51.428571 0 0 51.428571 0 1453.830946 Tm 6.241667 0 Td 52.662037 Tz (then ) Tj 1.613889 0 Td 39.969136 Tz (all ) Tj 1.088889 0 Td 47.314815 Tz (films ) Tj 1.769444 0 Td 49.691358 Tz (are ) Tj 1.244444 0 Td 58.693416 Tz (submerged ) Tj 3.519444 0 Td 45.37037 Tz (in ) Tj 0.913889 0 Td 56.712963 Tz (25 ) Tj 1.069444 0 Td 59.953704 Tz (ml ) Tj 1.069444 0 Td 61.574074 Tz (of ) Tj 1.05 0 Td 57.253086 Tz (100 ) Tj 1.4 0 Td 54.444444 Tz (ug/ml ) Tj 1.983333 0 Td 63.194444 Tz (2x ) Tj 51.428571 0 0 51.428571 0 1414.605232 Tm 6.261111 0 Td 45.37037 Tz (crystallized, ) Tj 3.713889 0 Td 53.703704 Tz (chicken ) Tj 2.430556 0 Td 58.333333 Tz (egg ) Tj 1.244444 0 Td 53.796296 Tz (white ) Tj 1.808333 0 Td 57.928241 Tz (lysozyme ) Tj 2.955556 0 Td 72.376543 Tz (\(MP ) Tj 1.497222 0 Td 52.932099 Tz (Biomedicals\) ) Tj 51.428571 0 0 51.428571 0 1371.189591 Tm 6.280556 0 Td 70.216049 Tz (PBS ) Tj 1.477778 0 Td 45.730453 Tz (solution. ) Tj 2.663889 0 Td 62.654321 Tz (The ) Tj 1.302778 0 Td 55.555556 Tz (samples ) Tj 2.508333 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 52.211934 Tz (incubated ) Tj 2.994444 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 61.574074 Tz (20 ) Tj 0.894444 0 Td 53.796296 Tz (hours ) Tj 1.788889 0 Td 45.37037 Tz (at ) Tj 0.680556 0 Td 56.17284 Tz (37 ) Tj 51.428571 0 0 51.428571 0 1329.03163 Tm 6.261111 0 Td 53.472222 Tz (C. ) Tj 0.855556 0 Td 43.75 Tz (in ) Tj 0.680556 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 53.148148 Tz (convection ) Tj 3.383333 0 Td 47.638889 Tz (incubator. ) Tj 3.013889 0 Td 51.851852 Tz (After ) Tj 1.672222 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.555556 Tz (incubation ) Tj 3.188889 0 Td 49.074074 Tz (period, ) Tj 2.236111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1289.979641 Tm 6.261111 0 Td 58.333333 Tz (lysozyme ) Tj 3.033333 0 Td 48.206019 Tz (solution ) Tj 2.566667 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 60.648148 Tz (removed ) Tj 2.761111 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 47.314815 Tz (films ) Tj 1.633333 0 Td 51.851852 Tz (are ) Tj 1.127778 0 Td 54.12037 Tz (dehydrated ) Tj 3.636111 0 Td 50.231481 Tz (40 ) Tj 51.428571 0 0 51.428571 0 1245.893733 Tm 6.241667 0 Td 53.148148 Tz (using ) Tj 1.983333 0 Td 50.771605 Tz (the ) Tj 1.302778 0 Td 63.194444 Tz (same ) Tj 1.925 0 Td 60.493827 Tz (method ) Tj 2.566667 0 Td 54.282407 Tz (with ) Tj 1.691667 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 52.5 Tz (convection ) Tj 3.577778 0 Td 52.5 Tz (oven. ) Tj 1.983333 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1207.827225 Tm 6.261111 0 Td 59.41358 Tz (lysozyme/PBS ) Tj 4.666667 0 Td 48.206019 Tz (solution ) Tj 2.702778 0 Td 37.268519 Tz (is ) Tj 0.836111 0 Td 51.041667 Tz (replaced ) Tj 2.8 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 47.800926 Tz (film ) Tj 1.555556 0 Td 53.240741 Tz (weights ) Tj 2.586111 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 1162.842105 Tm 6.261111 0 Td 58.333333 Tz (measured ) Tj 3.013889 0 Td 53.148148 Tz (every ) Tj 1.827778 0 Td 61.574074 Tz (20 ) Tj 0.933333 0 Td 54.444444 Tz (hours ) Tj 1.866667 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 43.425926 Tz (total ) Tj 1.497222 0 Td 59.953704 Tz (of ) Tj 0.913889 0 Td 58.333333 Tz (100 ) Tj 1.244444 0 Td 49.151235 Tz (hours. ) Tj 2.002778 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 65.895062 Tz (new ) Tj 51.428571 0 0 51.428571 0 1122.825822 Tm 6.261111 0 Td 47.800926 Tz (film ) Tj 1.380556 0 Td 53.240741 Tz (weights ) Tj 2.411111 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 54.73251 Tz (measured, ) Tj 3.130556 0 Td 58.981481 Tz (which ) Tj 1.944444 0 Td 54.62963 Tz (enabled ) Tj 2.488889 0 Td 51.557239 Tz (degradation ) Tj 3.597222 0 Td 45.37037 Tz (to ) Tj 0.719444 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 1081.826531 Tm 6.261111 0 Td 53.472222 Tz (expresseed ) Tj 3.519444 0 Td 48.611111 Tz (as ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.166667 0 Td 51.851852 Tz (percent ) Tj 2.488889 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 47.800926 Tz (film ) Tj 1.497222 0 Td 45.37037 Tz (that ) Tj 1.438889 0 Td 52.211934 Tz (remained. ) Tj 3.15 0 Td 63.734568 Tz (The ) Tj 1.536111 0 Td 48.611111 Tz (45 ) Tj 51.428571 0 0 51.428571 0 1038.922403 Tm 6.261111 0 Td 51.388889 Tz (percent ) Tj 2.391667 0 Td 55.092593 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.990741 Tz (film ) Tj 1.361111 0 Td 46.990741 Tz (that ) Tj 1.322222 0 Td 56.712963 Tz (remained ) Tj 2.936111 0 Td 62.654321 Tz (was ) Tj 1.361111 0 Td 54.12037 Tz (determined ) Tj 3.5 0 Td 52.5 Tz (using ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1000.769045 Tm 6.261111 0 Td 52.572016 Tz (following ) Tj 3.111111 0 Td 46.118234 Tz (relationship: ) Tj 3.908333 0 Td 51.388889 Tz (Percent ) Tj 2.45 0 Td 58.333333 Tz (Remaining ) Tj 3.422222 0 Td 51.527778 Tz (\(%\)=\(Petri ) Tj 3.363889 0 Td 51.851852 Tz (dish ) Tj 51.428571 0 0 51.428571 0 957.938303 Tm 6.261111 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 47.800926 Tz (film ) Tj 1.458333 0 Td 55.632716 Tz (weight ) Tj 2.255556 0 Td 46.990741 Tz (at ) Tj 0.836111 0 Td 58.333333 Tz (x ) Tj 0.641667 0 Td 51.262626 Tz (hours-Petri ) Tj 3.694444 0 Td 49.421296 Tz (dish ) Tj 1.516667 0 Td 52.777778 Tz (weight\) ) Tj 2.488889 0 Td 48.905724 Tz (\(mg\)/\(Petri ) Tj 51.428571 0 0 51.428571 0 916.718471 Tm 6.261111 0 Td 49.421296 Tz (dish ) Tj 1.458333 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 39.814815 Tz (initial ) Tj 1.925 0 Td 47.800926 Tz (film ) Tj 1.419444 0 Td 52.121914 Tz (weight-Petri ) Tj 3.986111 0 Td 50.231481 Tz (dish ) Tj 1.477778 0 Td 52.777778 Tz (weight\) ) Tj 2.469444 0 Td 56.17284 Tz (\(mg\)x100. ) Tj 44.285714 0 0 44.285714 0 875.55082 Tm 7.293548 0 Td 49.951124 Tz (Statistical ) Tj 3.567742 0 Td 61.155914 Tz (Analysis ) Tj 17.206452 0 Td 54.569892 Tz (50 ) Tj 51.428571 0 0 51.428571 0 830.338731 Tm 7.019444 0 Td 56.712963 Tz (Data ) Tj 1.672222 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 50.231481 Tz (reported ) Tj 2.702778 0 Td 50.231481 Tz (as ) Tj 0.933333 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 56.339031 Tz (meantstandard ) Tj 4.725 0 Td 47.314815 Tz (deviation. ) Tj 3.188889 0 Td 79.938272 Tz (One ) Tj 51.428571 0 0 51.428571 0 792.840336 Tm 6.241667 0 Td 68.055556 Tz (way ) Tj 1.361111 0 Td 83.611111 Tz (ANOVA ) Tj 2.683333 0 Td 62.654321 Tz (was ) Tj 1.283333 0 Td 55.902778 Tz (used ) Tj 1.516667 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 53.703704 Tz (analyze ) Tj 2.411111 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 42.12963 Tz (statistically ) Tj 3.480556 0 Td 45.959596 Tz (significant ) Tj 51.428571 0 0 51.428571 0 749.136309 Tm 6.261111 0 Td 46.450617 Tz (differences. ) Tj 3.616667 0 Td 46.990741 Tz (If ) Tj 0.7 0 Td 42.12963 Tz (statistically ) Tj 3.519444 0 Td 45.959596 Tz (significant ) Tj 3.266667 0 Td 47.727273 Tz (differences ) Tj 3.383333 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 51.311728 Tz (found, ) Tj 51.428571 0 0 51.428571 0 707.955414 Tm 6.241667 0 Td 52.662037 Tz (then ) Tj 1.516667 0 Td 55.902778 Tz (each ) Tj 1.575 0 Td 49.421296 Tz (pair ) Tj 1.438889 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 47.314815 Tz (variations ) Tj 3.130556 0 Td 58.333333 Tz (were ) Tj 1.652778 0 Td 59.953704 Tz (compared ) Tj 3.130556 0 Td 52.5 Tz (using ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 65.895062 Tz (Stu ) Tj 51.428571 0 0 51.428571 0 665.474419 Tm 6.261111 0 Td 52.662037 Tz (dent ) Tj 1.477778 0 Td 37.962963 Tz (t-test. ) Tj 1.827778 0 Td 50.378788 Tz (Differences ) Tj 3.538889 0 Td 57.407407 Tz (between ) Tj 2.605556 0 Td 50.636574 Tz (chitosan ) Tj 2.644444 0 Td 54.208754 Tz (composition ) Tj 3.791667 0 Td 53.148148 Tz (prop- ) Tj 2.041667 0 Td 43.75 Tz (55 ) Tj 51.428571 0 0 51.428571 0 621.851948 Tm 6.261111 0 Td 43.75 Tz (erties ) Tj 1.866667 0 Td 49.691358 Tz (are ) Tj 1.225 0 Td 54.12037 Tz (determined ) Tj 3.538889 0 Td 53.148148 Tz (using ) Tj 1.886111 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 52.777778 Tz (Student ) Tj 2.527778 0 Td 39.969136 Tz (t-test ) Tj 1.75 0 Td 52.662037 Tz (with ) Tj 1.613889 0 Td 61.574074 Tz (Bonff ) Tj 51.428571 0 0 51.428571 0 582.763441 Tm 6.261111 0 Td 49.259259 Tz (eroni ) Tj 1.925 0 Td 47.138047 Tz (correction. ) Tj 3.538889 0 Td 65.277778 Tz (Two-way ) Tj 3.15 0 Td 84.259259 Tz (ANOVA ) Tj 2.916667 0 Td 38.888889 Tz (is ) Tj 0.913889 0 Td 55.902778 Tz (used ) Tj 1.769444 0 Td 45.37037 Tz (to ) Tj 1.011111 0 Td 46.990741 Tz (identify ) Tj 51.428571 0 0 51.428571 0 541.606318 Tm 6.261111 0 Td 48.021886 Tz (differences ) Tj 3.402778 0 Td 57.407407 Tz (between ) Tj 2.683333 0 Td 53.619529 Tz (independent ) Tj 3.791667 0 Td 45.694444 Tz (variables. ) Tj 2.975 0 Td 52.256944 Tz (Analysis ) Tj 2.741667 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 64.814815 Tz (per ) Tj 51.428571 0 0 51.428571 0 499.773869 Tm 6.261111 0 Td 58.333333 Tz (formed ) Tj 2.333333 0 Td 52.5 Tz (using ) Tj 1.769444 0 Td 76.697531 Tz (JMP ) Tj 1.555556 0 Td 45.37037 Tz (7.0.1 ) Tj 1.691667 0 Td 48.611111 Tz (\(Cary, ) Tj 2.022222 0 Td 55.092593 Tz (N. ) Tj 0.933333 0 Td 48.611111 Tz (Dak.\). ) Tj 2.002778 0 Td 43.308081 Tz (Statistical ) Tj 3.111111 0 Td 48.611111 Tz (signifi ) Tj 51.428571 0 0 51.428571 0 458.944654 Tm 6.261111 0 Td 55.092593 Tz (cance ) Tj 2.080556 0 Td 52.391975 Tz (occurs ) Tj 2.313889 0 Td 64.00463 Tz (when ) Tj 1.983333 0 Td 52.777778 Tz (p-0.05. ) Tj 2.625 0 Td 56.481481 Tz (Tukey's ) Tj 2.8 0 Td 53.240741 Tz (honest ) Tj 2.644444 0 Td 45.959596 Tz (significant ) Tj 3.5 0 Td 43.75 Tz (60 ) Tj 51.428571 0 0 51.428571 0 414 Tm 6.261111 0 Td 48.611111 Tz (difference ) Tj 3.461111 0 Td 64.814815 Tz (\(HSD\) ) Tj 2.197222 0 Td 53.796296 Tz (could ) Tj 1.847222 0 Td 48.611111 Tz (also ) Tj 1.419444 0 Td 58.333333 Tz (be ) Tj 0.933333 0 Td 49.259259 Tz (used. ) Tj 38.571429 0 0 38.571429 0 343 Tm 14.648148 0 Td 108.024691 Tz (OTHER ) Tj 3.62963 0 Td 106.453423 Tz (EMBODIMENTS ) Tj 51.428571 0 0 51.428571 0 255.655484 Tm 7.019444 0 Td 63.194444 Tz (From ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 52.211934 Tz (foregoing ) Tj 3.111111 0 Td 47.260802 Tz (description, ) Tj 3.694444 0 Td 34.027778 Tz (it ) Tj 0.661111 0 Td 46.990741 Tz (will ) Tj 1.419444 0 Td 56.712963 Tz (be ) Tj 0.933333 0 Td 53.06713 Tz (apparent ) Tj 2.780556 0 Td 46.990741 Tz (that ) Tj 1.575 0 Td 43.75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 210.63 Tm 6.261111 0 Td 47.638889 Tz (variations ) Tj 3.091667 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 50.356125 Tz (modifications ) Tj 4.180556 0 Td 68.055556 Tz (may ) Tj 1.477778 0 Td 56.712963 Tz (be ) Tj 0.952778 0 Td 64.814815 Tz (made ) Tj 1.75 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 51.131687 Tz (invention ) Tj 51.428571 0 0 51.428571 0 169.776699 Tm 6.261111 0 Td 51.851852 Tz (described ) Tj 2.936111 0 Td 50.231481 Tz (herein ) Tj 1.963889 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 54.444444 Tz (adopt ) Tj 1.788889 0 Td 34.027778 Tz (it ) Tj 0.544444 0 Td 45.37037 Tz (to ) Tj 0.758333 0 Td 49.537037 Tz (various ) Tj 2.255556 0 Td 53.472222 Tz (usages ) Tj 2.061111 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 48.021886 Tz (conditions. ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.540541 0 Td 77.252252 Tz (30 ) Tj 51.428571 0 0 51.428571 0 2913.848939 Tm 25.219444 0 Td 59.143519 Tz (Such ) Tj 1.652778 0 Td 59.217172 Tz (embodiments ) Tj 4.122222 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 49.421296 Tz (also ) Tj 1.419444 0 Td 51.311728 Tz (within ) Tj 2.080556 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 55.092593 Tz (scope ) Tj 1.866667 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 59.41358 Tz (follow ) Tj 51.428571 0 0 51.428571 0 2874.509804 Tm 25.2 0 Td 51.851852 Tz (ing ) Tj 1.186111 0 Td 48.611111 Tz (claims. ) Tj 51.428571 0 0 51.428571 0 2831.503218 Tm 25.919444 0 Td 63.734568 Tz (The ) Tj 1.341667 0 Td 45.37037 Tz (recitation ) Tj 2.897222 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 43.055556 Tz (listing ) Tj 1.963889 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 54.282407 Tz (elements ) Tj 2.8 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 57.253086 Tz (any ) Tj 1.263889 0 Td 46.018519 Tz (definition ) Tj 2.936111 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 2788.544554 Tm 25.2 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 48.611111 Tz (variable ) Tj 2.508333 0 Td 50.231481 Tz (herein ) Tj 2.041667 0 Td 49.826389 Tz (includes ) Tj 2.605556 0 Td 46.548822 Tz (definitions ) Tj 3.266667 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 44.560185 Tz (that ) Tj 1.283333 0 Td 48.611111 Tz (variable ) Tj 2.508333 0 Td 50.231481 Tz (as ) Tj 0.797222 0 Td 59.41358 Tz (any ) Tj 51.428571 0 0 51.428571 0 2747.851675 Tm 25.219444 0 Td 48.070988 Tz (single ) Tj 1.905556 0 Td 55.092593 Tz (element ) Tj 2.469444 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 54.79798 Tz (combination ) Tj 3.830556 0 Td 46.450617 Tz (\(or ) Tj 1.030556 0 Td 54.012346 Tz (Subcombination\) ) Tj 5.055556 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 43.75 Tz (listed ) Tj 40 0 0 40 0 2713 Tm 32.4 0 Td 65.277778 Tz (elements. ) Tj 3.85 0 Td 80.555556 Tz (The ) Tj 1.775 0 Td 58.333333 Tz (recitation ) Tj 3.85 0 Td 70.833333 Tz (of ) Tj 1.05 0 Td 72.916667 Tz (an ) Tj 1.2 0 Td 77.916667 Tz (embodiment ) Tj 4.975 0 Td 64.583333 Tz (herein ) Tj 2.65 0 Td 64.583333 Tz (includes ) Tj 51.428571 0 0 51.428571 0 2665.425743 Tm 25.180556 0 Td 46.990741 Tz (that ) Tj 1.341667 0 Td 60.601852 Tz (embodiment ) Tj 3.830556 0 Td 51.851852 Tz (as ) Tj 0.836111 0 Td 58.333333 Tz (any ) Tj 1.283333 0 Td 48.611111 Tz (single ) Tj 1.963889 0 Td 60.925926 Tz (embodiment ) Tj 3.888889 0 Td 50.231481 Tz (or ) Tj 0.816667 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 64.814815 Tz (combina ) Tj 51.428571 0 0 51.428571 0 2623.931034 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.4 0 Td 52.662037 Tz (with ) Tj 1.536111 0 Td 57.253086 Tz (any ) Tj 1.283333 0 Td 51.203704 Tz (other ) Tj 1.730556 0 Td 59.217172 Tz (embodiments ) Tj 4.161111 0 Td 53.472222 Tz (or ) Tj 0.855556 0 Td 49.421296 Tz (portions ) Tj 2.625 0 Td 46.180556 Tz (thereof. ) Tj 51.428571 0 0 51.428571 0 2584.751412 Tm 25.919444 0 Td 53.472222 Tz (This ) Tj 1.711111 0 Td 48.611111 Tz (application ) Tj 3.655556 0 Td 49.421296 Tz (includes ) Tj 2.819444 0 Td 49.074074 Tz (Subject ) Tj 2.469444 0 Td 51.851852 Tz (matter ) Tj 2.255556 0 Td 45.37037 Tz (that ) Tj 1.516667 0 Td 65.895062 Tz (may ) Tj 1.633333 0 Td 58.333333 Tz (be ) Tj 51.428571 0 0 51.428571 0 2540.13369 Tm 24.461111 0 Td 45.37037 Tz (O ) Tj 0.758333 0 Td 46.759259 Tz (related ) Tj 2.391667 0 Td 45.37037 Tz (to ) Tj 1.011111 0 Td 49.074074 Tz (subject ) Tj 2.527778 0 Td 51.311728 Tz (matter ) Tj 2.255556 0 Td 51.49177 Tz (described ) Tj 3.208333 0 Td 46.990741 Tz (in ) Tj 1.030556 0 Td 51.851852 Tz (U.S. ) Tj 1.75 0 Td 49.494949 Tz (Provisional ) Tj 51.428571 0 0 51.428571 0 2498.694344 Tm 25.2 0 Td 51.851852 Tz (Application ) Tj 3.675 0 Td 55.902778 Tz (Nos. ) Tj 1.613889 0 Td 52.146465 Tz (61/160,539, ) Tj 3.713889 0 Td 52.146465 Tz (61/171,805, ) Tj 3.675 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 52.146465 Tz (61/227,606, ) Tj 51.428571 0 0 51.428571 0 2458.686869 Tm 25.2 0 Td 50.231481 Tz (as ) Tj 0.836111 0 Td 51.851852 Tz (well ) Tj 1.438889 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 53.472222 Tz (U.S. ) Tj 1.516667 0 Td 45.37037 Tz (Utility ) Tj 2.1 0 Td 49.494949 Tz (application ) Tj 3.480556 0 Td 46.180556 Tz (Ser. ) Tj 1.361111 0 Td 57.253086 Tz (No. ) Tj 1.322222 0 Td 52.146465 Tz (13/256,585; ) Tj 3.675 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2416.234858 Tm 25.2 0 Td 45.910494 Tz (entire ) Tj 1.847222 0 Td 50.636574 Tz (contents ) Tj 2.663889 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 55.092593 Tz (each ) Tj 1.555556 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 58.981481 Tz (which ) Tj 2.002778 0 Td 49.691358 Tz (are ) Tj 1.127778 0 Td 50.771605 Tz (incorporated ) Tj 3.85 0 Td 50.771605 Tz (herein ) Tj 2.041667 0 Td 61.574074 Tz (by ) Tj 40 0 0 40 0 2381 Tm 32.375 0 Td 56.25 Tz (this ) Tj 1.7 0 Td 61.25 Tz (reference. ) Tj 51.428571 0 0 51.428571 0 2335.467532 Tm 25.919444 0 Td 51.851852 Tz (All ) Tj 1.166667 0 Td 49.074074 Tz (patents ) Tj 2.313889 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 49.151235 Tz (publications ) Tj 3.811111 0 Td 56.532922 Tz (mentioned ) Tj 3.305556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 42.939815 Tz (this ) Tj 1.302778 0 Td 51.131687 Tz (specifica ) Tj 51.428571 0 0 51.428571 0 2292.236025 Tm 25.180556 0 Td 46.990741 Tz (tion ) Tj 1.341667 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 50.231481 Tz (herein ) Tj 2.041667 0 Td 50.771605 Tz (incorporated ) Tj 3.85 0 Td 59.953704 Tz (by ) Tj 0.952778 0 Td 50.05144 Tz (reference ) Tj 2.877778 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 62.384259 Tz (same ) Tj 1.691667 0 Td 49.691358 Tz (extent ) Tj 51.428571 0 0 51.428571 0 2253.601017 Tm 25.2 0 Td 50.231481 Tz (as ) Tj 0.894444 0 Td 42.12963 Tz (if ) Tj 0.7 0 Td 54.282407 Tz (each ) Tj 1.613889 0 Td 53.619529 Tz (independent ) Tj 3.791667 0 Td 49.691358 Tz (patent ) Tj 2.061111 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 49.494949 Tz (publication ) Tj 3.577778 0 Td 61.574074 Tz (was ) Tj 1.4 0 Td 50.462963 Tz (specifi ) Tj 51.428571 0 0 51.428571 0 2210.858958 Tm 25.2 0 Td 46.666667 Tz (cally ) Tj 1.652778 0 Td 60.493827 Tz (and ) Tj 1.341667 0 Td 48.611111 Tz (individually ) Tj 3.772222 0 Td 49.691358 Tz (indicated ) Tj 2.955556 0 Td 43.75 Tz (to ) Tj 0.816667 0 Td 56.712963 Tz (be ) Tj 0.952778 0 Td 51.041667 Tz (incorporated ) Tj 3.927778 0 Td 59.953704 Tz (by ) Tj 1.011111 0 Td 57.253086 Tz (ref ) Tj 27.142857 0 0 27.142857 0 2173 Tm 47.821053 0 Td 159.649123 Tz (CCC. ) Tj 40 0 0 40 0 2090 Tm 33.325 0 Td 85.416667 Tz (What ) Tj 2.35 0 Td 50 Tz (is ) Tj 0.9 0 Td 71.428571 Tz (claimed ) Tj 3.325 0 Td 44.444444 Tz (is: ) Tj 51.428571 0 0 51.428571 0 2043.77261 Tm 25.938889 0 Td 42.12963 Tz (1. ) Tj 0.7 0 Td 87.5 Tz (A ) Tj 0.738889 0 Td 59.953704 Tz (method ) Tj 2.372222 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 54.73251 Tz (producing ) Tj 3.15 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 53.098291 Tz (biodegradable ) Tj 4.375 0 Td 49.826389 Tz (chitosan ) Tj 2.644444 0 Td 47.800926 Tz (film ) Tj 51.428571 0 0 51.428571 0 2003.779661 Tm 25.2 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 52.777778 Tz (sponge, ) Tj 2.430556 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 59.41358 Tz (method ) Tj 2.391667 0 Td 54.444444 Tz (comprising ) Tj 51.428571 0 0 51.428571 0 1958.696306 Tm 25.938889 0 Td 43.209877 Tz (\(a\) ) Tj 1.030556 0 Td 50.231481 Tz (dissolving ) Tj 3.266667 0 Td 49.826389 Tz (chitosan ) Tj 2.663889 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 47.530864 Tz (3:1 ) Tj 1.205556 0 Td 43.425926 Tz (ratio ) Tj 1.575 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 42.669753 Tz (lactic ) Tj 1.788889 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 46.990741 Tz (acetic ) Tj 48.571429 0 0 48.571429 0 1917 Tm 28.226471 0 Td 53.186275 Tz (acid ) Tj 1.544118 0 Td 49.183007 Tz (solution; ) Tj 51.428571 0 0 51.428571 0 1876.508371 Tm 25.938889 0 Td 46.450617 Tz (\(b\) ) Tj 1.341667 0 Td 55.555556 Tz (forming ) Tj 2.819444 0 Td 50.771605 Tz (the ) Tj 1.419444 0 Td 49.826389 Tz (chitosan ) Tj 2.916667 0 Td 46.180556 Tz (into ) Tj 1.613889 0 Td 55.092593 Tz (a ) Tj 0.816667 0 Td 50 Tz (desired ) Tj 2.586111 0 Td 55.740741 Tz (shape ) Tj 2.138889 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1835.833795 Tm 26.658333 0 Td 48.881173 Tz (lyophilizing ) Tj 3.791667 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (chitosan ) Tj 2.702778 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 57.523148 Tz (form ) Tj 1.652778 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 53.472222 Tz (dehydrated ) Tj 3.480556 0 Td 48.070988 Tz (acidic ) Tj 51.428571 0 0 51.428571 0 1795.870662 Tm 26.658333 0 Td 50.231481 Tz (chitosan ) Tj 2.683333 0 Td 52.121914 Tz (composition; ) Tj 51.428571 0 0 51.428571 0 1753.953342 Tm 25.938889 0 Td 43.209877 Tz (\(c\) ) Tj 1.030556 0 Td 48.070988 Tz (neutralizing ) Tj 3.655556 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 51.557239 Tz (dehydrated, ) Tj 3.597222 0 Td 49.151235 Tz (acidic ) Tj 1.983333 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 63.888889 Tz (composi ) Tj 51.428571 0 0 51.428571 0 1713.145275 Tm 26.638889 0 Td 46.990741 Tz (tion ) Tj 1.419444 0 Td 59.953704 Tz (by ) Tj 1.011111 0 Td 51.851852 Tz (hydrating ) Tj 3.072222 0 Td 35.648148 Tz (it ) Tj 0.680556 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 58.333333 Tz (an ) Tj 0.991667 0 Td 56.481481 Tz (aqueous ) Tj 2.663889 0 Td 58.873457 Tz (Sodium ) Tj 2.391667 0 Td 55.092593 Tz (hydroxide ) Tj 48.571429 0 0 48.571429 0 1668 Tm 28.247059 0 Td 48.801743 Tz (Solution; ) Tj 52.857143 0 0 52.857143 0 1626.169231 Tm 25.237838 0 Td 46.246246 Tz (\(d\) ) Tj 1.002703 0 Td 56.306306 Tz (washing ) Tj 2.554054 0 Td 49.399399 Tz (the ) Tj 1.078378 0 Td 48.873874 Tz (chitosan ) Tj 2.554054 0 Td 52.743653 Tz (composition ) Tj 3.689189 0 Td 45.720721 Tz (in ) Tj 0.756757 0 Td 52.972973 Tz (water ) Tj 1.721622 0 Td 50.45045 Tz (to ) Tj 0.832432 0 Td 58.333333 Tz (remove ) Tj 51.428571 0 0 51.428571 0 1584.331237 Tm 26.658333 0 Td 47.800926 Tz (residual ) Tj 2.527778 0 Td 48.070988 Tz (acidic ) Tj 1.983333 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 49.259259 Tz (basic ) Tj 1.711111 0 Td 50.05144 Tz (products; ) Tj 51.428571 0 0 51.428571 0 1543.133593 Tm 25.938889 0 Td 43.209877 Tz (\(e\) ) Tj 1.011111 0 Td 54.62963 Tz (soaking ) Tj 2.488889 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 54.208754 Tz (composition ) Tj 3.830556 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 48.611111 Tz (acetate ) Tj 2.255556 0 Td 49.151235 Tz (buffer ) Tj 51.428571 0 0 51.428571 0 1500.270588 Tm 26.677778 0 Td 47.800926 Tz (solution ) Tj 2.586111 0 Td 47.530864 Tz (for ) Tj 1.069444 0 Td 54.444444 Tz (about ) Tj 1.847222 0 Td 43.75 Tz (thirty ) Tj 1.866667 0 Td 51.041667 Tz (minutes; ) Tj 2.683333 0 Td 61.574074 Tz (and ) Tj 51.428571 0 0 51.428571 0 1461.338983 Tm 25.938889 0 Td 38.888889 Tz (\(f\) ) Tj 0.933333 0 Td 49.826389 Tz (freezing ) Tj 2.586111 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 48.611111 Tz (lyophilizing ) Tj 3.713889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 47.800926 Tz (film ) Tj 1.419444 0 Td 50.231481 Tz (or ) Tj 0.816667 0 Td 52.314815 Tz (sponge. ) Tj 51.428571 0 0 51.428571 0 1415.519041 Tm 25.919444 0 Td 43.75 Tz (2. ) Tj 0.816667 0 Td 62.654321 Tz (The ) Tj 1.438889 0 Td 59.41358 Tz (method ) Tj 2.411111 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 53.796296 Tz (claim ) Tj 1.944444 0 Td 42.12963 Tz (1, ) Tj 0.797222 0 Td 55.092593 Tz (wherein ) Tj 2.586111 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 49.691358 Tz (buffer ) Tj 2.022222 0 Td 51.851852 Tz (has ) Tj 1.244444 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 74.537037 Tz (pH ) Tj 40 0 0 40 0 1382 Tm 32.375 0 Td 74.404762 Tz (between ) Tj 3.45 0 Td 75 Tz (5 ) Tj 0.775 0 Td 76.388889 Tz (and ) Tj 1.675 0 Td 54.166667 Tz (6. ) Tj 48.571429 0 0 48.571429 0 1334 Tm 27.444118 0 Td 46.323529 Tz (3. ) Tj 0.844118 0 Td 67.48366 Tz (The ) Tj 1.544118 0 Td 62.908497 Tz (method ) Tj 2.552941 0 Td 60.04902 Tz (of ) Tj 0.905882 0 Td 56.960784 Tz (claim ) Tj 2.038235 0 Td 44.607843 Tz (1, ) Tj 0.844118 0 Td 58.333333 Tz (wherein ) Tj 2.758824 0 Td 52.614379 Tz (the ) Tj 1.214706 0 Td 53.186275 Tz (chitosan ) Tj 2.861765 0 Td 50.612745 Tz (film ) Tj 1.544118 0 Td 54.901961 Tz (or ) Tj 51.428571 0 0 51.428571 0 1292.076923 Tm 25.219444 0 Td 56.712963 Tz (sponge ) Tj 2.275 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 50.771605 Tz (dissolved ) Tj 2.975 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (acid ) Tj 1.438889 0 Td 49.016204 Tz (solution ) Tj 2.586111 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 55.092593 Tz (time ) Tj 1.555556 0 Td 49.016204 Tz (selected ) Tj 51.428571 0 0 51.428571 0 1251.77147 Tm 25.2 0 Td 58.333333 Tz (from ) Tj 1.730556 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 55.740741 Tz (group ) Tj 2.022222 0 Td 49.259259 Tz (consisting ) Tj 3.266667 0 Td 58.333333 Tz (of ) Tj 1.011111 0 Td 38.888889 Tz (1, ) Tj 0.797222 0 Td 45.37037 Tz (3, ) Tj 0.894444 0 Td 42.12963 Tz (5, ) Tj 0.913889 0 Td 46.450617 Tz (10, ) Tj 1.225 0 Td 47.530864 Tz (15, ) Tj 1.186111 0 Td 49.691358 Tz (30, ) Tj 1.225 0 Td 50.771605 Tz (45, ) Tj 1.263889 0 Td 58.333333 Tz (60 ) Tj 48.571429 0 0 48.571429 0 1210 Tm 26.723529 0 Td 53.186275 Tz (minutes, ) Tj 2.820588 0 Td 49.754902 Tz (3, ) Tj 0.864706 0 Td 46.323529 Tz (5, ) Tj 0.905882 0 Td 49.183007 Tz (10, ) Tj 1.111765 0 Td 64.052288 Tz (and ) Tj 1.461765 0 Td 58.333333 Tz (12 ) Tj 0.947059 0 Td 52.614379 Tz (hours. ) Tj 48.571429 0 0 48.571429 0 1168 Tm 27.444118 0 Td 46.323529 Tz (4. ) Tj 0.802941 0 Td 67.48366 Tz (The ) Tj 1.502941 0 Td 63.480392 Tz (method ) Tj 2.532353 0 Td 60.04902 Tz (of ) Tj 0.885294 0 Td 56.27451 Tz (claim ) Tj 1.997059 0 Td 44.607843 Tz (1, ) Tj 0.802941 0 Td 58.333333 Tz (wherein ) Tj 2.717647 0 Td 52.614379 Tz (the ) Tj 1.173529 0 Td 54.901961 Tz (acid ) Tj 1.585294 0 Td 50.612745 Tz (solution ) Tj 2.676471 0 Td 58.333333 Tz (has ) Tj 40 0 0 40 0 1132 Tm 32.4 0 Td 70.833333 Tz (a ) Tj 0.7 0 Td 65.384615 Tz (concentration ) Tj 5.4 0 Td 74.404762 Tz (between ) Tj 3.45 0 Td 70 Tz (about ) Tj 2.425 0 Td 66.666667 Tz (0.05 ) Tj 1.9 0 Td 76.388889 Tz (and ) Tj 1.675 0 Td 66.666667 Tz (2.0 ) Tj 1.525 0 Td 63.888889 Tz (molar. ) Tj 48.571429 0 0 48.571429 0 1085 Tm 27.444118 0 Td 48.039216 Tz (5. ) Tj 0.720588 0 Td 68.627451 Tz (The ) Tj 1.420588 0 Td 63.480392 Tz (method ) Tj 2.45 0 Td 61.764706 Tz (of ) Tj 0.823529 0 Td 55.588235 Tz (claim ) Tj 1.914706 0 Td 44.607843 Tz (1, ) Tj 0.720588 0 Td 58.333333 Tz (wherein ) Tj 2.655882 0 Td 58.333333 Tz (a ) Tj 0.514706 0 Td 54.901961 Tz (0.25 ) Tj 1.502941 0 Td 62.622549 Tz (Macetate ) Tj 3.191176 0 Td 51.470588 Tz (buffer ) Tj 40 0 0 40 0 1049 Tm 32.4 0 Td 50 Tz (is ) Tj 0.925 0 Td 64.166667 Tz (used. ) Tj 48.571429 0 0 48.571429 0 1002 Tm 27.464706 0 Td 42.892157 Tz (6. ) Tj 0.823529 0 Td 67.48366 Tz (The ) Tj 1.544118 0 Td 62.908497 Tz (method ) Tj 2.552941 0 Td 60.04902 Tz (of ) Tj 0.905882 0 Td 56.960784 Tz (claim ) Tj 2.038235 0 Td 44.607843 Tz (1, ) Tj 0.844118 0 Td 58.333333 Tz (wherein ) Tj 2.758824 0 Td 52.614379 Tz (the ) Tj 1.214706 0 Td 52.757353 Tz (chitosan ) Tj 2.861765 0 Td 50.612745 Tz (film ) Tj 1.544118 0 Td 54.901961 Tz (or ) Tj 51.428571 0 0 51.428571 0 960.887139 Tm 25.219444 0 Td 56.712963 Tz (sponge ) Tj 2.333333 0 Td 53.472222 Tz (degrades ) Tj 2.838889 0 Td 61.574074 Tz (by ) Tj 1.030556 0 Td 43.75 Tz (at ) Tj 0.836111 0 Td 44.074074 Tz (least ) Tj 1.594444 0 Td 54.444444 Tz (about ) Tj 1.905556 0 Td 62.384259 Tz (20%, ) Tj 1.769444 0 Td 63.194444 Tz (30%, ) Tj 1.847222 0 Td 61.574074 Tz (40%, ) Tj 1.769444 0 Td 62.384259 Tz (50%, ) Tj 51.428571 0 0 51.428571 0 918.948104 Tm 25.219444 0 Td 71.296296 Tz (60% ) Tj 1.536111 0 Td 55.092593 Tz (or ) Tj 0.913889 0 Td 60.763889 Tz (more ) Tj 1.711111 0 Td 42.12963 Tz (in ) Tj 0.816667 0 Td 51.851852 Tz (vivo ) Tj 1.497222 0 Td 46.990741 Tz (in ) Tj 0.797222 0 Td 55.092593 Tz (about ) Tj 1.963889 0 Td 49.421296 Tz (10-days. ) Tj 51.428571 0 0 51.428571 0 877.281124 Tm 25.919444 0 Td 43.75 Tz (7. ) Tj 0.777778 0 Td 63.734568 Tz (The ) Tj 1.419444 0 Td 60.493827 Tz (method ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 53.148148 Tz (claim ) Tj 1.905556 0 Td 42.12963 Tz (1, ) Tj 0.758333 0 Td 48.148148 Tz (further ) Tj 2.236111 0 Td 54.768519 Tz (comprising ) Tj 3.538889 0 Td 47.530864 Tz (\(g\) ) Tj 1.108333 0 Td 57.037037 Tz (incor ) Tj 51.428571 0 0 51.428571 0 834.261034 Tm 25.2 0 Td 50.636574 Tz (porating ) Tj 2.683333 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 46.8107 Tz (effective ) Tj 2.8 0 Td 61.033951 Tz (amount ) Tj 2.45 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 43.75 Tz (at ) Tj 0.797222 0 Td 44.722222 Tz (least ) Tj 1.613889 0 Td 57.253086 Tz (one ) Tj 1.283333 0 Td 44.506173 Tz (anti-bacterial, ) Tj 51.428571 0 0 51.428571 0 796.118906 Tm 25.2 0 Td 43.013468 Tz (anti-viral, ) Tj 3.013889 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 48.316498 Tz (anti-fungal ) Tj 3.363889 0 Td 53.148148 Tz (agent ) Tj 1.75 0 Td 46.990741 Tz (into ) Tj 1.283333 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.586111 0 Td 55.092593 Tz (composition ) Tj 51.428571 0 0 51.428571 0 752.724138 Tm 25.2 0 Td 45.37037 Tz (at ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 51.203704 Tz (point ) Tj 1.769444 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 46.018519 Tz (care. ) Tj 48.571429 0 0 48.571429 0 711 Tm 27.444118 0 Td 46.323529 Tz (8. ) Tj 0.844118 0 Td 67.48366 Tz (The ) Tj 1.544118 0 Td 62.908497 Tz (method ) Tj 2.552941 0 Td 60.04902 Tz (of ) Tj 0.905882 0 Td 56.960784 Tz (claim ) Tj 2.038235 0 Td 44.607843 Tz (1, ) Tj 0.844118 0 Td 58.333333 Tz (wherein ) Tj 2.758824 0 Td 52.614379 Tz (the ) Tj 1.214706 0 Td 53.186275 Tz (chitosan ) Tj 2.861765 0 Td 50.612745 Tz (film ) Tj 1.544118 0 Td 54.901961 Tz (or ) Tj 51.428571 0 0 51.428571 0 671.338235 Tm 25.219444 0 Td 56.712963 Tz (sponge ) Tj 2.275 0 Td 42.12963 Tz (is ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 66.111111 Tz (wound ) Tj 2.255556 0 Td 61.574074 Tz (management ) Tj 3.947222 0 Td 48.148148 Tz (device. ) Tj 51.428571 0 0 51.428571 0 627.00768 Tm 25.919444 0 Td 43.75 Tz (9. ) Tj 0.933333 0 Td 64.814815 Tz (The ) Tj 1.613889 0 Td 58.873457 Tz (method ) Tj 2.547222 0 Td 59.953704 Tz (of ) Tj 1.011111 0 Td 53.796296 Tz (claim ) Tj 2.041667 0 Td 45.37037 Tz (7, ) Tj 0.952778 0 Td 55.555556 Tz (wherein ) Tj 2.761111 0 Td 48.611111 Tz (the ) Tj 1.302778 0 Td 53.148148 Tz (agent ) Tj 2.002778 0 Td 38.888889 Tz (is ) Tj 0.894444 0 Td 58.333333 Tz (an ) Tj 40 0 0 40 0 592 Tm 32.4 0 Td 61.607143 Tz (antimicrobial. ) Tj 48.571429 0 0 48.571429 0 544 Tm 27.464706 0 Td 51.470588 Tz (10. ) Tj 1.132353 0 Td 67.48366 Tz (The ) Tj 1.441176 0 Td 63.480392 Tz (method ) Tj 2.491176 0 Td 58.333333 Tz (of ) Tj 0.823529 0 Td 56.960784 Tz (claim ) Tj 1.976471 0 Td 42.892157 Tz (1, ) Tj 0.761765 0 Td 58.333333 Tz (wherein ) Tj 2.635294 0 Td 49.754902 Tz (at ) Tj 0.802941 0 Td 46.666667 Tz (least ) Tj 1.605882 0 Td 56.960784 Tz (about ) Tj 1.894118 0 Td 53.75817 Tz (30, ) Tj 1.152941 0 Td 53.75817 Tz (40, ) Tj 51.428571 0 0 51.428571 0 503.875158 Tm 25.219444 0 Td 61.574074 Tz (50 ) Tj 0.913889 0 Td 55.092593 Tz (or ) Tj 0.875 0 Td 71.296296 Tz (60% ) Tj 1.497222 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (chitosan ) Tj 2.644444 0 Td 48.611111 Tz (film ) Tj 1.380556 0 Td 55.092593 Tz (or ) Tj 0.875 0 Td 56.712963 Tz (sponge ) Tj 2.255556 0 Td 53.030303 Tz (biodegrades ) Tj 3.733333 0 Td 55.902778 Tz (over ) Tj 51.428571 0 0 51.428571 0 462.367347 Tm 25.2 0 Td 45.37037 Tz (at ) Tj 0.758333 0 Td 45.37037 Tz (least ) Tj 1.555556 0 Td 55.092593 Tz (about ) Tj 1.866667 0 Td 46.990741 Tz (three-five ) Tj 3.052778 0 Td 55.092593 Tz (days ) Tj 1.575 0 Td 64.814815 Tz (when ) Tj 1.827778 0 Td 53.292181 Tz (implanted ) Tj 3.15 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 46.180556 Tz (subject. ) Tj 51.428571 0 0 51.428571 0 420.971129 Tm 25.958333 0 Td 45.37037 Tz (11. ) Tj 1.011111 0 Td 87.5 Tz (A ) Tj 0.661111 0 Td 50.636574 Tz (chitosan ) Tj 2.663889 0 Td 46.990741 Tz (film ) Tj 1.361111 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 56.712963 Tz (sponge ) Tj 2.236111 0 Td 56.712963 Tz (produced ) Tj 2.897222 0 Td 61.574074 Tz (by ) Tj 0.952778 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 59.953704 Tz (method ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 40 0 0 40 0 384 Tm 32.4 0 Td 68.333333 Tz (claim ) Tj 2.45 0 Td 50 Tz (1. ) Tj 51.428571 0 0 51.428571 0 338.735409 Tm 25.938889 0 Td 48.611111 Tz (12. ) Tj 1.127778 0 Td 84.259259 Tz (A ) Tj 0.738889 0 Td 65.462963 Tz (wound ) Tj 2.236111 0 Td 61.898148 Tz (management ) Tj 3.947222 0 Td 52.932099 Tz (device ) Tj 2.138889 0 Td 54.768519 Tz (comprising ) Tj 3.538889 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 50.636574 Tz (chitosan ) Tj 51.428571 0 0 51.428571 0 296.339233 Tm 25.2 0 Td 47.800926 Tz (film ) Tj 1.4 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 57.253086 Tz (sponge ) Tj 2.275 0 Td 56.712963 Tz (produced ) Tj 2.955556 0 Td 59.953704 Tz (by ) Tj 0.972222 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 61.033951 Tz (method ) Tj 2.391667 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 53.148148 Tz (claim ) Tj 1.886111 0 Td 40.509259 Tz (1. ) Tj 51.428571 0 0 51.428571 0 252.95122 Tm 25.958333 0 Td 48.611111 Tz (13. ) Tj 1.05 0 Td 64.814815 Tz (The ) Tj 1.380556 0 Td 65.462963 Tz (wound ) Tj 2.197222 0 Td 61.574074 Tz (management ) Tj 3.888889 0 Td 52.932099 Tz (device ) Tj 2.1 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 53.148148 Tz (claim ) Tj 1.827778 0 Td 48.611111 Tz (12, ) Tj 1.108333 0 Td 56.018519 Tz (wherein ) Tj 51.428571 0 0 51.428571 0 212.474128 Tm 25.180556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 49.826389 Tz (chitosan ) Tj 2.547222 0 Td 47.800926 Tz (film ) Tj 1.322222 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 57.253086 Tz (sponge ) Tj 2.216667 0 Td 54.372428 Tz (comprises ) Tj 3.091667 0 Td 56.712963 Tz (an ) Tj 0.836111 0 Td 46.450617 Tz (effective ) Tj 2.663889 0 Td 61.033951 Tz (amount ) Tj 2.352778 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 171.005917 Tm 25.2 0 Td 56.712963 Tz (an ) Tj 0.913889 0 Td 44.722222 Tz (anti-bacterial, ) Tj 4.258333 0 Td 43.308081 Tz (anti-viral, ) Tj 3.111111 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 48.316498 Tz (anti-fungal ) Tj 3.422222 0 Td 48.611111 Tz (agent. ) Tj ET Q endstream endobj 149 0 obj << /Length 1 >> stream q endstream endobj 150 0 obj << /Length 4795 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.181818 0 Td 83.522727 Tz (US ) Tj 1.256818 0 Td 59.511785 Tz (9,662,400 ) Tj 3.515909 0 Td 72.916667 Tz (B2 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 14.113514 0 Td 74.099099 Tz (31 ) Tj 51.428571 0 0 51.428571 0 2914.943445 Tm 7.038889 0 Td 46.450617 Tz (14. ) Tj 1.030556 0 Td 64.814815 Tz (The ) Tj 1.380556 0 Td 65.462963 Tz (wound ) Tj 2.197222 0 Td 61.25 Tz (management ) Tj 3.888889 0 Td 52.932099 Tz (device ) Tj 2.080556 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 53.148148 Tz (claim ) Tj 1.827778 0 Td 49.691358 Tz (13, ) Tj 1.108333 0 Td 56.481481 Tz (wherein ) Tj 51.428571 0 0 51.428571 0 2875.1644 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 53.148148 Tz (agent ) Tj 1.769444 0 Td 40.509259 Tz (is ) Tj 0.661111 0 Td 58.333333 Tz (an ) Tj 0.894444 0 Td 46.018519 Tz (antibiotic ) Tj 2.975 0 Td 48.611111 Tz (selected ) Tj 2.527778 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 56.388889 Tz (group ) Tj 1.925 0 Td 48.935185 Tz (consisting ) Tj 51.428571 0 0 51.428571 0 2834.907015 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 54.208754 Tz (daptomycin, ) Tj 3.830556 0 Td 56.565657 Tz (Vancomycin, ) Tj 3.986111 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 52.932099 Tz (amikacin. ) Tj 51.428571 0 0 51.428571 0 2789.891808 Tm 7.038889 0 Td 46.450617 Tz (15. ) Tj 1.341667 0 Td 87.5 Tz (A ) Tj 1.05 0 Td 59.41358 Tz (method ) Tj 2.644444 0 Td 48.611111 Tz (for ) Tj 1.380556 0 Td 46.180556 Tz (treating ) Tj 2.722222 0 Td 56.712963 Tz (an ) Tj 1.225 0 Td 47.530864 Tz (infection ) Tj 3.091667 0 Td 55.092593 Tz (caused ) Tj 2.488889 0 Td 63.194444 Tz (by ) Tj 51.428571 0 0 51.428571 0 2749.747475 Tm 6.261111 0 Td 60.690236 Tz (Pseudomonas ) Tj 4.277778 0 Td 53.796296 Tz (aeruginosa ) Tj 3.480556 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 42.12963 Tz (S. ) Tj 0.797222 0 Td 52.932099 Tz (aureus ) Tj 2.177778 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 49.074074 Tz (Subject ) Tj 2.255556 0 Td 45.37037 Tz (at ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 42.939815 Tz (site ) Tj 1.594444 0 Td 42.12963 Tz (5 ) Tj 51.428571 0 0 51.428571 0 2708.256281 Tm 6.261111 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 52.314815 Tz (trauma, ) Tj 2.430556 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 59.41358 Tz (method ) Tj 2.411111 0 Td 54.444444 Tz (comprising ) Tj 3.519444 0 Td 50.555556 Tz (contacting ) Tj 3.286111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 42.939815 Tz (site ) Tj 1.283333 0 Td 54.282407 Tz (with ) Tj 51.428571 0 0 51.428571 0 2666.550336 Tm 6.241667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 65.462963 Tz (wound ) Tj 2.236111 0 Td 61.574074 Tz (management ) Tj 3.927778 0 Td 52.932099 Tz (device ) Tj 2.158333 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 52.5 Tz (claim ) Tj 1.866667 0 Td 47.530864 Tz (12. ) Tj 51.428571 0 0 51.428571 0 2625.834446 Tm 7.019444 0 Td 47.530864 Tz (16. ) Tj 1.147222 0 Td 84.259259 Tz (A ) Tj 0.738889 0 Td 43.209877 Tz (kit ) Tj 1.069444 0 Td 54.444444 Tz (comprising ) Tj 3.519444 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 65.462963 Tz (wound ) Tj 2.255556 0 Td 61.898148 Tz (management ) Tj 4.005556 0 Td 52.391975 Tz (device ) Tj 2.177778 0 Td 56.712963 Tz (of ) Tj 40 0 0 40 0 2589 Tm 8.05 0 Td 68.333333 Tz (claim ) Tj 2.425 0 Td 61.111111 Tz (12. ) Tj 51.428571 0 0 51.428571 0 2540.312411 Tm 7.038889 0 Td 46.450617 Tz (17. ) Tj 1.225 0 Td 87.5 Tz (A ) Tj 0.894444 0 Td 60.493827 Tz (method ) Tj 2.566667 0 Td 48.611111 Tz (for ) Tj 1.244444 0 Td 46.585648 Tz (treating ) Tj 2.625 0 Td 55.092593 Tz (an ) Tj 1.108333 0 Td 47.170782 Tz (infection ) Tj 2.955556 0 Td 53.472222 Tz (with ) Tj 1.691667 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 68.865741 Tz (Gram ) Tj 2.158333 0 Td 43.75 Tz (10 ) Tj 51.428571 0 0 51.428571 0 2501.261501 Tm 6.261111 0 Td 48.206019 Tz (positive ) Tj 2.488889 0 Td 46.090535 Tz (bacteria, ) Tj 2.683333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 59.953704 Tz (method ) Tj 2.372222 0 Td 53.796296 Tz (comprising ) Tj 3.461111 0 Td 50.231481 Tz (contacting ) Tj 3.188889 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 42.939815 Tz (site ) Tj 51.428571 0 0 51.428571 0 2458.292609 Tm 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